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| 1 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 2 | Multilayer 3D Chirality and Its Synthetic Assembly显示文摘3D chirality of sandwich type of organic molecules has been discovered.Te key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane.Individual enantiomers of these molecules have been fully characterized by spectroscopies with their enantiomeric purity measured by chiral HPLC.Te absolute confguration was unambiguously assigned by X-ray difraction analysis.Tis is the frst multilayer 3D chirality reported and is anticipated to lead to a new research area of asymmetric synthesis and catalysis and to have a broad impact on chemical,medicinal,and material sciences in future. | Guanzhao Wu Yangxue Liu Zhen Yang Nandakumar Katakam Hossein Rouh Sultan Ahmed Daniel Unruh Kazimierz Surowiec Guigen Li | 2019 | Research2019，，1： | 3 |
| 3 | Multi-layer 3D chirality:new synthesis,AIE and computational studies显示文摘New synthesis of multi-layer 3 D chiral molecules has been developed under novel conditions to give better outcomes.The aggregation-induced emission(AIE),UV irradiation/excitation,charge transfer(CT)and local excited(LE)ππ*transitions have been investigated on a representative individual enantiomer of pseudo C_2 asymmetry which was made possibly by differentiating moieties on phosphorous on N-phosphonyl ring of chiral sandwich framework.Meanwhile,a new tandem C–N/C–C coupling reaction was unexpectedly rendered providing a novel access to special benzo[a]carbazoles. | Yangxue Liu Guanzhao Wu Zhen Yang Hossein Rouh Nandakumar Katakam Sultan Ahmed Daniel Unruh Zhonghua Cui Hans Lischka Guigen Li | 2020 | Science China Chemistry2020，63，5： | 1 |
| 4 | Gold nanoparticle amplified optical microfiber evanescent wave absorption biosensor for cancer biomarker detection in serum 显示文摘 | Kaiwei Li Guigen Liu Yihui Wu | 2014 | Talanta2014，120，： | 1 |
| 5 | Enantioselective assembly of multi-layer 3D chirality显示文摘The first enantioselective assembly of sandwich-shaped organo molecules has been achieved by conducting dual asymmetric Suzuki-Miyaura couplings and nine other reactions.This work also presents the first fully C-C anchored multi-layer 3D chirality with optically pure enantiomers.As confirmed by X-ray diffraction analysis that this chiral framework is featured by a unique C2-symmetry in which a nearly parallel fashion consisting of three layers:top,middle and bottom aromatic rings.Unlike the documented planar or axial chirality,the present chirality shows its top and bottom layers restrict each other from free rotation,i.e.,this multi-layer 3D chirality would not exist if either top or bottom layer is removed.Nearly all multi-layered compounds showed strong luminescence of different colors under UV irradiation,and several randomly selected samples displayed aggregation-induced emission(AIE)properties.This work is believed to have broad impacts on chemical,medicinal and material sciences including optoelectronic materials in future. | Guanzhao Wu Yangxue Liu Zhen Yang Tao Jiang Nandakumar Katakam Hossein Rouh Liulei Ma Yao Tang Sultan Ahmed Anis URahman Hongen Huang Daniel Unruh Guigen Li | 2020 | National Science Review2020，7，3： | 1 |
| 6 | Timing noise study of four pulsars显示文摘Analyzing up to ten years of pulsar timing data observed by the 25-m Nanshan telescope at Urumqi,China,we studied power spectra of timing residuals for four pulsars based on orthogonal polynomials.Our work reveals that an index of 4 is consistent with a power law model and reveals random walk noise in the rotating frequency.Stability with 8 is investigated and found to be consistent with previous results.A new method called the morphology filter is applied to denoise the pulsar timing residuals and to perform further spectrum analysis.The spectra obtained with this method are improved in accuracy compared with those from timing residuals of pulsars directly. | ZHANG CaiHong WANG Na YUAN JianPing LIU ZhiYong LIU JingNan NIE GuiGen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 0 |
| 7 | Highly efficient twin-field quantum key distribution with neural networks显示文摘Quantum key distribution(QKD)allows two legitimate parties,Alice and Bob,to share a series of random bits that are secured by the laws of quantum mechanics.As a remarkable theoretical progress towards longer distances. | Jingyang LIU Qingqing JIANG Huajian DING Xiao MA Mingshuo SUN Jiaxin XU Chun-Hui ZHANG Shipeng XIE Jian LI Guigen ZENG Xingyu ZHOU Qin WANG | 2023 | Science China(Information Sciences)2023，66，8： | 0 |
| 8 | Triple-Columned and Multiple-Layered 3D Polymers:Design,Synthesis,Aggregation-Induced Emission(AIE),and Computational Study显示文摘Conjugated polymers and oligomers have great potentials in various fields,especially in materials and biological sciences because of their intriguing electronic and optoelectronic properties.In recent years,the through-space conjugation system has emerged as a new assembled pattern of multidimensional polymers.Here,a novel series of structurally condensed multicolumn/multilayer 3D polymers and oligomers have been designed and synthesized through one-pot Suzuki polycondensation(SPC).The intramolecularly stacked arrangement of polymers can be supported by either X-ray structural analysis or computational analysis.In all cases,polymers were obtained with modest to good yields,as determined by GPC and 1 H-NMR.MALDI-TOF analysis has proven the speculation of the step-growth process of this polymerization.The computational study of ab initio and DFT calculations based on trimer and pentamer models gives details of the structures and the electronic transition.Experimental results of optical and AIE research confirmed by calculation indicates that the present work would facilitate the research and applications in materials. | Guanzhao Wu Yangxue Liu Zhen Yang Liulei Ma Yao Tang Xianliang Zhao Hossein Rouh Qixuan Zheng Peng Zhou Jia-Yin Wang Farhan Siddique Sai Zhang Shengzhou Jin Daniel Unruh Adelia JAAquino Hans Lischka Kristin M.Hutchins Guigen Li | 2021 | Research2021，，1： | 0 |
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