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| 1 | 高强度聚焦超声治疗不能手术胰腺癌的1年生存分析:中国和保加利亚的多中心临床研究显示文摘目的:通过多中心临床研究分析高强度聚焦超声治疗不能手术胰腺癌的1年生存情况。方法:2013年1月到2014年1月,中国和保加利亚的不能手术的胰腺癌患者32例,男/女=20/12,年龄41~81(59.8±9.1)岁。胰腺癌病灶最大径20~60(39.3±9.6)mm,远处转移/无转移的患者18/14例。接受HIFU和/或化疗。记录术后并发症,疼痛变化和生存情况。使用Kaplan-Meier法计算总生存率和中位生存时间,比较化疗与否、是否发生远处转移的患者生存率有无差异(Log-Rank检验)。结果:术后1月,皮肤浅Ⅱ°烧伤者2例,经保守处理后1~2周愈合。伴有胰腺癌相关性疼痛症状的患者30例与术前比较,减轻的24例(80.0%),不变的5例(16.7%),加重的1例(3.3%)。所有患者的1年生存率为38.4%,中位生存时间为12个月。接受辅助化疗的患者1年生存率为57.4%,中位生存时间12月;未接受辅助化疗的患者1年生存率为20.8%,中位生存时间为6月;二者间比较有显著性差异。伴有远处转移的患者1年生存率为0%,中位生存时间为7月;无远处转移的患者1年生存率为49.2%,中位生存时间为12月;二者间比较无统计学差异。结论:中国和保加利亚的不能手术胰腺癌患者均能安全完成HIFU治疗,1年生存率和中位生存时间优于其它非手术治疗手段。辅助化疗能增加生存受益,远处转移是预后不良因素。 | 周崑 Dobromir Dimitrov Dimitrov Tihomir Vencislavov Andreev 汪亮 Hyuliya Erdzhanova Feradova Grigor Angelov Gorchev 朱辉 王智彪 | 2015 | 重庆医科大学学报2015，40，3： | 11 |
| 2 | Existence of positive solutions to some nonlinear equations on locally finite graphs显示文摘Let G =(V,E) be a locally finite graph,whose measure μ(x) has positive lower bound,and A be the usual graph Laplacian.Applying the mountain-pass theorem due to Ambrosetti and Rabinowitz(1973),we establish existence results for some nonlinear equations,namely △u+hu=f(x,u),x∈V.In particular,we prove that if h and f satisfy certain assumptions,then the above-mentioned equation has strictly positive solutions.Also,we consider existence of positive solutions of the perturbed equation △u+hu=f(x,u)+∈g.Similar problems have been extensively studied on the Euclidean space as well as on Riemannian manifolds. | GRIGOR''YAN Alexander LIN Yong YANG YunYan | 2017 | Science China Mathematics2017，60，7： | 6 |
| 3 | 并联机器人结构合成第一部分,方法论显示文摘机器人这个术语的起源可以在Karl Capek创作的科学幻想剧本中找到。这个剧本是R.U.R于1920年在捷克出版。并联机器人机械手被认为是对包括机械加工、制导、测试、跟踪、触觉力反馈在内的许多应用的一种被广泛接收的选择。一个典型的并联机器人机械手(PM)由一个通过至少两个被称为臂的运动链连接到底座(固定平台)的移动平台组成。 | Grigore Gogu 胡光华 | 2008 | 国外科技新书评介2008，，4： | 5 |
| 4 | Pseudomembranous colitis associated with a triple therapy for Helicobacter pylori eradication显示文摘Helicobacter pylori(H.pylori)is one of the most common chronic bacterial infections in humans,affecting half of world’s population.Therapy for H.pylori infection has proven to be both effective and safe.The oneweek triple therapy including proton pump inhibitor,clarithromycin,and amoxicillin or metronidazole is still recommended as a first-line treatment to eradicate H.pylori infection in countries with low clarithromycin resistance.Generally,this therapy is well-tolerated,with only a few and usually minor side effects.However,rare but severe adverse effects such as pseudomembranous colitis have been reported,Clostridium difficile(C.difficile)infection being the main causative factor in all cases.We report the cases of two women who developed pseudomembranous colitis after a 1-wk triple therapy consisting of pantoprazole 20 mg bid,clarithromycin 500 mg bid,and amoxicillin 1 g bid to eradicate H.pylori infection.A limited colonoscopy showed typical appearance of pseudomembranous colitis,and the stool test for C.difficile toxins was positive.Rapid resolution of symptoms and negative C.difficile toxins were obtained in both patients with oral vancomycin.No relapse occurred during a four and eleven-month,respectively,follow up.These cases suggest that physicians should have a high index of suspicion for pseudomembranous colitis when evaluate patients with diarrhea following H.pylori eradication therapy. | Anca Trifan Irina Girleanu Camelia Cojocariu Catalin Sfarti Ana Maria Singeap Carmen Dorobat Lucia Grigore Carol Stanciu | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 5 | Carotid Artery Intima-media Thickness in Nonalcoholic Fatty Liver Disease显示文摘 | Anna Ludovica Fracanzani Larry Burdick Sara Raselli Paola Pedotti Liliana Grigore Gennaro Santorelli Luca Valenti Alessandra Maraschi Alberico Catapano Silvia Fargion | 2008 | The American Journal of Medicine2008，，1： | 5 |
| 6 | 并行机器人结构刚度有限元数值模拟显示文摘通过有限元数值模拟对并行机器人的结构刚度进行了分析,并行机器人的刚度可以通过有限元数值模拟方法对其进行分析.基于子结构的概念并鉴于大多数并行机器人都具有结构对称性特征,提出了一种有效的数值模拟方法——模块设计方法,并通过一个应用实例显示了这种方法的有效性.对数值模拟结果进行了整理并在此基础上绘制了Isog lide3-T 3并行机器人的刚度图. | 吴镇 Grigore Gogu 于蒙 | 2006 | 武汉理工大学学报(交通科学与工程版)2006，30，4： | 3 |
| 7 | Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer显示文摘 | Edwards J Krishna NS Grigor KM | 2003 | Br J Cancer2003，89，8： | 2 |
| 8 | Triglyceride-rich lipoproteins from hypertriglyceridemic subjects induce a pro-inflammatory response in the endothelium: Molecular mechanisms and gene expression studies显示文摘 | G.D. Norata L. Grigore S. Raselli P.M. Seccomandi A. Hamsten F.M. Maggi P. Eriksson A.L. Catapano | 2006 | Journal of Molecular and Cellular Cardiology2006，，4： | 2 |
| 9 | Carotid Artery Intima-media Thickness in Nonalcoholic Fatty Liver Disease显示文摘 | Anna Ludovica Fracanzani Larry Burdick Sara Raselli Paola Pedotti Liliana Grigore Gennaro Santorelli Luca Valenti Alessandra Maraschi Alberico Catapano Silvia Fargion | 2008 | The American Journal of Medicine2008，，1： | 2 |
| 10 | Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery显示文摘 | Groeott H Maekensen G Grigore A | 2002 | Stroke2002，33，： | 1 |
| 11 | Comparison of volatiles,phenolics, sugars, antioxidant vitamins, and sensory quality of different colored carrot varieties显示文摘 | Alasalvar C Grigor J M Zhang D | 2001 | J Agric Food Chem2001，49，： | 1 |
| 12 | The effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder eancer:a further report with 7 years of follow up 显示文摘 | Tolley DA Parmar MK Grigor KM | 1996 | J Urol1996，155，4： | 1 |
| 13 | The effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer:a further report with7years of follow up显示文摘 | Tolley D A Parmar M K Grigor K M | 1996 | J Uro11996，155，4： | 1 |
| 14 | A core review of temperature regimens and neuroprotection during cardiopulmonary bypass:does rewarming rate matter显示文摘 | Grigore AM Murray CF Ramakrishna H | 2009 | Anesth Analg2009，109，6： | 1 |
| 15 | Elasto- hydrodynamic (EHD) traction properties of seed oils 显示文摘 | BIRESAW Girma BANTCHEV GRIGOR B | 2012 | Tribology Transactions2012，53，4： | 1 |
| 16 | Influence of mineral matter on reactivity with carbon dioxide显示文摘 | Grigore M Sakurovs R French D | 2006 | ISIJ international2006，46，4： | 1 |
| 17 | Thiocyanate decomposition under aerobic and oxygen-free conditions by the aboriginal bacterial community isolated from the waste water of a metallurgical works显示文摘 | N. V. Grigor’eva Yu. V. Smirnova L. E. Dulov | 2009 | Microbiology2009，，4： | 1 |
| 18 | Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer显示文摘 | Edwards J Krishna NS Grigor KM | 2003 | Br J Cancer2003，89，3： | 1 |
| 19 | Quantifiea-tion of mineral matter in commercial cokes and their parent coals显示文摘 | David French Mihaela Grigore | 2007 | International Journal of Coal Geology2007，，1： | 1 |
| 20 | Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: Molecular mechanisms and gene expression studies显示文摘 | Norata GD Grigore L Raselli S | 2007 | Atherosclerosis2007，193，2： | 1 |
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