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| 1 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 2 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 3 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 4 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 5 | Angiopoietins 3 and 4:Diverging gene counter part sin mice and humans显示文摘 | Valenzuela DM Griffiths JA Rojas J | 1999 | Proc Natl Acad Sci USA1999，96，5： | 2 |
| 6 | Change in pore size distribution due to consolidation of clays显示文摘 | Griffiths F J Joshi R C | 1989 | Gèotechnique1989，39，1： | 2 |
| 7 | Perinatal and early life risk factors for inflammatory bowel disease显示文摘AIM:To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.METHODS:Record linked abstracts of birth registrations,maternity,day case and inpatient admissions in a defined population of southern England.Investigation of 20 perinatal factors relating to the maternity or the birth:maternal age,Crohn's disease (CD) or ulcerative colitis (UC) in the mother,maternal social class,marital status,smoking in pregnancy,ABO blood group and rhesus status,pre-eclampsia,parity,the infant's presentation at birth,caesarean delivery,forceps delivery,sex,number of babies delivered,gestational age,birthweight,head circumference,breastfeeding and Apgar scores at one and five minutes.RESULTS:Maternity records were present for 180 children who subsequently developed IBD.Univariate analysis showed increased risks of CD among children of mothers with CD (P=0.011,based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy.Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio=2.04,95% CI=1.06-3.92) and for older mothers aged 35+ years (4.81,2.32-9.98).Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated.It also showed that,for UC,there were no significant associations with the perinatal factors studied.CONCLUSION:This study shows an association between CD in mother and child;and elevated risks of CD in children of older mothers and of mothers who smoked. | Stephen E Roberts Clare J Wotton John G Williams Myfanwy Griffith Michael J Goldacre | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 8 | Microorganisms and heavy metal toxicity 显示文摘 | Gadd G M Griffiths A J | 1978 | Microb Ecol1978，4，： | 1 |
| 9 | Virtu-alness and Knowledge in Teams:Managing the Love Triangle of Organizations,Individuals,And Information Technology 显示文摘 | GRIFFITH T L SAWYER J E NEALE M A | 2003 | MIS Quarterly2003，，2： | 1 |
| 10 | Primary dysthymia:a study of several psychosocial,endocrine and immune correlates显示文摘 | Ravindran AV Griffiths J Meralin Z | 1996 | J Affect Disord1996，40，12： | 1 |
| 11 | Anaesthesia for hip fracture surgery in adults显示文摘 | Parker M J Handoll H H Griffiths R | 2004 | Coehrane Database Syst Rev2004，18，00： | 1 |
| 12 | Time-domain analysis of lossy coupled transmission lines显示文摘 | Griffith J R Nakhla M S | 1990 | IEEE Trans on Microwave Theory and Techniques1990，38，10： | 1 |
| 13 | Hospital admissions for asthma in preschool children relationship to major roads in Birmingham, United Kingdom显示文摘 | Edwards J Waiters S Griffiths BK | 1994 | Arch Environ Health1994，49，4： | 1 |
| 14 | Emotional distress in infertile womenand failure of assisted reproductive technologies : meta -? analysis of pro-spective psychosocial studies显示文摘 | Boivin J Griffiths E Venetis CA | 2011 | BMJ2011，342，： | 1 |
| 15 | Thirty - four cases of esophage-al perforation : the experience of a district general hospital in the UK显示文摘 | Griffiths EA Yap N Poulter J | 2009 | Dis Esophagus2009，22，7： | 1 |
| 16 | Pathology and pathogenesis of ovine pulmonary adenocarcinoma 显示文摘 | Griffiths D J | 2010 | J Comp Path2010，，142： | 1 |
| 17 | Outbursts and mines: A review显示文摘 | Shepherd J Rixon L K geological structure in coal Griffiths L | 1981 | Int J Rock Mech Min Sei Geomeb Abstr1981，18，4： | 1 |
| 18 | Plant responses to water stress显示文摘 | Griffiths H Parry M A J | | 0，，07： | 1 |
| 19 | The neural control of mie- turition显示文摘 | Clare J Fowler Derek Griffiths | 2008 | Nature Reviews Neuroscienee2008，9，： | 1 |
| 20 | Nitric oxide synthases:properties and catalytic mechanism显示文摘 | Griffith O W Stuehr D J | 1995 | Annu Rev Physiol1995，57，： | 1 |
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