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| 1 | Perinatal and early life risk factors for inflammatory bowel disease显示文摘AIM:To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.METHODS:Record linked abstracts of birth registrations,maternity,day case and inpatient admissions in a defined population of southern England.Investigation of 20 perinatal factors relating to the maternity or the birth:maternal age,Crohn's disease (CD) or ulcerative colitis (UC) in the mother,maternal social class,marital status,smoking in pregnancy,ABO blood group and rhesus status,pre-eclampsia,parity,the infant's presentation at birth,caesarean delivery,forceps delivery,sex,number of babies delivered,gestational age,birthweight,head circumference,breastfeeding and Apgar scores at one and five minutes.RESULTS:Maternity records were present for 180 children who subsequently developed IBD.Univariate analysis showed increased risks of CD among children of mothers with CD (P=0.011,based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy.Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio=2.04,95% CI=1.06-3.92) and for older mothers aged 35+ years (4.81,2.32-9.98).Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated.It also showed that,for UC,there were no significant associations with the perinatal factors studied.CONCLUSION:This study shows an association between CD in mother and child;and elevated risks of CD in children of older mothers and of mothers who smoked. | Stephen E Roberts Clare J Wotton John G Williams Myfanwy Griffith Michael J Goldacre | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 2 | Effects of temperature and moisture on carbon respired from decomposing woody roots显示文摘 | Chen H Harmon M E Griffiths R P | 2000 | Forest Ecology and Management2000，138，： | 1 |
| 3 | Virtu-alness and Knowledge in Teams:Managing the Love Triangle of Organizations,Individuals,And Information Technology 显示文摘 | GRIFFITH T L SAWYER J E NEALE M A | 2003 | MIS Quarterly2003，，2： | 1 |
| 4 | Emotional distress in infertile womenand failure of assisted reproductive technologies : meta -? analysis of pro-spective psychosocial studies显示文摘 | Boivin J Griffiths E Venetis CA | 2011 | BMJ2011，342，： | 1 |
| 5 | Regulation of mitotic en-try by microcephalin and its overlap with ATR signalling显示文摘 | Alderton GK Galbiati L Griffith E | 2006 | Nat Cell Biol2006，8，7： | 1 |
| 6 | A framework for biological criteria for Florida streams using benthic macroinvertebrates 显示文摘 | BARBOUR M T GERRITSEN J GRIFFITH G E | 1996 | Journal of the North American Benthological Society1996，15，2： | 1 |
| 7 | A framework for biological criteria for Florida streams using benthic macroinvertebrates显示文摘 | Barbour M T Gerritsen J Griffith G E | 1996 | Journal of the North American Benthological Society1996，15，： | 1 |
| 8 | Imaging the fetal spine using inutero MR:diagnostic accuracy and impact on management显示文摘 | Griffiths PD Widjaja E Paley MN | 2006 | PediatrRadiol2006，36，9： | 1 |
| 9 | Mitochondrial non - specific pores remain closed during cardiac ischemia but open upon reperfusion 显示文摘 | Griffiths E J Halestrap AP | 1995 | Biochem J1995，307，1： | 1 |
| 10 | Evolution of quasiparticle charge in the fractional quantum hall regime 显示文摘 | Griffiths T G Comforti E Heiblum M | 2000 | Phvs Rev Lett2000，85，18： | 1 |
| 11 | The effects of frequency of feeding on some quantitative aspects of digestion in the tureens of growing steers 显示文摘 | McAllan A B Lewis P E Griffith E S | 1987 | Arch Tierernahr1987，37，9： | 1 |
| 12 | Mechanism of adhesion of electroless-deposited silver on poly(ether urethane) 显示文摘 | GRAY J E NORTON P R GRIFFITHS K | 2005 | Thin Solid Films2005，484，12： | 1 |
| 13 | The interaction of HzO2 with exchanged titanium oxide systems(TS-l, TiO2, -APO-5, Ti-ZSM-5) 显示文摘 | Karen L A Damien M M Griffiths E | 2003 | Physical Chemistry Chemical Physics2003，5，： | 1 |
| 14 | Understanding thermal behavior in the LENS process显示文摘 | GRIFFITH M L SCHLIENGER M E HARWELL L D | 1999 | Materials and Design1999，20，： | 1 |
| 15 | Consumer food handling in the home: a review of food safety studies显示文摘 | REDMOND E C GRIFFITH CJ | 2003 | J Food Prot2003，66，1： | 1 |
| 16 | Consumer food handling in the home: areview of food safety studies显示文摘 | Redmond E C Griffith C J | 2003 | J Food Pro2003，66，1： | 1 |
| 17 | Preliminary comparison of landscape pattern-Normalized difference vegetation index (NDVI) relationships to central plains stream conditions 显示文摘 | Griffith J A Martinko E A Whistler J L | 2002 | Journal of Environmental Quality2002，31，： | 1 |
| 18 | A survey of clinical experience with ciprofloxacin, a new quinolone antimicrobial 显示文摘 | Arcieri G Griffith E Grueawaldt G | 1988 | The Journal of Clinical Pharmacology1988，28，2： | 1 |
| 19 | Mito-chondrial non-specific pores remain closed during cardiac ischaemia,but open upon reperfusion显示文摘 | GRIFFITHS E J HALESTRAP A P | 1995 | Biochem J1995，307，1： | 1 |
| 20 | Anterior shoulder dislocation:Quantification of glenoid bone loss with CT显示文摘 | Griffith J F Antonio G E Tong C W | | 0，，05： | 1 |
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