|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 2 | Respiratory mechanics,ventilator-associated pneumonia and outcomes in intensive care unit显示文摘AIM To evaluate the predictive capability of respiratory mechanics for the development of ventilator-associated pneumonia (VAP) and mortality in the intensive care unit(ICU) of a hospital in southern Brazil. METHODS A cohort study was conducted between, involving a sample of 120 individuals. Static measurements of compliance and resistance of the respiratory system in pressure-controlled ventilation (PCV) and volumecontrolled ventilation(VCV) modes in the 1 st and 5 th days of hospitalization were performed to monitor respiratory mechanics. The severity of the patients' illness was quantified by the Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ). The diagnosis of VAP was made based on clinical, radiological and laboratory parameters.RESULTS The significant associations found for the development of VAP were APACHE Ⅱ scores above the average(P = 0.016), duration of MV (P = 0.001) and ICU length of stay above the average(P = 0.003), male gender(P = 0.004), and worsening of respiratory resistance in PCV mode(P = 0.010). Age above the average(P < 0.001), low level of oxygenation on day 1(P = 0.003) and day 5 (P = 0.004) and low lung compliance during VCV on day 1 (P = 0.032) were associated with death as the outcome.CONCLUSION The worsening of airway resistance in PCV mode indicated the possibility of early diagnosis of VAP. Low lung compliance during VCV and low oxygenation index were death-related prognostic indicators. | Kelser de Souza Kock Rosemeri Maurici | 2018 | World Journal of Critical Care Medicine2018，7，1： | 7 |
| 3 | Local Entropy Production in Turbulent Shear Flows:A Tool for Evaluating Heat Transfer Performance显示文摘热转移设备的表演评估能在这些设备基于全面的熵生产。在我们的学习,我们因此由于机械精力的驱散并且由于热传导为本地熵生产的系统、详细说明的决心提供方程,两个在狂暴的流动。在当模特儿的骚乱为波动的部分被合并了以后,全面的熵生产能被集成关于整个流动领域决定。然而,从那时起,熵生产率证明很陡峭的坡度关门到墙,数字答案与墙功能是更加有效的熵生产术语。当高级雷纳兹数字骚乱模型被使用时,这些墙功能是强制的。为在有一盘插入的扭曲的磁带的一根管子中的狂暴的流动,作为热转移倡导者,基于全面的熵生产率,从一个热力学的观点的清楚的陈述是可能的,这被显示出。没有,为扭曲力量的某个范围,在与盒子相比的全面的熵生产有减少插入。另外,最佳扭曲力量能是坚定的。当仅仅压力落下和热转移数据被给时,这个信息是无法获得的。关键词熵生产 - 狂暴的热转移 - 墙功能 CLC 数字 | H. HERWIG F. KOCK | 2006 | Journal of Thermal Science2006，15，2： | 5 |
| 4 | Antimicrobial chemical constituents from endophytic fungus Phoma sp.显示文摘Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma sp.and the tentative identification of their active constituents.Methods:The extract and compounds were screened for antimicrobial activity using the Agar Well Diffusion Method.Four compounds were purified using column chromatography and tlieir structures were assigned using~1H and~(13)C NMR spectra,DEPT,2D COSY,HMQC and HMBC experiments.Results:The ethyl acetate fraction of Phoma sp.showed good antifungal,antibacterial,and algicidal properties.One new dihydrofuran derivative,named phomafuranol(1),together with tliree known compounds,phomalacton(2),(3R)-5-hydroxymellein(3)and emodin(4)were isolated from the ethyl acetate fraction of Phoma sp.Preliminary studies indicated that phomalacton(2)displayed strong antibacterial,good antifungal and antialgal activities.Similarly(3R)-5-hydroxymellein(3)and emodin(4)showed good antifungal,antibacterial and algicidal properties.Conclusions:Antimicrobial activities of the ethyl acetate fraction of the endophytic fungus Phoma sp.and isolated compounds clearly demonstrate that Phoma sp.and its active compounds represent a great potential for the food,cosmetic and pharmaceutical industries. | Hidayat Hussain Ines Kock Ahmed Al-Harrasi Ahmed Al-Rawahi Ghulam Abbas Ivan R.Green Afzal Shah Amin Badshah Muhammad Saleem Siegfried Draeger Barbara Schulz Karsten Krohn | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，9： | 3 |
| 5 | 钽的加工,性能及应用显示文摘 | Kock,W. 郑爱勤 | 1990 | 国外稀有金属1990，，5： | 2 |
| 6 | Evidence of clonality in chronic neutrophilic leukaemia显示文摘 | J BOHM S KOCK H E SCHAEFER | 2003 | J Clin Pathol2003，56，： | 1 |
| 7 | Pelvic lipomatosis associated with cystitis glandularis and adenocarcinoma of the bladder显示文摘 | HEYNS C F KOCK D E KIRSTEN P H | 1991 | J Urol1991，145，2： | 1 |
| 8 | Design optimization of a single-strand continuous caster tundish using residence time distribution data显示文摘 | Craig K J de Kock D J Makgata K W | 2001 | ISIJ International2001，41，10： | 1 |
| 9 | Slip geometry in partially con- strained deformation显示文摘 | Kocks U F Chandra H | 1982 | Acta Metall1982，30，3： | 1 |
| 10 | Adhesion to metal sulfide surfaces by cells of Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Leptospirillum ferrooxidans 显示文摘 | Hameit K Goksel A Kock D | 2006 | Hydrometallurgy2006，83，5： | 1 |
| 11 | A review of the literature on nonsurgical treatment in tubal pregnancies 显示文摘 | Kooi S Kock HC | 1992 | Obstet Gynecol Surv1992，47，： | 1 |
| 12 | Clinical outcome after Chev- ron- Akin double osteotomy versus isolated Chevron procedure: a prospective matched group analysis 显示文摘 | Lechler P Feldmann C Kock FX | 2012 | Arch Orthop Trauma Surg2012，1，： | 1 |
| 13 | Structureactivity relationship study on a novel series of cyclopentanecontaining macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350显示文摘 | Raboisson P De Kock H Rosenquist A | 2008 | Bioorg Med Chem Lett2008，18，： | 1 |
| 14 | Mechanical stresses in carotid plaques using MRI based fluid structure interaction mod- els显示文摘 | Kock S A Nygaard J y Eldrup N | 2008 | J Bomech2008，41，8： | 1 |
| 15 | Ramsdellite-MnO2 for lithium batteries: The ramsdellite to spinel transformation显示文摘 | THACKERAY M M ROSSOUW M H GUMMOW R J LILES D C PEARCE K KOCK A D DAVID W I F HULLS S | 1993 | Electrochim Acta1993，38，9： | 1 |
| 16 | Regulation of Dectin-l- mediated dendritic cell activation by peroxisome proliferator- activated receptor-gamma ligand troglitazone 显示文摘 | Kock G Bringmann A Held S A | 2011 | Blood2011，17，13： | 1 |
| 17 | Internal urethrotomy versus dilation as treatment for male urethral, strictures : A prospective, randomized comparison 显示文摘 | Steenkamp JW Heyns CF de Kock ML | 1997 | J Urol1997，157，1： | 1 |
| 18 | Zoonosis emergence linked to agricultural intensification and environmental change显示文摘 | Jones BA Grace D Kock R | 2013 | Proc Nat Acad Sci USA2013，110，21： | 1 |
| 19 | Analysis of the Earliest Steps of Hepadnavirus Replication : Genome Repair after Infectious Entry into Hepatocytes does not Depend on Viral Polymerase Activity 显示文摘 | KOCK J SCHLICHT H J | 1993 | J Virol1993，67，8： | 1 |
| 20 | Anesthesia and cerebral apoptosis显示文摘 | Bree B Gourdin M De Kock M | 2008 | Acta Anaesthesiol Belg2008，59，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员