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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Alternate-day steroids affect carpal maturation more than radius, ulna and short bones显示文摘 | Polito C Greco N Opallo A Cimmaruta E La Manna A | 1994 | Pediatr Nephrol1994，8，4： | 1 |
| 4 | On the description of the basin effective drainage structure显示文摘 | Roth G La Barbera P Greco M | 1996 | Journal of Hydrolgoy1996，187，12： | 1 |
| 5 | I get by with a little help from my family and friends:adolescents' support for diabetes care显示文摘 | La Greea AM Auslander WF Greco P | 1995 | J Pediatr Psyehol1995，20，4： | 1 |
| 6 | I get by with a little help from my family and friends:adolescents' support for diabetes care显示文摘 | La Greea AM Auslander WF Greco P | 1995 | J Pediatr Psyehol1995，20，4： | 1 |
| 7 | Randomised trial comparing Lichtenstein vs Trabucco vs Valenti techniques in inguinal hernia re- pair显示文摘 | Ripetti V La Vaccara V Greco S | 2014 | Hernia2014，18，2： | 1 |
| 8 | Neutrophil Adhe- sion to Vascular ProstbeticSurfaces Triggers Nonapoptotic Cell Death 显示文摘 | Nadzam GS De La Cruz C Greco RS | 2000 | Ann Surg2000，231，4： | 1 |
| 9 | On the description of the basin effective drainage structure显示文摘 | Giorgio Roth Paolo La Barbera Michele Greco | 1996 | Journal of Hydrology1996，，1： | 1 |
| 10 | Treating childhood shyness and related be- havior: Empirically evaluated approaches to promote positive social interactions 显示文摘 | Greco LA Morris TL | 2001 | Clin Child Faro Psychol Rev2001，4，4： | 1 |
| 11 | Randomised trial comparing Lichtenstein vs Trabucco vs Valenti techniques in inguinal hernia repair 显示文摘 | Ripetti V Vaccara V La Greco S | 2014 | Hernia2014，18，2： | 1 |
| 12 | Immobilized IgG and fibrinogen differentially affect the cytoskeletal organization and bactericidal function of adherent neutrophils 显示文摘 | De La Cruz C Haimovich B Greco RS | 1998 | J Surg Res1998，80，： | 1 |
| 13 | NeutrophilAdhesion to Vascular Prosthetic Surfaces Triggers Nonapop-totic Cell Death显示文摘 | Nadzam G S De La Cruz C Greco R S | 2000 | Annals of surgery2000，231，4： | 1 |
| 14 | Arterialization of the portal stump by right renal artery after portocaval shunt in the rat显示文摘 | Li Destri G La Greca G Greco L | 2004 | Microsurgery2004，24，1： | 1 |
| 15 | Arterialization of the por- tal stump by right renal artery after portocaval shunt in the rat 显示文摘 | Li Destri G La Greca G Greco L | 2004 | Microsurgery2004，24，1： | 1 |
| 16 | Psychological inflexibility in childhood and adolescence:development and evaluation of the Avoidance and Fusion Questionnaire for Youth显示文摘 | Greco LA Lambert W Baer RA | 2008 | Psychol Assess2008，20，2： | 1 |
| 17 | Arterialization of the portal stump by right renal artery after portocaval shunt in the rat显示文摘 | Li DG La Greca G Greco L | | 0，，： | 1 |
| 18 | Psychological inflexibility in childhood and adolescence:development and evaluation of the Avoidance and Fusion Questionnaire for youth显示文摘 | Greco LA Baer RA Lambert W | 2008 | Psychol Assess2008，20，2： | 1 |
| 19 | Arterialization of the portal stump by right renal artery after portocaval shunt in the rat显示文摘 | Li Destri G La Greca G Greco L | 2004 | Microsurgery2004，24，1： | 1 |
| 20 | Neutrophil Adhesion toVascular ProstheticSurfaces Triggers Nonapoptotic Cell Death显示文摘 | Nadzam GS De La Cruz C Greco RS | 2000 | Ann Surg2000，231，4： | 1 |
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