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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Oxidative polymerisation of phenols by a phenol oxidase from green olives显示文摘 | Toseano G Letizia Colarieti M Greco G | 2003 | Enzyme and Microbial Technology2003，33，： | 1 |
| 4 | Effect of phase and range gate pull-off delay quantization on jammer signal显示文摘 | Greco M Gini F Farina A | 2006 | IEE Pro- ceedings Radar Sonar and Navigation2006，153，5： | 1 |
| 5 | Evolution and identification of lactic acid bacteria isolated during the ripening of Sardinian sausage显示文摘 | Greco M Mazzette R | 2005 | Meat Science2005，69，4： | 1 |
| 6 | Oxidized-LDL/beta(2)- glycoprotein I complexes are associa- ted with disease severity and increased risk for adverse out- comes in patients with acute coronary syndromes显示文摘 | GRECO T P CONTI-KELLY A M ANTHONY J R | 2010 | Am J Clin Pathol2010，133，5： | 1 |
| 7 | Effect of Phase and Range Gate Pull-off Delay Quantization on Jammer Signal 显示文摘 | Greco M Gini F Farina A | 2006 | IEE Proceedings-Radar Sonar and Navigation2006，153，5： | 1 |
| 8 | Robust ordinal regression for multiple criteria group decision: UTA(GMS)-GROUP and UTA- DIS (GMS) -GROUP 显示文摘 | GRECO S KADZINSKI M MOUSSEAU V | 2012 | Decision Support Systems2012，52，3： | 1 |
| 9 | Efficient treatment of infertility due to sperm DNA damage by ICSI with tes ticular spermatozoa显示文摘 | Greco E Scarselli F Iacobelli M | 2005 | Hum Reprod2005，20，1： | 1 |
| 10 | Enhanced recovery after surgery:a survey among anaesthesiologists from 27 countries显示文摘 | Greco M Gemma M Braga M | 2014 | Eur J Anaesthesiol2014，31，5： | 1 |
| 11 | Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells 显示文摘 | Steven J Greco Sraboni Sarkar Jane M Johnston | 2008 | Biochemical and Biophysical Research Communications2008，376，3： | 1 |
| 12 | The contribution of water hyacinth ( Eichhornia erassipes) and zooplankton to the internal cycling of Phosphorus in the eutrophic Pampulba Reservoir 显示文摘 | Pinto-Coelho R M Greco M K B | 1999 | Brazil Hydrobiologia1999，411，： | 1 |
| 13 | The use of titanium miniscrews for molar protraction in extraction treatment显示文摘 | Giancotti A Greco M Mampieri G et al | 2004 | Prog Ort hod2004，5，2： | 1 |
| 14 | Cell surface overex pression of galeetin 3 and the presence of its ligand 90k in the blood plasma as determinants in colon neoplastic lesions显示文摘 | Greco C Vona R Cosimelli M | 2004 | Glycobiology2004，14，9： | 1 |
| 15 | Is there a link be- tween insulin resistance and inflammatory activation in preeclampsia?显示文摘 | Scioscia M Greco P Selvaggi LE | 2009 | Med Hypotheses2009，73，5： | 1 |
| 16 | microRNA:Emerging therapeutic targets in acute ischemic diseases显示文摘 | Fasanaro P Greco S Ivan M | 2010 | Pharmacol Ther2010，125，1： | 1 |
| 17 | Redox homeostasis and epigenetics in non-alcoholic fatty liver disease(NAFLD)显示文摘 | Podrini C Borghesan M Greco A | | 0，，： | 1 |
| 18 | Selection of a representative value function in robust multiple criteria ranking and choice显示文摘 | KADZINSKI M GRECO S SLOWINSKI R | 2012 | Euro- pean Journal of Operational Research2012，217，3： | 1 |
| 19 | Covariance matrix estimation for CFAR detection in correlated heavy tailed clutter显示文摘 | Gini F and Greco M | 2002 | Signal Processing2002，82，： | 1 |
| 20 | Noncoding RNA in age-related cardiovascular diseases显示文摘 | Greco S Gorospe M Martelli F | 2015 | JMol Cell Cardiol2015，83，： | 1 |
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