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| 1 | Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases显示文摘AIM To establish a relevant animal model ofhuman gastrointestinal cancer, which can beused for repetitive investigations, so as toimprove our understanding and management ofcarcinogenesis and cancer metastasis.METHODS Intact tissues of human colorectaland pancreatic cancers were transplanted innude mice. The biological characteristics of theoriginal and the corresponding transplantedtumors were investigated by HE staining, PASstaining and immunostaining. The metastases inthe livers and lungs of nude mice wereinvestigated by immunostaining withbiotinylated mab KL-1 and by RT-PCR using CK20specific primers.RESULTS There were totally 9 of 16 surgicalspecimens growing in nude mice subcutaneouslyand/.or orthotopically (4 of 6 colorectal and 5 of10 pancreatic cancer). Tumor cell content of thespecimens and freezing of tissue specimens areimportant factors influencing the growth oftransplanted tumor. In the group of fresh tumortissues with greater than 50% tumor cellcontent, the success rate of the transplantationwas 100% (3 cases of pancreatic cancer and 3cases of colorectal cancer). The orthotopicallytransplanted tumors resemble the original tumormorphologically and biologically, including TAAexpression such as CEA byimmunohistochemistry, and CEA level in theserum of mice. Ki-67 labeling index and theexpression of TAA especially K-ras, 17-lA andRA-96, are associated with the potential of tumorgrowth in nude mice. Micrometastases in thelungs and livers of tumor bearing mice can bedetected by immunostaining with biotinylatedmab KL-1 and CK20-specific RT-PCR.CONCLUSION An orthotopic transplantationmodel for human colon and pancreatic cancer innude mice has been set up. We have alsoestablished sensitive detection methods withCK-immunohistochemistry and CK20-RT-PCR tostudy xenotransplanted human cancer and itsmetastatic cancer cells in the liver and lung ofnude mice. This study may be helpful inunderstanding the mechanism of cancermetastasis and in developing new diagnosticmethods and therapeutic strategies formetastases including micrometastases. | Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 2 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 3 | 2型糖尿病患者服用吡格列酮的膀胱癌风险显示文摘背景
吡格列酮是一种有争议的噻唑烷二酮类口服降糖药物,可以有效降低糖化血红蛋白(HbA1c)浓度,且降低心血管事件的发生风险,但同时也与体重增加和充血性心力衰竭风险的增加有关。尽管目前数据有限,但还是有证据显示它可能还与膀胱癌患病风险的增加有关。 | Laurent Azoulay assistant professor Hui Yin statistician Kristian B Filion assistant professor Jonathan Assayag graduate student 王子贤(编译) | 2012 | 中国处方药2012，10，5： | 17 |
| 4 | Emergency assessment of seismic landslide susceptibility: a case study of the 2008 Wenchuan earthquake affected area显示文摘The 8.0 Mw Wenchuan earthquake triggered widespread and large scale landslides in mountainous regions.An approach was used to map and assess landslide susceptibility in a given area.A numerical rating system was applied to fi ve factors that contribute to slope instability.Factors such as lithology,topography,streams and faults have an important influence as event-controlling factors for landslide susceptibility assessment.A f inal map is provided to show areas of low,medium,and high landslide susceptibility.Areas identifi ed as having high landslide susceptibility were located in the central,northeastern,and far south regions of the study area.The assessment results will help decision makers to select safe sites for emergency placement of refuges and plan for future reconstruction.The maps may also be used as a basis for landslide risk management in the study area. | Tang Chuan,Zhu Jing and Liang Jingtao State Key Laboratory of Geo-Hazard Prevention,Chengdu University of Technology,Chengdu 610059,China Professor Associate Professor Graduate Student | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 16 |
| 5 | Building damage in Dujiangyan during Wenchuan Earthquake显示文摘A field damage survey of 1,005 buildings damaged by the Wenchuan Earthquake in Dujiangyan City was carried out and the resulting data was analyzed using the statistical method. It is shown that buildings that were seismically designed achieved the desired seismic fortification target; they sustained less damage than the non-seismically designed buildings. Among the seismically designed buildings investigated, RC frame buildings performed the best in terms of seismic resistance. Masonry buildings with a ground story of RC frame structure were the second best, and masonry buildings performed the worst. Considering building height, multistory buildings sustained more severe damage than high-rise buildings and 2- and 3-story buildings. Compared to residential buildings, public buildings, such as schools and hospitals, suffered more severe damage. | Zhang Minzheng and Jin Yingjie Institute of Engineering Mechanics, China Earthquake Administration, Harbin 150080, China Professor Graduate Student | 2008 | Earthquake Engineering and Engineering Vibration2008，7，3： | 13 |
| 6 | Dynamic Response Behaviors of Upright Breakwaters Under Breaking Wave Impact显示文摘- The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impulse duration (or oscillation period) on the translation, rotation, sliding force, overturning moment, and corresponding dynamic amplifying factors are studied. It is concluded that the ampli-ying factors only depend on the ratio of the system natural period to impulse duration (or oscillation period) under a certain damping ratio. Moreover, the equivalent static approach to breakwater design is also discussed. | Wang Yuanzhan , Chi Lihua and Pan Houzhi Associate Professor, Department of Water Resources and Harbour Engineering, Tianjing University, Tianjin 300072Lecturer, Computer Center, Tianjing University, Tianjin 300072 Graduate student, Department of Water Resources and Harbour Engineering, Tianjing University, Tianjin 300072 | 1996 | China Ocean Engineering1996，11，3： | 12 |
| 7 | Ethylene oligomerization by novel iron(Ⅱ) diimine complexes/MAO显示文摘Two novel Fe(Ⅱ) diimine complexes have been synthesized. In combination with MAO, they generate active catalytic systems that oligomerize ethylene with both high catalytic activity and high selectivity for a-olefins. The effects of substituents on the aryl ring, reaction temperatures and molar ratios of Al/Fe on catalytic activity and product distribution are studied. | WANG Hang, YAN Weidong, JIANG Tao, LIU Binbin, XU Wenqing, MA Jianjiang & HU YouliangState Key Laboratory of Engineering Plastics, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Graduate Student of | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 8 | Generation and Deformation of Solitary Waves显示文摘Base on the Lagrangian description and finite differencing of the time step, the generation, propagation and deformation of solitary waves are simulated numerically by means of boundary element method. An algorithm to generate waves with any prescribed form is also implanted in the scheme, but in this research, solitary waves are studied. The numerical model is first verified by studying the case of a solitary wave impinging against a vertical wall. Time histories of evolution of a soliton running up on a sloping beach, as well as over a submerged obstacle are then presented. Applications to scattering problems due to solitary waves progressing over a slope onto a shelf are also shown. | Chou Chung-Ren Shih Ruey-Syan Professor, Dept. of Harbor and River Engineering, National Taiwan Ocean University . Graduate Student, Dept. of Harbor and River Engineering, National Taiwan Ocean University | 1996 | China Ocean Engineering1996，11，4： | 6 |
| 9 | A new seismic isolation system and its feasibility study显示文摘这份报纸介绍称为一个周期的基础(PF ) 的一个新地震隔离系统,在包括周期性地被安排的地方。PF 与传统的基础隔离不同因为它在结构引起基本频率移动,因此减少它的反应并且产生频率差距。如果一个震波的频率内容掉进差距,它不能在基础宣传。因此,它不对上面的结构施加影响。为 2D PF 的频率差距的乐队的系统的研究被进行。象密度和有弹性的模量以及频率差距的乐队上的 PF 和它的材料的充满的部分那样的物理、几何的参数的影响被调查,并且有象 2.49 鈥 ?.72 Hz 一样低的频率差距的一个图案被完成。频率差距的这个乐队在地震工程对应于很好设计系列。有不同基础的六故事的框架结构的数字模拟证明一个建议 PF 罐头极大地减少孤立的结构的地震反应。这调查证明 PF 在地震隔离技术的未来应用有大潜力。关键词地震隔离 - 周期的基础 - 频率差距的乐队旁边支持了:在资助 No.90715006 | Jia Gaofeng~+ and Shi Zhifei~(++) School of Civil Engineering,Beijing Jiaotong University,Beijing 100044,China Graduated Student ++ Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 6 |
| 10 | APPLICABILITY OF SEDIMENT TRANSPORT FORMULAS显示文摘The paper provides a comprehensive testing of the applicability of 13 sediment transport formulas under different flow and sediment conditions. The dimensionless parameters used for testing the reliability and sensitivity of formulas are dimensionless particle diameter, relative depth, Froude number, relative shear velocity, dimensionless unit stream power, and sediment concentration. A total of 3,391 sets of laboratory and river data are used in the tests. Engineers may find the test results useful to their selection of formulas under different flow and sediment conditions. | Chih Ted YANG and Caian HUANG Manager, Sedimentation and River Hydraulics Group, Technical Service Center, U.S. Bureau of Reclamation, Denver, Colorado 80225. Graduate student, College of Harbour, Waterway and Coastal Engineering, Hohai University, Nanjin | 2001 | International Journal of Sediment Research2001，16，3： | 4 |
| 11 | Stability Analysis of Bohai Oil-Drilling Ship No. 6 Under Static and Cyclic Loads显示文摘- This paper presents a procedure to calculate the safety factor against sliding of a marine gravity structure subjected to a combination of static and cyclic loads. This procedure claculates the stress at the sliding surface by the finite element method (FEM) and takes the dynamic properties of clay into account. With this procedure, the stability of a Bohai oil-drilling ship is analyzed. The calculated safety factor is much smaller than 1, indicating that this oil-drilling ship would fail just as what had happened to it. | Qiu Changlin Yan Shuwang Graduate student, Dept. of Hydraulic Engrg., Tianjin University . Professor, Dept. of Hydraulic Engrg., Tianjin University | 1996 | China Ocean Engineering1996，11，4： | 3 |
| 12 | Calculation of Wave Reflection Coefficient for Perforated-Pipe Breakwater显示文摘The hollow-pipe perforated breakwater is of low reflection. In this paper the functions of reflection coefficients of both regular and random waves are theoretically derived, based on the concept of linear superimposition of reflected and incident waves and with the total flow rate continuity of integral form instead of the non-continuity of the boundary condition, and based on the concept of linear wave spectrum theory. Comparisons between theoretical results presented here and measurements of model tests show reasonable agreement. | Li Chunzhu , Cai Yi and Wei Shoulin Associate Professor, Ocean University of Qingdao. Qingdao Graduate Student, Ocean University of Qingdao, Qingdao | 1991 | China Ocean Engineering1991，6，4： | 1 |
| 13 | High-temperature deformation behavior of a gamma TiAl alloy—Microstructural evolution and mechanisms显示文摘 | Jeoung Han Kim Graduate Ph.D. Candidate Student Young Won Chang Chong Soo Lee Tae Kwon Ha | 2003 | Metallurgical and Materials Transactions A2003，，10： | 1 |
| 14 | Timequake: A Unity of Incredulity to Metanarratives and Historiographic Metafiction显示文摘A textual analysis of Kurt Vonnegut’s Timequake shows that its postmodern features can be illustrated in the light of Francois Lyotard’s metanarrative theory and Linda Hutcheon’s historiographic metafiction. Even though Timequake has left on readers an impression of fragmentary and chaotic narration and thereby may be accused of being intentionally misleading and meaningless, we can still probe the underlying meaning of the fiction and find it, at least part of it, to be a unity of incredulity to metanarratives and historiographic metafiction. | Ren Xiaojin the College of Foreign Languages and Literature, Wuhan University. His major research area is the 19 th -century American literature and culture. He Jiawei graduate student at the College of Foreign Languages and Literature, Wuhan University. | 2005 | 外国文学研究2005，27，6： | 1 |
| 15 | Instability of an annular viscous liquid jet显示文摘 | Graduate Student J. Shen Assoc. Prof. Dr. X. Li | 1996 | Acta Mechanica (-)1996，，1： | 1 |
| 16 | Three-dimensional Motion of Multichain-Buoy Mooring System in shallow Water and Survival Conditions显示文摘An engineering numerical model for three-dimensional motion of multichain-buoy mooringsystem in shallow water and survival condition is given in this paper.Shooting-aim method is employedfor solving the dynamic equations of chain system in order to match the computation of buoy motion.Theresponses of buoy and chain have been computed for different wind-wave-current directions and differentrigidity of chain.The results show that the present numerical model is reasonable. | Zhang Ting Sun Mingguang Graduate student, Department of Applied Mechanics and Engineering, Zhongshan University,Guangzhou 510275Professor, Department of Applied Mechanics and Engineering, Zhongshan University, Guangzhou 510275 | 1997 | China Ocean Engineering1997，12，3： | 1 |
| 17 | A Study on the Spectral Form of Nearshore Water Waves显示文摘- The spectral form of wind waves is investigated based on the ocean wave data observed at three nearshore stations of Taiwan. In this study, the generalized forms of Pierson-Moskowitz spectrum and JONSWAP spectrum are used to describe the local wave spectrum by selecting suitable spectral form parameters. It is shown that, at a specific site, the similarity of wave spectral form exists. Thus it is possible to use a representative spectral form for a given nearshore region to describe the wave spectrum at this nearshore. On the other hand, the effects of relative water depth on spectral form are examined. The feasibility of two spectral models in finite water depth is evaluated by using the same field wave data. | Kuo Yiyu Chien Chungching Professor, Department of Civil Engineering, National Chiao-Tung University, Wuchi, Taichung District,taiwan Graduate Student for Ph. D., Department of Civil Engineering, National Chiao-Tung University, Wuchi, Taichung District, Taiwan | 1993 | China Ocean Engineering1993，8，3： | 1 |
| 18 | A Simple Eddy Viscosity Model of Rough Turbulent Wave Boundary Layer显示文摘- A one-layer time-invariant eddy viscosity model is specified to develop a mathematical model for describing the essential features of the turbulent wave boundary layer over a rough bed. The functional form of the eddy viscosity is evaluated based on computational results from a two-equation turbulence model in which the eddy viscosity varies with time and space. The present eddy viscosity model simplifies much of the mathematical complexity in many existing models. Predictions from the present model have been compared with a wide range of experimental data. It is found that the eddy viscosity model adopted in the present study is physically reasonable. | Hsu Tai-Wen and Lin Hwung-Yui Associate Professor, Department of Hydraulics and Ocean Engineering, National Cheng Kung University, Tainan Graduate student, Department of Hydraulics and Ocean Engineering, National Cheng Kung University, Tainan | 1996 | China Ocean Engineering1996，11，3： | 0 |
| 19 | Analysis of the Scope of 'Protected Persons' in the Fourth Geneva Convention of 1949显示文摘As the core of the International Humanitarian Law, the Geneva Conventions of 1949 have just celebrated their 61st anniversary. Here after a brief historic background introduction, the writer detailed analyzed the | YAN GUANZHU a graduate student at China University of Political Science and Law | 2011 | The Journal of Human Rights2011，10，1： | 0 |
| 20 | Action of Cnoidal Waves on Vertical Walls显示文摘Based on the 2nd order cnoidal wave theory, the characters of shallow water standing waves and their action on vertical walls are studied in this paper. The theoretical expressions of the wave surface elevation in front of and the wave pressure on the vertical wall are obtained. In order to verify the theoretical results, model tests were made in the State Key Laboratory of Coastal and Offshore Engineering at DUT. For the wave surface elevation in front of the wall and the wave forces on the wall at the moment when the wave surface at the wall surface goes down to the bottom of the wave trough, the calculated results coincide quite well with the experimental results. For the wave forces on the wall at the moment when the wave surface at the wall surface goes up to the top of the wave crest, the theoretical expressions are modified by the experimental results. For the convenience of practical use, calculations are made for the wave conditions which usually occur in enginering practice by use of the | Qiu Dahong , Zang Jun and Jia Ying Academician of the Chinese Academy of Sciences, Professor, the State Key Laboratory of Coastal and Offshore Engineering (SLCOE), Dalian University of Technology (DUT), Dalian 116024. Former Ph. D Graduate Student, SLCOE, DUT, Dalian 116024. . Former M. S. Graduate Student, SLCOE, DUT, Dalian 116024 | 1996 | China Ocean Engineering1996，11，2： | 0 |
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