|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases显示文摘AIM To establish a relevant animal model ofhuman gastrointestinal cancer, which can beused for repetitive investigations, so as toimprove our understanding and management ofcarcinogenesis and cancer metastasis.METHODS Intact tissues of human colorectaland pancreatic cancers were transplanted innude mice. The biological characteristics of theoriginal and the corresponding transplantedtumors were investigated by HE staining, PASstaining and immunostaining. The metastases inthe livers and lungs of nude mice wereinvestigated by immunostaining withbiotinylated mab KL-1 and by RT-PCR using CK20specific primers.RESULTS There were totally 9 of 16 surgicalspecimens growing in nude mice subcutaneouslyand/.or orthotopically (4 of 6 colorectal and 5 of10 pancreatic cancer). Tumor cell content of thespecimens and freezing of tissue specimens areimportant factors influencing the growth oftransplanted tumor. In the group of fresh tumortissues with greater than 50% tumor cellcontent, the success rate of the transplantationwas 100% (3 cases of pancreatic cancer and 3cases of colorectal cancer). The orthotopicallytransplanted tumors resemble the original tumormorphologically and biologically, including TAAexpression such as CEA byimmunohistochemistry, and CEA level in theserum of mice. Ki-67 labeling index and theexpression of TAA especially K-ras, 17-lA andRA-96, are associated with the potential of tumorgrowth in nude mice. Micrometastases in thelungs and livers of tumor bearing mice can bedetected by immunostaining with biotinylatedmab KL-1 and CK20-specific RT-PCR.CONCLUSION An orthotopic transplantationmodel for human colon and pancreatic cancer innude mice has been set up. We have alsoestablished sensitive detection methods withCK-immunohistochemistry and CK20-RT-PCR tostudy xenotransplanted human cancer and itsmetastatic cancer cells in the liver and lung ofnude mice. This study may be helpful inunderstanding the mechanism of cancermetastasis and in developing new diagnosticmethods and therapeutic strategies formetastases including micrometastases. | Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 2 | SEDIMENT TRANSPORTED BY DEBRIS FLOWTO THE LOWER JINSHA RIVER显示文摘The lower Jinsha River is an area with the highest sediment yield in the upper Yangze basin. Itcovers only 9.27% of the total area of the basin but supplies about 40% of the total sediment recordedat the Yichang Hydrological Station. The present study shows that besides strong slope erosion andwaste discharge from engineering works, debris-flow transport is an important source of the sedimentload in the river. Based on field investigation and measurement, the annual sediment transport intothe lower Jinsha River basin was estimated at 1.54×10 to 67.07×10. | CUI Peng1 WEI Fangqiang2 and LI Yong3(1 Prof. Dongchuan Debris Flow Observation and Research Station. Institute of Mountain Hazards and Environment,CAS, Chengdu 610041. China.)(2 Ph.D. student, Institute of Mountain Hazards and Environment, CAS. and Sou | 1999 | International Journal of Sediment Research1999，14，4： | 19 |
| 3 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 4 | 2型糖尿病患者服用吡格列酮的膀胱癌风险显示文摘背景
吡格列酮是一种有争议的噻唑烷二酮类口服降糖药物,可以有效降低糖化血红蛋白(HbA1c)浓度,且降低心血管事件的发生风险,但同时也与体重增加和充血性心力衰竭风险的增加有关。尽管目前数据有限,但还是有证据显示它可能还与膀胱癌患病风险的增加有关。 | Laurent Azoulay assistant professor Hui Yin statistician Kristian B Filion assistant professor Jonathan Assayag graduate student 王子贤(编译) | 2012 | 中国处方药2012，10，5： | 17 |
| 5 | Emergency assessment of seismic landslide susceptibility: a case study of the 2008 Wenchuan earthquake affected area显示文摘The 8.0 Mw Wenchuan earthquake triggered widespread and large scale landslides in mountainous regions.An approach was used to map and assess landslide susceptibility in a given area.A numerical rating system was applied to fi ve factors that contribute to slope instability.Factors such as lithology,topography,streams and faults have an important influence as event-controlling factors for landslide susceptibility assessment.A f inal map is provided to show areas of low,medium,and high landslide susceptibility.Areas identifi ed as having high landslide susceptibility were located in the central,northeastern,and far south regions of the study area.The assessment results will help decision makers to select safe sites for emergency placement of refuges and plan for future reconstruction.The maps may also be used as a basis for landslide risk management in the study area. | Tang Chuan,Zhu Jing and Liang Jingtao State Key Laboratory of Geo-Hazard Prevention,Chengdu University of Technology,Chengdu 610059,China Professor Associate Professor Graduate Student | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 16 |
| 6 | Building damage in Dujiangyan during Wenchuan Earthquake显示文摘A field damage survey of 1,005 buildings damaged by the Wenchuan Earthquake in Dujiangyan City was carried out and the resulting data was analyzed using the statistical method. It is shown that buildings that were seismically designed achieved the desired seismic fortification target; they sustained less damage than the non-seismically designed buildings. Among the seismically designed buildings investigated, RC frame buildings performed the best in terms of seismic resistance. Masonry buildings with a ground story of RC frame structure were the second best, and masonry buildings performed the worst. Considering building height, multistory buildings sustained more severe damage than high-rise buildings and 2- and 3-story buildings. Compared to residential buildings, public buildings, such as schools and hospitals, suffered more severe damage. | Zhang Minzheng and Jin Yingjie Institute of Engineering Mechanics, China Earthquake Administration, Harbin 150080, China Professor Graduate Student | 2008 | Earthquake Engineering and Engineering Vibration2008，7，3： | 13 |
| 7 | Dynamic Response Behaviors of Upright Breakwaters Under Breaking Wave Impact显示文摘- The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impulse duration (or oscillation period) on the translation, rotation, sliding force, overturning moment, and corresponding dynamic amplifying factors are studied. It is concluded that the ampli-ying factors only depend on the ratio of the system natural period to impulse duration (or oscillation period) under a certain damping ratio. Moreover, the equivalent static approach to breakwater design is also discussed. | Wang Yuanzhan , Chi Lihua and Pan Houzhi Associate Professor, Department of Water Resources and Harbour Engineering, Tianjing University, Tianjin 300072Lecturer, Computer Center, Tianjing University, Tianjin 300072 Graduate student, Department of Water Resources and Harbour Engineering, Tianjing University, Tianjin 300072 | 1996 | China Ocean Engineering1996，11，3： | 12 |
| 8 | Structural condition assessment of long-span suspension bridges using long-term monitoring data显示文摘这份报纸集中于用监视系统的结构的健康测量的长期的监视数据开发一种联机结构的条件评价技术。为 Runyang 暂停桥的频率温度和横梁结束排水量温度的季节的关联首先被执行。然后,用一个六顺序的多项式的一种统计建模技术进一步被使用提出频率温度和排水量温度,测量频率和排水量的反常变化用吝啬的价值控制图表从被检测的关联。分析结果证明更高的颤动模式和排水量的形式的频率与环境温度和建议方法展览有显著季节的关联为检测形式的频率和排水量的微导致损坏的变化的一个好能力。结果证明建议方法能有效地从频率和排水量时间系列消除温度复杂并发症并且很好适合长跨度的暂停桥监视的联机状况。监视的关键词结构的健康 - 形式的频率 - 横梁结束排水量 - 温度 - 季节的关联 - 暂停桥牌旁边支持了:在资助号码下面的中国的国家自然科学基础 50725828 与号码 50808041;不到资助号码 200802861011 的中国的教育部的博士节目基础;东南大学在下面的研究生院的科学研究基础资助没有。 | Deng Yang~+,Ding Youliang~(++) and Li Aiqun~§Key Laboratory of Concrete & Prestressed Concrete Structures of Ministry of Education,Southeast University,Nanjing 210096,China PhD Student ++ Assistant Professor ~§Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 12 |
| 9 | 宝鸡石嘴头东区发掘报告显示文摘一、地理位置和自然环境石嘴头位于宝鸡市渭滨区石坝河乡东面的台地上,北临渭河,与宝鸡市区遥遥相望,东濒茵香河,南倚石鼓山,西宝公路由石嘴头上崖和石鼓山间东西穿过,距离宝鸡市区约6公里。这里地势高隆,依山傍水,自古即为人类生活活动的重要场所(图一;图版叁,1)。 | Student Team of Class 82, Speciality of Archaeology, Department of History, Northwestern University | 1987 | 考古学报1987，，2： | 11 |
| 10 | Housing Wealth, Financial Wealth and Consumption in China显示文摘纸在城市的中国在财产财富和家庭消费的趋势运动调查在变化之间的关系。用向量错误修正 cointegration 模型,我们证明在城市的中国在家庭消费,可处理的收入,金融财富和住房财富之间有一种唯一的长期间 cointegrating 关系。当 cointegrated 系统被外部震动扰乱时,我们发现住房财富是恢复长期间平衡关系的唯一的因素。另外,我们的永久临时的变化分解分析都显示那在消费的运动的变化是永久的,支持消费行为的古典随机的散步假设。然而,在住房财富的短期的运动的变化的一个大比例被发现临时。 | Jie Chen Feng Guo Aiyong Zhu Associate Professor,School of Management,Fudan University,Shanghai,China. Senior Research Economist and Economics Lecturer,Haile/US Bank College of Business,Northern Kentucky University,Highland Heights,USA. Master Student,School of Economics,Fudan University,Shanghai,China. | 2009 | China & World Economy2009，17，3： | 10 |
| 11 | Ethylene oligomerization by novel iron(Ⅱ) diimine complexes/MAO显示文摘Two novel Fe(Ⅱ) diimine complexes have been synthesized. In combination with MAO, they generate active catalytic systems that oligomerize ethylene with both high catalytic activity and high selectivity for a-olefins. The effects of substituents on the aryl ring, reaction temperatures and molar ratios of Al/Fe on catalytic activity and product distribution are studied. | WANG Hang, YAN Weidong, JIANG Tao, LIU Binbin, XU Wenqing, MA Jianjiang & HU YouliangState Key Laboratory of Engineering Plastics, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Graduate Student of | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 12 | Research on Relationships Between Built Environment and Criminal Behavior in Parking Areas: A Case Study on Pudong New Area, Shanghai | MAO Yuanyuan, PhD Candidate, School of Architecture & Urban Planning, Tongji University, Shanghai, P. R. China. DAI Shenzhi, Professor, School of Architecture & Urban Planning, Tongji University, Shanghai, P. R. China. DENG Tian, China Overseas Property Group Co., Ltd (Eastern China), Shanghai, P. R. China. XU Bin, Off icer, Shanghai Municipal Public Security Bureau Pudong Branch, Shanghai, P. R. China. ZHU Wei, PhD, Eindhoven University of Technology, Eindhoven, the Netherlands. DONG Hengping, Postgraduate student, School of Architecture & Urban Planning, Tongji University, Shanghai, P. R. China. | 2009 | China City Planning Review2009，18，2： | 7 |
| 13 | Generation and Deformation of Solitary Waves显示文摘Base on the Lagrangian description and finite differencing of the time step, the generation, propagation and deformation of solitary waves are simulated numerically by means of boundary element method. An algorithm to generate waves with any prescribed form is also implanted in the scheme, but in this research, solitary waves are studied. The numerical model is first verified by studying the case of a solitary wave impinging against a vertical wall. Time histories of evolution of a soliton running up on a sloping beach, as well as over a submerged obstacle are then presented. Applications to scattering problems due to solitary waves progressing over a slope onto a shelf are also shown. | Chou Chung-Ren Shih Ruey-Syan Professor, Dept. of Harbor and River Engineering, National Taiwan Ocean University . Graduate Student, Dept. of Harbor and River Engineering, National Taiwan Ocean University | 1996 | China Ocean Engineering1996，11，4： | 6 |
| 14 | 关于老市区屋顶绿化的初步设想显示文摘本文认为屋顶绿化是老市区绿化工作的重要出路,并提出屋顶绿化的基本原则。 | StudentReporters of Environmental Protection, Middle SchoolAttached to the Guangzhou Normal University(Tutors: He Weijiang, Qi Donghai) | 1998 | 广州师院学报(社会科学版)1998，19，1： | 6 |
| 15 | A new seismic isolation system and its feasibility study显示文摘这份报纸介绍称为一个周期的基础(PF ) 的一个新地震隔离系统,在包括周期性地被安排的地方。PF 与传统的基础隔离不同因为它在结构引起基本频率移动,因此减少它的反应并且产生频率差距。如果一个震波的频率内容掉进差距,它不能在基础宣传。因此,它不对上面的结构施加影响。为 2D PF 的频率差距的乐队的系统的研究被进行。象密度和有弹性的模量以及频率差距的乐队上的 PF 和它的材料的充满的部分那样的物理、几何的参数的影响被调查,并且有象 2.49 鈥 ?.72 Hz 一样低的频率差距的一个图案被完成。频率差距的这个乐队在地震工程对应于很好设计系列。有不同基础的六故事的框架结构的数字模拟证明一个建议 PF 罐头极大地减少孤立的结构的地震反应。这调查证明 PF 在地震隔离技术的未来应用有大潜力。关键词地震隔离 - 周期的基础 - 频率差距的乐队旁边支持了:在资助 No.90715006 | Jia Gaofeng~+ and Shi Zhifei~(++) School of Civil Engineering,Beijing Jiaotong University,Beijing 100044,China Graduated Student ++ Professor | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 6 |
| 16 | NUTRIENT LOAD ESTIMATION METHODS FOR RIVERS显示文摘Pollutant load estimation is essential for watershed management and water pollution control. For most watersheds, only sparse water quality measurements (e.g. monthly data) are available. The influence of input data on the accuracy of non-point source pollution load estimation is studied using the water quality and stream flow data from a small watershed in Hong Kong. Comparison and analysis of the results using 8 different methods show that the accuracy of stream-flow runoff is the single most important factor for the calculation of pollutant load. Based on the results, the stream flow correction coefficient is advanced to provide a more reliable load estimation. The improved method of pollutant load estimation can be easily applied in practice since the stream-flow runoff can be measured by hydrological station or estimated with various hydrological methods. | Huai-en LI. Joseph Hun-Wei LEE and Ming CM Professor, Environmental Science Institute, Xi’an University of Technology. Xi’an 710048. Shaanxi, P.R. China.Professor, Department of Civil Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong.P.R. China, 1 Ph.D. student in Hydrology and Water Resources. Environmental Science Institute, Xi’an University ofTechnology, Xi’an 710048, Shaanxi, P.R. China | 2003 | International Journal of Sediment Research2003，18，4： | 5 |
| 17 | Experimental study on hysteretic behavior of prestressed truss concrete composite beams显示文摘这篇论文描述 hysteretic 行为的试验性的研究对在周期的装载下面捆绑具体合成横梁(PTCCB ) 。五个横梁模型被设计并且测试,在哪个严峻的参数包括全球加强索引尾 0, prestress 水平位和在潜在的塑料的马镫蟻 sv 的比率依赖地区。基于测试结果,失败模式和测试模型的 hysteretic 行为被获得。另外, P- 螖和部分 M- 蠁 hysteretic 当模特儿因为在 midspan 的 PTCCB 被建立。P- 螖 hysteretic 模型与测试结果显示出好同意。关键词对 - 捆绑 - 合成横梁 - hysteretic 行为 - 全球加强索引 - 对旁边支持的水平:在资助号码 2006BAJ03A10-07 下面的国家科技支持节目副主题;Changjiang | Zheng Wenzhong,Wang Kun~(++) and Zhang Geming~§School of Civil Engineering,Harbin Institute of Technology,Harbin 150090,China ~+Changjiang Scholars Professor ++ PhD Student | 2010 | Earthquake Engineering and Engineering Vibration2010，9，1： | 5 |
| 18 | APPLICABILITY OF SEDIMENT TRANSPORT FORMULAS显示文摘The paper provides a comprehensive testing of the applicability of 13 sediment transport formulas under different flow and sediment conditions. The dimensionless parameters used for testing the reliability and sensitivity of formulas are dimensionless particle diameter, relative depth, Froude number, relative shear velocity, dimensionless unit stream power, and sediment concentration. A total of 3,391 sets of laboratory and river data are used in the tests. Engineers may find the test results useful to their selection of formulas under different flow and sediment conditions. | Chih Ted YANG and Caian HUANG Manager, Sedimentation and River Hydraulics Group, Technical Service Center, U.S. Bureau of Reclamation, Denver, Colorado 80225. Graduate student, College of Harbour, Waterway and Coastal Engineering, Hohai University, Nanjin | 2001 | International Journal of Sediment Research2001，16，3： | 4 |
| 19 | Grain refinement induced by electromagnetic stirring: A dendrite fragmentation criterion显示文摘 | T. Campanella Ph.D. Student Project Manager C. Charbon M. Rappaz | 2004 | Metallurgical and Materials Transactions A2004，，10： | 4 |
| 20 | Exploring New City Building Types,Weaving Urban Context:A Case Study on Old City of Jinan显示文摘1. The loss of identities and context: not just a story for one city Located at the north foot of Mount Lishan and to the south of Xiaoqinghe River and Huanghe (Yellow) River, the ' | ZHANG Jie,Professor,School of Architecture,Tsinghua University,Beijing,China DENG Xiangyu,PhD candidate,School of Architecture,Tsinghua University,Beijing,China YUAN Luping,Postgraduate student,School of Architecture,Tsinghua University,Beijing,China.LI Caige | 2006 | China City Planning Review2006，15，2： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员