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128篇 您的检索式：作者名="Gorczynski"

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	题名	作者	年代	出处	被引量
1	Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis显示文摘AIM To determine the effect of overexpression of fibrinogenlike protein 2(FGL2) on regulatory T cell(Treg) and effector T(Teff) cell function on T cell-induced colitis in Rag1-/-mice.METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2 Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/-mice. RESULTS In vitro, fgl2 Tg Treg had enhanced immunosuppressive activity, and fgl2 Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice(fgl2+/+) into Rag1-/-mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2 Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/-Treg were only partially protective. In mice that received fgl2 Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2 Tg mice did not produce colitis. CONCLUSION Here we show that fgl2 Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2 Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease.	Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy	2017	World Journal of Gastroenterology2017，23，15：	2
2	Anti-CD200R ameliorates collagen-induced arthritis in mice显示文摘	CHEN Z Q LEE L	2002	Clin Immunol2002，104，3：	1
3	Evidence of a role for CD200 in regulation of immune rejection of leukaemic tumour cells in C57BL/6 mice显示文摘	CHEN Z Q HU J	2001	Clin Exp Immunol2001，126，：	1
4	Exercise therapy for schizophrenia 显示文摘	Gorczynski P Faulkner G	2010	Cochrane Database Syst Rev2010，，00：	1
5	Biomechanics of the pulmonary autograft valve in the aortic position显示文摘	Gorczynski A Trenkner M Anisimowicz L et ai	1982	Thorax1982，37，：	1
6	dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival显示文摘	Min WP Gorczynski R Huang XY	2000	J Immunol2000，164，1：	1
7	Aging and the immune system显示文摘	Reginald M. Gorczynski Ender Terzioglu	2008	International Urology and Nephrology2008，，4：	1
8	Dentritic cells genetically engineered to express Fas ligand induce donor specific hyporesponsive and prolong allograft survival 显示文摘	Min WP Gorczynski R Huang XY	2000	J Immunol2000，164，1：	1
9	Major histocompatibility complex expression and lung ischemia reperfusioninrats显示文摘	Waddell T K Gorczynski R M DeCampos K N	1996	AnnThoracSurg1996，62，86：	1
10	Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival显示文摘	Min WP Gorczynski R Huang XY	2000	J Immunol2000，164，：	1
11	Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival显示文摘	Min WP Gorczynski R Huang XY	2000	J Immunol2000，164，1：	1
12	Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival 显示文摘	Min WP Gorczynski R Huang XY	2000	J Imaunol2000，164，1：	1
13	Inheritance of acquired immunological tolerance to foreign histocompatibility antigens in mice显示文摘	Steele E J	1980	PANS(USA)1980，77，：	1
14	Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and non-cirrhotic human livers显示文摘	Clavien PA Camargo CA Gorczynski R	1996	Hepatology1996，23，：	1
15	Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival显示文摘	Min WP Gorczynski R Huang XY		0，，1：	1
16	An interaction between CD200 and monoclonal antibody agonists to CD200R2 in development of dendritic cells that preferentially induce populations of CD4+CD25+T regulatory cells显示文摘	Gorczynski R Khatri I Lee L	2008	J Immunol2008，180，：	1
17	Simultaneous yet independent inheritance of somatically acquired tolerance to two distinct H-2 antigenic haplotype determinants in mice显示文摘	Steele E J	1981	Nature1981，289，：	1
18	Major histocompatibility complex expression and lung ischemia-reperfusion in rats显示文摘	Waddell TK Gorczynski RM DeCampos KN	1996	Ann Thorac Surg1996，62，3：	1
19	Transfusion-related immunomodulation due to peripheral blood dendritic cells expressing the CD200 tolerance signaling molecule and alloantigen 显示文摘	Clark DA Gorczynski RM Blajchman MA	2008	Tansfusion2008，48，5：	1
20	Expression of a CD200 transgene is necessary for induction but not maintenance of tolerance to cardiac and skin allografts显示文摘	Gorczynski RM Chen Z He W		0，，03：	1

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