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| 1 | Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis显示文摘AIM To determine the effect of overexpression of fibrinogenlike protein 2(FGL2) on regulatory T cell(Treg) and effector T(Teff) cell function on T cell-induced colitis in Rag1-/-mice.METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2 Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/-mice. RESULTS In vitro, fgl2 Tg Treg had enhanced immunosuppressive activity, and fgl2 Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice(fgl2+/+) into Rag1-/-mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2 Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/-Treg were only partially protective. In mice that received fgl2 Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2 Tg mice did not produce colitis. CONCLUSION Here we show that fgl2 Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2 Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease. | Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy | 2017 | World Journal of Gastroenterology2017，23，15： | 2 |
| 2 | Biomechanics of the pulmonary autograft valve in the aortic position显示文摘 | Gorczynski A Trenkner M Anisimowicz L et ai | 1982 | Thorax1982，37，： | 1 |
| 3 | IL-8, IL-10, TGF-β, and GCSF levels were increased in severe persistent allergic asthma patients with the anti-lgE treatment显示文摘 | Yalcin AD Bisgin A Gorczynski RM | 2012 | Mediators Inflamm2012，，72： | 1 |
| 4 | IL-8, IL-10, TGF- ,and GCSF levels were increased in severe persistent allergic asthma patients with the anti-IgE treatment 显示文摘 | Yalcin AD Bisgin A Gorczynski RM | 2012 | Mediators of Inflammation2012，1，2012： | 1 |
| 5 | Circulating soluble tumor necrosis factor related apoptosis inducing-ligand (TRAIL) is decreased in type-2 newly diagnosed, non- drug using diabetic patients显示文摘 | Bisgin A Yalcin AD Gorczynski RM | 2012 | Diabetes Res Clin Pract2012，96，3： | 1 |
| 6 | ALK-positive cancer: still a growing entity显示文摘 | Gorczynski A Prelowska M Adam P | 2014 | Future Oncol2014，10，2： | 1 |
| 7 | Biomechanics of the pulmonary autograft valve in the aortic position显示文摘 | Gorczynski A Trenkner M Anisimowicz L | 1982 | Thorax1982，37，7： | 1 |
| 8 | Low-dose enoximone improves exercise capacity in chronic heart failure ? ? A list of the Enoximone Study Group Members and institutional affiliations is provided in the appendix .显示文摘 | Brian D Lowes Michael Higginbotham Lawrence Petrovich Marcus A DeWood Mark A Greenberg Peter S Rahko G.William Dec Thierry H LeJemtel Robert L Roden Margo M Schleman Alastair D Robertson Richard J Gorczynski Michael R Bristow | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 9 | Biomechanics of the pulmonary autograft valve in the aortic position显示文摘 | Gorczynski A Trenkner M Anisimowicz L | 1982 | Thorax1982，37，： | 1 |
| 10 | Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2显示文摘 | Ding J W Yu G Levy G A Gorczynski R M | 2001 | Mol Hum Reprod2001，7，2： | 1 |
| 11 | Correlation of peripheral blood lymphocyte and intragraft cytokine mRNA expression with rejection in orthotopic liver transplantation 显示文摘 | GORCZYNSKI R M ADAMS R B LEVY G A | 1996 | Surgery1996，120，： | 1 |
| 12 | Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface显示文摘 | CHEN Z CLARK D A | 2004 | Am J Reprod Immunol2004，52，2： | 1 |
| 13 | Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and noncirrhotic human livers显示文摘 | Clavien P A Camargo C A Jr Gorczynski R | 1996 | Hepatology1996，23，6： | 1 |
| 14 | Receptor engagement on cells expressing a ligand for the tolerance-inducing molecule OX2 induces an immunoregulatory population that inhibits alloreactivity in vitro and In vivo显示文摘 | YU K CLARK D A | 2000 | J Immunol2000，165，： | 1 |
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