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| 1 | Geochemistry and petrogenesis of Jurassic high Sr/low Y granitoids in eastern China: Constrains on crustal thickness显示文摘The Jurassic high Sr/low Y granitoids in eastern China are characterized by high Sr/Y (27-166) and La/Yb (14-66) ratios, low abundance in Y (6-21μg/g) and Yb (0.5-2.0μg/g), comparable with those of adakites defined by Defant et al. Thus, they were recently considered as adakitic rocks by some researchers. Compared with the typical adakites in circum-Pacific margins, however, these high Sr/low Y granitoids have higher K2O (-3.5%) but lower A12O3 (-16.0%) as well as lower Mg#(-38) and δSrN (-1.23) values. Furthermore, they show relatively flat HREE patterns with Y/Yb values of -10 close to the chondritic value. These geochemical characteristics indicate a residue mineral assemblage of hornblende, garnet and plagioclase for these high Sr/low Y granitoids melt. Thus, they were generated by partial melting at 9-13 kbar (30-45 km in depth), similar to the Archaean high-Al TTG rather than the modern adakites. Generation of these high Sr/low Y granitoids cannot be considered as evidence for a thickened | Ge, XY Li, XH Chen, ZG Li, WP | 2002 | Chinese Science Bulletin2002，47，11： | 51 |
| 2 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 3 | Comparison of epinephrine and Shen-Fu injection on resuscitation outcomes in a porcine model of prolonged cardiac arrest显示文摘 | Yin WP Lics GuoZJ | 2014 | Chinese Medical Journal2014，，4： | 12 |
| 4 | Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts显示文摘Periprosthetic joint infection(PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively(4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one ormore positive culture results. Debridement, antibiotics and implant retention(DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus(aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one- or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. | Jesse WP Kuiper Robin Tjeenk Willink Dirk Jan F Moojen Michel PJ van den Bekerom Sascha Colen | 2014 | World Journal of Orthopedics2014，5，5： | 12 |
| 5 | DSA analysis of hepatic arteriovenous fistula concurrent with hepatic cancer and its clinical significance显示文摘INTRODUCTIONIntervention therapy has become one of the maintherapies of hepatic cancer.Theintroduction of hepatic arterial perfusion andembolization has provided opportunities for asecondary operation on patients with intermediateand advanced cancer,thus | Guo WP Zhang HX Wang ZM Wang YQ Ni DH Li WX Guan Y | 2000 | World Journal of Gastroenterology2000，6，6： | 11 |
| 6 | 傅里叶变换红外光谱衰减全反射谱研究聚氨酯和聚脲显示文摘用傅里叶变换红外光谱(FTIR)衰减全反射谱(ATR)研究了溶液聚合的四种模型嵌段聚氨酯(聚氨酯-氨酯、聚脲-氨酯、聚氨酯-脲和聚脲-脲)。用ATR谱说明了在硬段微区和硬段微区软段微区的相界面区,不同键对这些聚合物热性质和力学性质的影响,并详细讨论了ATR谱的羟基C=O、醚氧键C—O—C、酰胺Ⅱ谱带及氢键的情况。 | 陈竹生 Yang WP Macosko CW. | 1992 | 高分子材料科学与工程1992，8，6： | 10 |
| 7 | Determination of global mean sea surface WHU2000 using multi-satellite altimetric data显示文摘In this study, the overall editing criteria for altimetric data are considered and the geophysical correction models is improved. The datum for various altimetric data is also unified and the method of a full-combined crossover adjustment for different altimetric tracks is used to improve the radial orbits of Geosat, ERS-1 and ERS-2 data. In addition, the method for determining mean sea surface (MSS) by using multi-altimetric data is developed. The data used to compute WHU2000 MSS include 7-year Topex/Poseidon data (cycles 11-249), 2-year Geosat ERM data (cycles 1-44), 5-year ERS2 data (cycles 1-52) and all ERS-1 168-day data. The WHU2000 MSS is determined with a grid resolution of 2’×2’ within the ± 82° latitude and its precision is better than 0.05 m. Comparing WHU 2000MSS with 3.75’×3.75’ CLS_SHOM98.2 MSS, 3’×3’ GFZ MSS95A and 3.75’×3.75’ OSU MSS95, as external checks, the corresponding standard deviation (STD) of their differences is 0.090 m, 0.211 m and 0.079 m respectively. | Jiang, WP Li, JC Wang, ZG | 2002 | Chinese Science Bulletin2002，47，19： | 9 |
| 8 | 聚氨酯和聚脲的傅里叶变换红外透射光谱的研究显示文摘用傅里叶变换红外透射光谱研究了溶液聚合的四种模型嵌段共聚物——聚氨酯-氨酯、聚脲-氨酯、聚氨酯-脲、聚脲-脲——在硬段微区和相界面区氢键的情况,并与衰减全射谱在分析这些模型嵌段共聚物时的情况进行了对比。 | 陈竹生 Yang WP Macosko CW | 1993 | 高分子材料科学与工程1993，9，3： | 9 |
| 9 | WONCA研究论文摘要汇编--老年亚临床甲状腺功能减退治疗策略的国际变化趋势:一项基于案例的调查显示文摘背景关于亚临床甲状腺功能减退治疗效果的证据十分有限,特别是对于老年患者的治疗效果。目的探讨全科医生在不同国家和针对不同类型的患者对老年亚临床甲状腺功能减退治疗的不同方式。设计和环境在荷兰、德国、英格兰、爱尔兰、瑞士和新西兰进行基于案例的全科医生调查。方法评估全科医生对于8例表现为亚临床甲状腺功能减退患者的治疗策略(治疗是/否,起始剂量甲状腺素)。患者的特征如年龄(70岁与85岁),活力状态(充满活力与脆弱)和促甲状腺激素(TSH)浓度(6 m U/L与15 m U/L)均有差异。结果共有526名全科医生参与此项研究(瑞士262名、荷兰129名、德国61名、新西兰31名、英格兰22名、爱尔兰21名,总有效率为19%)。不同国家的治疗策略会有所不同。相比较于来自德国(平均治疗比例为73%)、爱尔兰(平均治疗比例为62%)和瑞士(平均治疗比例为52%)的全科医生,来自荷兰(平均治疗比例为34%)、英格兰(平均治疗比例为40%)和新西兰(平均治疗比例为39%)的全科医生更加不倾向于实施治疗(P=0.05)。总体来讲,全科医生更倾向于对70岁的女性患者实施治疗,而不是85岁的女性患者〔比值比=0.74,95%CI(0.63,0.87)〕。TSH为15 m U/L的患者比TSH为6m U/L的患者更易于得到治疗〔比值比=9.49,95%CI(5.81,15.5)〕。结论全科医生对于不同国家和不同类型的老年亚临床甲状腺功能减退患者的治疗策略有很大差异,而这种差异说明有必要建立新一代基于初级卫生医疗随机临床试验的国际指南。 | den Elzen WP Lefèbre-van de Fliert AA Virgini V 周淑新 | 2015 | 中国全科医学2015，18，12： | 4 |
| 10 | 粗饲料种类、可代谢蛋白质浓度、碳水化合物来源对奶牛养分消化率及生产性能的影响显示文摘本试验采用中心组合试验设计对粗饲料来源、可代谢蛋白质(MP)浓度、碳水化合物种类及其互作效应对奶牛养分消化率和生产性能的影响进行了评价。所有日粮(干物质基础)均有50%由苜蓿青贮、玉米青贮构成的粗饲料、10.7%的瘤胃降解蛋白质(RDP)、4.1%~7.1%的瘤胃未降解蛋白质(RUP)、8.8%~12%的MP和22%~30%的淀粉组成。本试验共有15种日粮,试验牛分为6个区组,每个区组6头荷斯坦奶牛,分别进行3个为期21 d的试验。每期按特定顺序饲喂3种日粮后测定试验牛的产奶量、乳成分、采食量及主要营养物质消化率,还考虑了几个主要影响因素间的互作效应。结果表明:日粮淀粉浓度对奶牛养分消化率和生产性能影响较小;用苜蓿青贮代替玉米青贮可降低奶牛的氮消化率、提高中性洗涤纤维(NDF)消化率,还能增加奶牛对日粮干物质(DM)和日粮消化能(DE)摄入量,从而提高能量校正乳(ECM)、乳脂及乳蛋白产量;增加日粮MP浓度可提高奶牛对氮的消化率、ECM和乳蛋白产量,但乳蛋白含量的变化远小于NRC所推荐模型的预测值;DE浓度随淀粉浓度升高呈线性升高,但同时受粗饲料种类和MP浓度互作的影响,即日粮MP浓度较低时,DE浓度会随苜蓿青贮比例升高而降低,而日粮MP浓度较高时,DE浓度会随苜蓿青贮比例升高而升高。 | 郑宇慧 李胜利 Weiss WP St-Pierre N R Willett L B | 2018 | 中国畜牧杂志2018，54，11： | 4 |
| 11 | 一项关于恩替卡韦联合聚乙二醇干扰素治疗HBeAg阳性慢性乙型肝炎的多中心随机对照研究显示文摘恩替卡韦可以强有力地抑制HBV的复制,但是需要长期治疗。荷兰鹿特丹Erasmus MC大学医学中心的Brouwer WP等人通过一项全球、开放的多中心随机对照试验,研究恩替卡韦联合聚乙二醇干扰素是否可以提高病毒学应答效率。他们初始采用恩替卡韦(0.5 mg/d)单药治疗HBe Ag阳性慢性乙型肝炎(CHB)的代偿性肝病患者,在治疗24周后,将患者按1∶1随机分为2组,恩替卡韦联合聚乙二醇干扰素(180μg/周)治疗组和恩替卡韦单药治疗组,治疗至48周。 | Brouwer WP 王欢 赵旭 | 2015 | 临床肝胆病杂志2015，31，1： | 3 |
| 12 | 胃癌组织Ⅱ型β转化生长因子受体基因突变的研究显示文摘目的 β转化生长因子 ( transforming growth factorβ,TGF- β) 型受体 TGF- βR 基因突变是某些肿瘤细胞逃逸 TGF- β生长抑制调控的机制之一。有报道表明 TGF- βR 基因的两个突变热点 ( c DNA70 9- 718,1931- 1936)在人类结肠癌细胞系有高的突变率。据此我们检测了 TGF- βR 基因这两个热点在 4 4例人胃癌组织的改变。方法 组织 DNA提取后进行 PCR- SSCP银染分析 ,将阳性标本进行荧光测序。结果 在 TGF- β R 的 c DNA70 9- 718位点突变率为 6.8% ( 3/ 4 4 ) ,而另一位点 c DNA1931- 1936未发现突变 ( 0 / 4 4 )。结论 TGF- β R 基因在人胃癌组织较之结肠癌具有低的突变率。 | 柯杨 K Hagiwara 苏秀兰 冯莉雅 张建明 王永信 WP Bennet | 1997 | 中华肿瘤杂志1997，19，1： | 3 |
| 13 | Can the rat donor liver tolerate prolonged warm ischemia?显示文摘INTRODUCTIONThe last two decades of the twentieth century havewitnessed increasingly successful rates of livertransplantation.The number of liver transplantations hasincreased steadily while the number of organ donors | Yan JQ Li HW Cai WY Zhang MJ Yang WP | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 14 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 15 | 甘醇脱水装置设计准则(二)显示文摘甘醇脱水装置设计准则(二)(美)W·P·Manning,H·SWood本三甘醇吸收工艺设计准则将减少水合物的堵塞问题,杜绝因天然气中含水而引起的停工停产。另外,设备可按下述方法合理确定尺寸,这些设计准则和控制方法帮助你正确计算吸收塔和再生装置。泵可用... | Mann.,WP 王小康 | 1996 | 天然气与石油1996，14，4： | 2 |
| 16 | Follow-up in the micronucleus frequencies and its subsets in human population with chronic low-dose gamma irradiation exposure显示文摘 | Chang WP Tsai WS Hwang JS | 1999 | Mutat Res1999，428，： | 2 |
| 17 | ELISA检测鸡传染性贫血病病毒抗体中的非特异性反应问题显示文摘为了监测CSIROSPF鸡群,经常用商业ELISA试剂盒检测鸡群的抗鸡传染性贫血病毒(CAV)抗体。近来发现个别鸡群的阳性率达18.2%,占总数的2.7%。但后来采血发现大部分可疑鸡都为阴性,可见前面的结果存在假阳性。 | Mich.,WP 胡青海 | 1997 | 国外兽医学(畜禽传染病)1997，17，2： | 2 |
| 18 | FBC中含S和Cl煤燃烧下的碳钢退化研究显示文摘在实验室规模的流化床 (FBC)中分别燃烧低S(0 97mass% )与低Cl(0 0 2 6mass% ) ,中S(1 6 8mass% )与高Cl(0 4 2mass % ) ,高S(4 4 8mass% )与高Cl(0 4 1mass% )三种煤各 10 0 0小时后 ,对放置于接近沸腾床位置的A2 10 -C碳钢管的退化情况进行了研究 .结果表明 ,(1)碳钢退化明显受温度影响 ,随表面温度的升高显著加快 ;(2 )碳钢退化明显受飞行粒子带来的冲蚀影响 ;(3)燃烧低S低Cl煤对碳钢的耗损影响最小 ,而燃烧高S高Cl煤对碳钢耗损影响最大 .同时根据对腐蚀产物的观测分析 。 | 彭晓 WP Pan RT Riley | 2003 | 腐蚀科学与防护技术2003，15，3： | 2 |
| 19 | The unsatisfactory nargin in breast cancer surgery 显示文摘 | Luu HH Otis CN Reed WP Jr | 1999 | Am J Surg1999，178，5： | 2 |
| 20 | Structural and functional variations in human apolipoprotein E3 and E4.显示文摘 | Chou CY Jen WP Hsieh YH Shiao MS Chang GG | 2006 | 中国生物学文摘2006，20，9： | 2 |
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