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| 1 | Targeting mast cells in gastric cancer with special reference to bone metastases显示文摘Bone metastases from gastric cancer(GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells(MCs) positive to tryptase(MCPT) in primary gastric tumor angiogenesis. Recently,we analyzed infiltrating MCs and neovascularization in bone tissue metastases from primary GC patients, and observed a significant correlation between infiltrating MCPT and angiogenesis. Such a finding suggested the involvement of peritumoral MCPT by infiltrating surrounding tumor cells, and in bone metastasis angiogenesis from primary GC. Thus, an MCPT-stimulated angiogenic process could support the development of metastases in bone tissue. From this perspective, we aim to review the hypothetical involvement of tumorinfiltrating,peritumoral MCPT in angiogenesis-mediated GC cell growth in the bone microenvironment and in tumor-induced osteoclastic bone resorption. We also focus on the potential use of MCPT targeting agents,such as MCs tryptase inhibitors(gabexate mesylate,nafamostat mesylate) or c-KitR tyrosine kinase inhibitors(imatinib, masitinib), as possible new anti-angiogenic and anti-resorptive strategies for the treatment of GC patientsaffected by bone metastases. | Christian Leporini Michele Ammendola Ilaria Marech Giuseppe Sammarco Rosario Sacco Cosmo Damiano Gadaleta Caroline Oakley Emilio Russo Giovambattista De Sarro Girolamo Ranieri | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 2 | Targeting Mast Cells Tryptase in Tumor Microenvironment: A Potential Antiangiogenetic Strategy显示文摘 | Michele Ammendola Christian Leporini Ilaria Marech Cosmo Damiano Gadaleta Giovanni Scognamillo Rosario Sacco Giuseppe Sammarco Giovambattista De Sarro Emilio Russo Girolamo Ranieri Xiaokun Li | 2014 | BioMed Research International2014，，： | 1 |
| 3 | Mast Cells Density Positive to Tryptase Correlates with Angiogenesis in Pancreatic Ductal Adenocarcinoma Patients Having Undergone Surgery显示文摘 | Michele Ammendola Rosario Sacco Giuseppe Sammarco Giuseppe Donato Valeria Zuccalà Maria Luposella Rosa Patruno Ilaria Marech Severino Montemurro Nicola Zizzo Cosmo Damiano Gadaleta Girolamo Ranieri Niccola Funel | 2014 | Gastroenterology Research and Practice2014，，： | 1 |
| 4 | Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated显示文摘 | Michele Ammendola Rosario Sacco Giuseppe Sammarco Giuseppe Donato Valeria Zuccalà Roberto Romano Maria Luposella Rosa Patruno Carlo Vallicelli Giorgio Maria Verdecchia Davide Cavaliere Severino Montemurro Girolamo Ranieri Chunping Jiang | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 5 | What paradigm shifts occurred in the management of acute diverticulitis during the COVID-19 pandemic?A scoping review显示文摘BACKGROUND Acute colonic diverticulitis(ACD)is common in Western countries,with its prevalence increasing throughout the world.As a result of the coronavirus disease 2019(COVID-19),elective surgery and in-patients’visits have been cancelled or postponed worldwide.AIM To systematically explore the impact of the pandemic in the management of ACD.METHODS MEDLINE,Embase,Scopus,MedxRiv,and the Cochrane Library databases were searched to 22 December 2020.Studies which reported on the management of patients with ACD during the COVID-19 pandemic were eligible.For cross sectional studies,outcomes of interest included the number of hospital admission for ACD,as well as key features of disease severity(complicated or not)across two time periods(pre-and during lockdown).RESULTS A total of 69 papers were inspected,and 21 were eligible for inclusion.Ten papers were cross sectional studies from seven world countries;six were case reports;three were qualitative studies,and two review articles.A 56%overall decrease in admissions for ACD was observed during lockdown,peaking 67%in the largest series.A 4%-8%decrease in the rate of uncomplicated diverticulitis was also noted during the lockdown phase.An initial non-operative management was recommended for complicated diverticulitis,and encouraged to an out-of-hospital regimen.Despite initial concerns on the use of laparoscopy for Hinchey 3 and 4 patients to avoid aerosolized contamination,societal bodies have progressively mitigated their initial recommendations as actual risks are yet to be ascertained.CONCLUSION During the COVID-19 pandemic,fewer patients presented and were diagnosed with ACD.Such decline may have likely affected the spectrum of uncomplicated disease.Established outpatient management and follow up for selected cases may unburden healthcare resources in time of crisis. | Gaetano Gallo Monica Ortenzi Ugo Grossi Gian Luca Di Tanna Francesco Pata Mario Guerrieri Giuseppe Sammarco Salomone Di Saverio | 2021 | World Journal of Clinical Cases2021，9，23： | 0 |
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