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| 1 | Hepatic echinococcosis:Clinical and therapeutic aspects显示文摘Echinococcosis or hydatid disease(HD)is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus.Hepatic echinococcosis is a life-threatening disease,mainly differentiated into alveolar and cystic forms,associated with Echinoccus multilocularis(E.multilocularis)and Echinococcus granulosus(E.granulosus)infection,respectively.Cystic echinococcosis(CE)has a worldwide distribution,while hepatic alveolar echinococcosis(AE)is endemic in the Northern hemisphere,including North America and several Asian and European countries,like France,Germany and Austria.E.granulosus young cysts are spherical,unilocular vesicles,consisting of an internal germinal layer and an outer acellular layer.Cyst expan-sion is associated with a host immune reaction and the subsequent development of a fibrous layer,called the pericyst;old cysts typically present internal septations and daughter cysts.E.multilocularis has a tumorlike,infiltrative behavior,which is responsible for tissue destruction and finally for liver failure.The liver is the main site of HD involvement,for both alveolar and cystic hydatidosis.HD is usually asymptomatic for a long period of time,because cyst growth is commonly slow;the most frequent symptoms are fatigue and abdominal pain.Patients may also present jaundice,hepatomegaly or anaphylaxis,due to cyst leakage or rupture.HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis;furthermore,the improvement of surgical techniques,the introduction of minimally invasive treatments[such as puncture,aspiration,injection,re-aspiration(PAIR)]and more effective drugs(such as benzoimidazoles)have deeply changed life expectancy and quality of life of patients with HD.The aim of this article is to provide an up-todate review of biological,diagnostic,clinical and therapeutic aspects of hepatic echinococcosis. | Giuseppe Nunnari Marilia R Pinzone Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo | 2012 | World Journal of Gastroenterology2012，18，13： | 72 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | Estrogen induces retinoid receptor expression in mouse cervical epithelia 显示文摘 | Giulia C Nadine D Luig M | 1996 | Experimental Cell Research1996，226，： | 1 |
| 4 | 1 - Cysteine reduces oral ethanolself - administration and reinstatement of ethanol- drinking behav- ior in rats显示文摘 | Alessandra TP Giulia M | 2010 | Pharmacology Biochemistry and Behavior2010，94，3： | 1 |
| 5 | Heated humidified high-hlow nasal oxy- gen in adults 显示文摘 | Giulia Spoletini M D Mona Alotaibi M D Francesco Blasi M D | 2015 | Chest2015，1481，1： | 1 |
| 6 | Flavonoids: old and new aspects of a class of natural therapeutic drugs 显示文摘 | GIULIA D C NICOLA M ANGELO A I | 1999 | Life Sciences1999，65，4： | 1 |
| 7 | Antioxidant capacities,carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy显示文摘 | Claudio D V Giulia G Luigi M Annunziata C Alberto R | | 0，，： | 1 |
| 8 | Local-regional staging of endometrial carcinoma:Role of MR Imaging in surgical planning显示文摘 | Riccardo M Paoletta M Giulia M | 2004 | Radiology2004，231，5： | 1 |
| 9 | Eph receptor signaling and ephrins显示文摘 | Lisabeth E M Giulia F Pasquale E B | 2013 | Cold Spring Harb Perspect Biol2013，5，9： | 1 |
| 10 | A landscape analysis of land cover change in the Municipality of Rome (Italy) : spa- tio-temperal characteristics and ecological implications of land cover transitions from 1954 to 2001 显示文摘 | Raffaella F Barbara M Giulia C | 2011 | Landscape Urban Plan2011，，100： | 1 |
| 11 | Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H20: induced lipid peroxidation in renal tubular epithelial ceils 显示文摘 | Deiana M incani A Giulia C | 2008 | Food and Chemical Toxicology2008，469，2： | 1 |
| 12 | The interleukin 1-? Exonic (+3 953) polymorphism does not alter in Vitro protein secretion显示文摘 | Roberto D Giulia M Claudio M | 2002 | Exp Mol Pathol2002，73，2： | 1 |
| 13 | FLAG assay as a novel method for real-time signal generation during PCR:application to detection and genotyping of k-ras colon 12 mutations显示文摘 | Giulia A Erlet S Mike M | 2007 | Nucleic Acids Res2007，35，19： | 1 |
| 14 | p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling 显示文摘 | Elisa Maria M Anna Giulia S Arianna G | 2015 | Proc Natl Acad Sci U S A2015，112，： | 1 |
| 15 | miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation显示文摘 | Michela Garofalo Gianpiero Di Leva Giulia Romano Gerard Nuovo Sung-Suk Suh Apollinaire Ngankeu Cristian Taccioli Flavia Pichiorri Hansjuerg Alder Paola Secchiero Pierluigi Gasparini Arianna Gonelli Stefan Costinean Mario Acunzo Gerolama Condorelli Carlo M | 2009 | Cancer Cell2009，，6： | 1 |
| 16 | Quantitative visualization of DNA G-quadruplex structures in human cells显示文摘 | Giulia B David T John M | 2013 | Nature Chem2013，5，3： | 1 |
| 17 | miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation显示文摘 | Michela Garofalo Gianpiero Di Leva Giulia Romano Gerard Nuovo Sung-Suk Suh Apollinaire Ngankeu Cristian Taccioli Flavia Pichiorri Hansjuerg Alder Paola Secchiero Pierluigi Gasparini Arianna Gonelli Stefan Costinean Mario Acunzo Gerolama Condorelli Carlo M | 2009 | Cancer Cell2009，，6： | 1 |
| 18 | Sexual function of the aging Male显示文摘 | Giovanni C Giulia R Elisa M | 2013 | Best Prac & Res Clin Endocrin & Metabol2013，，27： | 1 |
| 19 | Treatment of heparin-indueed thrombocytopenia after cardiac surgery: preliminary experience with fondaparinux 显示文摘 | FEDERICO P ANNAMARA S GIULIA M | 2009 | J Thora Cardiovase Surg2009，139，3： | 1 |
| 20 | Isolation, heterologous expression and characterization of an endo-polygalacturonase produced by the phytopathogen Burkholderia cepacia 显示文摘 | Claudia M Giuliano D Giulia D | 2007 | Protein Expression and Purification2007，54，2： | 1 |
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