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| 1 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 2 | Blunt diaphragmatic lesions: Imaging findings and pitfalls显示文摘Blunt diaphragmatic lesions(BDL) are uncommon in trauma patients, but they should be promptly recognized as a delayed diagnosis increases morbidity and mortality. It is well known that BDL are often overlooked at initial imaging, mainly because of distracting injuries to other organs. Sonography may directly depict BDL only in a minor number of cases. Chest X-ray has low sensitivity in detecting BDL and lesions can be reliably suspected only in case of intra-thoracic herniation of abdominal viscera. Thanks to its wide availability, timeeffectiveness and spatial resolution, multi-detector computed tomography(CT) is the imaging modality of choice for diagnosing BDL; several direct and indirect CT signs are associated with BDL. Given its high tissue contrast resolution, magnetic resonance imaging can accurately depict BDL, but its use in an emergency setting is limited because of longer acquisition times and need for patient's collaboration. | Matteo Bonatti Fabio Lombardo Norberto Vezzali Giulia A Zamboni Giampietro Bonatti | 2016 | World Journal of Radiology2016，8，10： | 5 |
| 3 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | Next-generation sequencing:toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure显示文摘A large proportion of patients with idiopathic spermatogenic failure(SPGF;oligozoospermia or nonobstructive azoospermia[NOA])do not receive a diagnosis despite an extensive diagnostic workup.Recent evidence has shown that the etiology remains undefined in up to 75%of these patients.A number of genes involved in germ-cell proliferation,spermatocyte meiotic divisions,and spermatid development have been called into play in the pathogenesis of idiopathic oligozoospermia or NOA.However,this evidence mainly comes from case reports.Therefore,this study was undertaken to identify the molecular causes of SPGF.To accomplish this,15 genes(USP9Y,NR5A1,KLHL10,ZMYND15,PLK4,TEX15,TEX11,MEIOB,SOHLH1,HSF2,SYCP3,TAF4B,NANOS1,SYCE1,and RHOXF2)involved in idiopathic SPGF were simultaneously analyzed in a cohort of 25 patients with idiopathic oligozoospermia or NOA,accurately selected after a thorough diagnostic workup.After next-generation sequencing(NGS)analysis,we identified the presence of rare variants in the NR5A1 and TEX11 genes with a pathogenic role in 3/25(12.0%)patients.Seventeen other different variants were identified,and among them,13 have never been reported before.Eleven out of 17 variants were likely pathogenic and deserve functional or segregation studies.The genes most frequently mutated were MEIOB,followed by USP9Y,KLHL10,NR5A1,and SOHLH1.No alterations were found in the SYCP3,TAF4B,NANOS1,SYCE1,or RH0XF2 genes.In conclusion,NGS technology,by screening a specific custom-made panel of genes,could help increase the diagnostic rate in patients with idiopathic oligozoospermia or NOA. | Rossella Cannarella Rosita A Condorelli Stefano Paolacci Federica Barbagallo Giulia Guerri Matteo Bertelli Sandro La Vignera Aldo E Calogero | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 5 | Female urinary incontinence during pregnancy and after delivery: Clinical impact and contributing factors显示文摘Urinary incontinence(UI) is a common condition affecting adult women of all ages and it could have a negative infl uence on quality of life. The etiology of UI is multifactorial, but some of the most important risk factors are obesity and ageing, as well as adverse obstetric events. Pregnancy and delivery per se have been implicated in the etiology of UI. Although several studies have demonstrated a direct association between UI and vaginal delivery in short, medium and long-term, the role of childbirth on the risk of UI remains controversial. The mechanical strain during delivery may induce injuries to the muscle, connective and neural structures. Vaginal birth can be associated with relaxation or disruption of fascial and ligamentous supports of pelvic organs. Parity, instrumental delivery, prolonged labor and increased birth weights have always been considered risk factors for pelvic floor injury. Also genetic factors have been recently raised up but still there are not appropriate guidelines or measures to reduce signifi cantly the incidence of UI. The role of pelvic fl oor muscle training(PFMT) in the prevention and treatment of UI is still unclear. However, PFMT seems to be useful when supervised training is conducted and it could be incorporated as a routine part of women's exercise programmes during pregnancy and after childbirth. | Paolo Mannella Giulia Palla Gonzalo Pérez-Roncero María T López-Baena Faustino R Pérez-López | 2013 | World Journal of Obstetrics and Gynecology2013，2，4： | 2 |
| 6 | Yellow Pr-zircon Pigments:The Role of Praseodymium and of the Mineralizer显示文摘 | Giulia D N Giuseppe C Silvia A | 2004 | Journal of European Ceramic Society2004，24，14： | 1 |
| 7 | Heart rate variability as an index of sympathovagal Interaction after acute myocardial Infarction显示文摘 | FEDRICO L O GIULIA S A SILVIA P E | 1987 | Am J Cardiol1987，60，： | 1 |
| 8 | An enhanced model for small-signal analysis of the phase-shifted full- bridge converter显示文摘 | Giulia D C Seyed A S Michael A H | 2014 | IEEE Transactions on Power Electron- ics2014，99，： | 1 |
| 9 | Flavonoids: old and new aspects of a class of natural therapeutic drugs 显示文摘 | GIULIA D C NICOLA M ANGELO A I | 1999 | Life Sciences1999，65，4： | 1 |
| 10 | Taking care of suicidal patients with new technologies and reaching-out means in the post-discharge period显示文摘Suicide is a global public health problem with over one million people dying by suicide each year worldwide.Research efforts have focused on developing and testing novel suicide prevention strategies employing recent technological advances.In order to provide a review regarding the role of new technologies(e.g.,postcards/letters,text messages,crisis cards,telephone contacts,online interventions) in suicide prevention,we searched Pub Med,Science Direct,Research Gate,and Crisis to identify all papers in English from 1977 to 2016.Our results indicated that brief contact interventions show promise in reducing the number of episodes of repeated self-harm and/or suicide attempts following discharge from the Emergency Department or psychiatric units.Innovative methods of contact(e.g.,text messages) are easily implemented by clinicians and received by patients in the period of post discharge and have been shown to be beneficial.However,more research employing randomized clinical trials investigating the potential benefits of these novel suicide prevention methods is warranted.Future researchers should continue improving and testing new technologies in the prevention of suicide. | Giulia Falcone Adele Nardella Dorian A Lamis Denise Erbuto Paolo Girardi Maurizio Pompili | 2017 | World Journal of Psychiatry2017，7，3： | 1 |
| 11 | Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H20: induced lipid peroxidation in renal tubular epithelial ceils 显示文摘 | Deiana M incani A Giulia C | 2008 | Food and Chemical Toxicology2008，469，2： | 1 |
| 12 | HFA:a new potential early biomarker for the recurrence of ovarian cancer显示文摘 | Emanuela A Giulia GM Valentina V | 2010 | Tumor Biol2010，31，2： | 1 |
| 13 | Agmatine inhibits the proliferation of rat hepatoma cells by modulation of polyamine metabolism显示文摘 | Giulia G Carlo C Riccardo A | 2003 | J Hepatol2003，39，5： | 1 |
| 14 | Heart rate variability as an index of sympathovagal Interaction after acute myocardial Infarction显示文摘 | FEDRICO L O GIULIA S A SILVIA P E | 1987 | Am J Cardiol1987，60，： | 1 |
| 15 | FLAG assay as a novel method for real-time signal generation during PCR:application to detection and genotyping of k-ras colon 12 mutations显示文摘 | Giulia A Erlet S Mike M | 2007 | Nucleic Acids Res2007，35，19： | 1 |
| 16 | An improvedfive-parameter model for photovoltaic modules 显示文摘 | Brano V L Orioli A Giulia G | 2010 | SolarEnergy Materials & Solar GeUs2010，94，8： | 1 |
| 17 | Shedding of the matrix metalloproteinase mmp-2,mmp-9 and MT1-MMP as membrane vesicle-Associated components by endothelial cells显示文摘 | Giulia Taraboltti Sandra D'A scenzo | 2002 | Am J Path2002，160，： | 1 |
| 18 | Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla显示文摘 | Rossella A Paola Z Giulia P et ai | 2000 | Biochemical Pharmacology2000，59，： | 1 |
| 19 | Fibroblast involvement in soft connective tissue calcification 显示文摘 | Ivonne R Federica B Giulia A | 2013 | Front Genet2013，4，： | 1 |
| 20 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 1 |
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