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5篇 您的检索式:作者名="Neil McIntyre"
    题名 作者 年代 出处 被引量
1Protein tolerance to standard and high protein meals in patients with liver cirrhosis显示文摘AIM To investigate the plasma amino acid response and tolerance to normal or high protein meals in patients with cirrhosis.METHODS The plasma amino acid response to a 20 g mixed protein meal was compared in 8 biopsy-proven compensated cirrhotic patients and 6 healthy subjects.In addition the response to a high protein meal(1 g/kg body weight) was studied in 6 decompensated biopsy-proven cirrhotics in order to evaluate their protein tolerance and the likelihood of developing hepatic encephalopathy(HE) following a porto-caval shunt procedure.To test for covert HE,the 'number connection test'(NCT) was done on all patients,and an electroencephalogram was recorded in patients considered to be at Child-Pugh C stage.RESULTS The changes in plasma amino acids after a 20 g protein meal were similar in healthy subjects and in cirrhotics except for a significantly greater increase(P < 0.05) in isoleucine,leucine and tyrosine concentrations in the cirrhotics.The baseline branched chain amino acids/aromatic amino acids(BCAA/AAA) ratio was higher in the healthy persons and remained stable-but it decreased significantly after the meal in the cirrhotic group.After the high protein meal there was a marked increase in the levels of most amino acids,but only small changes occurred in the levels of taurine,citrulline,cysteine andhistidine.The BCAA/AAA ratio was significantly higher 180 and 240 min after the meal.Slightly elevated basal plasma ammonia levels showed no particular pattern.Overt HE was not observed in any patients.CONCLUSION Patients with stable liver disease tolerate natural mixed meals with a standard protein content.The response to a high protein meal in decompensated cirrhotics suggests accumulation of some amino acids but it did not precipitate HE.These results support current nutritional guidelines that recommend a protein intake of 1.2-1.5 g/kg body weight/day for patients with cirrhosis.Octavio Campollo Dirk Sprengers Gitte Dam Hendrik Vilstrup Neil McIntyre 2017World Journal of Hepatology2017,9,14:3
2Regression analysis of rainfall-runoff data from an arid catchment in Oman 显示文摘Neil McIntyre Aisha AI-Qurashi Howard Wherter 2007HydrologicalSciences Journal2007,52,6:1
3Estimation and propagation of parametric uncertainty in environmental models显示文摘 Howard Wheater Matthew Lees 2002Journal of Hydroinformatics2002,4,3:1
4Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study显示文摘Neil A Martinson Alan Karstaedt WD Francois Venter Tanvier Omar Peter King Tumi Mbengo Else Marais James McIntyre Richard E Chaisson Martin Hale 2007AIDS2007,,15:1
5Regression analysis of rainfall-runoff data from an arid catchment in Oman 显示文摘Neil McIntyre Aisha AI-Qurashi Howard Wherter 2007Hydrological Sciences Journal2007,52,6:1
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