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| 1 | 慢生花生根瘤菌的遗传多样性研究(英文)显示文摘用REP1R1和REP21DNA为引物,对22株四川土著慢生花生根瘤菌染色体DNA的基因外回文重复序列(RepetitiveExtrogenicpalindromicsequenceREP)进行了PCR扩增和凝胶电泳,并对电泳结果的指纹图型进行了相似性聚类分析.结果表明了四川土著慢生花生根瘤菌的遗传多样性. | 张小平 李登煜 NICK Giselle LINDSTR M Kristina | 1998 | 应用与环境生物学报1998，4，1： | 9 |
| 2 | In vitro antibacterial effect of aqueous and ethanolic Moringa leaf extracts显示文摘Objective:To evaluate the antibacterial effect of aqueous and ethanolic moringa leaf extracts (Moringa oleifera) on the growth of gram-positive and negative bacteria.Methods:Paper disks were soaked with 100,200,300 and 400μL of extract at 20 g/180mL and 10 g/190 mL.All extracts were tested against Escherichia coli(ATCC25922),Staphylococcus aureus(ATCC25923),Vibrio parahaemolyticus,Enterococcus faecalis(ATCC29212),Pseudomonas aeruginosa(ATCC27853), Salmonella enteritidis(IH) and Aeromonas caviae.The susceptibility tests were performed using the modified disk diffusion method.Results:The strains E.coli,P.aeruginosa and S.enteritidis (IH) were resistant to all treatments.In general,disks with 400μL extract were the most efficient against S.aureus,V.parahaemolyticus,E.faecalis and A.caviae.Conclusions:The study indicates a promising potential for aqueous and ethanolic Moringa leaf extracts as alternative treatment of infections caused by the tested strains. | Jackson Rafael Oliveira Peixoto Giselle Cristina Silva Renata Albuquerque Costa Joseires Lira de Sousa Fontenelle Gustavo Hitzschky Fernandes Vieira Antonio Adauto Fonteles Filho Regine Helena Silva dos Fernandes Vieira | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 7 |
| 3 | Pathophysiology of cystic fibrosis and drugs used in associated digestive tract diseases显示文摘Cystic fibrosis(CF)causes chronic infections in the respiratory tract and alters the digestive tract.This paper reviews the most important aspects of drug treatment and changes in the digestive tract of patients with CF.This is a review of the literature,emphasizing the discoveries made within the last 15 years by analyzing scientific papers published in journals indexed in the Scientific Electronic Library Online,Sciences Information,United States National Library of Medicine and Medical Literature Analysis and Retrieval System Online databases,both in English and Portuguese,using the key words:cystic fibrosis,medication,therapeutic,absorption,digestion.Randomized,observational,experimental,and epidemiological clinical studies were selected,among others,with statistical significance of 5%.This review evaluates the changes found in the digestive tract of CF patients including pancreatic insufficiency,constipation and liver diseases.Changes in nutritional status are also described.Clinical treatment,nutritional supplementation and drug management were classified in this review as essential to the quality of life of CF patients,and became available through public policies for monitoring and treating CF.The information gathered on CF and a multi professional approach to the disease is essential in the treatment of these patients. | Adriana Haack Giselle Gonalves Arago Maria Rita Carvalho Garbi Novaes | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 4 | Mitochondrial GPX1 silencing triggers differential photosynthesis impairment in response to salinity in rice plants显示文摘The physiological role of plant mitochondrial glutathione peroxidases is scarcely known. This study attempted to elucidate the role of a rice mitochondrial isoform(GPX1) in photosynthesis under normal growth and salinity conditions. GPX1 knockdown rice lines(GPX1s) were tested in absence and presence of 100 mM NaCl for 6 d.Growth reduction of GPX1 s line under non-stressful conditions, compared with non-transformed(NT) plants occurred in parallel to increased H_2O_2 and decreased GSH contents. These changes occurred concurrently with photosynthesis impairment, particularly in Calvin cycle's reactions, since photochemical efficiency did not change.Thus, GPX1 silencing and downstream molecular/metabolic changes modulated photosynthesis differentially. In contrast, salinity induced reduction in both phases of photosynthesis, which were more impaired in silenced plants.These changes were associated with root morphology alterations but not shoot growth. Both studied lines displayed increased GPX activity but H_2O_2 content did not change in response to salinity. Transformed plants exhibited lower photorespiration, water use efficiency and root growth, indicating that GPX1 could be important to salt tolerance. Growth reduction of GPX1 s line might be related to photosynthesis impairment, which in turn could have involved a cross talk mechanism between mitochondria and chloroplast originated from redox changes due to GPX1 deficiency. | Yugo Lima-Melo Fabricio E.L.Carvalho Márcio O.Martins Gisele Passaia Rachel H.V.Sousa Milton C.Lima Neto Márcia Margis-Pinheiro Joaquim A.G.Silveira | 2016 | Journal of Integrative Plant Biology2016，58，8： | 7 |
| 5 | Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls显示文摘Acetaminophen(APAP)is a widely used analgesic and antipyretic drug,which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses.The mouse model of APAP hepatotoxicity recapitulates closely the human pathophysiology.As a result,this clinically relevant model is frequently used to study mechanisms of drug-induced liver injury and even more so to test potential therapeutic interventions.However,the complexity of the model requires a thorough understanding of the pathophysiology to obtain valid results and mechanistic information that is translatable to the clinic.However,many studies using this model are flawed,which jeopardizes the scientific and clinical relevance.The purpose of this review is to provide a framework of the model where mechanistically sound and clinically relevant data can be obtained.The discussion provides insight into the injury mechanisms and how to study it including the critical roles of drug metabolism,mitochondrial dysfunction,necrotic cell death,autophagy and the sterile inflammatory response.In addition,the most frequently made mistakes when using this model are discussed.Thus,considering these recommendations when studying APAP hepatotoxicity will facilitate the discovery of more clinically relevant interventions. | Hartmut Jaeschke Olamide B.Adelusi Jephte Y.Akakpo Nga T.Nguyen Giselle Sanchez-Guerrero David S.Umbaugh Wen-Xing Ding Anup Ramachandran | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 3 |
| 6 | Perioperative care in older adults显示文摘 | Giselle A Baquero Michael W Rich | 2015 | Journal of Geriatric Cardiology2015，12，5： | 3 |
| 7 | Dyslipidemia: evidence of efficacy of the pharmacological and non-pharmacological treatment in the elderly显示文摘为心血管的疾病(CVD ) 控制风险因素在的临床的决定老考虑下列:(1 ) 老预期寿命;(2 ) 老生物年龄和功能的能力;(3 ) 在老组的心血管的疾病的角色;(4 ) 风险因素在的流行老;并且(5 ) 风险因素在的治疗的有效性老。很多研究显示出 dyslipidemia 的第二等、主要的预防的功效在老。然而,在 80 年包括了病人的唯一的审判是心保护学习(HPS ) 。Statins 为阴沉的低密度的脂蛋白胆固醇(LDL-C ) 被认为第一线治疗。因为生活方式变化是很困难的完成,医生们一般来说趋于开许多药控制心血管的风险因素。然而,健康食物消费在主要、第二等的心血管的预防仍然是一块奠基石并且应该被每个人实现。 | Claudia F Gravina Marcelo Bertolami Giselle HP Rodrigues | 2012 | Journal of Geriatric Cardiology2012，9，2： | 3 |
| 8 | Fatty acid content in epididymal fluid and spermatozoa during sperm maturation in dogs显示文摘Background: During sperm maturation, there is a reorganization of fatty acids from plasmatic membrane of the spermatozoa, which allows higher membrane integrity and acquisition of sperm motility. However, the fatty acid profile during sperm maturation remains unclear in dogs. Thus, the aim of this study was to identify the fatty acids from the epididymal spermatozoa and plasma during the sperm maturation, and observed changes in the motility and plasmatic membrane parameters. Twenty one adult dogs were used, subsequently to bilateral orchiectomy and epididymal storage, sperm samples were collected from the different segments of the epididymis. Samples were evaluated for conventional microscopy, computer-assisted motility analysis, sperm plasma membrane permeability and the fatty acid analysis(lipids were extracted, transmethylated and analyzed by chromatography).Results: Caput and corpus sperm showed lower values for the motility variables evaluated and plasmatic membrane integrity, indicating different levels of the fatty acids organization. Saturated, monounsaturated and polyunsaturated fatty acids were in higher concentrations in the spermatozoa from epididymis cauda. Highlighting the presence of caprylic, stearic and docosahexaenoic acids.Conclusions: These findings demonstrate the influence of the fatty acid profile during sperm maturation, assigning physical and chemical changes in sperm cells, essential for fertilization. | Daniel S.Ramos Angrimani Marcilio Nichi Joāo Diego A.Losano Cristina F.Lucio Gisele A.Lima Veiga Márcia V.M.Junqueira Franco Camila I.Vannucchi | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 3 |
| 9 | Heart Valve Injury Induced by Mediastinum Radiotherapy in Cancer Treatment显示文摘 | Patricia Fraga Paiva Alice Assumpcao Soares Guilherme Sotto Maior do Valle Pinheiro Carolina Fraga Paiva Gisele Maria Campos Fabri Emanoel Guimaraes Paiva Carlos M. Campos Jose Fabfi Junior | 2018 | Journal of Pharmacy and Pharmacology2018，6，6： | 2 |
| 10 | 等径角挤压对Cu-0.81Cr-0.07Zr合金第二相颗粒分布、硬度和电导率的影响显示文摘研究在室温和300℃下等径角挤压(ECAP)对Cu-0.81Cr-0.07Zr合金中第二相分布的影响,及其对硬度和电导率的影响。显微组织表征表明,经ECAP后,粗大的富Cr颗粒面积分数减小,这是由于塑性变形导致Cr的溶解。在室温下进行4道次ECAP后,由于固溶体中较高的Cr含量和基体中较高的缺陷密度导致电子散射的增加,合金的电导率下降了12%。仅在ECAP样品中观察到的Cu晶格常数的减小和差示扫描量热分析(DSC)过程中发生的放热反应证实了这些结果。经ECAP后的时效热处理促进额外的硬化效果和导电性的完全恢复,这是由于部分溶解颗粒的再沉淀造成的。在室温下进行4道次ECAP,然后在380℃时效处理1 h的合金具有更高的硬度(191 HV)和电导率(83.5%(IACS))。 | Filipe CALDATTO DALAN Gisele Ferreira de LIMA ANDREANI Dilermando Nagle TRAVESSA Ilshat Albertovich FAIZOV Svetlana FAIZOVA Kátia Regina CARDOSO | 2022 | Transactions of Nonferrous Metals Society of China2022，32，1： | 2 |
| 11 | Dysphagia in the elderly: management and nutritional considerations显示文摘 | Michael Crary Giselle Carnaby-Mann Aarthi Madhavan Livia Sura | 2012 | Clinical Interventions in Aging (default)2012，，： | 2 |
| 12 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 13 | Long-term study of at-sea distribution of seabirds and marine mammals in the Scotia Sea, Antarctica显示文摘The Scotia Sea is one of the most biologically rich regions of Antarctica, and it hosts a large community of upper trophic-level predators. Long-term at-sea monitoring provides valuable information on the Antarctic marine ecosystem and relationships among top predators. This paper presents the results of at-sea monitoring of seabirds and cetaceans over five consecutive summer seasons(2010—2014) in the Scotia Sea, Antarctica. A total of 11 656 flying birds belonging to 24 species were recorded in 884 ten-minute counts. Six Procellariiformes species were abundant: Black-browed Albatross, Cape Petrel, Southern Fulmar, Antarctic Prion, Wilson's Storm-petrel, and Black-bellied Storm-petrel. Only three of these species accounted for 82% of the total abundance: Antarctic Prion(40%), Southern Fulmar(22%), and Cape Petrel(20%). A total of 678 baleen whales belonging to five species were recorded along a sampling effort of 2 351 nautical miles: Humpback, Sei, Southern Right, Fin, and Minke whales, which had different abundances during the study. The Fin Whale had the highest mean encounter rate for the 5 years(0.29 whales per nautical mile), followed by the Humpback Whale(0.09 whales per nautical mile). Annual dissimilarity in abundance of both seabirds and cetaceans occurred in conjunction with changes in the sea surface temperature and ice cover, showing the dependence of top predators on environmental changes. The largest aggregations of all top predators(seabirds and cetaceans) were recorded in two regions, west and south of the South Orkney Islands, suggesting important prey availability(especially krill) in those areas. | José Luis Orgeira Mariela del Carmen Alderete Yohana Gisell Jiménez Juan Cruz González | 2015 | Advances in Polar Science2015，26，2： | 2 |
| 14 | miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection显示文摘 | Qi-Jing Li Jacqueline Chau Peter J.R. Ebert Giselle Sylvester Hyeyoung Min Gwen Liu Ravi Braich Muthiah Manoharan Juergen Soutschek Petra Skare Lawrence O. Klein Mark M. Davis Chang-Zheng Chen | 2007 | Cell2007，，1： | 2 |
| 15 | 动物饲料中的二恶英显示文摘二恶英 二恶英和二恶英类化合物是一个有400种以上不同分子的族类(75种多氯代二苯并二恶英-PCDD,135种多氯代二苯并呋喃-PCDF和209种多氯代联苯-PCB),其特点是具有共同的化学结构。其中,7种多氯代二苯并二恶英。 | 陈茜 Gisele Gizzi | 1999 | 国外畜牧学(饲料)1999，，5： | 2 |
| 16 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 17 | Metabolic Surgery for Non-Obese Type 2 Diabetes: Incretins, Adipocytokines, and Insulin Secretion/Resistance Changes in a 1-Year Interventional Clinical Controlled Study显示文摘 | Bruno Geloneze Sylka Rodovalho Geloneze Elinton Chaim Fernanda Filgueira Hirsch Ana Claudia Felici Giselle Lambert Marcos Antonio Tambascia José Carlos Pareja | 2012 | Annals of Surgery2012，，1： | 2 |
| 18 | Crotalphine,a novel potent analgesic peptide from the venom of the south American rattlesnake Crotalus durissus terrificus显示文摘 | Katsuhiro K Gisele P Vanessa PG | 2008 | Peptides2008，29，8： | 1 |
| 19 | Interventions and outcomes for children with dysPhagia显示文摘 | Gisel E | 2008 | Dev Disabil2008，14，： | 1 |
| 20 | Infant sucking abili- ty, non-organic failure to thrive, maternal characteristics and feeding practices: a prospective cohort study显示文摘 | Ramsey M Gisel EG Mccusker J | 2002 | Dev IVied Child Neuro12002，44，6： | 1 |
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