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| 1 | Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells显示文摘肝是有有免疫力的规定的优美机制的一个 tolerogenic 机关保证本地、全身的有免疫力的忍耐的保养到自我和外国抗原,但是那也能对病原体装有效有免疫力的回答。尽管有主要 histo 相容性建筑群失配,肝 allografts 的有免疫力的特权在猪首先被认出,并且称为 “肝忍耐 effect”。而且,肝移植自发地与仅仅低剂量的免疫力的抑制被接受,并且为一样的施主的非肝的共同移植的 allografts 导致忍耐。尽管这 immunotolerogenic 环境在机关移植的背景是有利的,它在象肝炎 B 一样的长期的传染的肝疾病是有害的,导致 tumorigenesis 完成的病原体坚持和弱反肿瘤或 C,疟疾,血吸虫病或。肝是 T 房间激活的一个主要地点,但是它得到 T 房间的差或不完全的激活,导致他们的未成功的激活,疲劳,他们的受动器功能的抑制和早死亡。这被病原体利用并且能损害病原体控制和清理或允许肿瘤生长。T 房间的肝的 priming 被传统的很多个本地人和 nonconventional 调停介绍抗原的房间(APC ) 由有免疫力的偏差支持忍耐, T 房间变应力缺乏或 apoptosis 感应,并且产生并且膨胀规章的 T 房间。这评论将集中于通讯在之间古典并且在在感应的忍耐和愿望的肝的 nonclassical APC 和淋巴细胞在这个过程讨论最近的卓见进天生的淋巴细胞的角色。 | Andrea Kristina Horst Katrin Neumann Linda Diehl Gisa Tiegs | 2016 | Cellular & Molecular Immunology2016，13，3： | 26 |
| 2 | Antigen presentation,autoantibody production,and therapeutic targets in autoimmune liver disease显示文摘The liver is an important immunological organ that controls systemic tolerance.The liver harbors professional and unconventional antigen-presenting cells that are crucial for tolerance induction and maintenance.Orchestrating the immune response in homeostasis depends on a healthy and well-toned immunological liver microenvironment,which Is maintained by the crosstalk of liver-resident antigen-presenting cells and intrahepatic and liver-infiltrating leukocytes.In response to pathogens or autoantigens,tolerance is disrupted by unknown mechanisms.Intrahepatic parenchymal and nonparenchymal cells exhibit unique antigen-presenting properties.The presentation of microbial and endogenous lipid-,metabolite-and peptide-derived antigens from the gut via conventional and nonconventional mechanisms can educate intrahepatic immune cells and elicit effector responses or tolerance.Perturbation of this balance results in autoimmune liver diseases,such as autoimmune hepatitis,primary biliary cholangitis,and primary sclerosing cholangitis.Although the exact etiologies of these autoimmune liver diseases are unknown,it is thought that the disruption of tolerance towards self-antigens and microbial metabolites and lipids,as well as alterations in bile acid composition,may result in changes in effector cell activation and polarization and may reduce or impair protective antiinflammatory regulatory T and B cell responses.Additionally,the canonical and noncanonical transmission of antigens and antigen:MHC complexes via trogocytosis or extracellular vesicles between different(non)immune cells in the liver may play a role in the induction of hepatic inflammation and tolerance.Here,we summarize emerging aspects of antigen presentation,autoantibody production,and the application of novel therapeutic approaches in the characterization and treatment of autoimmune liver diseases. | Andrea Kristina Horst Kingsley Gideon Kumashie Katrin Neumann Linda Diehl Gisa Tiegs | 2021 | Cellular & Molecular Immunology2021，18，1： | 2 |
| 3 | The Flame Retardants Tetrabromobisphenol A-Bisallylether Suppress the Induction of Interleukin-2 Receptor a Chain (CD25) in Murine Splenocytes显示文摘 | Sabine Pullen Ronald Boecker Gisa Tiegs | 2003 | Toxicology2003，184，： | 1 |
| 4 | DNA Substrate Dependence of p53-Mediated Regulation of Double-Strand Break Repair显示文摘 | Akyuz N Gisa S Susse BS | 2002 | Molecular And Cellular Biology2002，2，1： | 1 |
| 5 | Do distinct populations of dor- sal root ganglion neurons account for the sensory peptidergic inner- ration of the kidney 显示文摘 | Tilmann D Gisa T Kristina R | 2009 | Am J Physiol Renal Physiol2009，297，5： | 1 |
| 6 | Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9显示文摘 | Ulrike K. Schmerwitz Gabriele Sass Alexander G. Khandoga Jos Joore Bettina A. Mayer Nina Berberich Frank Totzke Fritz Krombach Gisa Tiegs Stefan Zahler Angelika M. Vollmar Robert Fürst | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，2： | 1 |
| 7 | Concanavalin A - induced T - cell - mediated hepatic injury in mice : the role of tumor necrosis factor显示文摘 | Florian G Marcel L Ansgar W Paul G Gisa T | 1995 | Hepatology1995，21，： | 1 |
| 8 | Immune-mediated liver injury显示文摘 | Ansgar W. Lohse Christina Weiler-Normann Gisa Tiegs | 2009 | Journal of Hepatology2009，，1： | 1 |
| 9 | Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines显示文摘 | Alexander Vogt Margaret A. Scull Tamar Friling Joshua A. Horwitz Bridget M. Donovan Marcus Dorner Gisa Gerold Rachael N. Labitt Charles M. Rice Alexander Ploss | 2013 | Virology2013，，： | 1 |
| 10 | Effects of the CYP2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam显示文摘 | Toshiaki Aoshima Takashi Fukasawa Yohei Otsuji Naoyuki Okuyama Gisa Gerstenberg Masatomo Miura Tadashi Ohkubo Kazunobu Sugawara Koichi Otani | 2002 | Progress in Neuropsychopharmacology & Biological Psychiatry2002，，3： | 1 |
| 11 | Immune tolerance: What is unique about the liver显示文摘 | Gisa Tiegs Ansgar W. Lohse | 2009 | Journal of Autoimmunity2009，，1： | 1 |
| 12 | The link between preschoolers’ executive function and theory of mind and the role of epistemic states显示文摘 | Anne Henning Frank M. Spinath Gisa Aschersleben | 2010 | Journal of Experimental Child Psychology2010，，： | 1 |
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