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| 1 | Investigation and prediction of enteral nutrition problems after percutaneous endoscopic gastrostomy显示文摘AIM:To investigate and predict enteral nutrition problems after percutaneous endoscopic gastrostomy (PEG). METHODS:We retrospectively analyzed data for 252 out of 285 patients who underwent PEG at our hospital from 1999 to 2008.Enteral nutrition problems after PEG were defined as:(1)patients who required ≥1 mo after surgery to switch to complete enteral nutrition,or who required additional parenteral alimentation continuously;or(2)patients who abandoned switching to enteral nutrition using the gastrostoma and employed other nutritional methods. We attempted to identify the predictors of problem cases by using a logistic regression analysis that examined the patients’backgrounds and the specific causes that led to their problems. RESULTS:Mean age of the patients was 75 years,and in general,their body weight was low and their overall condition was markedly poor.Blood testing revealed that patients tended to be anemic and malnourished.A total of 44 patients(17.5%)were diagnosed as having enteral nutrition problems after PEG.Major causes ofthe problems included pneumonia,acute enterocolitis (often Clostridium difficile-related),paralytic ileus and biliary tract infection.A multivariate analysis identified the following independent predictors for problem cases:(1)enteral nutrition before gastrectomy(a risk reduction factor);(2)presence of esophageal hiatal hernia;(3)past history of paralytic ileus;and(4) presence of chronic renal dysfunction. CONCLUSION:Enteral nutrition problems after PEG occurred at a comparatively high rate.Patient background analysis elucidated four predictive factors for the problem cases. | Shiro Yokohama Masaru Aoshima Yukiomi Nakade Junya Shindo Junichi Maruyama Masashi Yoneda | 2009 | World Journal of Gastroenterology2009，15，11： | 14 |
| 2 | Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis显示文摘AIM: To investigate the efficacy of angiotensinⅡreceptor antagonist on hepatic stellate cells (HSCs) activation in the patients with non-alcoholic steatohepatitis (NASH). METHODS: Seven patients with NASH were prescribed losartan, a selective angiotensinⅡtype 1 receptor antagonist (50 mg/d) for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 andα-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver (NAFL) were also examined as controls. RESULTS: In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk losartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION: Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensinⅡreceptor antagonist on patients with NASH. | Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 3 | Facile and Scalable Synthesis of a Highly Hydroxylated Water-Soluble Fullerenol as a Single Nanoparticle显示文摘水溶性的 polyhydroxylated fullerene,即 fullerenol 与 44 个氢氧根组和 8 个第二等的界限水分子一起, C60 (哦) | Ken Kokubo Shogo Shirakawa Naoki Kobayashi Hisae Aoshima Takumi Oshima | 2011 | Nano Research2011，4，2： | 5 |
| 4 | Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids显示文摘 | KASHIWADA Y AOSHIMA A IKESHIRO Y | 2005 | Bioorg Med Chem2005，13，2： | 1 |
| 5 | Copolymerization of dienes with neodymium tricarboxyl,ate-based catalysts and cis-polymerization mechanism 显示文摘 | Kobayashi E Kaita S Aoshima S | 1998 | Journal of Polymer Science Part A: Polymer Chemistry1998，36，11： | 1 |
| 6 | Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera,and structure-activity correlations with related alkaloids显示文摘 | Kashiwada Y Aoshima A Ikeshiro Y | 2005 | Bioorganic﹠Medicinal Chemistry2005，，02： | 1 |
| 7 | Micropore size distri- bution of activated carbon fiber using the density functional the- ory and other method显示文摘 | E1-Merraoui M Aoshima M Kaneko K | 2000 | Langmuir2000，26，： | 1 |
| 8 | Anti- HIV benzyl isoquino line alkaloids and flavonoids from the leaves of Nelumbo nutifera,and structure-activity correlations with related alkaloids显示文摘 | Kahiwada Y Aoshima A Ikesiro Y | 2005 | Bioorganic&Medicinal Chemistry2005，13，2： | 1 |
| 9 | Living cationic polymerization of vinyl monomers by organoaluminum halides显示文摘 | Toshinobu Higashimura Yasuhisa Kishimoto Sadahito Aoshima | 1987 | Polymer Bulletin1987，，2： | 1 |
| 10 | Mechanisms of manganese spinels dissolution and capacity fade at high tem-perature 显示文摘 | Aoshima T Okahara K Kiyohara C | 2001 | J Power Sources2001，9798，： | 1 |
| 11 | Photooxidative Ndemethylene blue in aqueous TiO2 dispersions under UV irradiation 显示文摘 | Zhang T Y Oyama T Aoshima A | 2001 | J Photochem Photobio A2001，140，： | 1 |
| 12 | A successful diagnostic case of Pneumocystis pneumonia by the loop-mediated isothermal amplification method in a patient with dermatomyositis显示文摘 | Asai N Aoshima M Ohkuni Y | 2012 | Journal of Infection and Chemotherapy2012，，： | 1 |
| 13 | Living cationic polymerization of vinyl monomers by organoaluminium halides显示文摘 | Sadahito Aoshima Toshinobu Higashimura | 1986 | Polymer Bulletin1986，，5： | 1 |
| 14 | Production of decolorizing activity for molasses pigment by Coriolus versicolor Ps4a显示文摘 | Aoshima I Tozawa Y Ohmomo S | 1985 | Agricultural and Biological Chemistry1985，49，7： | 1 |
| 15 | Designed Polymers by Carbocationic Macromolecular Engineering Theory and Practice 显示文摘 | Aoshima S Sawamoto M | 1988 | Makromolek Chem Macromolec Syrmp1988，13，2： | 1 |
| 16 | Serum Lipoprotein (a) and apoLipoprotein(a) phenotypes in patients with rheumatoid arthritis显示文摘 | Asanuma Y Kawai S Aoshima H | 1999 | Arthritis Rheum1999，42，： | 1 |
| 17 | Crystal-face-selective adsorption of Au nanoparticles onto polycrystalline diamond surfaces显示文摘 | Kondo T Aoshima S Hirata K | 2008 | Langrnuir2008，24，14： | 1 |
| 18 | Quantitative and wideranging profiling of phospholipicls in human plasma by twodimensional liquid chromatography/mass spectrometry显示文摘 | Sato Y Nakamura T Aoshima K | 2010 | Anal Chem2010，82，23： | 1 |
| 19 | Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera,and structure-activity correlations with related alkaloids显示文摘 | Kashiwada Y Aoshima A Ikeshiro Y | | 0，，02： | 1 |
| 20 | Copolymerization of Butadiene and Styrene with a Gadolinium Tricarboxylate Catalyst显示文摘 | Kobayashi E Kaita S Aoshima S | 1995 | Journal of Polymer Science Part A: Polymer Chemistry1995，33，13： | 1 |
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