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| 1 | 急性脑卒中综合性治疗模式的优越性显示文摘目的 探讨综合性治疗 [卒中单元 ,(strokeunit) ]模式对急性脑卒中治疗的优越性。方法 选择在澳大利亚卒中单元治疗的 2 0 7例急性脑卒中病人为A组 ,同期在我科常规治疗的 32 6例为B组。入选标准统一为经CT或MRI确诊发病 48h内的急性脑卒中 ,比较两组主要临床指标。结果 A组 1 4d内病死率为 5 3 % ,其中死于非脑内原因占 2 7 3 % ,感染发生率 1 7 9% ,而B组分别为1 0 4%、64 7%、47 9% ,差异具有显著性 (P <0 0 1 )。 2 1d神经功能评分和随访 90dRankin积分差异也有显著性 (P <0 0 1 )。结论 在综合性治疗模式下急性脑卒中患者的预后 。 | 王少石 Daniel Kam Yin CHAN David Gillies | 2002 | 中华内科杂志2002，41，11： | 47 |
| 2 | Unsedated ultrathin upper endoscopy is better than conventional endoscopy in routine outpatient gastroenterology practice:A randomized trial显示文摘AIM: to compare the feasibility and patients' tolerance of esophagogastroduodenoscopy (EGD) using a thin endoscope with those of conventional oral EGD and to determine the optimal route of introduction of small-caliber endoscopes. METHODS: One hundred and sixty outpatients referred for diagnostic EGD were randomly allocated to 3 groups: conventional (C)-EGD (9.8 mm in diameter), transnasal (TN)-EGD and transoral (TO)-EGD (5.9 mm in diameter). Pre-EGD anxiety was measured using a 100-mm visual analogue scale (VAS). After EGD, patients and endoscopists completed a questionnaire on the pain, nausea, choking, overall discomfort, and quality of the examination either using VAS or answering some questions. The duration of EGD was timed. Blood oxygen saturation (SaO2) and heart rate (HR) were monitored during EGD. RESULTS: Twenty-one patients refused to participate in the study. The 3 groups were well-matched for age, gender, experience with EGD, and anxiety. EGD was completed in 91.1% (41/45), 97.5% (40/41), and 96.2% (51/53) of cases in TN-EGD, TO-EGD, and C-EGD groups, respectively. TN-EGD lasted longer (3.11 ± 1.60 min) than TO-EGD (2.25 ± 1.45 min) and C-EGD (2.49 ± 1.64 min) (P < 0.05). The overall tolerance was higher (P < 0.05) and the overall discomfort was lower (P < 0.05) in TN-EGD group than in C-EGD group. EGD was tolerated 'better than expected' in 73.2% of patients in TN-EGD group and 55% and 39.2% of patients in TO-EGD and C-EGD groups, respectively (P < 0.05). Endoscopy was tolerated 'worst than expected' in 4.9% of patients in TN-EGD group and 17.5% and 23.5% of patients in TO-EGD and C-EGD groups, respectively (P < 0.05). TN-EGDcaused mild epistaxis in one case. The ability to insufflate air, wash the lens, and suction of the thin endoscope were lower than those of conventional instrument (P < 0.001). All biopsies performed were adequate for histological assessment. CONCLUSION: Diagnostic TN-EGD is better tolerated than C-EGD. Narrow-diameter endoscope has a level of diagnostic accuracy comparable to that of conventional gastroscope, even though some technical characteristics of these instruments should be improved. Transnasal EGD with narrow-diameter endoscope should be proposed to all patients undergoing diagnostic EGD. | Lucio Trevisani Viviana Cifalà Sergio Sartori Giuseppe Gilli Giancarlo Matarese Vincenzo Abbasciano | 2007 | World Journal of Gastroenterology2007，13，6： | 24 |
| 3 | 兆伏级锥形束CT:系统说明及IGRT临床应用介绍显示文摘阐述临床用兆伏级锥形束CT(MV CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以非晶硅平板型EPID,能够适合兆伏级光子射线。一体化的计算机工作平台能够支持投照图像的自动采集,图像重建,CT到锥形束CT图像的注册,以及治疗床的移动计算。系统具有亚毫米级的定位精度和足够的软组织分辨率,能够显示前列腺等软组织结构。在我院,已经使用兆伏级锥形束CT系统检测脊髓的非刚性形变,监控肿瘤的生长和消退,以及肺内固定肿瘤的定位等。对于受到金属伪影干扰的结构,兆伏级锥形束CT还提高了其勾画的准确性。在过去的几年中,兆伏级锥形束CT有了较快的发展。现在的图像质量完全可以满足IGRT应用的需要。此外,我们希望兆伏级锥形束CT在临床上的应用将随着影像技术的发展而不断扩大。 | Olivier Morin Amy Gillis Josephine Chen Michèle Aubin M.Kara Bucci Jean Pouliot 索京涛 陆嘉德 | 2006 | 中国癌症杂志2006，16，6： | 9 |
| 4 | A dyadic study of interpersonal information search显示文摘 | Mary C. Gilly John L. Graham Mary Finley Wolfinbarger Laura J. Yale | 1998 | Journal of the Academy of Marketing Science1998，，2： | 6 |
| 5 | Post-Anaesthetic Discharge Scoring System to assess patient recovery and discharge after colonoscopy显示文摘AIM: To investigate whether discharge scoring criteria are as safe as clinical criteria for discharge decision and allow for earlier discharge.METHODS: About 220 consecutive outpatients undergoing colonoscopy under sedation with Meperidine plus Midazolam were enrolled and assigned to 2 groups: in Control-group(110 subjects) discharge decision was based on the clinical assessment; in PADSS-group(110subjects) discharge decision was based on the modified Post-Anaesthetic Discharge Scoring System(PADSS).Measurements of the PADDS score were taken every20 min after colonoscopy, and patients were discharged after two consecutive PADSS scores ≥ 9. The investigator called each patient 24-48 h after discharge to administer a standardized questionnaire, to detect any delayed complications. Patients in which cecal intubation was not performed and those who were not found at follow-up phone call were excluded from the study.RESULTS: Thirteen patients(7 in Control-group and6 in PADSS-group) were excluded from the study. Recovery from sedation was faster in PADSS-group than in Control-group(58.75 ± 18.67 min vs 95.14 ± 10.85min, respectively; P < 0.001). Recovery time resulted shorter than 60 min in 39 patients of PADSS-group(37.5%), and in no patient of Control-group(P < 0.001).At follow-up phone call, no patient declared any hospital re-admission because of problems related to colonoscopy and/or sedation. Mild delayed post-discharge symptoms occurred in 57 patients in Control-group(55.3%)and in 32 in PADSS-group(30.7%). The most common symptoms were drowsiness, weakness, abdominal distension, and headache. Only 3 subjects needed to take some drugs because of post-discharge symptoms.CONCLUSION: The Post-Anaesthetic Discharge Scoring System is as safe as the clinical assessment and allows for an earlier patient discharge after colonoscopy performed under sedation. | Lucio Trevisani Viviana Cifalà Giuseppe Gilli Vincenzo Matarese Angelo Zelante Sergio Sartori | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，10： | 5 |
| 6 | 细胞因子、纤维化与青光眼滤过术的失败显示文摘目前对青光眼滤过术后滤过口瘢痕化的治疗虽有效,但常产生有害的副作用。对纤维化反应细胞学基础的研究会有助于抗纤维化治疗。伤口的修复包括血管新生和成纤维细胞的活化,它们都是在细胞因子的参与下完成的。细胞因子在这复杂的网络中相互作用促使成纤维细胞趋化、增殖和收缩,并刺激产生葡萄糖胺聚糖及胶原。干扰素可能会抑制上述纤维化反应的多个环节,其在眼部抗纤维化治疗中的作用尚需作进一步的评价。 | Mark C Gillies Tao Su 余克明 | 1993 | 国外医学(眼科学分册)1993，17，1： | 5 |
| 7 | eTailQ: dimensionalizing, measuring and predicting etail quality显示文摘 | Mary Wolfinbarger Mary C Gilly | 2003 | Journal of Retailing2003，，3： | 4 |
| 8 | Intraperitoneal Chemohyperthermia Using a Closed Abdominal Procedure and Cytoreductive Surgery for the Treatment of Peritoneal Carcinomatosis: Morbidity and Mortality Analysis of 216 Consecutive Procedures显示文摘 | O. Glehen MD D. Osinsky MD E. Cotte MD F. Kwiatkowski MS G. Freyer MD PhD S. Isaac MD V. Trillet-Lenoir MD PhD A. C. Sayag-Beaujard MD Y. Fran?ois MD J. Vignal MD F. N. Gilly MD PhD | 2003 | Annals of Surgical Oncology2003，，8： | 4 |
| 9 | Selection of patients and staging of peritoneal surface malignancies显示文摘Peritoneal carcinomatosis (PC) is a common evolution of cancer of the gastrointestinal tract, and has been traditionally regarded as a terminal disease with short median survival. During the last 20 years, thanks to its favourable oncologic results, a new loco-regional therapeutic approach, combining cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), has an important development. Due to its significant, but acceptable, morbidity and mortality, and high cost, this comprehensive management plan requires knowledgeable patient selection. Quantitative prognostic indicators are required to assess a patient’s eligibility. Large multicenter studies have identified several prognostic factors, which can be used for a better selection of patients who would benefit from the combination of cytoreductive surgery with HIPEC. Indications for treatment of PC with cytoreduction and HIPEC are now validated for several diseases: peritoneal mesothelioma, pseudomyxoma peritonei, PC from the appendix, and colorectal cancer. Indications are still under discussion for gastric and ovarian carcinomatosis. Computed tomography is the best radiological for staging the disease. The extent of peritoneal carcinomatosis is, however, difficult to evaluate preoperatively, and precise evaluation is most often performed during surgical exploration. Cytoreductive surgery associated with HIPEC for the treatment of peritoneal carcinomatosis should be performed for young patients with limited and resectable carcino-matosis, in specialized institutions involved in the management of peritoneal surface malignancies. | Eddy Cotte Guillaume Passot Franois-Noёl Gilly Olivier Glehen | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 4 |
| 10 | Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment显示文摘 | Florian K.P. Sutter Judy M. Simpson Mark C. Gillies | 2004 | Ophthalmology2004，，11： | 3 |
| 11 | 黄斑囊样水肿患者自发荧光与黄斑色素密度的关系显示文摘目的探讨黄斑囊样水肿(CME)眼底自发荧光与黄斑色素密度的相关性,以提供对其预后有临床价值的技术参数。设计回顾性病例系列。研究对象2009年8月至2010年7月于北京同仁医院确诊CME的视网膜中央静脉阻塞、视网膜分支静脉阻塞及糖尿病视网膜病变的患者18例(24眼)。24只正常眼选自年龄及性别相匹配者。方法对所有患眼及正常对照眼行彩色眼底照相、荧光素眼底血管造影(FFA)及相干光断层扫描(OCT)确诊CME。采用海德堡公司HRA-2共焦激光扫描系统的IR(infrared)及FA(不注入荧光素钠)模式进行眼底自发荧光及黄斑色素密度的检测。黄斑色素密度按Zhang等分期法分为完整的黄斑色素、部分黄斑色素及黄斑色素缺失三级。采用Monte Carlo精确检验说明不同分级的黄斑色素密度与自发荧光的相关性,线性相关卡方检验分析两个变量之间的变化趋势。主要指标眼底自发荧光的分布及形态、黄斑色素的分布及密度。结果 24只CME眼自发荧光均为阳性(100%),并在黄斑区呈花瓣样表现,而正常对照眼的黄斑自发荧光均为阴性。CME眼中黄斑色素缺失22眼(91.7%),部分黄斑色素2眼(8.3%);正常对照眼黄斑色素密度均为完整的黄斑色素(100%)。黄斑色素密度与自发荧光的出现在本次研究中呈现负相关(χ2=45.123,P=0.0001)。结论 CME患者中黄斑色素密度大小与黄斑区自发荧光呈负相关,黄斑区自发荧光可做为其随诊的临床评价指标。 | 张新媛 Mark Gillies 朱晓青 王鑫 肖媛媛 顼晓琳 申令 高飞 | 2010 | 眼科2010，19，5： | 3 |
| 12 | Peritoneal Mesothelioma Treated by Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy: Results of a Prospective Study显示文摘 | C. Brigand MD O. Monneuse MD F. Mohamed MBChB MRCS A. C. Sayag-Beaujard MD S. Isaac MD F. N. Gilly MD PhD O. Glehen MD PhD | 2006 | Annals of Surgical Oncology2006，，3： | 3 |
| 13 | Incidents relating to the intra-hospital transfer of critically ill patients显示文摘 | Ursula Beckmann Donna M. Gillies Sean M. Berenholtz Albert W. Wu Peter Pronovost | 2004 | Intensive Care Medicine2004，，8： | 3 |
| 14 | Quality of life after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: A prospective study of 216 patients显示文摘 | G. Passot N. Bakrin A.S. Roux D. Vaudoyer F.-N. Gilly O. Glehen E. Cotte | 2013 | European Journal of Surgical Oncology2013，，： | 2 |
| 15 | Pseudomyxoma peritonei: A French multicentric study of 301 patients treated with cytoreductive surgery and intraperitoneal chemotherapy显示文摘 | D. Elias F. Gilly F. Quenet J.M. Bereder L. Sidéris B. Mansvelt G. Lorimier O. Glehen | 2010 | European Journal of Surgical Oncology2010，，5： | 2 |
| 16 | Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells-possibilities and current limitations显示文摘BACKGROUND Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients.They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells(RGCs)and Müller glia.AIM To refine human-induced pluripotent stem cells(hiPSCs)differentiated into threedimensional(3D)retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream analyses.METHODS In this study we described,evaluated,and refined methods with which to generate Müller glia and RGC progenitors,isolated them via magnetic-activated cell sorting,and assessed their lineage stability after prolonged 2D culture.Putative progenitor populations were characterized via quantitative PCR and immunocytochemistry,and the ultrastructural composition of retinal organoid cells was investigated.RESULTS Our study confirms the feasibility of generating marker-characterized Müller glia and RGC progenitors within retinal organoids.Such retinal organoids can be dissociated and the Müller glia and RGC progenitor-like cells isolated via magnetic-activated cell sorting and propagated as monolayers.CONCLUSION Enrichment of Müller glia and RGC progenitors from retinal organoids is a feasible method with which to study cell type-specific disease phenotypes and to potentially generate specific retinal populations for cell replacement therapies. | Kristine Karla Freude Sarkis Saruhanian Alanna McCauley Colton Paterson Madeleine Odette Annika Oostenink Poul Hyttel Mark Gillies Henriette Haukedal Miriam Kolko | 2020 | World Journal of Stem Cells2020，12，10： | 2 |
| 17 | A verification of the ’triangle’ method for obtaining surface soil water content and energy fluxes from remote measurements of the Normalized Difference Vegetation Index (NDVI) and surface e显示文摘 | R. R. Gillies W. P. Kustas K. S. Humes | 1997 | International Journal of Remote Sensing1997，，15： | 2 |
| 18 | Ginsenosides protect puonary vascular endothelium against free radical-induced injury 显示文摘 | Kim H Chen X Gillis C N | 1992 | Biochem Biophys Res Coun1992，189，： | 2 |
| 19 | Lack of prognostic significance of conventional peritoneal cytology in colorectal and gastric cancers: Results of EVOCAPE 2 multicentre prospective study显示文摘 | E. Cotte P. Peyrat E. Piaton F. Chapuis M. Rivoire O. Glehen C. Arvieux J.-Y. Mabrut J. Chipponi F.-N. Gilly | 2013 | European Journal of Surgical Oncology2013，，7： | 2 |
| 20 | Assessment of satellite remotely -sensed land cover parameters in quantitatively describing the climate effect of urbanization显示文摘 | Owen T W Carlson T N and Gillies R R | 1998 | International Journal of Remote sensing1998，19，9： | 2 |
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