|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 2 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 3 | Room temperature oxidation of acetone by ozone over alumina-supported manganese and cobalt mixed oxides显示文摘Volatile organic compounds(VOCs)are among the major sources of air pollution.Catalytic ozonation is an efficient process for removing VOCs at lower reaction temperature compared to catalytic oxidation.In this study,a series of alumina supported single and mixed manganese and cobalt oxides catalysts were used for ozonation of acetone at room temperature.The influence of augmenting the single Mn and Co catalysts were investigated on the performance and structure of the catalyst.The manganese and cobalt single and mixed oxides catalysts of the formula Mnl0%-CoX and Co10%-MnX(where X=0,2.5%,5%,or 10%)were prepared.It was found that addition of Mn and Co at lower loading levels(2.5%or 5%)to single metal oxide catalysts enhanced the catalytic activity.The mixed oxides catalysts of(Mnl0%-Co2.5%)and(Mn10%-Co5%)led to acetone conversion of about 84%.It is concluded that lower oxidation state of the secondary metal improves ozone decomposition and oxidation of acetone. | Mehraneh Ghavami Mostafa Aghbolaghy Jafar Soltan Ning Chen | 2020 | Frontiers of Chemical Science and Engineering2020，14，6： | 2 |
| 4 | Effects of cationic CTAB and anionic SDBS suffactants on the performance of Zn-MnO2 alkaline batteries显示文摘 | Ghavami R K Rafiei Z Tabatabaei S M | 2007 | J Power Sources2007，164，2： | 1 |
| 5 | Multi-criteria optimal design of stiffened plates, part 1: choice of the formula for the buckling load 显示文摘 | Brosowski B Ghavami K | 1996 | Thin-Walled Structures1996，24，4： | 1 |
| 6 | Etanercept in treatment of Felty's syndrome显示文摘 | Ghavami A Genevay S Fulpius T | 2005 | Ann Rheum Dis2005，64，7： | 1 |
| 7 | Role of BN IP3 in TNF - induced cell death TNF up regulates BN IP3 expression 显示文摘 | Ghavami S E shraghi M Kadkhoda K | 2009 | Biochim Biophys Acta2009，1793，3： | 1 |
| 8 | QSRR Models for Kova *ts,reten-lar and apolar gc stationary phases using molecular connectivi-ty indexes显示文摘 | GHAVAMI R FAHAM S | 2010 | Chromatographia2010，72，910： | 1 |
| 9 | Triple-frequency meandered monopole antenna with shorted parasitic strips for wireless application显示文摘 | LIU W C GHAVAMI M CHUNG W C | | 0，，01： | 1 |
| 10 | Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells显示文摘 | Hashemi M Ghavami S Eshraghi M Booy EP Los M | | 0，，01： | 1 |
| 11 | Bamboo as reinforcement in structural concrete ele- ments显示文摘 | GHAVAMI K | 2005 | Cement and Concrete Composites2005，27，6： | 1 |
| 12 | The role of FasFas L signaling pathway in induction of apoptosis in patients with sulfur mustard-induced chronic bronchiolitis显示文摘 | Pirzad G Jafari M Tavana S Sadrayee H Ghavami S Shajiei A | 2010 | J Toxicol2010，2010，37： | 1 |
| 13 | Apoptosis and cancer: Mutations within caspase genes 显示文摘 | Ghavami S Hashemi M Ande SR | 2009 | J Meal Genet2009，46，8： | 1 |
| 14 | Free, Restrained and Drying Shrinkage of Cement Mortar Composites Reinforced with Vegetable Fibers显示文摘 | Ghavami K | 2005 | Cement and Concrete Composites2005，27，4： | 1 |
| 15 | Growth impair- ment in β-thalassemia major,the role of trace element deficiency and other potential factors显示文摘 | Eshghi P Alavi S Ghavami S | 2007 | J Pediatr Hematol Oncol2007，29，1： | 1 |
| 16 | Apoptosis and cancer: mutations within caspase genes 显示文摘 | Ghavami S Hashemi M Ande SR | 2009 | Med Genet2009，46，8： | 1 |
| 17 | The five-step lower blephar-oplasty , blending the eyelid-cheekJunction显示文摘 | Rohrich RJ Ghavami A Mojallal A | 2011 | Plast Reconstr Surg2011，128，3： | 1 |
| 18 | The individualized component face lift:developing a systematic approach to facial rejuvenation显示文摘 | Rohrich RJ Ghavami A Lemmon JA | | 0，，： | 1 |
| 19 | Autophagy and apoptosis dysfunction in neurodegenerative disorders显示文摘 | Ghavami S Shojaei S Yeganeh B | 2014 | Prog Neurobiol2014，112，1： | 1 |
| 20 | Role of BNIP3 in TNF -induced cell death TNF up regulates BNIP3 expres- sion显示文摘 | GHAVAMI S E SHRAGHI M KADKHODA K | 2009 | Biochim Biophys Acta2009，1793，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员