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	题名	作者	年代	出处	被引量
1	Oxidative stress in humans following the Pringle manoeuvre显示文摘BACKGROUND: Oxidative stress is induced in the liver by application of the Pringle manoeuvre. Malondialdehyde is a carbonyl compound formed during lipid peroxidation and prostaglandin biosynthesis, which combines with DNA to form a number of adducts. Among them is the DNA ad-duct; 3-(2-deoxybeta-dierythropentafuranosyl) pyr [1,2-alpha]-purin-10(3H) one or M1G. This study was undertaken to determine the suitability of M1G as a novel marker of ischemia-reperfusion injury in the liver and its correlation with both the length of Pringle clamp application and the overall length of the operation. METHODS: Normal and colorectal liver metastatic tissues were obtained in 12 patients before and after application of the Pringle manoeuvre. All samples were snap-frozen in liquid nitrogen at -80 ℃. DNA was extracted and M1G quantification was performed by immunoslotblot analysis. RESULTS: M1G levels in normal liver tissue were 4.0 + 1.0 per 107 nucleotides before the Pringle manoeuvre and 7.4 ± 1.0 per 10 nucleotides after the Pringle manoeuvre (mean ± standard deviation) (P<0.05 by ANOVA). M1G levels in malignant liver tissue were 2.5 ±1.4 per 107 nucleotides before the Pringle manoeuvre and 6. 5 ±1.9 adducts per 10 nucleotides after the Pringle manoeuvre (P <0. 05). Ad-duct levels in normal liver tissue showed a significant correlation with cumulative period of Pringle application. CONCLUSIONS: This is the first time that the tissue levels of M1G before and after application of the Pringle manoeuvre have been studied. The results show that the Pringle manoeuvre exerts significant oxidative stress in human hepa-tocytes, which is Pringle-time dependent. The results highlight the potential for oxidative DNA adducts levels as a tool for measuring the severity of ischemia-reperfusion injury.	Giuseppe Garcea Andreas Gescher William Steward Ashley Dennison David Berry	2006	Hepatobiliary & Pancreatic Diseases International2006，5，2：	4
2	Resveratrol in the management of human cancer:how strong is the clinical evidence显示文摘	Gescher A Steward WP Brown K	2013	Ann NY Acad Sci2013，1290，：	1
3	Angiogenesis of gastrointestinal tumours and their metastases-a target, for intervention?显示文摘	Garcea G Lloyd TD Gescher A	2004	Eur J Cancer2004，40，：	1
4	Analogs of staurosporine potential anticancer drugs?显示文摘	Gescher A	1998	Gen Pharmacol1998，31，5：	1
5	Pharmacokinetics and pharmacodynamics of curcumin 显示文摘	Sharma RA Steward WP Gescher AJ	2007	Adv Exp Med Biol2007，595，：	1
6	Cytostatic and cytotoxic properties of the marine product bistratene A and analysis of the role of protein kinase C in its mode of action显示文摘	Stanwell C Gescher Watters D	1993	Biochem Pharmacol1993，45，9：	1
7	Colorectal cancer chemo-prevention:biochemical targets and clinical development of promising agents显示文摘	Sharma RA Manson MM Gescher A	2001	Eur J Cancer2001，37，：	1
8	Pharmacokinetics and pharmacodynamics of curcumin显示文摘	Sharma R A Steward W P Gescher A J		0，，：	1
9	Metabolism of N, N-Dimethylformamide: key to the understanding of its toxicity 显示文摘	Gescher A	1993	Chem Res Toxicol1993，6，：	1
10	Curcumin: the story so far 显示文摘	SHARMA R A GESCHER A J STEWARD W P	2005	EurJCancer2005，41，13：	1
11	Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta显示文摘	Gill PK Gescher A Gant TW	2001	EurJ Biochem2001，268，15：	1
12	Curcumin : the story so far 显示文摘	Sharma R A Gescher A J Steward W P	2005	Eur J Cancer2005，41，：	1
13	Pharmaeoldy- namic and pharmacokinetic study of oral curcuma extract in patientswith colorectal cancer显示文摘	Sharma R Gescher A J McLelland H R	2001	Clin Cancer Res2001，7，7：	1
14	Curcumin: The story so far显示文摘	R.A. Sharma A.J. Gescher W.P. Steward	2005	European Journal of Cancer2005，，：	1
15	An investigation of the re- lationship between the hepatotoxicity and the metabolism of N-alkylfor- mamides 显示文摘	Kestell P Threadgill M D Gescher A	1987	J Pharmacol ExpTher1987，240，1：	1
16	Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepato- cytes 显示文摘	Shaw A J Gescher A Mrg J	1988	Toxicol Appl Pharmacol1988，95，1：	1
17	Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies显示文摘	S.K. Pathak R.A. Sharma W.P. Steward J.K. Mellon T.R.L. Griffiths A.J. Gescher	2004	European Journal of Cancer2004，，1：	1
18	Innovative agents in cancer prevention显示文摘	Manson M M Farmer P B Gescher A	2005	Recent Results Cancer Res2005，166，：	1
19	Curcumin: thestory so far显示文摘	Sharma R A Gescher A J Steward W P	2005	Eur J Cancer2005，41，13：	1
20	Curcum in the story so far 显示文摘	Shama RA Gescher A J Steward WP	2005	Eur J Cancer2005，41，13：	1

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