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| 1 | Clinical features,histology,and histogenesis of combined hepatocellular-cholangiocarcinoma显示文摘Combined hepatocellular-cholangiocarcinoma(CHC) is a rare tumor with poor prognosis,with incidence ranging from 1.0%-4.7% of all primary hepatic tumors.This entity will be soon renamed as hepato-cholangiocarcinoma.The known risk factors for hepatocellular carcinoma(HCC) have been implicated for CHC including viral hepatitis and cirrhosis.It is difficult to diagnose this tumor pre-operatively.The predominant histologic component within the tumor largely determines the predominant radiographic features making it a difficult distinction.Heterogeneous and overlapping imaging features of HCC and cholangiocarcinoma should raise the suspicion for CHC and multiple core biopsies(from different areas of tumor) are recommended before administering treatment.Serum tumor markers CA19-9 and alpha-fetoprotein can aid in the diagnosis,but it remains a challenging diagnosis prior to resection.There is sufficient data to support bipotent hepatic progenitor cells as the cell of origin for CHC.The current World Health Organization classification categorizes two main types of CHC based on histo-morphological features:Classical type and CHC with stem cell features.Liver transplant is one of the available treatment modalities with other management options including transarterial chemoembolization,radiofrequency ablation,and percutaneous ethanol injection.We present a review paper on CHC highlighting the risk factors,origin,histological classification and therapeutic modalities. | Shweta Gera Mark Ettel Gabriel Acosta-Gonzalez Ruliang Xu | 2017 | World Journal of Hepatology2017，9，6： | 13 |
| 2 | 选区激光熔化和传统粉末冶金法制备Cu−Al−Ni−Mn−Zr形状记忆合金的对比显示文摘研究和分析选区激光熔化(SLM)与传统粉末冶金(PM)法制备Cu−11.3Al−3.2Ni−3.0Mn−0.5Zr形状记忆合金的显微组织特征和热稳定性差异。PM样品是将106~180μm预合金粉末在氩气气氛、1060℃下烧结制备的,无辅助加工,SLM样品是在Cu−10Sn基板上熔化32~106μm的预合金粉末制备的。通过维氏硬度试验评价材料的力学性能,采用差示扫描量热法测定马氏体相变温度,采用X射线衍射谱鉴定相成分,利用光学显微镜和扫描电子显微镜分析显微组织特征。结果表明,两种方法制备的合金中均发现β′1马氏体相,而在PM样品中存在粗大的马氏体变体。传统的粉末冶金样品在室温下会形成晶间共析成分和稳定的奥氏体。PM样品具有与SLM样品相似的平均硬度值,而与孔隙率相关的标准偏差较高。SLM样品具有可逆的马氏体相变(T0=171℃),而PM样品没有形状记忆效应。 | Dennis GERA Jonadabe SANTOS Cláudio SKIMINAMI Piter GARGARELLA | 2020 | Transactions of Nonferrous Metals Society of China2020，30，12： | 4 |
| 3 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 4 | Endoscopic management of recurrent epistaxis: The experience of two metropolitan hospitals in Italy显示文摘 | Antonio Minni Alberto Dragonetti Roberto Gera Marco Barbaro Giuseppe Magliulo Roberto Filipo | 2010 | Acta Oto-Laryngologica2010，，9： | 3 |
| 5 | Lessons from look-back in acute liver failure? A single centre experience of 3300 patients显示文摘 | William Bernal Anna Hyyrylainen Amit Gera Vinod K. Audimoolam Mark J.W. McPhail Georg Auzinger Mohammed Rela Nigel Heaton John G. O’Grady Julia Wendon Roger Williams | 2013 | Journal of Hepatology2013，，1： | 2 |
| 6 | Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor显示文摘 | Shay Soker Seiji Takashima Hua Quan Miao Gera Neufeld Michael Klagsbrun | 1998 | Cell1998，，： | 2 |
| 7 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance显示文摘 | Christopher B. Newgard Jie An James R. Bain Michael J. Muehlbauer Robert D. Stevens Lillian F. Lien Andrea M. Haqq Svati H. Shah Michelle Arlotto Cris A. Slentz James Rochon Dianne Gallup Olga Ilkayeva Brett R. Wenner William S. Yancy Howard Eisenson Gera | 2009 | Cell Metabolism2009，，4： | 2 |
| 8 | Novel steroid receptor phyto-modulator compound a inhibits growth and survival of prostate cancer cells显示文摘 | Yemelyanov A CzwomogJ Gera L | 2008 | Cancer Res2008，68，12： | 1 |
| 9 | Comparative radiation impact on biota and man in the area affected by the accident at the Chernobyl nuclear power plant显示文摘 | ALEXAKHIN R M GERAS′KIN S A | 2005 | J Environ Radioact2005，80，： | 1 |
| 10 | Paranasal sinus mycoses显示文摘 | Castelnuovo P Gera R Di-Giulio G | 2000 | Acta Otorhinolaryngol Ital2000，20，： | 1 |
| 11 | AKT activity determines sensitivity to manunalian target of rapamycin(mTOR) inhibitors by regulating cyclin D1 and c - myc expression显示文摘 | GERA JF MELLINGHOFF IK SHI Y | 2004 | J Biol Chem2004，279，4： | 1 |
| 12 | Prognostic factors for local in recurrent carcinoma treated with IORT; Report of the French IORT group显示文摘 | Make MA Romestaing P Gera JP | 1997 | Front Radiat Ther Oncol1997，，31： | 1 |
| 13 | AKT activity determines sensitivity to mammalian target of rapamycin(roTOR) inhibitors by regulating cyclin D1 and c-myc expression显示文摘 | Gera JF Mellinghoff IK Shi Y | 2004 | J Biol Chem2004，279，4： | 1 |
| 14 | Protein coat of two strains of cumumber mosaic virus affect transmission by Aphid gossypii 显示文摘 | Gera A Loebenstein G Raccah B | 1979 | Phytopathol1979，69，： | 1 |
| 15 | Posterior reversible encephalopathy syndrome in children with kidney disease显示文摘 | Gera DN Patil SB Iyer A et al | 2014 | Indian J Nephrol2014，24，1： | 1 |
| 16 | Nontraumatic convexity subarachnoid hemorrhage : different etiologies and outcomes 显示文摘 | Gera]des R Sousa PR Fonseca AC | 2014 | J Stroke Cerebrovasc Dis2014，23，1： | 1 |
| 17 | Analysis of shell colour determinism in the Manila clam Ruditapes philippinarum 显示文摘 | Peignon J M Geraed A Naciri Y | 1995 | Aquatic Living Resources1995，8，： | 1 |
| 18 | Subeellular dynamics and role of Arabidopsis 1]-1,3 glucanases in cell-to-cell movement of to- bamoviruses显示文摘 | ZAVALIEV R LEVY A GERA A | 2013 | Molecular Plant-Microbe Interactions2013，26，9： | 1 |
| 19 | Immunolo- calization of AQP5 in resting and stimulated normal labial glands and in Sj6gren's syndrome显示文摘 | Gresz V Horvath A Gera I | 2014 | Oral Dis2014，21，1： | 1 |
| 20 | Bringing Marx to Justice:AnAddendum and Rejoinder显示文摘 | Norman Geras | 1992 | New Left Review 1951992，，： | 1 |
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