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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Cerebral gnathostomiasis as a cause of an extended intracranial bleeding显示文摘 | Germann R Sch chtele M Nessler G | 2003 | Kiln Padiatr2003，215，4： | 1 |
| 3 | Regulation of laccase synthesis in induced Neurospora crassa cultures显示文摘 | Linden R M Schilling B C Germann U A | 1991 | Current Genetics1991，19，5： | 1 |
| 4 | Washing Away Your Sins?Corporate Social Responsiblity, Corporate Social Irresponsibility, and Firm Performance 显示文摘 | Kang C Germann F Grewal R | 2016 | Journal of Marketing2016，80，2： | 1 |
| 5 | Craniomedial pedicled mammaplasty based on Würinger′s horizontal septum显示文摘 | Ryssel H Germann G Reichenberger R | 2010 | Aesthetic Plast Surg2010，34，4： | 1 |
| 6 | Ophthalmic diagnoses in the ED:optic neuritis 显示文摘 | GERMANN C A BAUMANN M R HAMZAVI S | 2007 | Am J Emerg Med2007，25，7： | 1 |
| 7 | Identifying patterns and relationships among the responses of seventh-grade students to the science process skill of designing experiment显示文摘 | Germann P.J Aram R Burke G | | 0，，： | 1 |
| 8 | The impact of risk factors and pre-existing conditions on the mortality of burn pa- tients and he precision of predictive admission-scoring systems 显示文摘 | Germann G Barthold U Lefering R | 1997 | Burns1997，23，3： | 1 |
| 9 | Concrete protection via internal hydrophobization显示文摘 | STANDKE B SCHAFROTH R GERMANN A | 2003 | Materials Science and Restoration MSR-VI Aedificatio Publishers2003，2003，： | 1 |
| 10 | Silicon oxynitride layers for optical waveguide applications 显示文摘 | Germann R Salemink H W M Beyeler R | 2000 | Journal of the Electrochemical Society2000，147，6： | 1 |
| 11 | SiON high-refractive-index waveguide and planar lightwave circuits 显示文摘 | Bona G L Germann R Offrein B J | 2003 | IBM Journal of Research and Development2003，47，23： | 1 |
| 12 | A gener- al method for the purification of synthetic oligodeoxyri- bonucleotides containing strong secondary structure by reversed-phase high-performance liquid chromatography on PRP-1 resin 显示文摘 | Germann M W Pon R T van de Sande J H | 1987 | Analytical Biochemistry1987，165，： | 1 |
| 13 | Craniomedial pedicled mammaplasty based On Wuringer's horizontal septurn显示文摘 | Ryssel H Germann G Reiehenberger R | 2010 | Aesth Plast Surg2010，34，4： | 1 |
| 14 | Pointlng,acquisition,and tracking subsystem for spacebased laser communications显示文摘 | Young P W Germann L M Nelson R | 1986 | SPIE1986，616，： | 1 |
| 15 | Compact tunable FIR dispersion compensator in SiON technology显示文摘 | Horst F Germann R Bapst U | 2003 | IEEE Photonics Technol Lett2003，15，： | 1 |
| 16 | Apodised Bragg gratings in planar waveguides for add-drop filters 显示文摘 | David C Wiesmann D Germann R | 2001 | Microelectronie Engineering2001，5758，： | 1 |
| 17 | Energy Dependenoe and Depth Distribution of Dry Etching-Induced Damage in III/V Semiconductor Heterostructures显示文摘 | Germann R Forchel A Bresch M | 1989 | J Vac Sci Technol1989，7，6： | 1 |
| 18 | Pointing,acquisition and tracking subsystem for space-based laser communication显示文摘 | Germann L M Nelson R | 1986 | Proceedings of SPIE1986，616，： | 1 |
| 19 | Applying blood-brain barrier in vitro models to study the influence of drugs on endothelial cells--effects of selected COX-inhibitors 显示文摘 | Germann B Neuhaus W Hofer-Warbinek R | 2008 | Pharmazie2008，63，： | 1 |
| 20 | Performance of bioprostheses and mechanical pros- theses assessed by composites of valve-related compli- cations to 15 years after aortic valve replacement显示文摘 | CHAN V JAMIESON W R E GERMANN E | 2006 | J Thoracic Cardiovasc Surg2006，131，： | 1 |
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