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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Paroxetine hydrochloride显示文摘 | P Germann D Ma G Han F | 2013 | rofiles Drug Subst Excip Relat Methodol2013，38，： | 1 |
| 3 | Washing Away Your Sins?Corporate Social Responsiblity, Corporate Social Irresponsibility, and Firm Performance 显示文摘 | Kang C Germann F Grewal R | 2016 | Journal of Marketing2016，80，2： | 1 |
| 4 | Scales and dimensions of momentum dissipation during preferential flow in soils显示文摘 | Germann P F Pietro L D | 1999 | Water Resources Reserches1999，35，5： | 1 |
| 5 | Investigation of hydrogen discharging and recharging processes of Ti-doped NaAlH4 by X-ray diffraction analysis (XRD) and solid-state NMR spectroscopy 显示文摘 | BOGDANOVIC B FELDERHOFF M GERMANN M HARTEL M POMMERIN A SCHUTH F WEIDENTHALER C ZIBROWIUS B | 2003 | J Alloys Compd2003，350，： | 1 |
| 6 | Throughflow and solute transport in an isolated sloping soil block in a forested catchment 显示文摘 | Hornberger G M Germann P F Beven K J | 1991 | Journal of Hydrology1991，124，12： | 1 |
| 7 | Impact of initial and boundary conditions on preferential flow显示文摘 | I-Iincapi~ I Germann P F | 2009 | Journal of contaminant hydrology2009，104，1： | 1 |
| 8 | Kinematic Wave Approximation to The Initiation of Subsurface Storm Flow in a Sloping Forest Soil显示文摘 | Germann Peter F Pierce Robert S Beven Keith | 1986 | Advances in Water Resources1986，9，2： | 1 |
| 9 | Anthmcyclines during -: embryo-fetal outcome in 160 patients 显示文摘 | Germann N Goffinet F Goldwasser F | 2004 | Ann Oneol2004，15，1： | 1 |
| 10 | Converging hydrostatic and hydromechanic concepts of preferential flow definitions显示文摘 | KUTILEK M GERMANN P F | 2009 | Journal of Contaminant Hydrology2009，104，1： | 1 |
| 11 | Impact of initial and boundary conditions on preferential flow显示文摘 | HINCAPIE I GERMANN P F | 2009 | Journal of Contaminant Hydrology2009，104，1234： | 1 |
| 12 | Profiles of bromide and increased soil moisture after infiltration into soils with macropores显示文摘 | Germann P F Edwards W M Owens L B | 1984 | Soil Sci Soc Am J1984，48，1： | 1 |
| 13 | Profiles of bromide and increased soil moisture after infiltration into soils with macropores显示文摘 | GERMANN P F EDWARDS W M OWENS L B | 1984 | Soil Sci Soc Am J1984，48，1： | 1 |
| 14 | Poiseuille flow geometry inferred from velocities of wetting fronts in soils 显示文摘 | Germann P F Hensel D | 2006 | Vadose Zone Journal2006，5，3： | 1 |
| 15 | Inferences about solute transport in macroporous forest soils from time series models显示文摘 | Homberger G M Beven K J Germann P F | 1990 | Geoderma1990，46，： | 1 |
| 16 | Impact of initial and boundary conditions on preferential flow显示文摘 | HincapiéIngrid Germann Peter F | 2009 | Journal of Contaminant Hydrology2009，104，4： | 1 |
| 17 | Anthracyclines during pregnancy: embryo-fetal outcome in 160 patients显示文摘 | Germann N Goffinet F Goldwasser F | 2004 | Ann Oncol2004，15，1： | 1 |
| 18 | Paroxetine hydrochloride显示文摘 | Germann D Ma G Han F | 2013 | Profiles Drug Subst Exeip Relat Methodol2013，38，： | 1 |
| 19 | Anthracyclines during pregnancy:embryo-fetal outcome in 160 patients显示文摘 | GERMANN N GOFFINET F GOLDWASSER F | 2004 | Ann Oncol2004，15，1： | 1 |
| 20 | The Arabidopsis LHP1 protein is a component of euchromatin显示文摘 | Libault M Tessadori F Germann S | 2005 | Planta2005，222，： | 1 |
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