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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derivedstem cells by promoting osteogenic and endothelial differentiation显示文摘 | Behr B Tang C Germann G | 2011 | Stem Cells2011，29，2： | 1 |
| 3 | The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient显示文摘 | Raff T Germann G Hartmann B | 1997 | Burns1997，23，4： | 1 |
| 4 | Regulation of laccase synthesis in induced Neurospora crassa cultures显示文摘 | Linden R M Schilling B C Germann U A | 1991 | Current Genetics1991，19，5： | 1 |
| 5 | Alteration of the glycocalyx of two blood-brain barrier mimicking cell lines is induc- ible by glioma conditioned media 显示文摘 | Neuhaus W Germann B Plattner VE | 2009 | Brain Res2009，1279，1： | 1 |
| 6 | Correlations between Car- diac Output, Stroke Volume, Central Venous Pressure, Intra-abdonai- nal Pressure and Total Circulating Blood Volume in Resuscitation of Major Bums 显示文摘 | Kuntscher MV Germann G Hartmann B | 2006 | Resuscitation2006，70，1： | 1 |
| 7 | Standardized Serum- Free Cryomedia Maintain Peripheral Blood Mononuclear Cell Viabil- ity, Recovery, and Antigen-Specific T-Cell Response Compared to Fetal Calf Serum-Based Medium 显示文摘 | Germann A Schulz JC Kemp-Kamke B | 2011 | Biopreserv Biobank2011，9，3： | 1 |
| 8 | Investigation of hydrogen discharging and recharging processes of Ti-doped NaAlH4 by X-ray diffraction analysis (XRD) and solid-state NMR spectroscopy 显示文摘 | BOGDANOVIC B FELDERHOFF M GERMANN M HARTEL M POMMERIN A SCHUTH F WEIDENTHALER C ZIBROWIUS B | 2003 | J Alloys Compd2003，350，： | 1 |
| 9 | Concrete protection via internal hydrophobization显示文摘 | STANDKE B SCHAFROTH R GERMANN A | 2003 | Materials Science and Restoration MSR-VI Aedificatio Publishers2003，2003，： | 1 |
| 10 | The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient显示文摘 | Raff T Germann G Harlmann B | 1997 | Burns1997，23，： | 1 |
| 11 | SiON high-refractive-index waveguide and planar lightwave circuits 显示文摘 | Bona G L Germann R Offrein B J | 2003 | IBM Journal of Research and Development2003，47，23： | 1 |
| 12 | Locally applied vascular en-dothelial growth factor a increases the osteogenic healing capacity of human adipose derived stem cells by promoting osteogenic andendothelial differentiation显示文摘 | Behr B Tang C Germann G | 2011 | Stem Cells2011，29，2： | 1 |
| 13 | Early intragastric feeding of seriourly burned and longterm ventilated patients: a review of 55 patients显示文摘 | Raff T Hartmann B Germann G | 1997 | Burns1997，23，： | 1 |
| 14 | Effect of thalidomide and structurally related compounds on corneal angiogenesis is comparable to their teratological potency显示文摘 | Germann T Kirchhof B | 1999 | Graefes Arch Clin Exp Ophthalmol1999，237，： | 1 |
| 15 | The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient显示文摘 | Raff T Germann G Hartmann B | 1997 | Burns1997，23，4： | 1 |
| 16 | Profiles of bromide and increased soil moisture after infiltration into soils with macropores显示文摘 | Germann P F Edwards W M Owens L B | 1984 | Soil Sci Soc Am J1984，48，1： | 1 |
| 17 | Outcome assessment after reconstruction of complex defects of the forearm and hand with osteocutaneous free flaps 显示文摘 | Kremer T Bichert B Germann G | 2006 | Plast Reconstr Surg2006，118，2： | 1 |
| 18 | Profiles of bromide and increased soil moisture after infiltration into soils with macropores显示文摘 | GERMANN P F EDWARDS W M OWENS L B | 1984 | Soil Sci Soc Am J1984，48，1： | 1 |
| 19 | Atomistic Mechanism for Hot Spot Initiation 显示文摘 | Holian B L Germann T C Maillet J B | 2002 | Phys Rev Lett2002，89，28： | 1 |
| 20 | Applying blood-brain barrier in vitro models to study the influence of drugs on endothelial cells--effects of selected COX-inhibitors 显示文摘 | Germann B Neuhaus W Hofer-Warbinek R | 2008 | Pharmazie2008，63，： | 1 |
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