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| 1 | Clinical applications of squamous cell carcinoma antigenimmunoglobulins M to monitor chronic hepatitis C显示文摘Hepatitis C virus(HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma(HCC), one of the most common fatal cancers worldwide- fourth for incidence rate. A high public health priority need is the development of biomarkers to screen for liver disease progression and for early diagnosis of HCC development, particularly in the high risk population represented by HCV-positive patients with cirrhosis. Several studies have shown that serological determination of a novel biomarker, squamous cell carcinoma antigen-immunoglobulins M(SCCA-Ig M), might be useful to identify patients with progressive liver disease. In the initial part of this review we summarize the main clinical studies that have investigated this new circulating biomarker on HCV-infected patients, providing evidence that in chronic hepatitis C SCCA-Ig M may be used to monitor progression of liver disease, and also to assess the virological response to antiviral treatment. In the last part of this review we address other, not less important, clinical applications of this biomarker in hepatology. | Andrea Martini Andrea Gallotta Patrizia Pontisso Giorgio Fassina | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 2 | Serum levels of soluble interleukin-2 receptors in acute and chronic viral hepatitis显示文摘 | Dr. Alfredo Alberti Liliana Chemello Giovanna Fattovich Patrizia Pontisso Giampietro Semenzato Cosimo Colletta Fabrizio Vinante Giovanni Pizzolo | 1989 | Digestive Diseases and Sciences1989，，10： | 2 |
| 3 | 对HBV和HCV合并感染的患者通过纵向评估揭示病毒学复合谱 | Raimondo G. Brunetto M.R. Pontisso P. 陈云茹 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，10： | 2 |
| 4 | Clinical,virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B显示文摘 | Fattovich G Rugge M Brollo L Pontisso P Noventa F Guido M Alberti A Realdi G | 1986 | Hepatology1986，6，2： | 1 |
| 5 | Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma显示文摘 | Pontisso P Calabrese F Benvegnu L | 2004 | Br J Cancer2004，90，： | 1 |
| 6 | Lack of correlation between hepatitis C virus genotypes and clinical course of hepatitis C virus-related cirrhosis显示文摘 | Benvegnu L Pontisso P Cavalletto D | 1997 | Hepatology1997，25，1： | 1 |
| 7 | Long-term follow-up of anti-HBe-positive chronic active hepatitis B显示文摘 | Fattovich G Brollo L Alberti A Pontisso P Giustina G Realdi G | 1988 | Hepatology1988，8，6： | 1 |
| 8 | Nature and display of hepatitis B virus envelope proteins and the humoral immune response显示文摘 | Alfredo Alberti Wolfram H. Gerlich Klaus-Hinrich Heermann Patrizia Pontisso | 1990 | Springer Seminars in Immunopathology1990，，1： | 1 |
| 9 | Hepatitis C genotypes in patients with dual hepatitis B and C virus infection显示文摘 | Pontisso P Gerotto M Ruvoletto MG | 1996 | J Med Virol1996，48，2： | 1 |
| 10 | Biological and clinical implications of HI3V infection in peripheral blood mononuclear cetls显示文摘 | Pontisso P Vidalino L Quarta S etal | 2008 | Autoimmun Rev2008，8，1： | 1 |
| 11 | The preS1 domain of hepatitis virus and IgA cross-react in their binding to the hepatocyte surface显示文摘 | Pontisso P Ruvoletto MG Tiribelli C | 1992 | J Gen Virol1992，73，8： | 1 |
| 12 | Over expression of squamouscell carcinoma antigen variants in hepatocellular carcinoma显示文摘 | Calabrese F Benveguu L | 2004 | Bf J Cancer2004，90，4： | 1 |
| 13 | Ove, rexprcssion of squamous cell carcinoma antigen variants in hepatoellular carcinoma 显示文摘 | Pontisso P | 2004 | British Journal of Cancer2004，90，4： | 1 |
| 14 | Biological and clinical implications of HBV infection in peripheral blood mononuclear cells显示文摘 | Pontisso P Vidalino L Quarta S | 2008 | Autoimmun Rev2008，8，1： | 1 |
| 15 | Identification of an attachment site for human liver plasma membranes on hepatitis B virus particles 显示文摘 | Pontisso P Ruvoletto M G Gerlich W H | 1989 | Virology1989，173，： | 1 |
| 16 | Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid-and long-term prediction of hepatocellular carcinoma among cirrhotic patients显示文摘BACKGROUND The combination of alpha-fetoprotein(AFP)and squamous cell carcinoma antigen immunocomplex(SCCA-IgM)have been proposed for its use in the screening of hepatocellular carcinoma(HCC).Current screening programs for all cirrhotic patients are controversial and a personalized screening is an unmet need in the precision medicine era.AIM To determine the role of the combination of SCCA-IgM and AFP in predicting mid-and long-term appearance of HCC.METHODS Two-hundred and three cirrhotic patients(Child A 74.9%,B 21.2%,C 3.9%)were followed-up prospectively every six months to screen HCC by ultrasound and AFP according to European Association for the Study of the Liver guidelines.The estimation cohort was recruited in Italy(30.5%;62/203)and validation cohort from Spain(69.5%;141/203).Patients underwent to evaluate SCCA-IgM by enzyme-linked immunosorbent assay(Hepa-IC,Xeptagen,Italy)and AFP levels at baseline.Patients were followed-up for 60 mo,being censored at the time of the appearance of HCC.RESULTS There were 10.8%and 23.1%of HCC development at two-and five-years followup.Patients with HCC showed higher levels of SCCA-IgM than those without it(425.72±568.33 AU/mL vs 195.93±188.40 AU/mL,P=0.009)during the fiveyear follow-up.In multivariate analysis,after adjusting by age,sex,aspartate transaminase and Child-Pugh,the following factors were independently associated with HCC:SCCA-IgM[Hazard ratio(HR)=1.001,95%CI:1.000-1.002;P=0.003],AFP(HR=1.028,95%CI:1.009-1.046;P=0.003)and creatinine(HR=1.56495%CI:1.151-2.124;P=0.004).The log-rank test of the combination resulted in 7.488(P=0.024)in estimation cohort and 11.061(P=0.004)in the validation cohort,and a 100%of correctly classified rate identifying a low-risk group in both cohorts in the two-year follow-up.CONCLUSION We have constructed a predictive model based on the combination of SCCA-IgM and AFP that provides a new HCC screening method,which could be followed by tailored HCC surveillance for individual patients,especially for those cirrhotic patients belonging to the subgroup identified as low-risk of HCC development. | Antonio Gil-Gómez Ángela Rojas Chang-Hai Liu Rocio Gallego-Duran Rocio Muñoz-Hernandez Giorgio Fassina Patrizia Pontisso Javier Ampuero Manuel Romero-Gómez | 2021 | World Journal of Gastroenterology2021，27，48： | 1 |
| 17 | Overexpression of aquamous cell carcinoma antigen variants in hepatocellular carcinoma显示文摘 | Pontisso P Calabrese F Benvegn L | 2004 | Br J Cancer2004，90，4： | 1 |
| 18 | Fine specificity of human antibody response to the PreS1 doman of hepatitis B virus显示文摘 | Alberti A Cavalletto D Chemello L Belussi F Fattovich G Pontisso P | 1990 | Hepatology1990，12，： | 1 |
| 19 | The preS1 domain of hepatitis B virus and IgA cross-react in their binding to the hepatocyte surface显示文摘 | PONTISSO P RUVOLETTO MG TIRIBELLI C | 1992 | J Gen Virol1992，73，8： | 1 |
| 20 | Serum markers of hepatic fibrugenesis in chronic hepatitis type C treated with alfa-2A interferon显示文摘 | Gallorini A Plebani M Pontisso P | 1994 | Liver1994，14，5： | 1 |
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