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| 1 | Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow显示文摘肺的动脉的背景反常 apoptosis 光滑的肌肉房间(PASMC ) 是在肺的动脉的一个重要 pathophysiological 过程结构的改变和肺的高血压。我们在 39 只男 Sprague-Dawley 老鼠随机被分到4星期的控制的高肺的血 flow.Methods 导致的肺的高血压的开发期间在 PASMC 的 apoptosis 上调查了内长的氢硫化物( H_2S )的可能的效果,4星期的分流,4星期的 shunt+propargylglycine ( PPG ),11星期的控制,11星期的分流和11星期的 shunt+sodium hydrosulfide ( NaHS )组织。在 4 星期的分流, 4 星期的 shunt+PPG, 11 星期的分流和 11 星期的 shunt+NaHS 组的老鼠经历了腹的主动脉晚辈静脉 cava 分流。在 4 星期的 shunt+PPG 组的老鼠 intraperitoneally 与 PPG 被注射,内长的 H_2S 生产的一个禁止者,为 4 个星期。在 11 星期的 shunt+NaHS 组的老鼠 intraperitoneally 与 NaHS 被注射,一个 H_2S 施主,为 11 个星期。肺织物 H_2S 被硫化物敏感的电极评估。PASMC 的 Apoptosis 被终端 deoxynucleotidyl transferase 检测标记的调停的 dUTP 刻痕结束(TUNEL ) 。在 PASMC 的船边交货, bcl-2 和 caspase-3 的表情四个星期在推延的操作以后与免疫化学的 staining.Results 被分析, PASMC 的 apoptosis 和船边交货和 caspase-3 的表示显著地被减少(P < 0.01 ) ,但是 bcl-2 的表示显著地增加了(P < 0.01 ) 。PPG 管理进一步禁止了 PASMC 的 apoptosis, downregulated 船边交货和 caspase-3 的表示(P < 0.01 ) ,但是增加了 bcl-2 的表示(P < 0.01 ) 。在 11 星期推延以后操作, PASMC 的 apoptosis 和船边交货和 caspase-3 的表示显著地被减少(P < 0.01 ) ,但是 bcl-2 的表示显然增加了(P < 0.01 ) 。NaHS 管理显著地增加了 PASMC 的 apoptosis, upregulated 船边交货和 caspase-3 的表示,但是禁止了 bcl-2.Conclusions H_2S 的表示在高肺的血的发展导致 PASMC 的 apoptosis 由激活船边交货小径并且禁止 bcl-2 小径的导致流动的肺的高血压。 | LI Wei JIN Hong-fang LIU Die SUN Jing-hui JIAN Pei-jun LI Xiao-hui TANG Chao-shu DU Jun-bao | 2009 | Chinese Medical Journal2009，，24： | 26 |
| 2 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 3 | 模具行业“十一五”规划显示文摘根据我国模具行业的现状,'十五'期间取得的成绩和存在的主要差距,以及我国模具行业持续发展的态势,不断增加的市场需求和良好的宏观环境,确定了'十一五'模具行业规划的发展总量和争取进入世界模具生产制造强国的具体目标。特别对模具产品发展的重点和模具技术发展的重点提出了具体措施意见及政策建议。 | (China Die&Mould Industrial Association) | 2005 | 模具工业2005，，7： | 11 |
| 4 | HCWCI/Carbon Steel Bimetal Liner by Liquid-Liquid Compound Lost Foam Casting显示文摘Impact, friction and corrosion from the grinding balls and the grinding medium during the mineral processing result in liner breakage. Liner, made from Hadfield steel or alloyed steel, could not have served in wet grinding environment for more than ten months. Composite liner, made from HCWCI (high Cr white cast iron) and carbon steel, has been developed successfully with liquid-liquid composing process based on LFC (lost foam casting). The microstructure of composite was analyzed with optical microscope, SEM (scanning electron microscope)/EDX energy-dispersive X-ray and XRD (X-ray diffraction). According to micrograph, the combination region of two metals was staggered like dogtooth, no mixtures occurred between two liquid metals, and its interface presented excellent metallurgical bonding state. The results of mechanical property test show that, the hardness of HRC, the fracture toughness, and the bending strength are more than 61, 16.5 J/cm2 and 1 600 MPa, respectively. Comparison between liners made from bimetal composite and alloyed steel has also been investigated in industrial hematite ball mill. The results of eight months test in wet grinding environment prove that the service life of bimetal composite liner is three times as long as that of one made from alloyed steel. | XIAO Xiao-feng1,2, YE Sheng-ping2, YIN Wei-xin3, XUE Qiong4 (1. School of Mechanical Engineering and Automation, Wuhan Textile University, Wuhan 430073, Hubei, China 2. State Key Laboratory of Material Processing and Die and Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China 3. Wuhan Zhike Abrasive-Resistant Material Science and Technology Development Co Ltd, Wuhan 430073, Hubei, China 4. College of Science, Wuhan University of Technology, Wuhan 430079, Hubei, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，10： | 11 |
| 5 | A LOOP DRAWBEAD RESTRAINING FORCE MODEL IN SHEET METAL DEEP DRAWING PROCESS显示文摘In sheet metal forming, drawbeads are often used to control uneven material flow which may cause defects such as wrinkles, fracture, surface distortion and springback. Appropriate setting and adjusting the drawbead force is one of the most important pa- rameters in sheet metal forming process control. This paper derives the model of loop drawbead restraining force (DBRF) using plastic forming theory, and gives the min imum blankholding force. Experiments are carried out to verify the proposed DBRF model. The good agreement between the calculated values and experiments data justi- fies the proposed loop drawbead restraining force model. | Y.J. Luo, S.P. Li, J.F. Zheng, D.N. He, Y.Q. Zhang, J.L. Cheng and J. Y. Jiang 1)National Mold & Die CAD Engineering Research Center, Shanghai 200030, China 2)Shanghai Volkswagen Automotive Company Ltd.(SVM), Shanghai 201805, China | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，5： | 11 |
| 6 | Acquisition of deleterious mutations duringpotato polyploidization显示文摘Potatoes(Solanum tuberosum L.) represent an important tuber crop, worldwide. During its prolonged clonal propagation, numerous deleterious mutations have accumulated in the potato genome,leading to severe inbreeding depression; however,the shaping of this mutation burden during polyploidization and improvement is largely unknown.Here, we sequenced 20 diploid landraces of the Stenotomum group, eight tetraploid landraces, and 20 tetraploid modern cultivars, to analyze variations in their deleterious mutations. We show that deleterious mutations accumulated rapidly during the polyploidization of tetraploid potatoes. This study provides a foundation for future potato improvement. | Qun Lian Die Tang Zhiyan Bai Jianjian Qi Fei Lu Sanwen Huang Chunzhi Zhang | 2019 | Journal of Integrative Plant Biology2019，61，1： | 8 |
| 7 | Effect of Powder Particle Size on the Properties and Microstructure of Ti(C,N)-Based Cermet显示文摘The influence of raw powder particle size on the properties and microstructures of Ti (C, N)-based cermets has been studied. The conclusions are as follows: The microsmictures of cermets were composed of two kinds of grains, the one with black cores surrounded by obvious rim structures, and the other whose cores were white with unconspicuous rim structures and adhesive phase. In the cermet made from fine powders, the amount of grains with white cores was much more than that in cermet made from coarse powders. In addition, their properties were also much better. | Yong Zheng, Weihao Xiong (Key State Laboratory of Die Technology, Huazhong University of Science and Technology, Wuhan 430074, China) | 2001 | Rare Metals2001，20，1： | 8 |
| 8 | Geochemistry and Zircon U–Pb age of the Yao'an pseudoleucite porphyry,Yunnan Province,China显示文摘The Yao'an Pb–Ag deposit, located in the Chuxiong Basin, western Yangtze Block, is an important component of the Jinshajiang–Ailaoshan alkaline porphyry–related polymetallic intrusive belt. This complex suite of rock bodies includes a vein of pseudoleucite porphyry within deposits of syenite porphyry and trachyte.The pseudoleucite is characterized by a variable greyish,greyish-white, and greyish-green porphyritic texture. Phenocrysts are mainly pseudoleucite with small amounts of alkali feldspar and biotite. In an intense event, leucite phenocrysts altered to orthoclase, kaolinite, and quartz.Both the pseudoleucite porphyry and the syenite porphyry samples were typical alkali-rich, K-rich, al-rich rocks with high LaN/YbNratios; enriched in light rare earth elements and large-ion lithophile elements, and depleted in high field strength elements; and with strongly negative Ta, Nb, and Ti(TNT) anomalies and slightly negative Eu anomalies—all characteristics of subduction-zone mantle-derived rock.We obtained a LA-ICP-MS zircon U–Pb age of 34.1 ± 0.3 Ma(MSWD = 2.4), which is younger than the established age of the Indian and Eurasian Plate collision.The magma derived from a Type-II enriched mantle formed in a post-collisional plate tectonic setting. The geochemical characteristics of the Yao'an pseudoleucite porphyry are powerful evidence that the porphyry'sdevelopment was closely linked to the Jinshajiang–Ailaoshan fault and to the Indian-Eurasian collision. | Chundi Sun Peng Wu Die Wang Shenjin Guan Xiaojun Jiang Longyan Jiang Longyan Wang | 2017 | Acta Geochimica2017，36，2： | 8 |
| 9 | Microstructure and shear strength of the brazed joint of Ti(C,N)-based cermet to steel显示文摘Firm joins were obtained between Ti(C,N)-based cermet and steel with Ag-Cu-Zn-Ni filler metal by vacuum brazing. The effects of technological parameters such as brazing temperature, holding time, and filler thickness on the shear strength of the joints were investigated. The microstructure of welded area and the reaction products of the filler metal were examined by scanning electron microscopy (SEM), metallographic microscope (OM), energy-dispersive X-ray analysis (EDS), and X-ray diffraction (XRD). The brazing temperature of 870°C, holding time of 15 min, and filler thickness of 0.4 mm are a set of optimum technological parameters, under which the maximum shear strength of the joints, 176.5 MPa, is achieved. The results of microstructure show that the wettability of the filler metal on Ti(C,N)-based cermet and steel is well. A mutual solution layer and a diffusion layer exist between the welding base materials and the filler metal. | YE Dameng, XIONG Weihao, Zhang Xiuhai, QU Jun, and YAO Zhenghua State Key Laboratory of Plastic Forming Simulation and Die & Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, China | 2010 | Rare Metals2010，29，1： | 7 |
| 10 | P2X7 Receptor Antagonism Attenuates the Intermittent Hypoxia-induced Spatial Deficits in a Murine Model of Sleep Apnea Via Inhibiting Neuroinflammation and Oxidative Stress显示文摘 | Yan Deng Xue-Ling Guo Xiao Yuan Jin Shang Die Zhu Hui-Guo Liu | 2015 | Chinese Medical Journal2015，，16： | 7 |
| 11 | EXPERIMENTS AND SIMULATIONS OF A NEW DEVELOPED FORMING TECHNOLOGY-SHEAR-EXTRUSION PROCESS OF COMPONENTS WITH BRANCHES显示文摘Shear-extrusion process and its forming parumeters are proposed, whilst its laborsav- ing characteristic is utilized to forge large-size shutoff valve body on middle-due press. This new process is intended for the manufacture of large-size forged tubular components with branches on middle-due press. Experiments are carried out and processing parameters are obtained regarding the shear-extrusion process of a large-size shutoff valve body. Daformation and metal flow in the shear-extrusion process are inves- tigated. In orber to verify the laborsaving characteristic of this new process some contrastive experiments of extrusion force are performed between shear-extrusion and upsetting-extrusion for forming tubular components with branches. Based on rigid plastic FEM a plane-stain model is established to analyze shear-extrusion process of tubular components with branches. The analysis results by 2-dimensions PEM are comparatively quite well consistent with those of experiments. Both simulated and experimental results show that this new forming process is feasible for forging large-size tubular components with branches on middle-due press. | H.L. Yang, D.C. Kang, Z.L. Zhang, X.H. Piao and Z.D. Shi (National Die and Mold CAD Engineering Research Center, Shanghai Jiaotong University, Shanghai 200030, China) (School of Materials Sci. & Eng., Harbin Institute of Technology, Harbin 150001, China) | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，3： | 6 |
| 12 | Cholestatic liver diseases:An era of emerging therapies显示文摘Recently the field of cholestasis has expanded enormously reflecting an improved understanding of the molecular mechanisms underlying bile secretion and its perturbation in chronic cholestatic disease. Novel anti-cholestatic therapeutic options have been developed for patients not favorably responding to ursodeoxycholic acid (UDCA), the current standard treatment for cholestatic liver disease. Important novel treatment targets now also include nuclear receptors involved in bile acid (BA) homoeostasis like farnesoid X receptor and G proteincoupled receptors e.g., the G-protein-coupled BA receptor “transmembrane G coupled receptor 5”. Fibroblast growth factor-19 and enterohepatic BA transporters also deserve attention as additional drug targets as does the potential treatment agent norUDCA. In this review, we discuss recent and future promising therapeutic agents and their potential molecular mechanisms in cholestatic liver disorders. | Hrishikesh Samant Wuttiporn Manatsathit David Dies Hosein Shokouh-Amiri Gazi Zibari Moheb Boktor Jonathan Steve Alexander | 2019 | World Journal of Clinical Cases2019，7，13： | 6 |
| 13 | 第十四届中国国际模具技术和设备展览会模具水平评述显示文摘对第十四届中国国际模具技术和设备展览会参展的各类模具、模具标准件及模具材料等进行了评述,介绍了我国模具、模具标准件、模具材料和模具CAD/CAE/CAM技术的发展现状和技术进步,分析了我国模具技术的发展趋势和存在的问题。 | Assess and Review Expert Team of the Technical Committee of China Die and Mould Association | 2012 | 模具工业2012，38，12： | 6 |
| 14 | OPTIMIZATION OF AUTOBODY PANEL STAMPING PROCESS BASED ON DYNAMIC EXPLICIT FINITE ELEMENT METHOD显示文摘Taking CPU time cost and analysis accuracy into account, dynamic explicit finite ele- ment method is adopted to optimize the forming process of autobody panels that often have large sizes and complex geometry. In this paper, for the sake of illustrating in detail how dynamic explicit finite element method is applied to the numerical simulation of the autobody panel forming process,an example of optimization of stamping process pain meters of an inner door panel is presented. Using dynamic explicit finite element code Ls-DYNA3D, the inner door panel has been optimized by adapting pa- rameters such as the initial blank geometry and position, blank-holder forces and the location of drawbeads, and satisfied results are obtained. | X. G. Bao D. N. He D. Lu C. X. Li J. L. Cheng and J. Y. Jiang( 1) National Mold and Dies CAD Engineering Research Center, Shanghai 200030, China 2) Shanghai Volkswagen Automotive Company Ltd.(SVW), Shanghai 201805, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 6 |
| 15 | Investigating on casting mold (or core) making with coated sand by the selected laser sintering显示文摘1 .Introduction Based on the parameters and cross-section’s information from a CAD model, the selected laser sintering (SLS) uses a laser beam to sinter selectively powdered solid materials (plastic, wax, ceramic, metal, etc.), and the solidified material is built up layer by layer to formthepart needed} As there are still some problems in material and technology, it is difficulty to sinter or produce | ~*Zitian FAN, Naiyu HUANG, Yan LI, Zhili LIU(State Key Laboratory of Plastic Simulation and Die & Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China) | 2004 | China Foundry2004，1，2： | 6 |
| 16 | Bridging the Gap between Western and Chinese Evidence in the International Education Market显示文摘Using a sample of 1674 international students in China,the present study explores sociocultural adaptation and its determinants.The results indicate that sociocultural adaptation among international students in China is largely shaped by the nature of the interaction with host nationals.In particular,among international students,those who experienced higher levels of social interaction with host nationals and received more social support were better poised for sociocultural adaptation.Rather contrary to similar research in the Western context,the study finds that international students from East Asia actually experienced more sociocultural difficulties in China than their counterparts from Western countries.These findings suggest the possibility of China and other oriental countries with sound higher education systems playing more active roles in the global higher education market. | Wen Wen Yan Luo Die Hu | 2014 | China & World Economy2014，22，6： | 5 |
| 17 | 第十五届中国国际模具技术和设备展览会模具水平评述显示文摘对第十五届中国国际模具技术和设备展览会参展的各类模具、模具标准件及模具材料等进行了评述,介绍了我国模具、模具标准件、模具材料和模具CAD/CAE/CAM、智能化模具等技术的发展现状,分析了我国模具技术的发展趋势和存在的问题。 | Assess and Review Expert Team of 15th China International Exhibition on Die & Mould | 2014 | 模具工业2014，40，12： | 4 |
| 18 | Crystallization and Corrosion Resistance of (Fe_(0.78)Si_(0.09)B_(0.13))100_(-x)Ni_x (x=0,2 and 5) Glassy Alloys显示文摘The crystallization of the (Fe0.78Si_(0.09)B0.13)100-xNix glassy alloys (x=0, 2 and 5) has been investigated by X-ray diffraction (XRD) and differential scanning calorimeter (DSC). Corrosion resistance analyses have been carried out using electrochemical measurements and corrosion products have been analyzed by scanning electron microscopy (SEM). The experimental results show that the addition of Ni can promote the nucleation of α-Fe, retard the decomposition of the metastable borides, and alter the crystallization mode of the present Fe-based glassy alloys. The lattice constant (a0Fe) of α-Fe in the annealed samples shows a decreasing trend with increasing annealing time. The Ni addition can improve the corrosion resistance of the as-quenched Fe-based glassy alloys in H2SO4, NaCl and NaOH solutions. The results indicate that Ni can promote the diffusion of Si atoms during quenching and annealing processes. | Haitian Ma Weimin Wang die Zhang Guihua Li Chongde Cao Hongdi Zhang | 2011 | Journal of Materials Science & Technology2011，27，12： | 4 |
| 19 | ROS-responsive cyclodextrin nanoplatform for combined photodynamic therapy and chemotherapy of cancer显示文摘Cyclodextrin(CD) has special spatial structure and well biological safety,so it has been widely used for constructing CD-based na noplatforms.Through functionalization,cyclodextrin can form various stimulusresponse nanoplatforms,such as pH,temperature,redox,light and magnetic fields.In this study,we designed a highly sensitive reactive oxygen species(ROS)-responsive polymer PCP which encapsulated doxorubicin(DOX) and purpurin 18(P18) to achieve the syne rgy of photodynamic and chemotherapy.The high content of reactive oxygen species(ROS) in the tumor microenvironment(TME) triggers the cleavage of the borate bond of MPEG-CD-PHB(PCP),thereby promoting the re lease of drugs.When irradiated with nea rinfrared laser,the photosensitizer P18 released by polymer micelles can produce reactive oxygen species to promote cell apoptosis.Compared with monotherapy,a series of experiments confirmed that our micelles had enhanced anti-cancer activity.This work was beneficial to the design of ROS-responsive materials and provides an effective strategy for the application of collaborative anti-tumor therapy. | Die Jia Xianbin Ma Yi Lu Xinyi Li Shengxin Hou Yuan Gao Peng Xue Yuejun Kang Zhigang Xu | 2021 | Chinese Chemical Letters2021，32，1： | 4 |
| 20 | Liquidity Dynamics Around Intraday Price Jumps in Chinese Stock Market显示文摘Using 4128 single jumps detected from high frequency data of 220 individual stocks in SZ300 P index, this paper investigates the liquidity dynamics around price jumps in Chinese market.Some interesting empirical results are obtained and the corresponding explanations are given. The frequency of positive jumps is quite higher than that of negative jumps. The trading volumes and average trade sizes are all in a high level around positive jumps. The relatively low liquidities around negative jumps show that negative jumps may be generated and enlarged by poor liquidity provision.The price reversal after price jumps is significant, and price reversal lasts longer after positive jumps.Moreover, the size and direction of jumps are significantly correlated with the returns and trades in the post-jump trading time. These findings are believed to be associated with the high proportion of retail investors and their herding behavior for price trend chasing. | WAN Die WEI Xianhua YANG Xiaoguang | 2017 | Journal of Systems Science & Complexity2017，30，2： | 4 |
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