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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D’Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 3 | Novel Targets for Inflammatory Bowel Disease Therapeutics显示文摘 | Mark L?wenberg Geert D’Haens | 2013 | Current Gastroenterology Reports2013，，2： | 2 |
| 4 | Diabetes, hyperglycaemia, and acute ischaemic stroke显示文摘 | Merel JA Luitse Geert Jan Biessels Guy EHM Rutten L Jaap Kappelle | 2012 | Lancet Neurology2012，，3： | 2 |
| 5 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D'Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 6 | Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells显示文摘 | Guimarǎes E L Empsen C Geerts A | | 0，，03： | 1 |
| 7 | Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization显示文摘 | Lieben Liesbet Masuyama Ritsuko Torrekens Sophie Van Looveren Riet Schrooten Jan Baatsen Pieter Lafage-Proust Marie-Hélène Dresselaers Tom Feng Jian Q Bonewald Lynda F Meyer Mark B Pike J Wesley Bouillon Roger Carmeliet Geert | 2012 | EN2012，，5： | 1 |
| 8 | ATETRA, a new soft- ware program to analyze tetraploid microsatellite data: comparison with TETRA and TETRASAT 显示文摘 | Van Puyvelde K Van Geert A Triest L | 2010 | Mol Ecol Resour2010，10，： | 1 |
| 9 | Prevention of venous thromboembolism:the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy显示文摘 | Geerts WH Pineo GF Heit JA et a l | 2004 | Chest2004，126，3： | 1 |
| 10 | Photochemical generation of highly destabilized vinyl cations : The effects of α- andβ-trifluoromethyl versus α- and β-methyl substituents 显示文摘 | Kaj V A Geerte B Gerrit L | 2005 | J Org Chem ( S0022 -3262 )2005，70，： | 1 |
| 11 | Naturalinhibitorsof neutrophilfunction in acute respiratory distress syndrome显示文摘 | Geerts L JorensPG WillemsJ etal | 2001 | Crit Care Med2001，，： | 1 |
| 12 | Space-time frequency-shift keying显示文摘 | Geert L | 2004 | IEEE Trans Commun2004，52，3： | 1 |
| 13 | Optimal training for ML and LMMSE channel estimation in MIMO systems 显示文摘 | GEERT L ALLE JAN V | 2005 | IEEE/SP Statistical Signal Processing2005，，： | 1 |
| 14 | Severe early onset pre - eclampsia: prognostic value of ultrasound and Doppler assessment 显示文摘 | Geerts L Odendaal HJ | 2007 | J Perinatol2007，27，： | 1 |
| 15 | Linking ultrastructure and function in four genera of anaerobic ammonium-oxidizing bacteria: Cell plan, glycogen storage, and localization of cytochrome c proteins显示文摘 | van Niftrik L Geerts W J C van Donselaar E G | 2008 | Journal of Bacteriology2008，190，2： | 1 |
| 16 | Novel Targets for Inflammatory Bowel Disease Therapeutics显示文摘 | Mark L?wenberg Geert D’Haens | 2013 | Current Gastroenterology Reports2013，，2： | 1 |
| 17 | A design based structural test method for a switched resistor DAC显示文摘 | MA L GEERT S | 2007 | Journal of Electronic Testing2007，23，6： | 1 |
| 18 | Venlafaxine compared with fluoxetine in outpatients with depression and concomitant anxiety 显示文摘 | De Nayer A Geerts S Ruelens L | 2002 | Int J Neurolasycholoharmacol2002，5，2： | 1 |
| 19 | Glibenclamide Treatment Recruits β-Cell Subpopulation Into Elevated and Sustained Basal Insulin Synthetic Activiy显示文摘 | Zhidong L Qidi W Geert S | 2006 | Diabetes2006，，55： | 1 |
| 20 | Development of reverse transcriptase PCR assays for detection of active human herpesvirus 6 infection显示文摘 | Vanden BG Locatelli G Geerts L | 2001 | Clin Microbiol2001，39，： | 1 |
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