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| 1 | Contrast-enhanced 3D ultrasound in the radiofrequency ablation of liver tumors显示文摘Liver metastases and hepatocellular carcinomas are two of the most common causes of cancer deaths in the world.Radiofrequency ablation(RFA) is a well recognized,effective and minimally invasive means of treating malignant hepatic tumors.This article describes the use of contrast-enhanced 3D ultrasound(CE-3DUS) in the staging,targeting and follow-up of patients with liver tumors undergoing RFA.In particular,its value in the management of large hepatic lesions will be illustrated.Current limitations of CE-3DUS and future developments in the technique will also be discussed.In summary,CE-3DUS is useful in the RFA of liver tumors with improved detection and display of occult lesions and recurrence,in the assessment of lesional geometry and orientation for a more accurate planning and guidance of multiple RFA needle electrodes in large tumors and in the evaluation of residual or recurrent disease within the immediate and/or subsequent follow-up periods. | Edward Leen Senthil Kumar Shahid A Khan Gavin Low Keh Oon Ong Paul Tait Mike Averkiou | 2009 | World Journal of Gastroenterology2009，15，3： | 19 |
| 2 | General review of magnetic resonance elastography显示文摘Magnetic resonance elastography(MRE) is an innovative imaging technique for the non-invasive quantification of the biomechanical properties of soft tissues via the direct visualization of propagating shear waves in vivo using a modified phase-contrast magnetic resonance imaging(MRI) sequence. Fundamentally,MRE employs the same physical property that physicians utilize when performing manual palpation- that healthy and diseased tissues can be differentiated on the basis of widely differing mechanical stiffness. By performing 'virtual palpation ',MRE is able to provide information that is beyond the capabilities of conventional morphologic imaging modalities. In an era of increasing adoption of multi-parametric imaging approaches for solving complex problems,MRE can be seamlessly incorporated into a standard MRI examination to provide a rapid,reliable and comprehensive imaging evaluation at a single patient appointment. Originally described by the Mayo Clinic in 1995,the technique represents the most accurate non-invasive method for the detection and staging of liver fibrosis and is currently performed in more than 100 centers worldwide. In this general review,the mechanical properties of soft tissues,principles of MRE,clinical applications of MRE in the liver and beyond,and limitations and future directions of this discipline-are discussed. Selected diagrams and images are provided for illustration. | Gavin Low Scott A Kruse David J Lomas | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 3 | 正磷酸活化木质素吸附Cr(Ⅵ)的固定床实验和模型(英文)显示文摘The advantage of using an available and abundant residual biomass,such as lignin,as a raw material for activated carbons is that it provides additional economical interest to the technical studies.In the current investigation,a more complete understanding of adsorption of Cr(VI) from aqueous systems onto H3PO4-acid activated lignin has been achieved via microcolumns,which were operated under various process conditions.The practice of using microcolumn is appropriate for defining the adsorption parameters and for screening a large number of potential adsorbents.The effects of solution pH(2-8),initial metal ion concentration(0.483-1.981 mmol·L-1),flow rate(1.0-3.1 cm3·min-1),ionic strength(0.01-0.30 mmol·L-1) and adsorbent mass(0.11-0.465 g) on Cr(VI) adsorption were studied by assessing the microcolumn breakthrough curve.The microcolumn data were fitted by the Thomas model,the modified Dose model and the BDST model.As expected,the adsorption capacity increased with initial Cr(VI) concentration.High linear flow rates,pH values and ionic strength led to early breakthrough of Cr(VI).The model constants obtained in this study can be used for the design of pilot scale adsorption process. | Ahmad B.Albadarin Chirangano Mangwandi Ala'a H.Al-Muhtaseb Gavin M.Walker Stephen J.Allen Mohammad N.M.Ahmad | 2012 | Chinese Journal of Chemical Engineering2012，20，3： | 3 |
| 4 | Role of senescence induction in cancer treatment显示文摘Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening,DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types,suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment. A growing body of evidence has documented that senescence induction in tumor cells is a frequent response to many anticancer modalities including cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapeutics and T helper-1 cytokine-mediated immunotherapy. This review discusses the recent advances and clinical relevance of therapy-induced senescence in cancer treatment. | Shenghui Qin Bradley A Schulte Gavin Y Wang | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
| 5 | Robotic surgery of the pancreas显示文摘Pancreatic surgery is one of the most challenging and complex fields in general surgery.While minimally invasive surgery has become the standard of care for many intra-abdominal pathologies the overwhelming majority of pancreatic surgery is performed in an open fashion.This is attributed to the retroperitoneal location of the pancreas,its intimate relationship to major vasculature and the complexity of reconstruction in the case of pancreatoduodenectomy.Herein,we describe the application of robotic technology to minimally invasive pancreatic surgery.The unique capabilities of the robotic platform have made the minimally invasive approach feasible and safe with equivalent if not better outcomes(e.g.,decreased length of stay,less surgical site infections)to conventional open surgery.However,it is unclear whether the robotic approach is truly superior to traditional laparoscopy;this is a key point given the substantial costs associated with procuring and maintaining robotic capabilities. | Daniel Joyce Gareth Morris-Stiff Gavin A Falk Kevin El-Hayek Sricharan Chalikonda R Matthew Walsh | 2014 | World Journal of Gastroenterology2014，20，40： | 2 |
| 6 | TGF-betal maintains suppressor function and Foxp3 expression in CD4^+ CD25^+ regulatory T cells显示文摘 | Marie J C Letterio J J Gavin M Rudensky A Y | 2005 | J Exp Med2005，201，： | 1 |
| 7 | Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Gavin M A Rudensky A Y | 2003 | Nature Immunology2003，4，4： | 1 |
| 8 | FoxP3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 9 | Proteome survey reveals modularity of the yeast cell machinery 显示文摘 | GAVIN A C ALOY P GRANDI P | 2006 | Nature2006，440，7084： | 1 |
| 10 | Foxp3 pro- grams the development and function of CD4 + CD25 + reg- ulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 11 | Centering decisions in hier- archical linear models: implications for research in organizations 显示文摘 | Hofmann D A Gavin M B | 1998 | Journal of Management1998，24，5： | 1 |
| 12 | Protein complexes and proteome organization from yeast to man显示文摘 | Gavin A C Superti Furga G | 2003 | Curr Opin Chem Biol2003，7，1： | 1 |
| 13 | An antigen produced by splicing of noncontiguous peptides in the reverse order 显示文摘 | Warren E H Vigneron N J Gavin M A | 2006 | Science2006，313，5792： | 1 |
| 14 | Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells 显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，： | 1 |
| 15 | Alternatives to cyanidein the gold mining industry:what prospects for the fu-ture显示文摘 | Gavin Hilson Monhemius A J | 2006 | Journal of Cleaner Production2006，14，： | 1 |
| 16 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells显示文摘 | Fontenot J D Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
| 17 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 18 | Centering decisions in hierarchical linearmodels: Implications for research in organizations显示文摘 | Hofmann D A Gavin M B | 1998 | Journal ofManagement1998，24，5： | 1 |
| 19 | Time,Teams,and Task Performance:Changing Effects of Surface and Deep Level Diversity on Group Functioning显示文摘 | Harrison D A K H Price J H Gavin A T Florey | 2002 | Academy of Management Journal2002，45，： | 1 |
| 20 | Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells显示文摘 | Gavin M A Rudensky A Y | 2003 | Nat Immunol2003，4，4： | 1 |
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