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262篇 您的检索式：作者名="Garcea"

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	题名	作者	年代	出处	被引量
1	Oxidative stress in humans following the Pringle manoeuvre显示文摘BACKGROUND: Oxidative stress is induced in the liver by application of the Pringle manoeuvre. Malondialdehyde is a carbonyl compound formed during lipid peroxidation and prostaglandin biosynthesis, which combines with DNA to form a number of adducts. Among them is the DNA ad-duct; 3-(2-deoxybeta-dierythropentafuranosyl) pyr [1,2-alpha]-purin-10(3H) one or M1G. This study was undertaken to determine the suitability of M1G as a novel marker of ischemia-reperfusion injury in the liver and its correlation with both the length of Pringle clamp application and the overall length of the operation. METHODS: Normal and colorectal liver metastatic tissues were obtained in 12 patients before and after application of the Pringle manoeuvre. All samples were snap-frozen in liquid nitrogen at -80 ℃. DNA was extracted and M1G quantification was performed by immunoslotblot analysis. RESULTS: M1G levels in normal liver tissue were 4.0 + 1.0 per 107 nucleotides before the Pringle manoeuvre and 7.4 ± 1.0 per 10 nucleotides after the Pringle manoeuvre (mean ± standard deviation) (P<0.05 by ANOVA). M1G levels in malignant liver tissue were 2.5 ±1.4 per 107 nucleotides before the Pringle manoeuvre and 6. 5 ±1.9 adducts per 10 nucleotides after the Pringle manoeuvre (P <0. 05). Ad-duct levels in normal liver tissue showed a significant correlation with cumulative period of Pringle application. CONCLUSIONS: This is the first time that the tissue levels of M1G before and after application of the Pringle manoeuvre have been studied. The results show that the Pringle manoeuvre exerts significant oxidative stress in human hepa-tocytes, which is Pringle-time dependent. The results highlight the potential for oxidative DNA adducts levels as a tool for measuring the severity of ischemia-reperfusion injury.	Giuseppe Garcea Andreas Gescher William Steward Ashley Dennison David Berry	2006	Hepatobiliary & Pancreatic Diseases International2006，5，2：	4
2	Early gastric cancer: diagnosis, staging, and clinical impact. Evaluation of 530 patients. New elements for an updated definition and classification显示文摘	Luca Saragoni Paolo Morgagni Andrea Gardini Caterina Marfisi Giovanni Vittimberga Domenico Garcea Emanuela Scarpi	2013	Gastric Cancer2013，，4：	3
3	The diagnosis and management of Sphincter of Oddi dysfunction: a systematic review显示文摘	Thomas Hall Ashley Dennison Giuseppe Garcea	2012	Langenbeck’s Archives of Surgery2012，，6：	2
4	Elevation of Carbohydrate Antigen 19.9 in Benign Hepatobiliary Conditions and Its Correlation with Serum Bilirubin Concentration显示文摘	S. L. Ong A. Sachdeva G. Garcea G. Gravante M. S. Metcalfe D. M. Lloyd D. P. Berry A. R. Dennison	2008	Digestive Diseases and Sciences2008，，12：	2
5	Management of benign rectal strictures 显示文摘	Garcea G Sutton CD Lloyd TD	2003	Dis Colon Rectum2003，46，11：	1
6	Synchro- nous -asynchronous digital woltage- mode control for DC - DC converters 显示文摘	TREVISAN D MATTAVELLI P GARCEA G	2007	IEEE Transactions on Power Electronics2007，22，4：	1
7	Angiogenesis of gastrointestinal tumours and their metastases-a target, for intervention?显示文摘	Garcea G Lloyd TD Gescher A	2004	Eur J Cancer2004，40，：	1
8	Predictors of severity and survival in acute pancreatitis:validation of the efficacy of eariy waming scores显示文摘	Garcea G Gouda M Hehbers C	2008	pancreas2008，37，30：	1
9	Prognostic molecular markers in hepatocellular carcinoma:a systematic review显示文摘	Mann CD Neal CP Garcea G	2007	Eur J Cancer2007，43，：	1
10	The emergent role of focal liver ablation techniques in the treatment of primary and secondary liver tumours显示文摘	GARCEA G LLOYD T D AYLOTT C	2003	Eur J Cancer2003，39，15：	1
11	WU and K/ polyomavirus infections in pediatric hematology/oncology patients with acute respiratory tract illness 显示文摘	Rao S Garcea R L Robinson C C	2011	J Clin Virol2011，52，1：	1
12	Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16 显示文摘	Chen X S Garcea R L Goldberg I	2000	Mol Cell2000，5，3：	1
13	Experimentally cross-wired lingual taste nerves can restore normal unconditioned gaping behavior in response to quinine stimulation显示文摘	King CT Garcea M Stolzenberg DS	2008	Am J Physiol Regul Integr Comp Physiol2008，294，3：	1
14	Molecular prognostic markers in resectable colorectal liver metastases:a systematic review显示文摘	Neal CP Garcea G Doucas H	2006	Eur J Cancer2006，42，12：	1
15	Structure of small virus- like particles assembled from the L1 protein of human papillomavirus 16显示文摘	Chen X S Garcea R L Goldberg I	2000	Mol Cell2000，5，3：	1
16	Elevation of Carbohydrate Antigen 19.9 in Benign Hepatobiliary Conditions and Its Correlation with Serum Bilirubin Concentration显示文摘	S. L. Ong A. Sachdeva G. Garcea G. Gravante M. S. Metcalfe D. M. Lloyd D. P. Berry A. R. Dennison	2008	Digestive Diseases and Sciences2008，，12：	1
17	Palliation of malignant obstructive jaundice显示文摘	Garcea G Ong S L Dennison A R	2009	Dig Dis Sci2009，54，6：	1
18	Preoperative neutrophil-to- lymphocyte ratio ( NLR ) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma显示文摘	Garcea G Ladwa N Neal CP	2011	World J Surg2011，35，4：	1
19	Distinct changes in theWnt signaling pathway in gastrointestinal cancers and theirprognostic significance显示文摘	Doucas H Garcea G Neal CP	2005	Eur J Cancer2005，41，3：	1
20	The emergent role of focal liver ablation techniques in the treatment of primary and secondary liver tumours显示文摘	Garcea G Lloyd TD Aylott C	2003	Eur J Cancer2003，39，15：	1

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