|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New findings showing how DNA methylation influences diseases显示文摘In 1975, Holliday and Pugh as well as Riggs independently hypothesized that DNA methylation in eukaryotes could act as a hereditary regulation mechanism that influences gene expression and cell differentiation. Interest in the study of epigenetic processes has been inspired by their reversibility as well as their potentially preventable or treatable consequences. Recently, we have begun to understand that the features of DNA methylation are not the same for all cells.Major differences have been found between differentiated cells and stem cells.Methylation influences various pathologies, and it is very important to improve the understanding of the pathogenic mechanisms. Epigenetic modifications may take place throughout life and have been related to cancer, brain aging, memory disturbances, changes in synaptic plasticity, and neurodegenerative diseases,such as Parkinson's disease and Huntington's disease. DNA methylation also has a very important role in tumor biology. Many oncogenes are activated by mutations in carcinogenesis. However, many genes with tumor-suppressor functions are 'silenced' by the methylation of CpG sites in some of their regions.Moreover, the role of epigenetic alterations has been demonstrated in neurological diseases. In neuronal precursors, many genes associated with development and differentiation are silenced by CpG methylation. In addition,recent studies show that DNA methylation can also influence diseases that do not appear to be related to the environment, such as IgA nephropathy, thus affecting,the expression of some genes involved in the T-cell receptor signaling. In conclusion, DNA methylation provides a whole series of fundamental information for the cell to regulate gene expression, including how and when the genes are read, and it does not depend on the DNA sequence. | Fabio Sallustio Loreto Gesualdo Anna Gallone | 2019 | World Journal of Biological Chemistry2019，10，1： | 2 |
| 2 | Mechanisms for acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo 显示文摘 | Khoury SJ Gallon L Chen W | 1995 | J Exp Med1995，182，： | 2 |
| 3 | Serum soluble urokinase-type plasminogen activator receptor levels and idiopathic FSGS in children:a single-center report 显示文摘 | Bock ME Price HE Gallon L | 2013 | Clin J Am Soc Nephrol2013，8，8： | 1 |
| 4 | Is Science A Public Good显示文摘 | Gallon M | 1994 | Science Technology and Human Values1994，，19： | 1 |
| 5 | Transition behavior of packed-bed dielectric barrier discharge in argon显示文摘 | Tu X Gallon H J Whitehead J C | | IEEE Transactions on Plasma Science0，39，11： | 1 |
| 6 | Anti- CD20 monoclonal antibody (rituximab) for the treatment of recurrent idiopathic membranous nephropathy in a renal transplant patient显示文摘 | GALLON L CHHABRA D | 2006 | Am J Transplant2006，6，12： | 1 |
| 7 | Effects of the phytoestrogens genistein and daidzein on BRCA2 tumor suppressor gene expression in breast cell lines 显示文摘 | Vissae-Sabatier C Bignon YJ Bernard Gallon DJ | 2003 | Nutr Cancer2003，45，2： | 1 |
| 8 | Tumor necrosis factor-alpha gene and cerebral aneurysms显示文摘 | Fontanella M Rainero I Gallone S | | 0，，04： | 1 |
| 9 | Tyrosinase gene expression in the Kupffer cells of Rana esculenta L显示文摘 | Guida G Gallone A Maida I | | 0，，06： | 1 |
| 10 | Putting Core Competeney Thin!dng into Praetice 显示文摘 | Gallon Mark R SfiUman | 1995 | Research Technology Management1995，38，3： | 1 |
| 11 | Multipe myeloma : increased circulatinglymphocytes carrying plasma cell-associated antigens as an indicator of poor survival 显示文摘 | Omede P Boccadoro M Gallone G | 1990 | Blood1990，76，： | 1 |
| 12 | Radiosensitivity of Hebe ‘Oratia Beauty’ and ‘Wiri Mist’ irradiated in vitro with γ-rays from 60 Co显示文摘 | A. Gallone A. Hunter G.C. Douglas | 2012 | Scientia Horticulturae2012，，： | 1 |
| 13 | Lack of association between the apolipoprotein E gene and aneurysmal subarachnoid hemorrhage in an Italian population 显示文摘 | Fontanella M Rainero IN Gallone SA | 2007 | J Neurosurgery2007，106，： | 1 |
| 14 | Putting core competence into practice 显示文摘 | GALLON M R STILLMAN H M COATES D | 1995 | Research Technology Management1995，，5： | 1 |
| 15 | Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population显示文摘 | Fontanella M Rainero I Gallone S | 2008 | J Neurol Neurosurg Psychiatry2008，79，4： | 1 |
| 16 | Modeling coagulation kinetics incorporating fractal theories: comparison with ob- served data 显示文摘 | Lee DG Bonner JS Gallon LS | 2002 | Water Research2002，36，： | 1 |
| 17 | Pro-Inflammatory Cytokine Genes Influence the Clinical Features of Frontotemporal Lobar Degeneration显示文摘 | Rainero Innocenzo Rubino Elisa Cappa Giorgetta Rota Eugenia Valfrè Walter Ferrero Patrizia Fenoglio Pierpaola Baci Denisa D’amico Giuseppina Vaula Giovanna Gallone Salvatore Pinessi Lorenzo | 2009 | Dementia and Geriatric Cognitive Disorders2009，，6： | 1 |
| 18 | Tumor necrosis factor- alpha gene and cerebral aneurysms 显示文摘 | Fontanella M Rainero I Gallone S | 2007 | Neurosurgery2007，60，4： | 1 |
| 19 | Putting core competency thinking into practice 显示文摘 | MARK R GALLON HAROLD M STILLMAN DAVID COATES | 1995 | Research Technology Management1995，，： | 1 |
| 20 | Dielectric Constant Enhancement in a Silicone Elastomer Filled with Lead Magnesiumniobate-lead Titanate显示文摘 | Gallone G Carpi F Rossi D D | 2007 | Materials Science&Engineering C2007，27，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员