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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | cis-acting element located in the bovine foamy virus internal promoter possesses the properties of a transcrip-tional enhancer显示文摘Bovine foamy virus encodes a transcriptional transactivitor, Tas or Borf-1, which governs the level of viral transcripts initiated by both the promoter in the long terminal repeat (LTR) and the internal promoter (IP) located in the env gene through their cis-acting targets. We have identified and characterized a 72 bp TBS (Borf-1) responsive element located in BFV3026, internal promoter (TREIP) by deletion mutant and transient expression assay. This cis-acting target element in the internal promoter has the properties of a transcriptional enhancer which functions independently of its orientation, position and also in heterologous promoters (BFV LTR and bovine immunodeficiency virus, BIV LTR). Alignments reveal that there are positional similarity and sequence homology among BFV TREIP, SFV-1 TREIP proximal element and SFV-3 TREIPH, which suggests that this kind of cis-acting elements possesses some common functional character. | Wentao Qiao Chunguang Guo Shuhui Wang Jinzhong Wang Qimin Chen Yunqi Geng | 2002 | Chinese Science Bulletin2002，47，13： | 2 |
| 3 | Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection显示文摘Orthopedic implants account for 99%of orthopedic surgeries,however,orthopedic implant-related infection is one of the most serious complications owing to the potential for limb-threatening sequelae and mortality.Current antibiotic treatments still lack the capacity to target bone infection sites,thereby resulting in unsatisfactory therapeutic effects.Here,the bone infection site targeting efficacy of D6 and UBI29-41 peptides was investigated,and bone-and-bacteria dual-targeted nanoparticles(NPs)with D6 and UBI29-41 peptides were first fabricated to target bone infection site and control the release of vancomycin in bone infection site.The results of this study demonstrated that the bone-and-bacteria dual-targeted mesoporous silica NPs exhibit excellent bone and bacteria targeting efficacy,excellent biocompatibility and effective antibacterial properties in vitro.Furthermore,in a rat model of orthopedic implant-related infection with methicillin-resistant Staphylococcus aureus,the growth of bacteria was evidently inhibited without cytotoxicity,thus realizing the early treatment of implant-related infection.Hence,the bone-and-bacteria dual-targeted molecule-modified NPs may target bacteria-infected bone sites and act as ideal candidates for the therapy of orthopedic implant-related infections. | Bin’en Nie Shicheng Huo Xinhua Qu Jingjing Guo Xi Liu Qimin Hong You Wang Jianping Yang Bing Yue | 2022 | Bioactive Materials2022，7，10： | 2 |
| 4 | Removal of SO2 from flue gas using a new semidry flue gas desulfurization process with a powder-parti- cle spouted bed显示文摘 | Ma Xiaoxun Kaneko Takao Guo Qimin | 1999 | Canadian Journal of Chemical En- gineering1999，77，2： | 1 |
| 5 | A new semi-dry desulfurization process using a powder-particle spouted Bed 显示文摘 | Xu Guangwen Guo Qimin Takao Kaneko | 2000 | Advances in Environmental Research2000，，4： | 1 |
| 6 | Deregulated expression and subcellular localization of CPSF6,a circRNA-binding protein,promote malignant development of esophageal squamous cell carcinoma显示文摘Objective:Cleavage and polyadenylation specific factor 6(CPSF6)has been documented as an oncoprotein in different types of cancer.However,functions of CPSF6 have not been investigated yet in esophageal squamous cell carcinoma(ESCC).Here,we aimed to investigate the potential clinical values and biological functions of CPSF6 in ESCC.Methods:For determining the expression level of CPSF6 in ESCC patients,we analyzed published data,performed quantitative real-time polymerase chain reaction(RT-qPCR)and immunohistochemistry assays.Kaplan-Meier curves and log-rank tests were used for survival analyses.GO and KEGG analyses were done for CPSF6-related genes.Cell proliferation,colony formation and xenograft assays were conducted to verify the effects of CPSF6 on ESCC.In addition,cell cycle and apoptosis assays were also performed to manifest the functions of CPSF6 and circCPSF6.RNA pulldown and radioimmunoprecipitation(RIP)assays were used for confirming the interaction between circCPSF6(hsa_circ_0000417)and CPSF6 protein.The regulatory relationship between CPSF6 protein and circCPSF6 was determined by RT-qPCR.Results:We found that CPSF6 was upregulated in ESCC tissues and overexpression of cytoplasmic CPSF6 was associated with poor prognosis.GO and KEGG analyses suggested that CPSF6 could mainly affect cell division in ESCC.Further experiments manifested that CPSF6 promoted cell proliferation and colony formation in vitro.Xenograft assay showed that knockdown of CPSF6 significantly decreased tumor growth rate in vivo.Subsequently,we verified that depletion of CPSF6 led to cell cycle arrest and apoptosis.Finally,we validated that CPSF6,as a circRNA-binding protein,interacted with and regulated its circular isoform circCPSF6(hsa_circ_0000417),of which depletion also resulted in cell cycle arrest and cell apoptosis in ESCC.Conclusions:These findings gave us insight that overexpression of cytoplasmic CPSF6 protein is associated with poor prognosis in ESCC and CPSF6 may function as an oncoprotein,at least in part,through regulating circCPSF6 expression. | Shichao Guo Guangchao Wang Zitong Zhao Dan Li Yongmei Song Qimin Zhan | 2022 | Chinese Journal of Cancer Research2022，34，1： | 1 |
| 7 | Removal of SO2 from Flue Gas Using a New Semidry Flue Gas Desulfurization Process with a Powder-Particle Spouted Bed 显示文摘 | MA XIAOXUN KANEKO TAKAO GUO QIMIN | 1999 | Canadian Journal of Chemical Engineering1999，77，2： | 1 |
| 8 | A new semidry desulfurization process using a powder-particle spouted bed 显示文摘 | XU GUANGWEN GUO QIMIN KANEKO TAKAO | 2000 | Japan:Advances in Environmental Research2000，，4： | 1 |
| 9 | 显示文摘 | Xu Guangwen Guo Qimin Takao Kancko | 2000 | Japan:Advances in Environmental Research2000，，4： | 1 |
| 10 | A new semi-dry desulfurization process using a powder-particle spouted bed 显示文摘 | Xu Guangwen Guo Qimin Kaneko Takao | 2000 | Advances in Environmental Research2000，4，1： | 1 |
| 11 | Methylation of TFPI-2 is an early event of esophageal carcinogenesis显示文摘 | Yan Jia Yunsheng Yang Malcolm V Brock Baoping Cao Qimin Zhan Yazhuo Li Yuanzi Yu James G Herman Mingzhou Guo | 2012 | Epigenomics2012，，2： | 1 |
| 12 | Removal of SO2 from flue gas desulfrization using a new semidry flue gas desulfurization process with a powder-particle spouted bed 显示文摘 | MA Xiaoxun KANEKO T GUO Qimin | 1999 | Canadian Journal of Chemical Engineering1999，77，2： | 1 |
| 13 | A new semidry desulfurization process using a powder-particle spouted bed 显示文摘 | XU Guangwen GUO Qimin TAKAO K | 2000 | Advances in Environmental Research2000，，4： | 1 |
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