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| 1 | Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies显示文摘Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction,angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action,and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke.We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research. | Guihong Li Fengbo Yu Ting Lei Haijun Gao Peiwen Li Yuxue Sun Haiyan Huang Qingchun Mu | 2016 | Neural Regeneration Research2016，11，6： | 22 |
| 2 | Evolution of the CBM reservoir-forming dynamic system with mixed secondary biogenic and thermogenic gases in the Huainan Coalfield,China显示文摘The secondary biogenic gas is an important original type of the coalbed methane (CBM) in China. Based on the analyses of sedimentary and burial history of the Permian coal-bearing strata, combined with thermal history and gas generation process of coals, the CBM reservoir-forming dynamic system with mixed secondary biogenic and thermogenic gases in the Huainan Coalfield is subdivided into four evolutionary stages as follows: (i) shallowly-buried peat and early biogenic gas stage; (ii) deeply buried coal seams and thermogenic gas stage; (iii) exhumation of coal-bearing strata and adsorbed gas lost stage; and (iv) re-buried coal-bearing strata and secondary biogenic gas supplement stage. The Huainan CBM reservoir-forming model has the features of the basin-centered gas accumulation. The evolution of the reservoir-forming dynamic system proves that the thermogenic gas is not the main gas source for the Huainan CBM reservoir. Only the secondary biogenic gases as an additional source replenish into the coal bed after basin-uplift, erosional unroofing and subsequent scattering of thermogenic gases. Then this kind of mixed CBM reservoirs can be formed under suitable conditions. | ZHANG Hong CUI Yongjun TAO Mingxin PENG Gelin JIN Xianglan LI Guihong | 2005 | Chinese Science Bulletin2005，50，S1： | 10 |
| 3 | The origin mechanism of coalbed methane in the eastern edge of Ordos Basin显示文摘In the eastern edge of the Ordos Basin,the coalbed methane(CBM)development has not made substantial progress in the past20 years,and the origin of gas can be used to guide the CBM block-selecting and development.Based on the 37 sets of carbon isotope data,the origin of the gas was determined and the origin mechanism was studied in this work.The 13CPDB of methane ranges from 70.5‰to 36.19‰in the eastern edge in the Ordos Basin and the value becomes heavier from the north to the south.The secondary biogenic gas and the thermogenic gas are mixed in the shallow area and the thermogenic gas occurs in the medium and deep levels.The phenomenon is controlled mainly by the distribution of coal rank and hydrodynamics.Firstly,based on the relationship between China coal rank and methane 13CPDB,the medium rank coal is dominant in the eastern edge of the Ordos Basin,and the mixture of the secondary biogenic gas and the thermogenic gas is formed in the coal of vitrinite reflectant ratio(Rmax)between 0.5%and 2.0%if there is appropriate hydrodynamics;at the same time,because of the shallow burial depth,and the well-developed coal outcrop,meteoric water and other surface water carrying bacteria recharge the coal reservoir,metabolize the organic compounds at a relatively low temperature,and generate methane and carbon dioxide.Wherever the trapping mechanisms occur in the coal,such as Liulin and Hancheng,modern gas content should be high. | LI GuiHong ZHANG Hong | 2013 | Science China Earth Sciences2013，56，10： | 8 |
| 4 | Coal reservoir characteristics and their controlling factors in the eastern Ordos basin in China显示文摘In the eastern Ordos basin, due to the diversity of the tectonic setting, coal rank, gas content and permeability, coal reservoirs have differing characteristics. In this paper, based on coal reservoir geometry, gas content, adsorption capacity, pores and fissures developments and permeability data, the coalbed methane(CBM) reservoir characteristics and their controlling factors in the eastern Ordos basin is discussed. The results show that, due to undergoing different paleo-temperatures in the geological history,coal rank has a higher trend from the north part to the south and from the shallow part to the inward basin, which determines CBM distribution and recoverability. In the north, although having large coal thickness and high permeability, Zhungeer-Xingxian coal rank is low, and gas content is small. In the central part, with medium rank, higher gas content and relatively high permeability, and the Wubao-Liulin area is the most favorable area in the eastern Ordos basin. In the southern part, medium and high metamorphism coal occurs, and although having the highest gas content, the permeability in the Hancheng area is low due to the development of sheared coal. | Li Guihong | 2016 | International Journal of Mining Science and Technology2016，26，6： | 7 |
| 5 | Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase(AMPK)-dependent pathway显示文摘Obesity is a worldwide epidemic. Promoting browning of white adipose tissue(WAT)contributes to increased energy expenditure and hence counteracts obesity. Here we show that cordycepin(Cpn), a natural derivative of adenosine, increases energy expenditure, inhibits weight gain, improves metabolic profile and glucose tolerance, decreases WAT mass and adipocyte size, and enhances cold tolerance in normal and high-fat diet-fed mice. Cpn markedly increases the surface temperature around the inguinal WAT and turns the inguinal fat browner. Further investigations show that Cpn induces the development of brown-like adipocytes in inguinal and, to a less degree, epididymal WAT depots. Cpn also increases the expression of uncoupling protein 1(UCP1) and other thermogenic genes in WAT and3T3-L1 differentiated adipocytes, in which AMP-activated protein kinase(AMPK) plays an important role. Our results provide novel insights into the function of Cpn in regulating energy balance, and suggest a potential utility of Cpn in the treatment of obesity. | Guihong Qi Yue Zhou Xiaopo Zhang Jiaqi Yu Xin Li Xiaoxue Cao Chongming Wu Peng Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 6 |
| 6 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 7 | Microwave strengthens decomposition of mixed rare earth concentrate: Microwave absorption characteristics显示文摘The potential application of microwave heating technology for processing the mixed rare earth concentrate was systematically investigated by analyzing the microwave absorption characteristics in this study. The complex permittivity was measured through resonant cavity perturbation method. The variations of permittivity, the loss factor, loss tangent and the penetration depth with the increasing temperature were investigated numerically. The results indicate that the permittivity increases as the temperature increases, and temperature has a pivotal effect on it. The mixed concentrate is high loss material at the temperature range from 600 to 800℃ according to theoretical analyses of loss tangent and penetration depth. The results of phase transition analysis prove that the variation of microwave absorption characteristics of mixed concentrate is caused by the changes of crystal and lattice structures.The reflectivity, loss factor and penetration depth of the mixed concentrate were also calculated, and the results indicate that processing the mixed concentrate by microwave heating is of high feasibility and industrial potential. | Yukun Huang Ting'an Zhang Zhihe Dou Guozhi Lv Guihong Han Weijun Peng | 2019 | Journal of Rare Earths2019，37，5： | 5 |
| 8 | High sensitive detection of presenilin-1 point mutation based on electrochemilumi-nescence显示文摘Electrochemiluminescence (ECL) is a high- sensitive detection method with broad biological applications. Ruthenium (Ⅱ) tris (bipyridyl) 2+3(Ru(bpy)) and tripro-pylamine (TPA) are most commomly used combination of the reactive species in ECL. The redox of 2+3Ru(bpy) with excess TPA at the surface of an electrode produces a highly efficient and stable light emission due to a rapid cycle of the reactions. This rapid, highly sensitive and accurate method has been applied to gene quantification. In this work, an ECL detection system is designed and applied in detection of presenilin-1 (PS-1) gene mutation. The results show that given the same polymerase chain reaction (PCR) cycle num-ber, the ECL intensities from the digested and the undigested wild-type samples are nearly identical, but the difference in ECL intensities between the digested and the undigested mutant samples is distinctive. This detection technology connects PCR with ECL and allows a reliable discrimination between the wild-type and the mutant genes. | ZHU Debin, XING Da, SHEN Xingyan & YAN Guihong Institute of Laser Life Science, South China Normal University, Guang-zhou 510631, China Correspondence should be addressed to Xing Da (e-mail: xingda@ scnu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，16： | 4 |
| 9 | Na2V6O16·2.14H2O nanobelts as a stable cathode for aqueous zinc-ion batteries with long-term cycling performance显示文摘Aqueous zinc-ion batteries(ZIBs) have been considered as one of the most promising electrochemical devices for large-scale energy storage system owing to their low cost and high safety. Herein, Na2V6O16·2.14H2O nanobelts are synthesized and applied as cathode material for ZIBs. The sample displays a high capacity of 466 m Ahg^-1 at 100 mAg^-1 and stable cycling performance with a capacity retention of 90% over 20 0 0 cycles at the 20 Ag^-1. Moreover, Na2V6O16·2.14H2O presents a capable rate ability and a high energy density of 312 Wh kg^-1 at a specific power of 70 Wkg^-1. The superior electrochemical performance is attributed to the large interlayer spacing and outstanding structure stability, which promise the highly reversible intercalation and extraction of zinc ion. The electrochemical kinetics and zinc ion storage mechanism are also investigated. This work demonstrates that nanoscale electrode materials with large interlayer spacing can effectively enhance the electrochemical performance of aqueous ZIBs, which can be extended to other metal ion batteries, such as magnesium ion batteries and aluminum ion batteries. | Fang Hu Di Xie Depeng Zhao Guihong Song Kai Zhu | 2019 | Journal of Energy Chemistry2019，28，11： | 4 |
| 10 | Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive and respiratory syndrome virus显示文摘Porcine reproductive and respiratory syndrome(PRRS) is considered to be one of the most important infectious diseases impacting the swine industry and is characterized by reproductive failure in late term gestation in sows and respiratory disease in pigs of all ages.The nonstructural protein 9 gene,Nsp9,encoding the RNA-dependent RNA polymerase,is generally regarded as fairly conserved when compared to other viral proteins.Antibodies against Nsp9 will be of great importance for the diagnosis and treatment of the causal agent,PRRS virus.A study was undertaken to generate polyclonal antibodies against the immunodominant Nsp9.For this purpose,the Nsp9 was expressed in Escherichia coli and subsequently used as an antigen to immunize New Zealand rabbits.Antiserum was identified via an indirect ELISA,and then verified based on the ability to react with both naturally and artificially expressed Nsp9.Results of virus neutralization test showed that this antiserum could not neutralize the PRRSV.Nevertheless,this antiserum as a diagnostic core reagent should prove invaluable for further investigations into the mechanism of PRRS pathogenesis. | Mengmeng ZHAO Juanjuan QIAN Jiexiong XIE Tiantian CUI Songling FENG Guoqiang WANG Ruining WANG Guihong ZHANG | 2016 | Frontiers of Agricultural Science and Engineering2016，3，2： | 2 |
| 11 | Impact of rain-induced sea surface roughness variations on salinity retrieval from the Aquarius/SAC-D satellite显示文摘Rainfall has two significant effects on the sea surface, including salinity decreasing and surface becoming rougher,which have further influence on L-band sea surface emissivity. Investigations using the Aquarius and TRMM 3B42 matchup dataset indicate that the retrieved sea surface salinity(SSS) is underestimated by the present Aquarius algorithm compared to numerical model outputs, especially in cases of a high rain rate. For example, the bias between satellite-observed SSS and numerical model SSS is approximately 2 when the rain rate is 25 mm/h. The bias can be eliminated by accounting for rain-induced roughness, which is usually modeled by rain-generated ring-wave spectrum. The rain spectrum will be input into the Small Slope Approximation(SSA) model for the simulation of sea surface emissivity influenced by rain. The comparison with theoretical model indicated that the empirical model of rain spectrumis more suitable to be used in the simulation. Further, the coefficients of the rain spectrum are modified by fitting the simulations with the observations of the 2–year Aquarius and TRMM matchup dataset. The calculations confirm that the sea surface emissivity increases with the wind speed and rain rate. The increase induced by the rain rate is rapid in the case of low rain rate and low wind speed. Finally, a modified model of sea surface emissivity including the rain spectrum is proposed and validated by using the matchup dataset in May 2014. Compared with observations, the bias of the rain-induced sea surface emissivity simulated by the modified modelis approximately 1e–4, and the RMSE is slightly larger than 1e–3. With using more matchup data, thebias between model retrieved sea surface salinities and observationsmay be further corrected,and the RMSE may be reduced to less than 1 in the cases of low rain rate and low wind speed. | MA Wentao YANG Xiaofeng YU Yang LIU Guihong LI Ziwei JING Cheng | 2015 | Acta Oceanologica Sinica2015，34，7： | 2 |
| 12 | Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies显示文摘Until now,there has been a lack of standard and effective treatments for patients with recurrent malignant tumors or abdominal and pelvic malignancies with extensive invasion(Morris,2000).Generally,these patients face problems such as inability to undergo surgery or chemotherapy resistance(Combs et al.,2016).Re-radiotherapy has achieved a prominent place in the treatment of patients who have received radiotherapy previously and developed in-field recurrences(Straube et al.,2018).However,re-radiotherapy is very complicated,requiring comprehensive consideration of appropriate radiation dose,interval from first radiotherapy,boundary of the radiotherapy target area,and damage to surrounding normal tissues(Straube et al.,2019).In other words,it is necessary to focus on the protection of surrounding normal tissues while maximizing the eflFicacy of re-radiotherapy in such patients. | Xin WEN Hui QIU Zhiying SHAO Guihong LIU Nianli LIU Aoxing CHEN Xingying ZHANG Xin DING Longzhen ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 2 |
| 13 | High-temperature wheat leaf rust resistance gene Lr13 exhibits pleiotropic effects on hybrid necrosis显示文摘Dear Editor,Wheat is one of the most important staple food crops.Leaf rust caused by Puccinia triticina Eriks.(Pt)is a destructive foliar disease that threatens world wheat production.Complementary wheat genes Necrosis 1(Ne1)and Necrosis 2(Ne2)on chromosome arms 5BL and 2BS,respectively,cause hybrid necrosis(Caldwell and Compton,1943;Chu et al.,2006).Ne2 shows extremely tight genetic linkage with leaf rust resistance gene Lr13(Zhang et al.,2016).We previously identified a temperature-sensitive leaf rust resistance gene LrZH22 in Chinese wheat cultivar Zhoumai 22(ZM,Figure 1A)that was effective against most Chinese Pt pathotypes(Wang et al.,2016)and shared an overlapping genetic interval with Lr13.In a separate study,a recessive early leaf senescence 1(els1)gene(Figure 1B)shared an overlapping interval with LrZH22/Lr13/Ne2(Chu et al.,2006;Wang et al.,2016;Zhang et al.,2016;Li et al.,2018).However,the function and relationship of LrZH22/Lr13/Ne2/els1 remained unknown for decades.Here,we report the map-based cloning of LrZH22 and els1 and characterize their relationship with Lr13 and Ne2 in conjunction with a companion paper(Hewitt et al.t 2021)studying the same gene. | Xiaocui Yan Miaomiao Li Peipei Zhang Guihong Yin Huaizhi Zhang Takele Weldu Gebrewahid Jianping Zhang Lingli Dong Daqun Liu Zhiyong Liu Zaifeng Li | 2021 | Molecular Plant2021，14，7： | 2 |
| 14 | Import of Rift Valley fever to China:a potential new threat?显示文摘Several recent studies in Virologica Sinica and other journals have highlighted the enormous international challenge of emerging arboviral diseases,such as Zika virus disease,dengue,and chikungunya(Islam et al.,2015;Maurice et al.,2015;Dai et al.,2016;Deng et al.,2016;Song et al.,2016;Wang et al.,2016;Xu et al.,2016;Zhang et al.,2016;Zhou | Xinliang FU Lifang Wang Bo Fang Ruirui Ma Yun Zheng San Huang Pei Zhou Zongxi Cao Jin Tian Shoujun Li Guihong Zhang | 2016 | Virologica Sinica2016，31，5： | 2 |
| 15 | Isolation and Sequence Analysis of NSP2, ORF3 and ORF5 of PRRSV XH-GD Strain from Guangdong Province显示文摘The diseased samples collected from Guangdong Province were inoculated to Marc-145 cells,PRRSV-specific cytopathogenic effects( CPE) such as cell aggregation,cell shrinkage and cell exfoliation were observed and a PRRSV strain XH-GD was obtained. By using primers designed in accordance with the published gene sequences of PRRSV in GenBank,NSP2,ORF3 and ORF5 fragments were amplified by reverse transcription polymerase chain reaction and analyzed by sequence alignment. The results demonstrated that PRRSV strain XH-GD belonged to the North American genotype and the NSP2 gene contained discontinuous deletions of 30 amino acids. NSP2,ORF3 and ORF5 genes of XH-GD shared 83. 3%- 98. 9%,88. 6%- 99. 2% and 88. 1%- 99. 2% nucleotide homology,and76. 8%- 98. 3%,83. 7%- 98. 8% and 88. 1%- 99. 2% amino acid homology with HUB1,NX06,BJsy06,VR-2332,HB-1( sh) 2002,HB-2( sh) 2002,CH-la and RespPRRS MLV,respectively; however,NSP2,ORF3 and ORF5 genes of XH-GD shared only 52. 9%,65. 0% and 64. 3% nucleotide homology,and31. 3%,57. 5% and 58. 9% amino acid homology with LV,respectively. Phylogenetic analysis revealed that XH-GD had a closer relationship with HUB1,NX06,BJsy06,VR-2332,HB-1( sh) 2002,HB-2( sh) 2002,CH-la and RespPRRS MLV strains compared with LV strain. | Zongxi CAO Quanhui PAN Zhemin LIN Liuwu KONG Yimin HE Guihong ZHANG | 2014 | Agricultural Biotechnology2014，3，1： | 2 |
| 16 | A facile disposal of Bayer red mud based on selective flocculation desliming with or- ganic humics显示文摘 | Huang Yangfang Han Guihong Liu Jiongtian | 2016 | Journal of Hazardous Materials2016，301，： | 1 |
| 17 | Information measure for performance of image fusion 显示文摘 | Qu Guihong ZHANG Dali VAN Pingfan | 2002 | Elec- tronics Letters2002，38，7： | 1 |
| 18 | Disulfide structure of the pheromone binding protein from the silkworm moth, Bombyx mori显示文摘 | Walter S Leal Larisa Nikonova Guihong Peng | 1999 | FEBS Letters1999，，1： | 1 |
| 19 | Research on the Nonlinearity of Infrared Focal Plane Arrays显示文摘 | Hu Guihong Chen Qian Shen Xiaoyan | 2003 | Journal of Optoeletronics Laser2003，14，5： | 1 |
| 20 | Li 2 MnSiO 4 cathodes modified by phosphorous substitution and the structural consequences显示文摘 | Rosalind J. Gummow Guihong Han Neeraj Sharma Yinghe He | 2014 | Solid State Ionics2014，，： | 1 |
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