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| 1 | Circulating microRNAs in patients with non-alcoholic fatty liver disease显示文摘AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease(NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The rela-tive expressions of miR-197, miR-146 b, miR-10 b, miR-181d, miR-34 a, miR-122, miR-99 a and miR-29 a were analyzed using real-time polymerase chain reaction. RESULTS: Serum levels of miR-181 d, miR-99 a, miR-197 and miR-146 b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum lev-els of miR-197 and miR-10 b were inversely correlated with degree of inflammation and miR-181 d and miR-99 a were inversely correlated with serum gamma glu-tamyl transferase levels in non-alcoholic steatohepatitis patients. CONCLUSION: NAFLD is associated with altered se-rum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD. | Serkan Dogan Gokmen Zararsiz Sebnem Gursoy Kadri Guven Omer Ozbakir Munis Dundar Mehmet Yucesoy | 2014 | World Journal of Hepatology2014，6，8： | 13 |
| 2 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 3 | Beyond 11% Efficiency: Characteristics of State‐of‐the‐Art Cu2ZnSn(S,Se)4 Solar Cells显示文摘 | Teodor K. Todorov Jiang Tang Santanu Bag Oki Gunawan Tayfun Gokmen Yu Zhu David B. Mitzi | 2012 | Adv. Energy Mater2012，，： | 2 |
| 4 | Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma显示文摘 | Gorio A Gokmen N Erbayraktar S Yilmaz O Madaschi L Cichehi C | 2002 | PNAS2002，99，4： | 1 |
| 5 | Thoracic involvement in Be-hcet; s disease: pathologic,clinical,and imaging features显示文摘 | Tunaci A Berkmen YM Gokmen E | 1995 | AJR1995，164，1： | 1 |
| 6 | Hybrid seed production in safflower (Carthamus tinctorius) followingtheinduction of male sterility by gibberellic acid显示文摘 | Baydar H Gokmen OY | 2003 | Plant Breeding2003，122，5： | 1 |
| 7 | Adsorption of maillard reaction products from aqueous solutions and sugar syrups using adsorbent resin显示文摘 | SERPEN A ATAC B GOKMEN V | | 0，，03： | 1 |
| 8 | 显示文摘 | Gokmen M T Du Prez F E | 2012 | Progress in Polymer Science2012，37，3： | 1 |
| 9 | Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury显示文摘 | Celik M Gokmen N Erbayraktar S | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 10 | The effect of hormone replacement therapy on uterine fibroids in postmenopausal women显示文摘 | Sener A Gokmen O Seckin N | 1996 | Fertil Steril1996，65，2： | 1 |
| 11 | Effect of nitrogen on root release of phytosiderophores and root uptake of Fe(III)- phytosiderophore in Fe-deficient wheat plants 显示文摘 | Aciksoz S B Ozturk L Gokmen O O | 2011 | Physiologia Plantarum2011，142，： | 1 |
| 12 | Erythropoietin pre- vents motor neuron apoptosis and neurologic disability in experi- mental spinal cord ischemic injury显示文摘 | Celik M Gokmen N Erbayraktar S | 2002 | Proc Nat Acad Sci USA2002，99，4： | 1 |
| 13 | Determination of 5-hydroxymethyl- furfural and 2-furfural in oils as indicators of heat pre-treatment显示文摘 | Durmaz G Gokmen V | 2010 | Food Chemistry2010，123，： | 1 |
| 14 | Gemcitabine and vinorelbine combination in patients with metastatic breast cancer 显示文摘 | Sanal S M Gokmen E Karabulut B | 2002 | Breast J2002，8，3： | 1 |
| 15 | Rapid reversed-phase liquid chromatographic determination of patulin in apple juice 显示文摘 | Gokmen V Acar J | 1996 | Journal of Chromatogr A1996，730，1： | 1 |
| 16 | Organic Acids and Phenolic Compounds in Pomegranates (Punica granatum)Grown in Turkey显示文摘 | Poyrazoglu E Gokmen V Artil N | 2002 | Juural of food com- position and analysis2002，15，5： | 1 |
| 17 | The effects of processing technology on the patulin content of juice during commercial apple juice concentrate production显示文摘 | Acar J Gokmen V Taydas E E | 1998 | Zeitschrift fur Lebensmittel-Untersuchung und Forschung A-Food Research and Technolgy1998，207，4： | 1 |
| 18 | Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury显示文摘 | Celik M Gokmen N Erbayraktar S | 2002 | Proc Natl Acad Sci USA2002，99，4： | 1 |
| 19 | Traffic sign recognition using Scale Invariant Feature Transform and color classifi- cation 显示文摘 | Kus M M Gokmen S Etaner-Uyar | 2008 | Computer and Information Sciences2008，，： | 1 |
| 20 | The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review显示文摘 | Gokmen MR Cosyns JP Arlt VM | 2013 | Ann Intern Med2013，158，6： | 1 |
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