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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Gold nanoparticles for biology andmedicine显示文摘 | Giljohann D Seferos DS Daniel WL | | 0，，19： | 1 |
| 3 | Oligonucleotide - Modified Gold Nanoparticles for Intracellular Gene Regulation 显示文摘 | Rosi N L Giljohann D A Thaxton S C Lytton -Jean A K Han M S Mirkin C A | 2006 | Science2006，312，5776： | 1 |
| 4 | Aptamer nano-ares for molecular detection in living cells显示文摘 | ZHENG D SEFEROS D S GILJOHANN D A | 2009 | Nano Letters2009，9，9： | 1 |
| 5 | Drivers ofbiodiagnostic development显示文摘 | Giljohann DA Mirkin CA | | 0，，7272： | 1 |
| 6 | Oligonucleotide- modified gold nanoparticles for intracellular gone regulation 显示文摘 | Rosi N L Giljohann D A Thaxton C S | 2006 | Science2006，312，： | 1 |
| 7 | Gold nan- oparticles for biology and medicine显示文摘 | Giljohann D A Seferos D S Daniel W L | 2010 | Angew Chem Int Ed2010，49，19： | 1 |
| 8 | Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles显示文摘 | Giljohann DA Seferos DS Patel PC | 2007 | Nano Lett2007，7，12： | 1 |
| 9 | Polyva- lent DNA nanopartiele conjugates stabilize nucleic acids 显示文摘 | Seferos D S Prigodich A E Giljohann D A | 2009 | Nano Letters2009，9，1： | 1 |
| 10 | Nano- flares : probes for transfection and mRNA detection in living cells 显示文摘 | SEFEROS D S GILJOHANN D A HILL H D | 2007 | Journal of the American Chemical Society2007，129，15： | 1 |
| 11 | Oligonucleo- tide-modified gold nanopartieles for intraeellular gene reg- ulation 显示文摘 | Rosi N L Giljohann D A Thaxton C S | 2006 | Science2006，312，5776： | 1 |
| 12 | Cellular Response of Polyva-lent Oligonucleotide-Gold Nanoparticle Conjugates显示文摘 | Massich M.D Giljohann D.A Schmucker A.L Patel P.C Mirkin C.A | | 0，，： | 1 |
| 13 | Gold nanoparticles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | 2010 | Angew Chern Int Ed Engl2010，49，19： | 1 |
| 14 | Gold nanoparticles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | | 0，，19： | 1 |
| 15 | 显示文摘 | Rosi N L Giljohann D A Thaxton C S | 2006 | Science2006，312，： | 1 |
| 16 | Gold nan- oparticles for biology and medicine显示文摘 | Giljohann DA Seferos DS Daniel WL | 2010 | Angew Chem Int EdEngl2010，49，19： | 1 |
| 17 | Topical deliv- ery of siRNA-based spherical nucleic acid nanoparticle conju gates for gene regulation 显示文摘 | ZHENG D GILJOHANN DA CHEN DL | 2012 | Proc Natl Acad Sci2012，109，11： | 1 |
| 18 | Oligonucleotide-modified gold nanoparticles for intracellular gene regulation显示文摘 | ROSI N L GILJOHANN D A THAXTON C S | 2006 | Science2006，312，5776： | 1 |
| 19 | Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles显示文摘 | GILJOHANN D A SEFEROS D S PATEL P C | 2007 | Nano Lett2007，7，12： | 1 |
| 20 | Oligonucleotide-modified gold nanoparticles for intracellular gene regulation显示文摘 | ROSI NL GILJOHANN DA THAXTON CS | | 0，，19： | 1 |
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