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| 1 | Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients显示文摘背景变应原微数组是为浆液 IgE-reactivity.In 屏蔽这学习变应原的强大的工具微数组被用来鉴别在选择中国过敏症 patients.Methods 之中统治IgE有约束力的变应原和跨反应的模式学习从广州的城市用耐心的 sera 被进行,南京,有 Dermatophagoides pteronyssinus ( Der p )的 Chengdu 和 Shenyang.In 总数 100 sera 比 50 kU/L 高的特定的IgE水平为对 103 | ZHENG Yi-wu LI Jing LAI Xu-xin ZHAO De-yu LIU Xiao-fan LIN Xiao-ping Birgitte Gjesing Paola Palazzo Adriano Mari ZHONG Nan-shan Michael D Spangfort | 2011 | Chinese Medical Journal2011，，24： | 16 |
| 2 | Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods显示文摘The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of awns.Several studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning algorithms.However,these methods have generally been calibrated and validated on limited datasets.High variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer vision.Further,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex.Through a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)dataset.It contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes.Guidelines for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection datasets.The GWHD dataset is publicly available at http://gffzzef49fa24bca249bbhq9vw6vvbkcw66kuc.ffgz.tsg.suse.edu.cn/and aimed at developing and benchmarking methods for wheat head detection. | Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo | 2020 | Plant Phenomics2020，2，1： | 13 |
| 3 | Affinity peptide developed by phage display selection for targeting gastric cancer显示文摘AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specific binders against tumor-adjacent normal appearing gastric mucosa and obtaining selective binding against freshly harvested gastric cancer tissues.Tumortargeted binding of selected peptides was confirmed by bound phage counts,enzyme-linked immunosorbent assay,competitive inhibition,fluorescence microscopy and semi-quantitative analysis on immunohistochemistry using different types of cancer tissues.RESULTS:Approximately 92.8% of the non-specific phage clones were subtracted from the original phage library after two rounds of biopanning against normal-appearing gastric mucosa.After the third round of positive screening,the peptide sequence AADNAKTKSFPV(AAD) appeared in 25%(12/48) of the analyzed phages.For the control peptide,these values were 6.8 ± 2.3,5.1 ± 1.7,3.5 ± 2.1,4.6 ± 1.9 and 1.1 ± 0.5,respectively.The values for AAD peptide were statistically signif icant(P < 0.01) for gastric cancer as compared with other histological classif ications and control peptide.CONCLUSION:A novel peptide is discovered to have a specific binding activity to gastric cancer,and can be used to distinguish neoplastic from normal gastric mucosa,demonstrating the potential for early cancer detection on endoscopy. | Wen-Jie Zhang Yan-Xia Sui Arun Budha Jian-Bao Zheng Xue-Jun Sun Ying-Chun Hou Thomas D Wang Shao-Ying Lu | 2012 | World Journal of Gastroenterology2012，18，17： | 12 |
| 4 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 5 | Preliminary discussion of low-salinity hydrothermal fluid mineralization显示文摘REVIEWING the history of the geology of mineral deposits, we may find that in the first fifty years of thetwentieth century the magmatic-hydrothermal theory of ore deposition was the most prevalent, whichgave impetus to the development of the geology of mineral deposits. In the 1960s, the drilling of theSalton Sea geothermal field, California, the United States, and discovery and study of the Red Sea seafloor hot brines and large amounts of metal sulfides removed therefrom led to the rise of the brine theory ofmineral deposition, thus elucidating the origin of massive metal sulfides and promoted the discoveryand exploration of metal deposits. After the 1970s and the 1980s, through a study of the hydrothermal ore fluids of modern hotsprings. geologists came to realize that there exist low-salinity hydrothermal ore fluids other than | ZHENG Mianping R & D Center of Saline Lake and Epithermal Deposits, Chinese Academy of Geological Sciences, Beijing 100037, China | 1999 | Chinese Science Bulletin1999，44，S2： | 5 |
| 6 | Chloroplast phylogeny of Cucurbita: Evolution of the domesticated and wild species显示文摘类 Cucurbita (Cucurbitaceae ) 包括在美洲独立地被驯养的五种,产生巨大的差异挤压,南瓜,和葫芦。获得 Cucurbita 和它的驯养的 taxa 的进化的改进理解,我们使用了四叶绿体 loci 估计 23 taxa 的发展史在 Cucurbita 以内代表女人级的差异。我们的结果为类的发展史提供一个强烈支持的框架假设,要用体力地证实 C 的基础位置。xerophytic perennials 的 digitata 组并且 monophyly mesophytic annuals 的一个大组在类代表大多数已知的差异,野、驯养。叶绿体证据为 mesophytic 组织年度 C 的一篇小说提供强壮的支持。ficifolia (仅仅从耕作知道) 与 xerophytic perennials C。foetidissima 和 C。pedatifolia。这研究也在基于 isozyme 的假设的支持提供第一条基于 DNA 的证据那 C。pepo subsp。ovifera var。ovifera (由很装饰的葫芦代表了并且几挤压) 从野 taxon C 被驯养。pepo subsp。ovifera var。ozarkana。这把支持借给假设那 var。ovifera 在东方美国和那被驯养作为大约 10 独立人士之一服务的这个区域人的农业的起源集中。尽管水平自举在 Cucurbita 为这和某些其它支持外部关系这些问题的低、权威的分辨率在活动范围以内,下一代的定序应该很快从类的全面采样交付全部细胞器染色体序列。 | Yi-Hong ZHENG Andrew J. ALVERSON Qing-Feng WANG Jeffrey D PALMER | 2013 | Journal of Systematics and Evolution2013，51，3： | 4 |
| 7 | Comparison of HER-2/neu,ER and PCNA expression in premenopausal and postmenopausal patients with breast carcinoma显示文摘 | Zheng W Zheng J Ma L Meng F Huang L Ma D | 2005 | 第二军医大学学报2005，26，8： | 4 |
| 8 | The effects of K^+ growth conditions on the accumulation of cesium by the bacterium Thermus sp. TibetanG6显示文摘The accumulation of cesium by the bacterium Thermus sp. TibetanG6 was examined under different K+ growth conditions. The effects of external pH and Na+ on the accumulation of ce-sium were also studied, and the mechanism involved was discussed. K+ regimes played an important role in the accumulation of cesium by the strain TibetanG6. The quantity of cesium accumulated (24 h) was much higher in K+-deficient regime than that in K+-sufficient regime. The pH and Na+ had different effects on the accumulation of cesium in the two K+ regimes. IR spectra analyses indicated that the biosorption is a process of homeostasis with cesium initially accumulated on the cell wall. | WANG Hailei1,2,3, KONG Fanjing1,2,3 & ZHENG Mianping1,2,3 1. R&D Center for Saline Lake and Epithermal Deposits, Chinese Academy of Geological Sciences, Beijing 100037, China 2. Key Open Laboratory of Saline Lake Resources and Environment, Chinese Academy of Geological Sciences, Beijing 100037, China 3. Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China | 2006 | Science China(Life Sciences)2006，49，2： | 3 |
| 9 | Indoor mite allergen levels, specific IgE prevalence and IgE cross-inhibition pattern among asthmatic children in Haikou, southern China显示文摘 | ZHENG Yi-wu CHEN Shi LAI Xu-xin Birgitte Gjesing ZHONG Nan-shan Michael D Spangfort | 2012 | Chinese Medical Journal2012，，17： | 3 |
| 10 | Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine显示文摘 | Xu Z Zheng H Law SL Dong So D Han Y Xue H | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 11 | 精神病病人和服用精神类药物病人接受和长期接受阿片类药物治疗:国家级商业保险索赔研究显示文摘越来越多的证据表明,美国的阿片类处方正遵循一种'逆向选择'模式,这种模式使得接受阿片类药物长期治疗的病人更可能处于阿片类药物不良反应的最大风险中,特别是那些物质使用障碍(SUD)和其他精神病病人。本研究调查了10311961位填写阿片类处方病人的医疗保险索赔情况,特别比较了患精神病及行为异常(比如阿片类和非阿片类SUD、自杀倾向或自残行为、机动车事故、抑郁症、焦虑症和睡眠障碍)和未患精神病及无行为异常病人、服用精神类药品(如抗抑郁药、苯二氮?类药物、安眠药、镇定剂、抗精神病药品和用于治疗SUD、烟草戒断、多动症的药物)和未服用精神类药品病人之间接受阿片类药物治疗的区别。相对于对照组,有精神病或服用精神类药品的病人随后须接受阿片类药物治疗的风险稍高,特别是,接受阿片类药物长期治疗的风险更高。利用校正型Cox回归模型可知,多动症病人接受阿片类药物长期治疗的风险是无多动症病人的1.5倍(危险比(HR)=1.53,95%可信区间:1.48-1.58),非阿片类SUD病人风险约是无此疾患病人的3倍(危险比(HR)=3.15,95%可信区间:3.06-3.24),阿片类使用障碍病人的风险是无此疾患病人的9倍(危险比(HR)=8.70,95%可信区间:8.20-9.24)。总而言之,本研究发现有精神疾病状态的商业保险病人更可能接受阿片类药物治疗。未来关于阿片类药物行为结局的研究需考虑病人的先存精神疾病状况。 | Patrick D Quinn Kwan Hur Zheng Chang 王艳娉 杨俊龙 张小梅 | 2017 | 中国疼痛医学杂志2017，23，9： | 3 |
| 12 | Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods显示文摘The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. | Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo | 2021 | Plant Phenomics2021，3，1： | 2 |
| 13 | Framingham高血压风险预测模型在中国农村人口中的预测价值显示文摘研究者从美国Framingham心脏研究(Framinghamheartstudy,FHS)人群中建立了个人发生高血压的风险评估预测模型。但这种模型尚未在其他群体广泛应用。该研究分析FHS预测模型在中国农村人口中的预测价值。方法:选取中国辽宁省农村人口24434人,年龄≥35岁。 | Zheng L Sun Z Zhang X Li J Hu D Chen J Sun Y 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，5： | 2 |
| 14 | On solutions of matrix equation AXB+CVD=F显示文摘 | Xu G Wei M Zheng D | 1998 | Linear Algebra Appl1998，279，： | 2 |
| 15 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 16 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 17 | Cesium accumulation by bacterium Thermus sp. TibetanG7:hints for biomineralization of cesium-bearing geyserite in hot springs in Tibet,China显示文摘The bacterium Thermus sp. TibetanG7, isolated from hot springs in Tibet, China, was examined for the ability to accumulate cesium from solutions. Environmental conditions were simulated and the effects of pH, K+, Na+ and K+-regimes were then studied to determine the possible role of the bacterium in the formation of cesium-bearing geyserite around these hot springs. In despite of the inhibition of K+ and Na+, the bacterium Thermus sp. TibetanG7 revealed noticeable accumulation of cesium from solutions, with maximum accumulations of 53.49 and 40.41 μmol Cesium/g cell dry weight in Na+ and K+ inhibition experiments, respectively. The accumulation of cesium by this microorganism is rapid, with 40%―50% accumulated within the first 5 min. K+-deficient cells showed a much higher capacity of cesium accu- mulation compared with K+-sufficient cells. It is evident that the bacteria within the genus thermus play a significant role in the cesium assembly. The formation of cesium-bearing geyserite is also considered. | WANG HaiLei1,2,3, ZHENG MianPing1,2,3 & HUANG XiaoXing4 1 Institute of Mineral Resources, Chinese Academy of Geological Sciences (CAGS), Beijing 100037, China 2 R&D Center for Saline Lake and Epithermal Deposits, CAGS, Beijing 100037, China 3 Open Laboratory of Saline Lake Resourses and Environment, CAGS, Beijing 100037, China 4 Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100081, China | 2007 | Chinese Science Bulletin2007，52，19： | 2 |
| 18 | Ohioensins and pallidisetins:ovel cytotoxic agents from the moss polytrichum pallidisetum 显示文摘 | ZHENG G HO D K ELDER P L | 1994 | J Nat Prod1994，57，1： | 2 |
| 19 | STEP-based product modeling for concurrent stamped part and die development显示文摘 | Tang D B Zheng L Li Z Z | 2001 | Computers in Industry2001，46，： | 2 |
| 20 | Simulated annealing with the state generator based on Cauchy and Gaussian distributions显示文摘 | Wang L Zheng D Z | 2000 | J of Tsinghua University2000，40，9： | 2 |
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