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| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the reRulation of sperm motility显示文摘 | Violeta Calle-Guisado Ana Hurtado de Llera David Martin-Hidalgo Jose Mijares Maria C Gil Ignacio S Alvarez Maria J Bragado Luis J Garcia-Marin | 2017 | Asian Journal of Andrology2017，19，6： | 5 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units显示文摘Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting.Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively included.Anemia was defined as hemoglobin<130 g/L in men and<120 g/L in women.The association between anemia and mortality or readmission at six months was assessed by the Cox regression method.Results A total of 629 patients were included.Mean age was 66.6 years.A total of 197 patients(31.3%)had anemia.Coronary angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score values.Patients with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement therapies.Both ICCU and hospital stay were significantly longer in patients with anemia.Both the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia.Most patients underwent coronary angiography.Anemia was independently associated to poorer outcomes at 6 months. | Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 | 2020 | Journal of Geriatric Cardiology2020，17，1： | 2 |
| 5 | Fluorescence studies of poly(p-phenyleneethynylene)s: The effect of antheancene substitution显示文摘 | Swager T M Gil C J Wrighton M S | 1995 | J Phys Chem 991995，，： | 2 |
| 6 | Novel BOD sensor using mediator-less microbial fuel cell 显示文摘 | Kim B H Chang I S Gil G C | 2003 | Biotechnology Letters2003，25，7： | 1 |
| 7 | Effects of flavonoids on naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice 显示文摘 | Gil B Sanz M J Terencio M C | 1994 | Life Sci1994，54，： | 1 |
| 8 | Functional as-sessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic func- tion显示文摘 | Urrea Moreno R Gil J Rodriguez-Sainz C | 2009 | Blood2009，113，2： | 1 |
| 9 | An analysis of environmental management, organizational context and performance of Spanish hotels显示文摘 | M.J álvarez Gil J Burgos Jiménez J.J Céspedes Lorente | 2001 | Omega2001，，： | 1 |
| 10 | Liver growth factor antifibrotic activity in vivo is associated with a decrease in activation of hepatic stellate cells显示文摘 | Diaz - Gil J J Garcia - Monzon C Rua C | 2009 | Histol Histopathol2009，24，4： | 1 |
| 11 | Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors 显示文摘 | Castro A Jerez MJ Gil C | 2005 | Med Res Rev2005，25，2： | 1 |
| 12 | Thermal behaviour and kinetics of coal/biomass blends during co-combustion显示文摘 | Gil M V Casal D Pevida C | 2010 | Bioresource Technology2010，101，14： | 1 |
| 13 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 14 | Land-cover change model validation by an ROC method for the Ipswich watershed, Massa-chuset, USA显示文摘 | PONTIUS R GIL J R LAURA C S | 2001 | Agriculture Ecosystems and Environ- ment2001，85，5： | 1 |
| 15 | Cortactin regulates cell migration through activation of N-WASP显示文摘 | Kowalski JR Egile C Gil S | 2005 | J Cell Sci2005，118，1： | 1 |
| 16 | A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa 显示文摘 | Manez S Recio M C Gil I | 1999 | Journal of Natural Products1999，62，4： | 1 |
| 17 | Aetiology of inflammatory bowel disease(IBD):role of intestinal microbiota and gut-associated lymphoid tissue immune response显示文摘 | Thompson-Chagoyán O C Maldonado J Gil A | 2005 | Clin Nutr2005，24，3： | 1 |
| 18 | Risk factors that have influence on acetabular ero- sion after a hip hemiarthroplasty in the treatment of subcapital fractures 显示文摘 | Trneba Davalillo C Minueza Mejia T Gil Orbezo F | 2007 | Acta Ortop Mex2007，21，3： | 1 |
| 19 | Absorption of nitric oxide into aqueous solutions of ferrous chelate accompanied by instantaneous reaction显示文摘 | DEMMINK J F VAN GILS I C BEENACKERS A A | 1997 | Industrial and Engineering Chemistry Research1997，36，： | 1 |
| 20 | CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example 显示文摘 | Castro A Jerez M J GIL C | 2008 | Eur J Med Chem2008，43，7： | 1 |
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