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| 1 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 2 | Antimicrobial-impregnated catheters for the prevention of catheter-related bloodstream infections显示文摘Central venous catheters are commonly used in critically ill patients. Such catheterization may entail mechanica and infectious complications. The interest in catheterrelated infection lies in the morbidity, mortality and costs that it involved. Numerous contributions have been made in the prevention of catheter-related infection and the current review focuses on the possible current role of antimicrobial impregnated catheters to reduce catheter-related bloodstream infections(CRBSI). There is evidence that the use of chlorhexidine-silver sulfadiazine(CHSS), rifampicin-minocycline, or rifampicin-miconazol impregnated catheters reduce the incidence of CRBSI and costs. In addition, there are some clinical circumstances associated with higher risk of CRBSI, such as the venous catheter access and the presence of tracheostomy. Current guidelines for the prevention of CRBSI recommended the use of a CHSS or rifampicin-minocycline impregnated catheter in patients whose catheter is expected to remain in place > 5 d and if the CRBSI rate has not decreased after implementation of a comprehensive strategy to reduce it. | Leonardo Lorente | 2016 | World Journal of Critical Care Medicine2016，5，2： | 7 |
| 3 | New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma显示文摘The outcome prediction of hepatocellular carcinoma(HCC) patients undergoing liver transplantation(LT) was classically established using various macromorphological factors and serum alpha-fetoprotein levels prior to LT. However, other biomarkers have recently been reported to be associated with the prognosis of HCC patients undergoing to LT. This review summarizes clinical data on these new biomarkers. High blood levels of malondialdehyde, total antioxidant capacity, caspasecleaved cytokeratin-18, soluble CD40 ligand, substance P, C-reactive protein, and vascular endothelial growth factor, increased neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in blood, high peripheral blood expression of human telomerase reverse transcriptase messenger ribonucleic acid, and high HCC expression of dickkopf-1 have recently been associated with decreased survival rates. In addition, high blood levels of des-gamma-carboxy prothrombin, and high HCC expression of glypican-3, E-cadherin and betacatenin have been associated with increased HCC recurrence. Additional research is necessary to establish the prognostic role of these biomarkers in HCC prior to LT. Furthermore, some of these biomarkers are also interesting because their potential modulation could help to create new research lines for improving the outcomes of those patients. | Leonardo Lorente | 2018 | World Journal of Gastroenterology2018，24，37： | 5 |
| 4 | A half century (1961-2011) of applying microsurgery to experimental liver research显示文摘The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies. | Maria-Angeles Aller Natalia Arias Isabel Prieto Salvador Agudo Carlos Gilsanz Laureano Lorente Jorge-Luis Arias Jaime Arias | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 5 | Visual and ocular effects from the use of flat-panel displays显示文摘AIM: To evaluate the prevalence of eye symptoms in a non-presbyopic population of video display unit(VDU)users with flat-panel displays.METHODS: One hundred and sixteen VDU users with flat-panel display from an urban population participated in the study; their ages ranging from 20 to 34 y. There were 60 females and 56 males. An eye examination to rule out the presence of significant uncorrected refractive errors, general binocular dysfunctions and eye conditions was carried out. In order to determine and quantify the type and nature of eye symptoms,participants were asked to answer written questionnaire and the results were grouped by gender, age and number of hours a day spent using a VDU. RESULTS: Seventy-two percent of participants reported eye symptoms related to VDU use. Eye symptoms from moderate-to-severe were found in 23%of participants. The main symptom was moderate-to-severe tired eyes(14%); followed by sensitivity to bright lights(12%), blurred vision at far distances(10%),eyestrain or dry eye or irritated or burning eyes(9%),difficulty in refocusing from one distance to another or headache(8%) and blurred vision at near or intermediate distances(<4%). Eye symptoms were greater among females(P =0.005) and increased with VDU use, markedly above 6h spent using a VDU in a typical day(P =0.01).CONCLUSION: Significant eye symptoms relate to VDU use often occur and should not be underestimated. The increasing use of electronic devices with flat-panel display should prompt users to take appropriate measures to prevent or to relieve the eye symptoms arising from their use. | Esteban Porcar Alvaro M.Pons Amalia Lorente | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 2 |
| 6 | Infectious endocarditis, cerebral haemorrhage and liver cirrhosis显示文摘 | D.I. Gentille Lorente J.M. Jaén Martínez | 2011 | Neurología (English Edition)2011，，1： | 2 |
| 7 | Inhibition of nitric oxide synthesis improves the vasoconstrictive effect of noradrenalline in sepsis显示文摘 | Landin L Lorente J A Renes E | 1994 | Chest1994，106，1： | 2 |
| 8 | Recent Advances and Applications of Hyperspectral Imaging for Fruit and Vegetable Quality Assessment显示文摘 | D. Lorente N. Aleixos J. Gómez-Sanchis S. Cubero O. L. García-Navarrete J. Blasco | 2012 | Food and Bioprocess Technology2012，，4： | 2 |
| 9 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 10 | Mechanical and thermal properties of carbon nanotubes 显示文摘 | Ruoff R S Lorents D C | 1995 | Carbon1995，33，： | 2 |
| 11 | Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units显示文摘Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical setting.Methods All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively included.Anemia was defined as hemoglobin<130 g/L in men and<120 g/L in women.The association between anemia and mortality or readmission at six months was assessed by the Cox regression method.Results A total of 629 patients were included.Mean age was 66.6 years.A total of 197 patients(31.3%)had anemia.Coronary angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score values.Patients with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement therapies.Both ICCU and hospital stay were significantly longer in patients with anemia.Both the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had anemia.Most patients underwent coronary angiography.Anemia was independently associated to poorer outcomes at 6 months. | Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 | 2020 | Journal of Geriatric Cardiology2020，17，1： | 2 |
| 12 | Mechanical and thermal properties of carbon nanotubes显示文摘 | Rodney S. Ruoff Donald C. Lorents | 1995 | Carbon1995，，7： | 2 |
| 13 | Recent Advances and Applications of Hyperspectral Imaging for Fruit and Vegetable Quality Assessment显示文摘 | D. Lorente N. Aleixos J. Gómez-Sanchis S. Cubero O. L. García-Navarrete J. Blasco | 2012 | Food and Bioprocess Technology2012，，4： | 2 |
| 14 | Multicellular natural convection in a high aspect ratio cavity:experimental and numerical results显示文摘 | Lartigue B Lorente S Bourret B | 2000 | Int J Heat Mass Transfer2000，43，： | 1 |
| 15 | Long-term survival of surgically staged IIIA-N2 non-small-cell lung cancer treated with surgical combined modality approach: analysis of a 7-year prospective experience显示文摘 | Lorent N De Leyn P Lievens Y | 2004 | Ann Oncol2004，15，11： | 1 |
| 16 | Neutralization of tumor necrosis factor in preclinical models of sepsis 显示文摘 | Lorente JA Marshall JC | 2005 | Shock2005，，： | 1 |
| 17 | Environmental performance as an operations objective显示文摘 | De Burgos J J Lorente J J C | 2001 | International Journal of Operations & Production Management2001，21，12： | 1 |
| 18 | The micro-organism responsible for central venous catheter related bloodstream infection depends on catheter site显示文摘 | Lorente L Jimenez A Iribarren JL | 2006 | Intensive Care Med2006，32，9： | 1 |
| 19 | An analysis of environmental management, organizational context and performance of Spanish hotels显示文摘 | M.J álvarez Gil J Burgos Jiménez J.J Céspedes Lorente | 2001 | Omega2001，，： | 1 |
| 20 | Multiple - center ,randomized, placebo - controlled, double - blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock显示文摘 | Lopez A Lorente JA Steingrub J | 2004 | Crit Care Med2004，32，： | 1 |
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