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| 1 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 2 | The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer显示文摘 | Craig P. Carden Adam Stewart Parames Thavasu Emma Kipps Lorna Pope Mateus Crespo Susana Miranda Gerhardt Attard Michelle D. Garrett Paul A. Clarke Paul Workman Johann S. de Bono Martin Gore Stan B Kaye Udai Banerji | 2012 | Molecular Cancer Therapeutics2012，，7： | 2 |
| 3 | 在结核病高疫情监狱进行入监筛查结核病?里约热内卢监狱的案例显示文摘地点:结核病高疫情的3所里约热内卢州监狱目的:调查里约热内卢州监狱的患病率,确定危险因素,并探寻在这些州监狱的囚犯中筛查结核病的最适当的方法。方法:里约热内卢的3所监狱里的1696名男性囚犯都进行了系统的胸部X线检查。如果囚犯的X线结果显示肺部、胸膜或纵隔有异常,这些犯人就必须接受痰涂片和痰培养检查。医生将根据细菌学结果做出诊断。如果细菌学结果是阴性,将根据实验性治疗的结果得出诊断结果。结果:结核病患病率为2.7%(46/1696)。32/46(69%)的患者有细菌学证据,其中包括19例涂片阳性的患者。接受检查的囚犯中43%的人胸部X线结果有异常。在logistic回归模型中,结核病的相关因素包括文盲(调整OR 2.10,95%CI 1.02-4.34),咳嗽超过3周(调整OR 2.85,95%CI 1.54-5.27),结核病治疗史(调整OR3.61,95%CI 1.76-7.39),生活在里约热内卢郊区(调整OR 4.54,95%CI 1.02-20.07)和生活在里约热内卢城区(调整OR 5.48,95%CI 1.29-23.33)。在对咳嗽超过3周的囚犯直接进行痰涂片检查,仅发现了46例患者中的9例。结论:结果显示在有条件的情况下应在监狱对入监囚犯进行胸部X线筛查。同时,结果证明了在拘所急需改善环境和医疗条件。 | A.Sanchez B. Larouze A.B. Espinola J. Pires D.Capone G. Gerhardt V.Cesconi M.J.Procopio M.Hijjar V. Massari 徐汉城(译) 何广学(审校) | 2009 | 国际结核病与肺部疾病杂志2009，4，4： | 2 |
| 4 | Electroporation of a suicide plasmid bearing a transposon into Brucella abortus 显示文摘 | Fang L Gerhardt G | 1990 | Mcrobial pathogensis1990，9，： | 1 |
| 5 | Proportional assist ventilation in low birth weight infants with acute respiratory disease: A comparison to assist/control and conventional mechanical ventilation显示文摘 | Schulze A Gerhardt T Musante G | 1999 | Pediatry1999，135，3： | 1 |
| 6 | Fetal exposures to sound and vibroacoustic stimulation显示文摘 | Gerhardt KJ Abrams RM: The Fetus | 2000 | J Perinatol2000，20，： | 1 |
| 7 | Effect of stress on cochlear glucocorticoid protein:acoustic stress显示文摘 | Rarey KE Gerhardt KJ Lisa M | 1995 | Hear Res1995，82，： | 1 |
| 8 | Troponin T and I assays show decreased concentrations in heparin plasma compared with serum:lower recoveries in early than late phases of myocardial injure显示文摘 | Gerhardt W Nordin G Herbert A K | 2000 | Clin Chem2000，46，6： | 1 |
| 9 | Diagnos is of peiroperative myocardial infarction with measure of cardial tropon in T显示文摘 | Gerhardt W | 1991 | Clin Chem1991，37，8： | 1 |
| 10 | Automated setup for non-tactile high-precision measurements of roundness and cylindricity using two laser interferometers显示文摘 | KOHNEL M ULLMANN V GERHARDT U | 2012 | Measurement Science and Technology2012，23，07： | 1 |
| 11 | Basic and therapeu- tic aspects of angiogenesis 显示文摘 | Potente M Gerhardt H Carmeliet P | 2011 | Cell2011，146，6： | 1 |
| 12 | Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor显示文摘 | Slevin JT Gerhardt GA Smith CD | 2005 | J Neurosurg2005，102，2： | 1 |
| 13 | Randomized crossover comparison of proportional assist ventilation and patient-triggered ventilation in extremely low birth weight infants with evolving chronic lung disease显示文摘 | Schulze A Rieger-Faekeldey E Gerhardt T etal | 2007 | Neonatology2007，92，1： | 1 |
| 14 | Endothelial-pericyte interactions in angiogenesis 显示文摘 | Gerhardt H Betsholtz C | 2003 | Cell Tissue Res2003，314，1： | 1 |
| 15 | Prediction, prevention, and treatment of venous thromboembolic disease in pregnancy 显示文摘 | Zotz RB Gerhardt A Scharf RE | 2003 | Semin Thromb Hemost2003，29，2： | 1 |
| 16 | Behavioural and devel- opmental toxicity of ehlorpyrifos and nickel chloride to ze- brafish (Danio rerio) embryos and larvae 显示文摘 | Kienle C Kohler H R Gerhardt A | 2009 | Ecotoxicology and Environmental Safety2009，72，6： | 1 |
| 17 | The influence of pH and media composition on the uptake of inorganic selenium by Chlamydomonas reinhardtii显示文摘 | Gerhardt F R James G S | 1996 | Environmental Toxicology and Chemistry1996，15，9： | 1 |
| 18 | Detecting insect flight sounds in the field:Implications for acoustical counting of mosquitoes显示文摘 | Raman D R Gerhardt R R Wilkerson J B | 2007 | Transactions of the ASABE2007，50，4： | 1 |
| 19 | Time course of low mo- lecular weight proteins in the early kidney transplantation period in- fluence of corticosteroids显示文摘 | Poge U Gerhardt T Bokenkamp A | 2004 | Nephrol Dial Transplant2004，19，11： | 1 |
| 20 | Improvement of bilateral motor functions in patients with Parkinson disease through the unilat- eral intraputaminal infusion of glial cell line - derived neurotrophic factor 显示文摘 | Slevin J T Gerhardt G A Smith C D | 2005 | Journal of Neurosurgery2005，102，2： | 1 |
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