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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Research advances in the Mesozoic tectonic regimes during the formation of Jiaodong ore cluster area显示文摘在诺思中国的东方区域在中生代时代在 Jiaodong 矿石簇区域和相关构造政体转变把构造政体的进展基于研究,在这篇论文,我们首先总结要求后面被学习的一些关键问题。然后,我们建议一条途径到处理这些问题。在 Jiaodong 矿石的金存款聚类区域,这被知道,它具有不同矿化作用式样,空间 istributions 和地质的背景,可能作为从在中生代的至少一个地质的事件的结果。到现在为止,特别在上述事件的 geodynamic 机制上,关于时间的进化和空间迁居顺序的这种研究是远非足够的。而且,描述行动模式和构造动态政体的时间空间的框架并且提出每构造动态政体的相对贡献因为 metallogensis 是静止的质问到地质学家在 Jiaodong 的形成上学习的份量上矿石簇区域。根据地区性的构造分析,结构的动力学,观察和矿化作用网络的探索的解释,我们建议有一些的一个 geological-physical-chemical 模型抑制从全面分析发源。我们然后使用这个模型模仿结构的变丑,热运输,液体流动和化学反应的联合过程。获得的结果显示模型在进一步在 Jiaodong 矿石簇区域并且在进一步理解集体 metallogensis 的性质分析构造政体的时间空间的进化小道是有效的。 | DENG Jun YANG Liqiang GE Liangsheng WANG Qingfei ZHANG Jing GAO Bangfei ZHOU Yinghua JIANG Shaoqing | 2006 | Progress in Natural Science:Materials International2006，16，8： | 51 |
| 3 | Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats显示文摘Objective:Our previous research showed that Naotaifang(a compound traditional Chinese herbal medicine)extract(NTE)has clinically beneficial effects on neurological improvement of patients with acute cerebral ischemia.In this study,we investigated whether NTE protected acute brain injury in rats and whether its effects on ferroptosis could be linked to the dysfunction of glutathione peroxidase 4(GPX4)and iron metabolism.Methods:We established an acute brain injury model of middle cerebral artery occlusion(MCAO)in rats,in which we could observe the accumulation of iron in neurons,as detected by Perl’s staining.Using assay kits,we measured expression levels of ferroptosis biomarkers,such as iron,glutathione(GSH),reactive oxygen species(ROS)and malonaldehyde(MDA);further the expression levels of transferrin receptor1(TFR1),divalent metal transporter 1(DMT1),solute carrier family 7 member 11(SLC7 A11)and GPX4 were determined using immunohistochemical analysis,real-time quantitative polymerase chain reaction and Western blot assays.Results:We found that treatment with NTE reduced the expression levels of TFR1 and DMT1,reduced ROS,MDA and iron accumulation and reduced neurobehavioral scores,relative to untreated MCAO rats.Treatment with NTE increased the expression levels of SLC7 A11,GPX4 and GSH,and the number of Nissl bodies in the MCAO rats.Conclusion:Taken together,our data suggest that acute cerebral ischemia induces neuronal ferroptosis and the effects of treating MCAO rats with NTE involved inhibition of ferroptosis through the TFR1/DMT1 and SCL7 A11/GPX4 pathways. | Bin Lan Jin-wen Ge Shao-wu Cheng Xi-long Zheng Jun Liao Chao He Zheng-qing Rao Guo-zuo Wang | 2020 | Journal of Integrative Medicine2020，18，4： | 37 |
| 4 | Metallogenic epoch and genesis of the gold deposits in Jiaodong Peninsula, Eastern China: a regional review显示文摘金存款被多来源,重迭,大规模和时间空间的集中在 Jiaodong 半岛描绘,东方中国。在这篇论文,我们在 metallogenic 年表和金存款的开始上考察历史和学习的发展,总结附加 metallogenesis 的主要特征,提供中生代复杂 metallogenic 系统的证据,并且从一个地区性的看法为 Jiaodong 金存款簇的进一步的研究指出一些问题。尽管金存款在基因类型,形成矿石的材料和地质的背景是不同的,我们的研究显示形成矿石的材料的累积和炮兵阵地 temporally 空间地被专注于大规模,和 Jiaodong 金存款的主要 metallogenic 时代在中生代被集中。Metallogenic 年表和 geological-geochemical 数据显示有金矿化作用的二个时期在 Jiaodong 分别地发生在 130-110 妈和 90-80 妈矿石簇。从 polygenetic 矿化作用的重迭的金存款簇结果,和进一步的学习被需要调查中生代复杂 metallogenic 系统的形成和进化。 | YANG Liqiang DENG Jun GE Liangsheng WANG Oingfei ZHANG Jing GAO Bangfei J IANGShaoqing XU Hao | 2007 | Progress in Natural Science:Materials International2007，17，2： | 30 |
| 5 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 6 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 7 | Treatment of chronic prostatitis in Chinese men显示文摘The aim of this study is to assess the status of treatment of chronic prostatitis(CP)in Chinese men.A population-based cross-sectional survey was performed,in which 15000 men aged between 15 and 60 years were randomly selected to receive a questionnaire designed to assess National Institutes of Health Chronic Prostatitis Symptoms Index(NIH-CPSI)status,therapeutic efficacy and 28 other items.A total of 12743 men(84.95%)completed the questionnaire,of whom 1071(8.4%)were identified as having prostatitis-like symptoms and 517(4.5%)were diagnosed with CP according to NIH-CPSI criteria and prostatitis-like symptomatology.Of the CP patients,372(65%)underwent long-term routine treatment 12 times per year.Additionally,217(72.8%)patients received antibiotic therapy and 215(79.3%)men showed therapeutic effects.The treatment cost USD 1151(8059 yuan)per person per year on average.Most CP patients received routine treatment,in most cases with antibiotics.Treatment was costly and most CP patients were not satisfied with its effectiveness.Antibacterial treatment might have been effective primarily in patients with bacterial disease. | Chao-Zhao Liang Hong-Jun Li Zhi-Ping Wang Jun-Ping Xing Wei-Lie Hu Tao-Fu Zhang Wei-Wei Ge Zong-Yao Hao Xian-Sheng Zhang Jun Zhou Yu Li Zheng-Xing Zhou Zhi-Guo Tang | 2009 | Asian Journal of Andrology2009，11，2： | 27 |
| 8 | A Mitochondrial Genome Sequence of the Tibetan Antelope(Pantholops hodgsonii)显示文摘To investigate genetic mechanisms of high altitude adaptations of native mammalson the Tibetan Plateau, we compared mitochondrial sequences of the endangeredPantholops hodgsonii with its lowland distant relatives Ovis aries and Capra hir-cus, as well as other mammals. The complete mitochondrial genome of P. hodgsonii(16,498 bp) revealed a similar gene order as of other mammals. Because of tandemduplications, the control region of P. hodgsonii mitochondrial genome is shorterthan those of O. aries and C. hircus, but longer than those of Bos species. Phy-logenetic analysis based on alignments of the entire cytochrome b genes suggestedthat P. hodgsonii is more closely related to O. aries and C. hircus, rather than tospecies of the Antilopinae subfamily. The estimated divergence time between P.hodgsonii and O. aries is about 2.25 million years ago. Further analysis on natu-ral selection indicated that the COXI (cytochrome c oxidase subunit I) gene wasunder positive selection in P. hodgsonii and Bos grunniens. Considering the sameclimates and environments shared by these two mammalian species, we proposedthat the mitochondrial COXI gene is probably relevant for these native mammalsto adapt the high altitude environment unique to the Tibetan Plateau. | Shu-Qing Xu Ying-Zhong Yang Jun Zhou Guo-En Jing Yun-Tian Chen Jun Wang Huan-Ming Yang Jian Wang Jun Wu Xiao-Guang Zheng and Ri-Li Ge | 2005 | Genomics, Proteomics & Bioinformatics2005，3，1： | 22 |
| 9 | Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial显示文摘OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma. | Rixin Chen Mingren Chen Jun Xiong Zhenhai Chi B0 Zhang Ning Tian Zhenhua Xu Tangfa Zhang Wanyao Li Wei Zhang Xiaofeng Rong Zhen Wang Gang Sun Baohe Ge Guoxiong Yu Nanchang Song | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 10 | Efficacy and safety of Shexiang Baoxin pill(MUSKARDIA)in patients with stable coronary artery disease:a multicenter,double-blind,placebo-controlled phase IV randomized clinical trial显示文摘Background:The Shexiang Baoxin Pill(MUSKARDIA)has been used for treating coronary artery disease(CAD)and angina for more than 30 years in China.Nevertheless,methodologically sound trials on the use of MUSKARDIA in CAD patients are scarce.The aim of the study is to determine the effects of MUSKARDIA as an add-on to optimal medical therapy(OMT)in patients with stable CAD.Methods:A total of 2674 participants with stable CAD from 97 hospitals in China were randomized 1:1 to a MUSKARDIA or placebo group for 24 months.Both groups received OMT according to local tertiary hospital protocols.The primary outcome was the occurrence of a major adverse cardiovascular event(MACE),defined as a composite of cardiovascular death,non-fatal myocardial infarction(MI),or non-fatal stroke.Secondary outcomes included all-cause mortality,non-fatal MI,non-fatal stroke,hospitalization for unstable angina or heart failure,peripheral revascularization,angina stability and angina frequency.Results:In all,99.7%of the patients were treated with aspirin and 93.0%with statin.After 2 years of treatment,the occurrence of MACEs was reduced by 26.9%in the MUSKARDIA group(MUSKARDIA:1.9%vs.placebo:2.6%;odds ratio=0.80;95%confidence interval:0.45-1.07;P=0.2869).Angina frequency was significantly reduced in the MUSKARDIA group at 18 months(P=0.0362).Other secondary endpoints were similar between the two groups.The rates of adverse events were also similar between the two groups(MUSKARDIA:17.7%vs.placebo:17.4%,P=0.8785).Conclusions:As an add-on to OMT,MUSKARDIA is safe and significantly reduces angina frequency in patients with stable CAD.Moreover,the use of MUSKARDIA is associated with a trend toward reduced MACEs in patients with stable CAD.The results suggest that MUSKARDIA can be used to manage patients with CAD.Trial registration:chictr.org.cn,No.ChiCTR-TRC-12003513. | Jun-Bo Ge Wei-Hu Fan Jing-Min Zhou Hai-Ming Shi Fu-Sui Ji Yang Wu Yu-Lan Zhao Jun Qian Yuan-Zhe Jin Ying-Wu Liu Sheng-Huang Wang Sheng-Hu He Ping Yang Jie Wu Feng Lu Zi-Shan Hou | 2021 | Chinese Medical Journal2021，，2： | 17 |
| 11 | Deep-seated structure and metallogenic dynamics of the Ailaoshan polymetallic mineralization concentration area, Yunnan Province, China显示文摘The Ailaoshan poly-metallic mineralization concentrated area (MCA) consists of the well known Ailaoshan metallogenic belt and adjacent mineral districts and/or deposits. Located in an area of several complex and intersecting tectonic units, the Ailaoshan poly-metallic MCA is controlled by deep crustal and mantle tectonism. Through interpretation of remote sensing images, we identified a large ring structure system that surrounds the MCA. This ring structure encloses regional deep-crustal faults, ductile shear zones, geothermal anomalies, magmatic rocks, and the major mineral deposits, all of which are the reflections of deep tectonic geodynamics that have been long active in this area. Geophysical data indicate that the crust is comprised of relatively stable two or three layers, with some irregular lower-velocity belts. The Moho in the ring sutures occurs as an area of local uplift. There exists an obvious transitional zone between the crust and mantle boundaries. Asthenopheric mantle shows multi-layer upwelling, which indicates multiple events during different geological epochs. It is believed that these mantle events or pulses were responsible for the formation of the regional shear zones, magmatic rocks, and polymetallic orebodies. Furthermore, an integrated metallogenic dynamics model related to the asthenopheric upwelling pulses in the MCA is established, defining events as old as Late Paleozoic. | GE LiangSheng DENG Jun GUO XiaoDong ZOU YiLin LIU YinChun | 2009 | Science China Earth Sciences2009，52，10： | 16 |
| 12 | 经腹股沟及腹股沟下显微精索静脉结扎术:精索静脉曲张的最佳手术治疗方式的荟萃分析显示文摘以往精索静脉曲张各种治疗方法疗效的荟萃分析存在不一致的结果。因此,我们进行了多种干预措施的荟萃分析,评估10种精索静脉曲张栓塞/硬化治疗方法的有效性和安全性,包括腹腔镜、腹膜后开放、经腹股沟开放和腹股沟下开放静脉结扎,腹股沟下显微和经腹股沟显微精索静脉结扎术,经皮静脉栓塞,TauberJl~行硬化,硬化逆行和期待治疗(无处理)。我们系统回顾了从1966年至2013年8月的35个随机对照试验和观察性研究。经腹股沟、腹股沟下显微手术、腹股沟开放、腹腔镜精索静脉结扎与期待治疗相比显著提高夫妻怀孕率(优势比[OR]分别为:3.48,2.68,2.92和2.9)。与腹膜后开放手术相比,经腹股沟显微手术显著提高患者的精子密度(平均差【MD]:10.60,95%CI:1.92—19.60)并改善精子运动(MD:9.09,95%CI:4.88—13.30)。经腹股沟下和腹股沟显微手术在复发率方面的表现优于开放腹膜后手术(OR分别为0.05,O.06)。Tauber顺行硬化和腹股沟下显微精索静脉结扎术的鞘膜积液形成的风险最低。与腹膜后开放精索静脉曲张术相比,腹股沟显微精索静脉结扎术的总的并发症率最低(OR=O.07,95%CI:0.02。0.19)。其次是腹股沟下显微(OR:O.09,95%CI:0.02.0.19)。经腹股沟显微和腹股沟下显微精索静脉曲张结扎术对提高患者怀孕率有良好的效果,能显著增加精子数量,并有着较低的并发症率。本文研究结果仍需要经过良好设计的随机对照临床研究进一步证实。 | Jun Wang Shu-Jie Xia Zhi-Hong Liu Le Tao Ji-Fu Ge Chen-Min Xu Jian-Xin Qiu | 2015 | Asian Journal of Andrology2015，17，1： | 16 |
| 13 | Plasmacytoid Dendritic Cell Function and Cytokine Network Profiles in Patients with Acute or Chronic Hepatitis B Virus Infection显示文摘 | Ming-Hui Li Lu Zhang Dan Zhang Wei-Hua Cao Tian-Lin Qi Hong-Xiao Hao Xing-Yue Wang Chong-Ping Ran Xiao-Jing Qu Shun-Ai Liu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Wen-Hao Hua Gang Wan Jun Cheng Yao Xie | 2018 | Chinese Medical Journal2018，，1： | 16 |
| 14 | Distribution of wire deformation within strands of wire ropes显示文摘Using ANSYS software, we developed a modeling program for several kinds of wire ropes with metal cores and built a geometric model for the 6×19 IWS wire rope. Through proper grid partitioning, a finite element model for calculating the deforma-tion of wire rope was obtained. Completely constraining one end of the wire rope and applying an axial force to the other end, we established the boundary conditions for solving the model. In addition, we numerically simulated the stress and deformation of the wire, obtaining the deformation distribution of each wire within the wire rope under different laying directions. At the end, a tensile test of the 6×19 IWS wire rope was carried out and the results of simulation and experiment compared. | MA Jun GE Shi-rong ZHANG De-kun | 2008 | Journal of China University of Mining and Technology2008，18，3： | 15 |
| 15 | Effect of Kuanxiong Aerosol(宽胸气雾剂)on Patients with Angina Pectoris:A Non-inferiority Multi-center Randomized Controlled Trial显示文摘Objective: To evaluate the effect and safety of Kuanxiong Aerosol(宽胸气雾剂, KA) on patients with angina pectoris. Methods: Block randomization was performed to randomly allocate 750 patients into KA(376 cases) and control groups(374 cases). During an angina attack, the KA group received 3 consecutive sublingual sprays of KA(0.6 m L per spray). The control group received 1 sublingual nitroglycerin tablet(NT, 0.5 mg/tablet). Log-rank tests and Kaplan-Meier estimations were used to estimate the angina remission rates at 6 time-points after treatment(1, 2, 3, 4, 5, and >5 min). Logistic regression analysis was performed to observe the factors influencing the rate of effective angina remission, and the remission rates and incidences of adverse reactions were compared for different Canadian Cardiovascular Society(CCS) classes of angina. Results: The 5-min remission rates in the KA and control groups were not significantly different(94.41% vs. 90.64%, P>0.05). The angina CCS class significantly influenced the rate of remission (95% confidence interval = 0.483–0.740, P<0.01). In the CCS subgroup analysis, the 3-and 5-min remission rates for KA and NT were similar in the CCSⅠ and Ⅳ subgroups(P>0.05), while they were significantly better for KA in the CCSⅡ and Ⅲ subgroups(P<0.05 or P<0.01). Furthermore, the incidence of adverse reactions was significantly lower in the KA group than in the control group for the CCSⅡ and Ⅲ subgroups(9.29% vs. 26.22%, 10.13% vs. 20.88%, P<0.05 or P<0.01). Conclusions: KA is not inferior to NT in the remission of angina. Furthermore, in CCSⅡ and Ⅲ patients, KA is superior to NT, with a lower incidence of adverse reactions. | YANG Qiao-ning BAI Rui-na DONG Guo-ju GE Chang-jiang ZHOU Jing-min HUANG Li HE Yan WANG Jun REN Ai-hua HUANG Zhan-quan ZHU Guang-li LU Shu XIONG Shang-quan XIAN Shao-xiang ZHU Zhi-jun SHI Da-zhuo LU Shu-zheng LI Li-zhi CHEN Ke-ji | 2018 | Chinese Journal of Integrative Medicine2018，24，5： | 15 |
| 16 | Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a显示文摘AIM: To examine the association between interferon(IFN) therapy and loss of hepatitis B surface antigen(HBs Ag) in inactive HBs Ag carriers. METHODS: This was a retrospective cohort study in inactive HBs Ag carriers, who were treatment-naive, with a serum HBs Ag level < 100 IU/m L and an undetectable hepatitis B virus(HBV) DNA level(< 100 IU/m L). All the 20 treated patients received subcutaneous PEG-IFN alfa-2a 180 μg/wk for 72 wk and were then followed for 24 wk. There were 40 untreated controls matched with 96 wk of observation. Serum HBs Ag, HBV DNA, and alanine aminotransferases were monitored every 3 mo in the treatment group and every 3-6 mo in the control group. RESULTS: Thirteen(65.0%) of 20 treated patients achieved HBs Ag loss, 12 of whom achieved HBs Ag seroconversion. Mean HBs Ag level in treated patients decreased to 6.69 ± 13.04 IU/m L after 24 wk of treatment from a baseline level of 26.22 ± 33.00 IU/m L. Serum HBV DNA level remained undetectable(< 100 IU/m L) in all treated patients during the study. HBs Ag level of the control group decreased from 25.72 ± 25.58 IU/m L at baseline to 17.11 ± 21.62 IU/m L at week 96(P = 0.108). In the control group, no patient experienced HBs Ag loss/seroconversion, and two(5.0%) developed HBV reactivation.CONCLUSION: IFN treatment results in HBs Ag loss and seroconversion in a considerable proportion of inactive HBs Ag carriers with low HBs Ag concentrations. | Ming-Hui Li Yao Xie Lu Zhang Yao Lu Ge Shen Shu-Ling Wu Min Chang Cai-Qin Mu Lei-Ping Hu Wen-Hao Hua Shu-Jing Song Shu-Feng Zhang Jun Cheng Dao-Zhen Xu | 2016 | World Journal of Hepatology2016，8，15： | 15 |
| 17 | LYRM03, an ubenimex derivative, attenuates LPS- induced acute lung injury in mice by suppressing the TLR4 signaling pathway显示文摘像使用费的受体(TLR4 ) 4 调停了表明戏在导致败血的尖锐的肺损害(ALI ) 的一个关键角色。LYRM03 (3-amino-2-hydroxy-4-phenyl-valyl-isoleucine ) 是 ubenimex 的新奇衍生物,广泛地使用的 antineoplastic 药。我们以前发现 LYRM03 在盲肠的结扎刺老鼠模型有反煽动性的效果。在这研究,我们决定了 LYRM03 是否在老鼠稀释了导致 LPS 的 ALI。导致 LPS 的 ALI 老鼠模型被与 LPS (5 mg/kg ) 的 intratracheal 注射质问老鼠建立,它随后与 LYRM03 被对待(10 mg/kg, ip ) 。LYRM03 管理显著地减轻了导致 LPS 的肺浮肿,煽动性的房间(neutrophils 和巨噬细胞) 渗入和 myeloperoxidase (军邮局) 活动,减少的支持 inflammatory 和趋化性的 cytokine (TNF- , IL-6, IL-1, MIP-2 ) 产生和在肺纸巾的 COX-2 表示。在有教养的老鼠在 vitro 的牙槽的巨噬细胞,有 LYRM03 (100 mol/L ) 的预告的处理由减少 Myd88 表示,增加 IB 稳定性并且禁止 p38 phosphorylation 压制了导致 LPS 的巨噬细胞激活。这些结果建议 LYRM03 有效地由在牙槽的巨噬细胞禁止支持 inflammatory 调停人和 Myd88 依赖的 TLR4 发信号小径的表示稀释导致 LPS 的 ALI。LYRM03 可以为调停败血的肺损害用作一个潜在的处理。 | Hui-qiong HE Ya-xian WU Yun-juan NIE Jun WANG Mei GE Feng QIAN | 2017 | Acta Pharmacologica Sinica2017，38，3： | 14 |
| 18 | The role of capsule endoscopy combined with double-balloon enteroscopy in diagnosis of small bowel diseases显示文摘小肠疾病的诊断仍然是相对低效的使用的背景传统的成像 techniques.Capsule 内视镜检查法(CE ) 和双汽球 enteroscopy (DBE ) 是为检验全部小肠的 enteroscopy 的二个新奇方法。这研究的目的是与怀疑的小肠疾病在病人评估察觉率和 CE 和 DBE 的诊断精确性并且调查这二新奇 modalities.Methods 的联合使用的临床的意义 218 个病人为怀疑的小肠疾病被评估,与阴暗胃肠的流血包括 116 并且 102 阴暗腹的疼痛或长期的腹泻地。165 首先从这些病人经历了 CE, 53 个病人经历了 DBE (在有 propofol 的麻醉下面) 第一。DBE 在 CE 和钳子上在否定或暖昧的评估以后被推荐。内诊镜的介绍口头上地或肛门地在 DBE 期间是,当没有畸形在第一个过程上被发现时,病人几天以后用相反的线路为第二个过程被提交。这二种形式的不利事件的察觉率,诊断精确性,忍耐和频率当时是过程的 analyzed.Results 失败与 DBE 与 CE 并且在二个病人在一个病人被看见。64 个 DBE 过程在 51 个病人被执行;由在 34 种情况中的口头的线路,在 4 的肛门线路和两个用 CE 处于小肠疾病的 13 cases.The 外套察觉率发送(72.0% , 118/164 ) 与 DBE (41.2%,21/51 ) 比那优异;2=16.1218, P0.0001。诊断的率(51.8% , 85/164 ) 与后者过程也比那高(39.2% , 20/51 ) ,但是不是显著地不同的(2=2.4771, P0.05 ) 。而且,在有用 CE 的阴暗胃肠的流血的病人的小肠疾病的察觉率(88.0% , 88/100 ) 比 DBE (60.0%,9/15 ) 的优异;2=7.7457, P=0.0054。损害被 DBE 从 CE 由 CE 在有否定 result.Suspected 调查结果的 4 个病人在 1 检测被从 15 个病人在 12 与活体检视相结合的 DBE 证实。在另一方面,小肠损害被 DBE 被 CE 在否定评估以后在所有 3 个病人识别。由 CE 的小肠疾病的察觉率是的二 procedures.Conclusions 没有严重复杂并发症在期间或在也以后很高。CE 应该与怀疑的小肠疾病在病人为起始的诊断被选择,特别在有阴暗胃肠的 bleeding.DBE 的病人看起来低于在小肠疾病的诊断的 CE。然而,畸形能被 DBE 仍然与正常图象在病人识别或过去常从 CE 证实怀疑的调查结果,这被显示出。DBE 能也用 CE 在起始的诊断成像以后用作一条好互补途径。 | LI Xiao-bo GE Zhi-zheng DAI Jun GAO Yun-jie LIU Wen-zhong HU Yun-biao XIAO Shu-dong | 2007 | Chinese Medical Journal2007，，1： | 13 |
| 19 | Synthesis and characterization of lower generation broom molecules显示文摘与亢奋的分支被迈克尔增加与 dodecylamine 和甲基压克力在甲醇综合的十二烷基组一起的树枝状的分子作为原料吃了。这新型的树枝状的分子生动地被叫“在这的扫帚分子”报导。扫帚分子的水溶液的表面张力解雇了氨基的组被使用落下卷方法测量。为油 / 水(O/W ) 的扫帚分子的反乳化表演模仿了原油乳状液被检验。试验性的结果揭示了那,作为一表面活化剂新型,扫帚分子解雇了为 O/W 给反乳化看的氨基的组模仿的原油乳状液。 | Jun Wang Cui Qin Li Shu Yan Zhang Fang Sun Teng Jie Ge | 2008 | Chinese Chemical Letters2008，19，1： | 13 |
| 20 | Multi-walled carbon nanotubes added to Na_2CO_3/MgO composites for thermal energy storage显示文摘Na_2CO_3/MgO composites with added multi-walled carbon nanotubes(MWCNTs) were prepared and tested as phase change materials(PCMs) for thermal energy storage.Na_2CO_3/MgO composite PCMs were prepared and their chemical compatibility and thermal stability were studied.MWCNTs introduced with Na_2CO_3/MgO composite PCMs were also investigated and scanning electron microscopy(SEM) characterization was used to demonstrate the uniform dispersion of MWCNTs in Na2C03/MgO composite PCMs.The composites with added MWCNTs still display good thermal stability with mass losses lower than 5%.Introducing MWCNTs into composite Na_2CO_3/MgO PCMs by material formation/calcination significantly enhances the thermal conductivity of the composite PCMs.The thermal conductivity of the composite PCMs was found to increase with an increase in the weight fraction of the added MWCNTs and an increase in the testing temperature.This study may present a promising way to prepare high temperature phase change materials with superior properties such as improved thermal stability. | Feng Ye Zhiwei Ge Yulong Ding Jun Yang | 2014 | Particuology2014，12，4： | 13 |
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