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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | Approach to the endoscopic resection of duodenal lesions显示文摘Duodenal polyps or lesions are uncommonly found on upper endoscopy. Duodenal lesions can be categorized as subepithelial or mucosally-based, and the type of lesion often dictates the work-up and possible therapeutic options. Subepithelial lesions that can arise in the duodenum include lipomas, gastrointestinal stromal tumors, and carcinoids. Endoscopic ultrasonography with fine needle aspiration is useful in the characterization and diagnosis of subepithelial lesions. Duodenal gastrointestinal stromal tumors and large or multifocal carcinoids are best managed by surgical resection. Brunner's gland tumors, solitary Peutz-Jeghers polyps, and non-ampullary and ampullary adenomas are mucosally-based duodenal lesions, which can require removal and are typically amenable to endoscopic resection. Several anatomic characteristics of the duodenum make endoscopic resection of duodenal lesions challenging. However, advanced endoscopic techniques exist that enable the resection of large mucosally-based duodenal lesions. Endoscopic papillectomy is not without risk, but this procedure can effectively resect ampullary adenomas and allows patients to avoid surgery, which typically involves pancreaticoduodenectomy. Endoscopic mucosal resection and its variations(such as cap-assisted, cap-band-assisted, and underwater techniques) enable the safe and effective resection of most duodenal adenomas. Endoscopic submucosal dissection is possible but very difficult to safely perform in the duodenum. | Jonathan P Gaspar Edward B Stelow Andrew Y Wang | 2016 | World Journal of Gastroenterology2016，22，2： | 17 |
| 3 | Effect of dephytinization on bioavailability of iron,calcium and zinc from infant cereals assessed in the Caco-2 cell model显示文摘AIM:To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells.METHODS:Both dephytinized (by adding an exogenous phytase) and non-dephytinized infant cereals were digested using an in vitro digestion protocol adapted to the gastrointestinal conditions of infants younger than 6 mo. Mineral cell retention, transport, and uptake from infant cereals were measured using the soluble fraction of the simulated digestion and the Caco-2 cells. RESULTS: Dephytinization of infant cereals significantly increased (P<0.05) the cell uptake efficiency (from 0.66%-6.05% to 3.93%-13%), retention (from 6.04%-16.68% to 14.75%-20.14%) and transport efficiency (from 0.14%-2.21% to 1.47%-6.02%), of iron, and the uptake efficiency (from 5.0%-35.4% to 7.3%-41.6%) and retention (from 4.05%-20.53% to 14.45%-61.3%) of zinc, whereas calcium only cell uptake showed a significant increase (P<0.05) after removing phytate from most of the samples analyzed. A positive relationship (P<0.05) between mineral solubility and the cell uptake and transport efficiencies was observed.CONCLUSION: Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water. Since in developing countries cereal-based complementary foods for infants are usually consumed mixed with water, exogenous phytase additions could improve the nutritional value of this weaning food. | Carmen Frontela Maria Laura Scarino Simonetta Ferruzza Gaspar Ros Carmen Martínez | 2009 | World Journal of Gastroenterology2009，15，16： | 7 |
| 4 | Two Axes Solar Tracker Based on Solar Maps, Controlled by a Low-Power Microcontroller显示文摘 | F. Duarte P.D. Gaspar L.C. Goncalves | 2011 | Journal of Energy and Power Engineering2011，5，7： | 3 |
| 5 | CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis显示文摘 | Matilde Todaro Miriam Gaggianesi Veronica Catalano Antonina Benfante Flora Iovino Mauro Biffoni Tiziana Apuzzo Isabella Sperduti Silvia Volpe Gianfranco Cocorullo Gaspare Gulotta Francesco Dieli Ruggero De Maria Giorgio Stassi | 2014 | Cell Stem Cell2014，，3： | 3 |
| 6 | Local Ablative Therapy of Oligoprogressive Disease Prolongs Disease Control by Tyrosine Kinase Inhibitors in Oncogene-Addicted Non–Small-Cell Lung Cancer显示文摘 | Andrew J. Weickhardt Benjamin Scheier Joseph Malachy Burke Gregory Gan Xian Lu Paul A. Bunn Dara L. Aisner Laurie E. Gaspar Brian D. Kavanagh Robert C. Doebele D. Ross Camidge | 2012 | Journal of Thoracic Oncology2012，，12： | 3 |
| 7 | Conformal and continuous deposition of bifunctional cobalt phosphide layers on p-silicon nanowire arrays for improved solar hydrogen evolution显示文摘垂直地排列的 p 硅 nanowire (SiNW ) 数组广泛地为太阳开车的氢进化作为有希望的光阴极在最近的年里被调查了。然而,有用一条简单、买得起的途径的两项高 photoelectrocatalytic 活动和长期的运作的稳定性的 SiNW 光阴极的制造是一项挑战性的任务。此处,我们报导 di 钴磷化物的保角、连续的免职(公司 2 P ) 经由一个划算的扔落下的方法的平版印刷术有图案的高度订的 SiNW 数组上的层由一个低温度的 phosphorization 处理列在后面。同样扔的公司 2 P 层由水晶的 nanoparticles 组成并且与 SiNWs 有亲密接触,形成明确的 SiNW@Co 2 P 核心 / 壳 nanostructure。保角、连续的公司 2 P 层作为能够实质地为氢进化反应改进 photoelectrocatalytic 活动的高度有效的催化剂工作(她的) 并且有效地使钝化保护他们免受相片氧化的伤害的 SiNWs,因此延长电极的一生。作为 aconsequence, SiNW@Co 2 有优化公司 2 P 层厚度展出一个高光电流密度 of-21.9 妈 ? 獡愠 ? 汥' 虪箳椰嬑郢 G? 祢愠猠牴楡桧晴牯慷摲洠汯整 ?慳瑬猠湹桴獥獩愠灰潲捡 | Sitaramanjaneva Mouli Thalluri Jerome Borme Kang Yu Junyuan Xu Isilda Amorim Joao Gaspar Liang Qiao Paulo Ferreira Pedro Alpuim Lifeng Liu | 2018 | Nano Research2018，11，9： | 2 |
| 8 | Endoscopic retrograde cholangiography for intrabiliary rupture of hydatid cyst显示文摘 | Gaspare Galati Antonio V. Sterpetti Maria Caputo Marianna Adduci Giorgio Lucandri Stefania Brozzetti Antonio Bolognese Antonino Cavallaro | 2006 | The American Journal of Surgery2006，，2： | 2 |
| 9 | Metabolic surgery and intestinal gene expression:Digestive tract and diabetes evolution considerations显示文摘AIM: To investigate the effects of bariatric surgery on metabolic parameters, incretin hormone secretion, and duodenal and ileal mucosal gene expression.METHODS: Nine patients with type 2 diabetes mellitus(T2DM), chronic serum hyperglycemia for more than2 years, and a body mass index(BMI) of 30-35 kg/m2 underwent metabolic surgery sleeve gastrectomy with transit bipartition between May 2011 and December2011. Blood samples were collected pre and 3, 6 and12 mo postsurgery. Duodenal and ileal mucosa samples were collected pre- and 3 mo postsurgery. Pre- and postoperative blood samples were collected in the fasting state before ingestion of a standard meal(520kcal) and again 30, 60, 90, and 120 min after the mealto determine hemoglobin A1c(HbA1c) levels and the lipid profile, which consisted of triglyceride and total cholesterol levels. Intestinal gene expression of p53 and transforming growth factor(TGF)-β was analyzed using quantitative reverse-transcription PCR. Gastric inhibitory polypeptide(GIP) and glucagon-like peptide-1(GLP-1)were quantified using the enzyme-linked immunoassay method and analyzed pre- and postoperatively.Student's t test or repeated measurements analysis of variance with Bonferroni corrections were performed as appropriate.RESULTS: BMI values decreased by 15.7% within the initial 3 mo after surgery(31.29 ± 0.73 vs 26.398± 0.68, P < 0.05) and then stabilized at 22% at 6mo postoperative, resulting in similar values 12 mo postoperatively(20-25 kg/m2). All of the patients experienced improved T2 DM, with 7 patients(78%)achieving complete remission(HbA1c < 6.5%), and 2patients(22%) achieving improved diabetes(HbA1c< 7.0% with or without the use of oral hypoglycemic agents). At 3 mo postoperatively, fasting plasma glucose had also decreased(59%)(269.55 ±18.24 mg/dL vs 100.77 ± 3.13 mg/dL, P < 0.05)with no further significant changes at 6 or 12 mo postoperatively. In the first month postoperatively,there was a complete withdrawal of hypoglycemic medications in all patients, who were taking at least2 hypoglycemic drugs preoperatively. GLP-1 levels significantly increased after surgery(149.96 ± 31.25 vs220.23 ± 27.55)(P < 0.05), while GIP levels decreased but not significantly. p53 gene expression significantly increased in the duodenal mucosa(P < 0.05, 2.06 fold)whereas the tumor growth factor-β gene expression significantly increased(P < 0.05, 2.52 fold) in the ileal mucosa after surgery.CONCLUSION: Metabolic surgery ameliorated diabetes in all of the patients, accompanied by increased antiproliferative intestinal gene expression in non-excluded segments of the intestine. | Marcos Ricardo da Silva Rodrigues Marco Aurelio Santo Giovani Marino Favero Elaine Cristina Vieira Roberto Ferreira Artoni Viviane Nogaroto Egberto Gaspar de Moura Patricia Lisboa Fabio Quirillo Milleo | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 10 | Folate targeted coated SPIONs as efficient tool for MRI显示文摘The development of more sensitive diagnostic tools allowing an early-stageand highly efficient medical imaging of tumors remains a challenge. Magneticnanoparticles seem to be the contrast agents with the highest potential, if properlyconstructed. Therefore, in this study, hybrid magnetic nanoarchitectures weredeveloped using a new amphiphilic inulin-based graft copolymer (INU-LA-PEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe304)superparamagnetic nanoparticles (SPION). Folic acid (FA) covalently linked tothe coating copolymer in order to be exposed onto the nanoparticle surface waschosen as the targeting agent because folate receptors are upregulated in manycancer types. Physicochemical characterization and in vitro biocompatibilitystudy was then performed on the prepared magnetic nanoparticles. The improvedtargeting and imaging properties of the prepared FA-SPIONs were furtherevaluated in nude mice using 7-Tesla magnetic resonance imaging (MRI).FA-SPIONs exhibited the ability to act as efficient contrast agents in conventionalMRI, providing a potential nanoplatform not only for tumor diagnosis but alsofor cancer treatment, through the delivery of anticancer drug or locoregional magnetic hvverthermia. | Cinzia Scialabba Roberto Puleio Davide Peddis Gaspare Varvaro Pietro Calandra Giovanni Cassata Luca Cicero Mariano Licciardi Gaetano Giammona | 2017 | Nano Research2017，10，9： | 2 |
| 11 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 12 | Finite element model with imposed slip surfaces for earth mass safety evaluation显示文摘The study of earth masses requires numerical methods that provide the quantification of the safety factor without requiring detrimental assumptions. For that, equilibrium analysis can perform fast computations but require assumptions that limit its potentiality. Limit analysis does not require detrimental assumptions but are numerically demanding. This work provides a new approach that combines the advantage of both the equilibrium method and the limit analysis. The defined hybrid model allows probabilistic analysis and optimization approaches without the assumption of interslice forces. It is compared with a published case and used to perform probabilistic studies in both a homogeneous and a layered foundation. Analyses show that the shape of the density probability functions is highly relevant when computing the probability of failure, and soil elasticity hardly affects the safety of factor of the earth mass. | Nuno ARAUJO Gaspar J.MACHADO Julio B.MARTINS Hugo M.R.D.SILVA | 2014 | Journal of Central South University2014，21，9： | 2 |
| 13 | 能否用协调变异性识别运动员的竞技表现和竞技水平?——以竞走为例(英文)显示文摘Background:Marginal changes in the execution of competitive sports movements can represent a significant change for performance success.However,such differences may emerge only at certain execution intensities and are not easily detectable through conventional biomechanical techniques.This study aimed to investigate if and how competition standard and progression speed affect race walking kinematics from both a conventional and a coordination variability perspective.Methods:Fifteen experienced athletes divided into three groups(elite,international,and national) were studied while race walking on a treadmill at two different speeds(12.0 and 15.5 km/h).Basic gait parameters,the angular displacement of the pelvis and lower limbs,and the variability in continuous relative phase between six different joint couplings were analyzed.Results:Most of the spatio-temporal,kinematic,and coordination variability measures proved sensitive to the change in speed.Conversely,non-linear dynamics measures highlighted differences between athletes of different competition standard when conventional analytical tools were not able to discriminate between different skill levels.Continuous relative phase variability was higher for national level athletes than international and elite in two couplings(pelvis obliquity—hip flex/extension and pelvis rotation—ankle dorsi/plantarflexion) and gait phases(early stance for the first coupling,propulsive phase for the second) that are deemed fundamental for correct technique and performance.Conclusion:Measures of coordination variability showed to be a more sensitive tool for the fine detection of skill-dependent factors in competitive race walking,and showed good potential for being integrated in the assessment and monitoring of sports motor abilities. | Dario Cazzola Gaspare Pavei Ezio Preatoni | 2016 | Journal of Sport and Health Science2016，5，1： | 2 |
| 14 | Preclinical development of siRNA therapeutics: Towards the match between fundamental science and engineered systems显示文摘 | M. Videira A. Arranja D. Rafael R. Gaspar | 2013 | Nanomedicine: Nanotechnology, Biology, and Medicine2013，，： | 2 |
| 15 | Extrahepatic portal vein aneurysm: Report of a case treated by thrombectomy and aneurysmorrhaphy显示文摘 | Sidney Glazer MD Max R. Gaspar MD Vincent Esposito MD Lawrence Harrison MD | 1992 | Annals of Vascular Surgery1992，，4： | 2 |
| 16 | Pleiotropic effects of lactate dehydrogenase inactivationin Lactobacillus casei显示文摘 | María J José L G Vicente M Gaspar P | 2005 | Research in Microbiology2005，156，： | 1 |
| 17 | Paclitaxelloaded plga nanoparticles : preparation, physicochemical characterization and in vitro anti-tumoral activity显示文摘 | Cristina Fonseca Sergio Simoes Rogerio Gaspar | 2002 | J controlled Release2002，83，： | 1 |
| 18 | X- Ray diffraction investigations of concentrated aqueous solutions of calcium halides显示文摘 | Gaspar M Alves Marques M Cabaco M I | 2004 | Mol Liq2004，110，： | 1 |
| 19 | Ratio between positive lymph no- and total dissected axillaries lymph nodes as an independent prognostic factor for disease free survival in patients with breast caneer显示文摘 | Megale Costa L J Soares H P Gaspar H A | 2004 | Am J Clin Oncol2004，27，3： | 1 |
| 20 | A xylan hydrolase gene clusterin Prevotella ruminicola B (l)4:Sequence relationships,synergisticin-teractions’and oxygen sensitivity of a novel enzyme with exoxy-lanase and beta-(l,4) - xylosi dase activities 显示文摘 | Gasparic A Martin J Daniel A S | 1995 | Environ microbi-ol1995，61，8： | 1 |
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