|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of inflammatory response in liver diseases: Therapeutic strategies显示文摘Inflammation and tumorigenesis are tightly linked pathways impacting cancer development. Inflammasomes are key signalling platforms that detect pathogenic microorganisms, including hepatitis C virus(HCV) infection, and sterile stressors(oxidative stress, insulin resistance, lipotoxicity) able to activate pro-inflammatory cytokines interleukin-1β and IL-18. Most of the inflammasome complexes that have been described to date contain a NOD-like receptor sensor molecule. Redox state and autophagy can regulate inflammasome complex and, depending on the conditions, can be either pro-or antiapoptotic. Acute and chronic liver diseases are cytokinedriven diseases as several proinflammatory cytokines(IL-1α, IL-1β, tumor necrosis factor-alpha, and IL-6) are critically involved in inflammation, steatosis, fibrosis, and cancer development. NLRP3 inflammasome gain of function aggravates liver disease, resulting in severe liver fibrosis and highlighting this pathway in the pathogenesis of non-alcoholic fatty liver disease. On the other hand, HCV infection is the primary catalyst for progressive liver disease and development of liver cancer. It is well established that HCV-induced IL-1β production by hepatic macrophages plays a critical and central process that promotes liver inflammation and disease. In this review, we aim to clarify the role of the inflammasome in the aggravation of liver disease, and how selective blockade of this main pathway may be a useful strategy to delay fibrosis progression in liver diseases. | José A Del Campo Paloma Gallego Lourdes Grande | 2018 | World Journal of Hepatology2018，10，1： | 25 |
| 2 | Determining indoor air quality and identifying the origin of odour episodes in indoor environments显示文摘A methodology for identifying volatile organic compounds(VOCs) and determining air quality of indoor air has been developed.The air samples are collected using pump samplers by the inhabitants when they perceive odorous and/or discomfort episodes.Glass multi-sorbent tubes are connected to the pump samplers for the retention of VOC.The analysis is performed by automatic thermal desorption(ATD) coupled with gas chromatography-mass spectrometry(GC/MS).This methodology can be applied in cases of sick building syndrome(SBS) evaluation,in which building occupants experience a series of varied symptoms that appear to be linked to time spent in the building.Chemical pollutants concentrations(e.g.,VOC) have been described to contribute to SBS.To exemplify the methodology,a qualitative determination and an evaluation of existing VOC were performed in a dwelling where the occupants experienced the SBS symptoms.Higher total VOC(TVOC) levels were detected during episodes in indoor air(1.33 ± 1.53 mg/m3) compared to outdoor air(0.71 ± 0.46 mg/m3).The concentrations of individual VOCs,such as ethanol,acetone,isopropanol,1-butanol,acetic acid,acetonitrile and 1-methoxy-2-propanol,were also higher than the expected for a standard dwelling.The external source of VOC was found to be an undeclared activity of storage and manipulation of solvents located at the bottom of a contiguous building. | Eva Gallego Xavier Roca Jose Francisco Perales Xavier Guardino | 2009 | Journal of Environmental Sciences2009，21，3： | 14 |
| 3 | 基于体波有限频层析成像的青藏高原南部和中部下方印度大陆岩石层俯冲和撕裂的三维图像显示文摘使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印度大陆岩石层(ICL)。印度大陆岩石层似乎在青藏高原中部比东部向北延伸更多——沿85°E在31°N到达350km深处,而沿91°E则是在30°N到达350km深度。P波和S波低速异常区在当惹雍错裂谷、亚东—谷露裂谷和错那裂谷下方从下地壳延伸至≥180km深度,这表明青藏高原南部的裂谷可能包含了整个岩石层的变形。当惹雍错裂谷下方的异常区向下延伸到约180km,而亚东—谷露裂谷西部和错那裂谷东部的异常延伸到了超过300km的深度。亚东—谷露裂谷西部的低速区上地幔延伸至最北,并且似乎与青藏高原中部下方广阔的上地幔低速区相连。于是,北向俯冲的印度板块沿着南北走向的裂缝撕裂。这些裂缝允许或者导致的软流层上涌同青藏高原北部上地幔相类似。 | Xiaofeng Liang Yun Chen Xiaobo Tian Yongshun John Chen James Ni Andrea Gallegos Simon L.Klemperer Minling Wang Tao Xu Changqing Sun Shaokun Si Haiqiang Lan Jiwen Teng 左思成 | 2016 | 世界地震译丛2016，47，6： | 8 |
| 4 | CCl_4诱导肝损伤对大鼠细胞免疫功能的影响显示文摘J.Gonzalez Gallego | 王丙云 陈龙 毛鑫智 J.GonzalezGallego | 1999 | 世界华人消化杂志1999，7，12： | 8 |
| 5 | The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle显示文摘Carbamoyl phosphate synthetase 1(CPS1) deficiency(CPS1D) is an inborn error of the urea cycle having autosomal(2q34) recessive inheritance that can cause hyperammonemia and neonatal death or mental retardation. We analyzed the effects on CPS1 activity, kinetic parameters and enzyme stability of missense mutations reported in patients with CPS1 deficiency that map in the 20-k Da C-terminal domain of the enzyme. This domain turns on or off the enzyme depending on whether the essential allosteric activator of CPS1, N-acetylL-glutamate(NAG), is bound or is not bound to it. To carry out the present studies, we exploited a novel system that allows the expression in vitro and the purification of human CPS1, thus permitting site-directed mutagenesis. These studies have clarified disease causation by individual mutations, identifying functionally important residues, and revealing that a number of mutations decrease the affinity of the enzyme for NAG. Patients with NAG affinity-decreasing mutations might benefit from NAG site saturation therapy with N-carbamyl-Lglutamate(a registered drug, the analog of NAG). Our results, together with additional present and prior site-directed mutagenesis data for other residues mapping in this domain, suggest an NAG-triggered conformational change in the b4-a4 loop of the C-terminal domain of this enzyme. This change might be an early event in the NAG activation process. Molecular dynamics simulations that were restrained according to the observed effects of the mutations are consistent with this hypothesis, providing further backing for this structurally plausible signaling mechanism by which NAG could trigger urea cycle activation via CPS1. | Carmen Díez-Fernández José Gallego Johannes H?berle Javier Cervera Vicente Rubio | 2015 | Journal of Genetics and Genomics2015，42，5： | 7 |
| 6 | Management of primary achalasia: The role of endoscopy显示文摘Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment. | Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 5 |
| 7 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 8 | 实验感染肝片吸虫水牛血液和肝中NO和TNF-α变化的研究显示文摘用酶法和放射免疫方法测定20 头健康水牛血清及肝匀浆中一氧化氮( N O) 和肿瘤坏死因子α( T N Fα) ,研究了水牛血液和肝组织中 N O 和 T N Fα的正常水平以及感染肝片吸虫后的动态变化。结果慢性、急性感染组水牛血清 N O 含量均从感染肝片吸虫后第3 周开始逐渐升高,并在第5 、7 、11 、13 周显著高于对照组,以后一直在高于对照组的水平波动,直至试验结束;感染肝片吸虫的水牛肝组织 N O 含量也高于对照组。慢性和急性感染组水牛血清 T N Fα都从感染后第5周开始升高,并分别在第7 、15 、21 周和13 、17 周显著或极显著高于对照组。且反映肝损伤的特征性酶谷草转氨酶( A S T) 、谷氨酸脱氢酶( G L D H) 和γ谷氨酰转肽酶( G G T) 在不同时期均有不同程度的升高。结果提示, N O 和 T N Fα可能参与宿主抗肝片吸虫和介导肝片吸虫诱导肝损伤的过程。 | 王丙云 陈龙 毛鑫智 J.GonzalezGallego | 1999 | 中国兽医科技1999，29，9： | 5 |
| 9 | 声发射层析成像技术在混凝土结构中的应用显示文摘针对传统声发射源定位算法(如时差定位)应用于各向异性介质的局限性,将声发射层析成像方法(AE tomography)引入混凝土结构损伤定位,该算法以声发射事件作为点源,结合源定位算法和层析成像算法,通过波速变化重建物体结构缺陷(损伤)的慢度图,既适合于各向同性材料,也适合于各向异性材料.为了验证提出算法的可行性,制作了有和无钢筋2个不同结构的混凝土样本并通过了实验.实验结果表明所提出的方法不仅能通过声发射波速度变化实现损伤定位的可视化,而且相对于传统定位算法,混凝土样本结构缺陷(损伤)的定位精度也获得了进一步提高. | 江煜 许飞云 许丙胜 Elisabet Suárez Antolin Gallego | 2014 | 东南大学学报(自然科学版)2014，44，4： | 3 |
| 10 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn’s Disease显示文摘 | Ingrid Ordás Jordi Rimola Sonia Rodríguez José M. Paredes María J. Martínez-Pérez Esther Blanc Juan A. Arévalo Marta Aduna Montserrat Andreu Alexander Radosevic Anna M. Ramírez-Morros Susana Pinó Marta Gallego Aranzazu Jauregui-Amezaga Elena Ricart Julián | 2013 | Gastroenterology2013，，： | 3 |
| 11 | Multicenter phase II study of oxaliplatin and sorafenib in advanced gastric adenocarcinoma after failure of cisplatin and fluoropyrimidine treatment. A gemcad study显示文摘 | M. Martin-Richard R. Gallego C. Pericay J. Garcia Foncillas B. Queralt E. Casado J. Barriuso V. Iranzo I. Juez L. Visa E. Saigi A. Barnadas X. Garcia-Albeniz J. Maurel | 2013 | Investigational New Drugs2013，，6： | 2 |
| 12 | Risk of developing tuberculosis under anti-TNF treatment despite latent infection screening显示文摘 | Aranzazu Jauregui-Amezaga Fanny Turon Ingrid Ordás Marta Gallego Faust Feu Elena Ricart Julián Panés | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 13 | syndecan-1和-2表达形式的变化可以预测前列腺癌生化复发显示文摘前列腺癌的临床特点不能准确确定患者是否会发生生化复发,因而不适合作为预后和复发的指标。需要新的分子标记物对患者进行适当的术前风险分层。本研究旨在评估syndecan-1和-2的表达改变是否可以预测临床局限性前列腺癌患者行前列腺根治术后的生化复发。取60份局限性前列腺癌患者的石蜡包埋组织标本,采用免疫组化染色检测syndecan-1和-2的表达。取10份良性前列腺增生患者的样本作为非恶性对照。利用半定量分析,对其进行染色评估。为探讨预后效果,用Kaplan—Meier生存曲线进行分析,并进行log—rank检验。在良性前列腺样本中,syndecan-1在基底层上皮细胞中有表达,在上皮分泌细胞的基侧膜上也有表达;syndecan-2则主要但挞底层上皮细胞中表达。前列腺癌样本中,两种syndecan的表达模式都转变成定位在颗粒状细胞质上。生存分析显示,在游离前列腺特异性抗原(fPSA)复发存活曲线中,正常和改变的syndecan-1和-2的表达存在显著差异(P〈0.05)。这些数据表明,syndecan—1和-2可以作为临床局灶性前列腺癌患者预后的标记物,从而改进前列腺特异性抗原(PSA)评估复发风险,增加风险分层。 | Rodrigo Ledezma Federico Cifuentes Ivan Gallegos Juan Fulla Enrique Ossandon Enrique A Castellon Hector R Contreras | 2011 | Asian Journal of Andrology2011，13，3： | 2 |
| 14 | Transmission system expansion planning by an extended genetic algorithm显示文摘 | Gallego R A Monticelli A Romero R | 1998 | IEE Proceedings-Generation Transmission and Distribution1998，145，3： | 2 |
| 15 | Role of urokinase in the superior mesenteric artery embolism显示文摘 | Gallego AM Ramirez P Rodriguez JM | 1996 | Surgery1996，120，1： | 2 |
| 16 | Remote sensing and land cover area estimation显示文摘 | F. J. Gallego | 2004 | International Journal of Remote Sensing2004，，15： | 2 |
| 17 | Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering显示文摘The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal pathologies.High-performance preclinical results have failed at clinical level,as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent brain pathologies such as stroke,Alzheimer’s and Parkinson’s diseases.An unquestionable reality is the current absence of effective therapies to neuroprotect the brain,to arrest neurodegeneration and rewire the impaired brain circuits.Part of the problem might arise from the lack of adequate in vitro and in vivo models and that most of the underlying pathophysiological mechanisms are not yet clarified.Another contributing factor is the lack of efficient systems to sustain drug release at therapeutic concentrations and enhance the survival and function of grafted cells in transplantation procedures.For medical applications the use of biomaterials of different compositions and formats has experienced a boom in the last decades.Although the greater complexity of central nervous system has probably conditioned their extensive use with respect to other organs,the number of biomaterials-based applications to treat the injured brain or in the process of being damaged has grown exponentially.Hydrogel-based biomaterials have constituted a turning point in the treatment of cerebral disorders using a new form of advanced therapy.Hydrogels show mechanical properties in the range of cerebral tissue resulting very suitable for local implantation of drugs and cells.It is also possible to fabricate three-dimensional hydrogel constructs with adaptable mesh size to facilitate axonal guidance and elongation.Along this article,we review the current trends in this area highlighting the positive impact of hydrogel-based biomaterials over the exhaustive control of drug delivery,cell engraftment and axonal reinnervation in brain pathologies. | Rocío Fernández-Serra Rebeca Gallego Paloma Lozano Daniel González-Nieto | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 18 | Recombination-Independent Mechanisms and Pairing of Homologous Chromosomes during Meiosis in Plants显示文摘成熟分裂是允许在 sexuallyreproducing 有机体平分为 gametogenesis 必要的 ploidy 的专业化真核细胞的房间部门。这复制由二个连续部门跟随了的 DNA 周围包含单人赛。保证 balancedsegregation,相应染色体对必须在分割和这工具 thatthey 必须预先与对方一起认出并且配对的第一 meiotic 移居到相反的杆。尽管有他们的相当或相同的事物的 meiotic chromosomesfind 和对极大地由进展了的机制理解,它远离充分被理解留下。与是的某著名 exceptionssuch,男果蝇,识别和在第一个 meiotic 部门的相当或相同的事物的物理连接包含相应再结合。除了这,然而,包括工厂,许多有机体也发展了一系列 recombination-independentmechanisms 便于相当或相同的事物识别并且配对,是清楚的。这些含有染色体结构和动力学, telomeres,着丝点,并且,最最近,小 RNA。与植物的一个特别焦点,我们在场这里在在第一个 meiotic division.Key 词期间配对相应染色体行动的这些早、再结合无关的事件的理解的概述: | Olivier Da Ines Maria E. Gallego Charles I. White | 2014 | Molecular Plant2014，7，3： | 2 |
| 19 | The thermal conductivity of ribbon-shaped carbon fibers显示文摘 | N.C. Gallego D.D. Edie B. Nysten J.P. Issi J.W. Treleaven G.V. Deshpande | 2000 | Carbon2000，，7： | 2 |
| 20 | The role of structure on the thermal properties of graphitic foams显示文摘 | KLETT J MCMILLAN A GALLEGO N | 2004 | Journal of Materials Science2004，39，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员