|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Super-Resolved and Dynamic Imaging of Membrane Proteins in Plant Cells Reveal Contrasting Kinetic Profiles and Multiple Confinement Mechanisms显示文摘Dear Editor, Microscopic techniques allow either a global mobility analysis of proteins with fluorescence recovery after photobleaching (FRAP) or single-protein mobility characterization with single-particle or quantum dot tracking.For instance,total internal reflection fluorescence microscopy allowed single-particle tracking (SPT) of Arabidopsis plasma membrane (PM) proteins,revealing their heterogeneous distribution,low lateral diffusion,and dynamic properties in response to salt stress (Li et al.,2011).Studies of SPT based on green fluorescent protein are unfortunately restricted by the density of proteins at the surface,since diffracted emission fluorescence prevents tracking of individual proteins separated by less than 1 μm.The recent emergence of high-density SPT techniques based on temporal emission decorrelation,such as single-particle tracking with photoactivated localization microscopy (sptPALM),allowed the diffraction limit of classic light microscopy to be broken and reach nanometerlevel spatial resolutions (Manley et al.,2008).Application of these techniques has rendered possible the characterization of the structural and dynamic heterogeneity of PM proteins with an accuracy of ~20-80 nm (Rossier et al.,2012).Such super-resolved dynamic imaging of membrane proteins has not yet been applied to any plant system.Here,we report the first use in plants of the live-cell sptPALM technique,providing a high-density super-resolved nanoscale map of individual membrane-protein motions. | Eric Hosy Alexandre Martiniere Daniel Choquet Christophe Maurel Doan- Trung Luu | 2015 | Molecular Plant2015，8，2： | 3 |
| 3 | Multicenter phase II study of oxaliplatin and sorafenib in advanced gastric adenocarcinoma after failure of cisplatin and fluoropyrimidine treatment. A gemcad study显示文摘 | M. Martin-Richard R. Gallego C. Pericay J. Garcia Foncillas B. Queralt E. Casado J. Barriuso V. Iranzo I. Juez L. Visa E. Saigi A. Barnadas X. Garcia-Albeniz J. Maurel | 2013 | Investigational New Drugs2013，，6： | 2 |
| 4 | A randomized phase II study to compare oxaliplatin plus 5-fluorouracil and leucovorin (FOLFOX4) versus oxaliplatin plus raltitrexed (TOMOX) as first-line chemotherapy for advanced colorectal cancer显示文摘 | Cristina Gravalos Antonieta Salut Carlos García-Girón Rocío García-Carbonero Ana León Isabel Sevilla Joan Maurel Beatriz Esteban Eduardo García-Rico Adolfo Murias Hernán Cortés-Funes | 2012 | Clinical and Translational Oncology2012，，8： | 2 |
| 5 | Poor prognosis Ewingrs sarcoma and peripheral primitive neuroectodermal tumours (PNET) 显示文摘 | Maurel J Rosell R Lorenzo JC | 1996 | Cancer Treat Rev1996，22，6： | 1 |
| 6 | In stent restenosis and thrombosis assessment after EP224283 injection in a rat model 显示文摘 | MAUREL B FENG CHAI F MATON M | 2013 | Atherosclerosis2013，229，2： | 1 |
| 7 | A three-dimensional parameterized finite element model of the lower cervical spine, study of the influence of the posterior articular facets 显示文摘 | Maurel N Lavaste F Skalli W | 1997 | Journal of Biomechanics1997，30，9： | 1 |
| 8 | Identification of neutral- izing conformational epitopes on the human papillomavirus type 31 major eapsid protein and functional implications 显示文摘 | Fleury MJ Touze A Maurel MC et cd | 2009 | Protein Sci2009，18，7： | 1 |
| 9 | Numerical and experimental analysis of high strength concrete beams, reinforced with high yield steel bars submitted to flexure 显示文摘 | Lorrain M Maurel O Boukari S | 1999 | Materials and Structures1999，32，224： | 1 |
| 10 | EPIC: Phase Ⅲ trial of cetuximab plus irinotecan after fluoropyfimidine and oxaliplatin failure in patients with metastatic eolorectal cancer 显示文摘 | Sobrero AF Maurel J Fehmnbacher L | 2008 | J Clin Oncol2008，26，14： | 1 |
| 11 | Sequence of the 5, flanking region of CYP3A5:comparative analysis with CYP3 A4 and CYP3 A7 显示文摘 | Jounaidi Y Guzelian PS Maurel P | 1994 | B iochem Res Commun1994，205，： | 1 |
| 12 | Plant aquaporins: membrane channels with multiple integrated functions 显示文摘 | Maurel C Verdoucq L Luu D T | 2008 | Annu Rev Plant Biol2008，59，： | 1 |
| 13 | Endovascular Approaches to Acute Aortic Type A Dissection: A CT-Based Feasibility Study显示文摘 | J. Sobocinski N. O’Brien B. Maurel M. Bartoli Y. Goueffic T. Sassard M. Midulla M. Koussa A. Vincentelli S. Haulon | 2011 | European Journal of Vascular & Endovascular Surgery2011，，4： | 1 |
| 14 | EPIC:phase Ⅲ trial of cemximab plus irinotecan after fluoropyrimidine and oxalipla-tin failure in patients with metastatic colorectal cancer显示文摘 | AIberto F Maurel Joan | 2008 | J Clin Oncol2008，26，14： | 1 |
| 15 | Poor prognosis Ewing's sarcoma and peripheral primitive neuroectodermal tumors (PNET) 显示文摘 | Maurel J Rosell R Lorenzo JC | 1996 | Cancer Treat Rev1996，22，6： | 1 |
| 16 | Aquaporins: a molecular entry into plant water relations 显示文摘 | MAUREL C CHRISPEELS M J | 2001 | Plant Physiology2001，125，： | 1 |
| 17 | Aquaporins and water permeability of plant membranes显示文摘 | | 1997 | Annu Rev Plant Physiol Mol Bio1997，，48： | 1 |
| 18 | Hemin prevents in-stent stenosis in rat and rabbit models by inducing heme-oxygenase-1显示文摘 | HYVELIN JM MAUREL B UZBEKOV R | 2010 | J Vasc Surg2010，51，2： | 1 |
| 19 | Alcohol and bone:Review of dose effects and mechanisms显示文摘 | MAUREL DB BOISSEAU N BENHAMOU CL | 2012 | Osteoporosis Int2012，23，1： | 1 |
| 20 | EPIC:PhaseⅢtrial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer显示文摘 | Sobrero A F Maurel J Fehrenbacher L | 2008 | J Clin Oncol2008，26，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员