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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Antimicrobial susceptibility patterns of Haemophilus parasuis from pigs in the United Kingdom and Spain显示文摘 | A.J. Martín de la Fuente A.W. Tucker J. Navas M. Blanco S.J. Morris C.B. Gutiérrez-Martín | 2006 | Veterinary Microbiology2006，，1： | 2 |
| 3 | Superior sagittal sinus reconstruction using a femoral venous graft after total removal of a meningioma 显示文摘 | Desse N Malikov S Fuentes S | 2013 | Case report Neurochirurgie2013，59，1： | 1 |
| 4 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 5 | Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells 显示文摘 | Zaba L C Fuentes D J Eungdamrong N J | 2009 | J Invest Dermatol2009，129，1： | 1 |
| 6 | Serial EEG findings in 27cases of creutzeldt Jacob Disease显示文摘 | Chiofalo N Fuentes A Galvezs | 1980 | Arch Neuro11980，37，3： | 1 |
| 7 | The tick protective antigen , 4D8, is a conserved protein involved in modulation of tick blood ingestion and reprocluction 显示文摘 | DE LA FUENTE J ALMAZ N C BLAS-MACHADO U | 2006 | Vuccine2006，24，19： | 1 |
| 8 | Effect of intermittent hypoxia on the reproduction of rats exposed to high altitude in the Chilean Altiplano显示文摘 | Cirkutovic M Fuentes N Bustos OE | 2009 | Hish Alt Med Biol2009，10，： | 1 |
| 9 | Characterization of sex chromosomes in rainbow trout and coho salmon using fluorescence in situ hybridization ( FISH ) 显示文摘 | Iturra P Lam N de la Fuente M | 2001 | Genetica2001，111，13： | 1 |
| 10 | Economic theory and subjective well-being: Mexico显示文摘 | FUENTES N ROJAS M | 2001 | Social Indicators Research2001，53，： | 1 |
| 11 | Influence of modifying additives on the electronic state of supported palladium显示文摘 | PESTRYAKOV A N LUNIN V V FUENTES S | 2003 | Chem Phys Lett2003，367，： | 1 |
| 12 | Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis显示文摘 | Rossen N G Fuentes S van der Spek MJ | 2015 | Gastroenterology2015，，00： | 1 |
| 13 | First lab-scale experimental results from a hybrid solar water purification and photovohaic system 显示文摘 | Vivar M Fuentes M Dodd N | 2012 | Solar Energy Materials and Solar Cells2012，98，： | 1 |
| 14 | , Interleukin6 stimulates hepatic triglyeeride secretion in rats显示文摘 | Nonogaki K Fuller G M Fuentes N L | 1995 | Endocrinology1995，136，5： | 1 |
| 15 | A ten-year review of commercial vaccine performance for control of tick infestations on cattle显示文摘 | DE LA FUENTE J ALMAZ N C CANAIJES M etal | 2007 | Anita Health Res Rev2007，8，1： | 1 |
| 16 | Baroreflex deficit blunts exercise training induced cardiovascular and autonomic adaptation in hypertensive rats显示文摘 | Moraes Silva I C De La Fuente R N Mostarda C | | 0，，03： | 1 |
| 17 | Nutritional status modulates plasma leptin, AMPK and TOR activation, and mitochondrial biogenesis:Implications for cell metabolism and growth in skeletal muscle of the fine flounder显示文摘 | Fuentes E N Safian D Einarsdottir I E | 2013 | General and Comparative Endocrinology2013，186，： | 1 |
| 18 | Ileal intussusception secondary to small bowel metastases from melanoma显示文摘 | Jean M. Butte Manuel Meneses Enrique Waugh Hugo Parada Hernán De La Fuente | 2009 | The American Journal of Surgery2009，，1： | 1 |
| 19 | Structural properties of Pd catalysts supported on Al2 O3La2 O3 prepared by sol-gel method显示文摘 | BOGDANCHIKOVA N E FUENTES S BORJA M A | 1998 | Applied Catalysis B:Environmental1998，17，： | 1 |
| 20 | Spontaneous aneurysmal portohepatic fistula:imaging diagnosis显示文摘 | Mayayo Sinués E Lidón Lorente MC Fuentes Olmo J | 2004 | Gastroenterol Hepatol2004，27，9： | 1 |
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