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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Blatella germanica as a possible cockroach vector of micro-organisms in a hospital显示文摘 | G. Risco Oliva C. Díaz O. Fuentes González M.D. Martínez C. Fernández R. Cordoví P. Más Lago N. Herrera | 2009 | Journal of Hospital Infection2009，，1： | 2 |
| 3 | Spinal alignment evolution with age:A prospective gait analysis study显示文摘AIM To describe,using gait analysis,the development of spinal motion in the growing child.METHODS Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis(9m-walk).Various kinematic parameters were recorded and analyzed such as thoracic angle(TA),lumbar angle(LA)and sagittal vertical axis(SVA).The kinetic parameters were the net reaction moments(N.m/kg)at the thoracolumbar and lumbosacral junctions.RESULTS TA and LA curves were not statistically correlated to the age(respectively,P=0.32 and P=0.41).SVA increased significantly with age(P<0.001).Moments in sagittal plane at the lumbosacral junction were statistically correlated to the age(P=0.003),underlining the fact that sagittal mechanical constraints at the lumbosacral junction increase with age.Moments in transversal plane at the thoracolumbar and lumbosacral junctions were statistically correlated to the age(P=0.0002and P=0.0006),revealing that transversal mechanical constraints decrease with age.CONCLUSION The kinetic analysis showed that during growth,a decrease of torsional constraint occurs while an increase of sagittal constraint is observed.These changes in spine biomechanics are related to the crucial role of the trunk for bipedalism acquisition,allowing stabilization despite lower limbs immaturity.With the acquisition of mature gait,the spine will mainly undergo constraints in the sagittal plane. | Sébastien Pesenti Benjamin Blondel Emilie Peltier Elke Viehweger Vincent Pomero Guillaume Authier Stéphane Fuentes Jean-Luc Jouve | 2017 | World Journal of Orthopedics2017，8，3： | 2 |
| 4 | Analytical validation of commercially available methods for acute phase proteins quantification in pigs显示文摘 | Tecles F Fuentes P Subiela S M | 2007 | Res Vet Sci2007，83，： | 1 |
| 5 | Superior sagittal sinus reconstruction using a femoral venous graft after total removal of a meningioma 显示文摘 | Desse N Malikov S Fuentes S | 2013 | Case report Neurochirurgie2013，59，1： | 1 |
| 6 | Structural analysis of nanocrystalline BaTiO3显示文摘 | CHA VEZ E FUENTES S ZARATE R A | 2010 | Journal of Molecular Structure2010，984，123： | 1 |
| 7 | Root biomass distribution and soil properties of an open woodland on a duplex soil 显示文摘 | MACINNIS-NG CMO FUENTES S O'GRADY AP 2010 | 2010 | Plant Soil2010，327，12： | 1 |
| 8 | Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development 显示文摘 | Colnot C de la Fuente L Huang S | 2005 | Development2005，132，5： | 1 |
| 9 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 10 | Open kyphoplasty for man- agement of severe osteoporotic spinal fractures 显示文摘 | Fuentes S Blondel B Mctellus P | 2009 | Neurosurgery2009，64，52： | 1 |
| 11 | Enhancement of stochastic resonance:The role of non-Gaussian noise 显示文摘 | FUENTES M A TORAL R WIO H S | 2001 | Physica A2001，295，： | 1 |
| 12 | People tracking in surveillance applications显示文摘 | FUENTES L M VELASTIN S A | 2006 | Image and Vision Computing2006，24，11： | 1 |
| 13 | Open kyphoplas-ty for management of metastatic and severe osteoporotic spinalfracture:technical note显示文摘 | Fuentes S Metellus P Pech-Gourg G | 2007 | J Neurosurg Spine2007，6，3： | 1 |
| 14 | Regional finance: a survey 显示文摘 | Dow S C Rodriguez - Fuentes C J | 1997 | Regional Studies1997，31，9： | 1 |
| 15 | The effects of silver nitrate and different carbohydrate sources on somatic embryogenesis in coffea canephora显示文摘 | Fuentes S L Calheiros M P Manetti-Filho J | 2000 | Plant Cell Tiss Org Cult2000，60，： | 1 |
| 16 | Characterization of spray deposited bismuth oxide thin films and their thermal conversion to bismuth silicate 显示文摘 | Fuentes O R Aguilera E S Veiasquez C | 2005 | Thin Solid Films2005，478，： | 1 |
| 17 | Specificity in lipases: a computational study of transestcrification of sucrose显示文摘 | FUENTES G L BALLESTEROS A R VERMA C S | 2004 | Protein Science2004，13，： | 1 |
| 18 | Fish Freshness Decay Measurement with a Colorimetric Array显示文摘 | Zaragoz~ P Ribes S Fuentes A | 2012 | Procedia Engineering2012，47，： | 1 |
| 19 | Methanol electrooxidation on PtRu nanoparticles suppor- ted on funetionalised carbon black 显示文摘 | G6mez de la Fuente J L Martinez-huerta M V Rojas S | 2006 | Catal Today2006，116，： | 1 |
| 20 | Direct synthesis of A2(Ti1-yZry)2O7(A=Gd3+,Y3+) solid solutions by ball milling constituent oxides显示文摘 | MORENO K J RODRIGO R S FUENTES A F | 2005 | J Alloys Compounds2005，390，12： | 1 |
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