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| 1 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 2 | Local Officials' Incentives and China's Economic Growth:Tournament Thesis Reexamined and Alternative Explanatory Framework显示文摘解释中国的戏剧的经济生长,研究人员们建议了一篇比赛论文。根据这篇论文,自从政治提升大部分基于本地经济生长,中央政府设置生长目标的能力在生长起了一个关键作用。我们使用省的官员的事业活动性数据测试这篇论文。为两个时间时期(19791995 和 19792002 ) ,经济性能,在年度、平均、相对的学期测量了,没影响这些官员的事业前进。我们然后勾略一个其他的分析框架为 developmentalism 解释中国本地官员的强壮的冲动并且最后,从这个解释框架拉政策含意。 | Fubing Su Ran Tao Lu Xi Ming Li | 2012 | China & World Economy2012，20，4： | 21 |
| 3 | Anti-tumor activity and immunological modification of ribosome-inactivating protein (RIP) from Momordica charantia by covalent attachment of polyethylene glycol显示文摘使核糖体失去活性的蛋白质(裂开) 是酶的一个家庭那 depurinate rRNA 并且禁止蛋白质生合成。这里,我们报导纯化,导致 apoptosis 活动,和聚乙烯乙二醇(木钉) 修正从痛苦的甜瓜种子裂开。蛋白质有 N-Asp-Val-Ser-Phe-Arg 的一个同质的 N 终端序列。而且, RIP 显示了强壮的导致 apoptosis 活动和压制的癌症细胞生长。这可能被归因于 caspases-3 的激活。使它可得到为在 vivo 申请, immunogenicity 裂开被化学修正与 20 kDa (mPEG ) 减少 2-Lys-NHS。PEGylated 和 non-PEGylated 的抑制活动对癌症房间裂开比对正常 PEGylated 的房间,和 antigenicity 裂开的强壮得多显著地被减少。我们的结果建议 PEGylated 裂开可能潜在地作为反癌症被开发药。 | Mengen Li Yiwen Chen Zhongyu Liu Fubing Shen Xiaoxiao Bian Yanfa Meng | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 11 |
| 4 | Liposomes for systematic delivery of vancomycin hydrochloride to decrease nephrotoxicity:Characterization and evaluation显示文摘Vancomycin hydrochloride(VANH),the first glycopeptide antibiotic,is a water-soluble drug for the treatment of acute osteomyelitis.Liposomal formulations of VANH have already been manipulated and characterized,which was a mean of increasing their therapeutic index,reducing their toxicity and altering drug biodistribution.One of the challenges for preparing VANH-Lips is their low encapsulation efficiency(EE).In the present study,we aim to improve the liposomal formulation of VANH for higher EE,longer systemic circulation,reduced nephrotoxicity and enhanced antimicrobial activities.Vancomycin hydrochloride-loaded liposomes(VANH-Lips)were formulated by the method of modified reverse phase evaporation.Based on the optimization of formulation with orthogonal experimental design,the average drug encapsulation efficiency and the mean particle size of VANH-Lips were found to be 40.78±2.56%and 188.4±2.77 nm.In vitro drug release of VANH-Lips possessed a sustained release characteristic and their release behavior was in accordance with the Weibull equation.After intravenous injection to mice,the mean residence time(MRT)of VANH-Lips group was significantly prolonged in vivo and the AUC value was improved as well compared with the vancomycin hydrochloride solution(VANH-Sol)group.Furthermore,the biodistribution results in mice showed that VANH-Lips decreased the accumulation of VANH in kidney after intravenous injection.In conclusion,VANH-Lips may be a potential delivery system for VANH to decrease nephrotoxicity in the treatment of osteomyelitis. | Junli Liu Zhonglan Wang Fubing Li Jinhua Gao Longmei Wang Guihua Huang | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 4 |
| 5 | Hydrocarbon resources potential and cooperation prospect along the line of the 'Belt and Road Initiative' 显示文摘 | Li Fubing Bai Guoping Yan Chunfeng | 2014 | China Mining Industry2014，24，10： | 1 |
| 6 | Mixed Cationic- Anionic Templating Route to A1-MCM-48 显示文摘 | Chen Fengxi Song Fubing Li Quanzhi | 1999 | Microporous MesoporousMater1999，29，3： | 1 |
| 7 | Pervaporation Properties of PDMS Membranes for Removal of Benzene from Aqueous Solution: Experimental and Modeling 显示文摘 | Peng Fubing Pan Fusheng Li Duo | 2005 | Chem EngJ2005，114，13： | 1 |
| 8 | A novel strategy for hydrous-ethanol utilization: Demonstration of a spark-ignition engine fueled with hydrogen-rich fuel from an onboard ethanol/steam reformer显示文摘 | Gesheng Li Zunhua Zhang Fubing You Zhixiang Pan Xintang Zhang Jian Dong Xiaohong Gao | 2013 | International Journal of Hydrogen Energy2013，，14： | 1 |
| 9 | Experimental determination of laminar burning velocities and Markstein lengths for 75% hydrous-ethanol, hydrogen and air gaseous mixtures显示文摘 | Zunhua Zhang Gesheng Li Lin Ouyang Zhixiang Pan Fubing You Xiaohong Gao | 2011 | International Journal of Hydrogen Energy2011，，20： | 1 |
| 10 | Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis显示文摘Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention. | Fubing Li Huichun Liang Hua You Ji Xiao Houjun Xia Xi Chen Maobo Huang Zhuo Cheng Chuanyu Yang Wenjing Liu Hailin Zhang Li Zeng Yingying Wu Fei Ge Zhen Li Wenhui Zhou Yi Wen Zhongmei Zhou Rong Liu Dewei Jiang Ni Xie Bin Liang Zhenzhen Liu Yanjie Kong Ceshi Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 11 | New lower bounds on eigenvalue of the Hadamard product of an matrix and its inverse显示文摘 | LI Yaotang CHEN Fubing WANG Defeng | 2009 | Linear Algebra Appl2009，430，： | 1 |
| 12 | Sedimentary and tectonic evolution of the Banquan pull-apart basin and implications for late Cenozoic dextral strike-slip movement of the Tanlu Fault Zone显示文摘The Banquan Basin is a pull-apart basin with the largest scale and the most prominent structure due to dextral slip of the Tanlu Fault Zone(TLFZ) in late Cenozoic. The depositional history of the basin records the start time and evolution of the right-lateral strike-slip movement of the TLFZ. This paper studies the sedimentary and tectonic evolution of the Banquan Basin by seismic reflection exploration, borehole detection and cosmogenic nuclide chronology. We analyze the coupling relationship between the pull-apart basin and the strike-slip fault and discuss the start time and tectonic significance of the right-lateral strikeslip of the TLFZ. Our study indicates that the Banquan Basin has undergone three evolutionary stages: weak rifting during the pre-pull-apart period, strong extension during the syn-pull-apart period and subsidence during the post-pull-apart period. This implies that the TLFZ, which controls the evolution of the basin, experienced an evolutionary process of weak activity,intensified activity and migration of activity toward the central basin. The sedimentary filling of the basin has strong response to the episodic pull-apart and extension of the basin. Lying upon the basement of the basin, a thin layer of Miocene mudstone slowly accumulated due to local rifting before the strong pull-apart event. Along with the dextral slipping and pull-apart process, the basin was filled with alluvial fan facies, fluvial facies and floodplain facies strata from bottom to top. The latest tectonic movement of the TLFZ in the North China Block in late Cenozoic was dominated by episodic dextral strike-slip motion, and this deformation pattern started at 4.01±1.27 Ma. The latest tectonic deformation in North China since late Cenozoic was governed by eastward extrusion and tectonic orogenesis of the eastern margin of the Qinghai-Xizang Plateau since late Miocene. The eastward thrusting of the Liupanshan fault zone and sinistral shearing of the Qinling fault zone led to the anticlockwise rotation and pushing of secondary blocks in North China, resulting in a planar bookshelf faulting and rotation pattern. This unique deformation pattern transferred eastwards to the North China Plain at ~4.01 Ma and the process continues to the present time.This planar bookshelf rotation, accompanied with regional sinistral strike-slip movement of the ~EW-trending boundary fault zones to the north and south of the North China Block and dextral strike-slip motion of the NNE-trending boundary faults between secondary blocks, is likely to be the long-range effect of the strong extrusion of the eastern margin of the QinghaiXizang Plateau. | Peng SHU Xiwei XU Shaoying FENG Baojin LIU Kang LI Paul TAPPONNIER Xiaojuan DENG Guihua CHEN Nuan XIA Hongtai XU Jingjing QIN Fubing HE Yan MA Rongzhang ZHENG | 2023 | Science China Earth Sciences2023，66，4： | 0 |
| 13 | A self-monitoring microneedle patch for light-controlled synergistic treatment of melanoma显示文摘Melanoma is the most aggressive and malignant form of skin cancer.Current melanoma treatment methods generally suffer from frequent drug administration as well as difficulty in direct monitoring of drug release.Here,a self-monitoring microneedle(MN)-based drug delivery system,which integrates a dissolving MN patch with aggregation-induced emission(AIE)-active PATC microparticles,is designed to achieve light-controlled pulsatile chemo-photothermal synergistic therapy of melanoma.The PATC polymeric particles,termed D/I@PATC,encapsulate both of chemotherapeutic drug doxorubicin(DOX)and the photothermal agent indocyanine green(ICG).Upon light illumination,PATC gradually dissociates into smaller particles,causing the release of encapsulated DOX and subsequent fluorescence intensity change of PATC particles,thereby not only enabling direct observation of the drug release process under light stimuli,but also facilitating verification of drug release by fluorescence recovery after light trigger.Moreover,encapsulation of ICG in PATC particles displays significant improvement of its photothermal stability both in vitro and in vivo.In a tumor-bearing mouse,the application of one D/I@PATC MN patch combining with two cycles of light irradiation showed excellent controllable chemo-photothermal efficacy and exhibited~97%melanoma inhibition rate without inducing any evident systemic toxicity,suggesting a great potential for skin cancer treatment in clinics. | Chenyuan Wang Yongnian Zeng Kai-Feng Chen Jiawei Lin Qianqian Yuan Xue Jiang Gaosong Wu Fubing Wang Yong-Guang Jia Wei Li | 2023 | Bioactive Materials2023，，9： | 0 |
| 14 | A hybrid CNN-LSTM model for diagnosing rice nutrient levels at the rice panicle initiation stage显示文摘Nitrogen(N)and potassium(K)are two key mineral nutrient elements involved in rice growth.Accurate diagnosis of N and K status is very important for the rational application of fertilizers at a specific rice growth stage.Therefore,we propose a hybrid model for diagnosing rice nutrient levels at the early panicle initiation stage(EPIS),which combines a convolutional neural network(CNN)with an attention mechanism and a long short-term memory network(LSTM).The model was validated on a large set of sequential images collected by an unmanned aerial vehicle(UAV)from rice canopies at different growth stages during a two-year experiment.Compared with VGG16,AlexNet,GoogleNet,DenseNet,and inceptionV3,ResNet101 combined with LSTM obtained the highest average accuracy of 83.81%on the dataset of Huanghuazhan(HHZ,an indica cultivar).When tested on the datasets of HHZ and Xiushui 134(XS134,a japonica rice variety)in 2021,the ResNet101-LSTM model enhanced with the squeeze-and-excitation(SE)block achieved the highest accuracies of 85.38 and 88.38%,respectively.Through the cross-dataset method,the average accuracies on the HHZ and XS134 datasets tested in 2022 were 81.25 and 82.50%,respectively,showing a good generalization.Our proposed model works with the dynamic information of different rice growth stages and can efficiently diagnose different rice nutrient status levels at EPIS,which are helpful for making practical decisions regarding rational fertilization treatments at the panicle initiation stage. | Fubing Liao Xiangqian Feng Ziqiu Li Danying Wang Chunmei Xu Guang Chu Hengyu Ma Qing Yao Song Chen | 2024 | Journal of Integrative Agriculture2024，23，2： | 0 |
| 15 | A Kirchhoff-approximation numerical model for three-dimensional acoustic scattering from rough under-ice surfaces显示文摘A KirchhofF-approximation numerical method of three-dimensional acoustic scattering from a rough under-ice surface is presented.Delaunay triangulation is used to triangulate a Gaussian rough under-ice surface,the Z-bufFer algorithm is used to remove the surface elements in the shadowed areas and obtain those in the bright areas,and the scattering intensity is calculated by the planar element method of Gordon's integration.In the numerical calculation model,the ice surface is regarded as one of local impedance,thereby incorporating it directly into the local reflection coefficient of the rough under-ice surface to calculate the scattering sound field and avoiding the approximation of the reflection coefficient in the analytical calculation model.The scattering intensities of the numerical and analytical models are compared for under-ice surfaces with large and small roughness at different incident angles and frequencies.Of the two types of results,those of the numerical calculation model are more consistent with measurements. | CHEN Wenjian LI Fubing YIN Jingwei ZHOU Shunbo SUN Hui LANG Pengyuan | 2021 | Chinese Journal of Acoustics2021，40，4： | 0 |
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