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| 1 | 脂质体镶囊的研究进展显示文摘脂质体镶囊(capsosome)是利用层层自组装技术将脂质体包埋在聚电解质微囊的囊壁中,从而形成'夹层式'结构的囊泡,其与生物膜有着极好的相容性,并兼备聚电解质微囊和脂质体的双重优点,作为药物载体具有很大的优势。本文主要介绍脂质体镶囊的特点、制备方法及影响因素和负载的药物种类,为将药物制成脂质体镶囊提供更广泛的思路和选择。 | 陈静怡 张莉 姬文捷 曹梓珍 | 2017 | 中国药学杂志2017，52，3： | 2 |
| 2 | 万古霉素载体的研究进展显示文摘万古霉素属于糖肽类窄谱抗生素,临床上主要用于治疗耐药金黄色葡萄球菌引起的严重感染,如骨髓炎、肺炎、心内膜炎等。因其不易产生细菌耐药性,受到了越来越多的关注,一直被专家称为'人类对付顽固性耐药菌株的最后一道防线'。但是,万古霉素在临床上有时需要长期大量给药,在体内会产生许多不良反应,如肾功能衰竭、耳毒性、过敏反应等。为了解决万古霉素的毒性问题,提高其疗效,研发万古霉素新剂型成为近年来新药研发的热点之一。通过检索文献,文章就万古霉素载体的研究进展进行综述。 | 田柳 杨振磊 黄桂华 | 2016 | 药物生物技术2016，23，6： | 1 |
| 3 | 纳米载药系统在骨科假体感染防治中的应用显示文摘尽管围手术期抗生素的使用和无菌技术在不断改进,但骨科手术中假体感染仍不可避免,给手术带来巨大挑战。骨科假体表面的粗糙或多孔结构,为细菌黏附、增殖和生物膜形成提供了优良的场所,是导致感染的主要原因。传统的抗生素治疗和清创手术无法完全阻止感染复发。近年来,纳米技术在生物材料、药物输送等方面展现出明显的优势,纳米药物载体能够局部缓释药物或在特定刺激下智能控释药物,可有效实现局部抗菌治疗、预防手术感染,且降低了药物的毒副作用,其独特优势可为感染防治提供新的思路和选择。目前纳米载药系统在防治骨科手术假体感染中的应用主要为骨科假体材料中添加纳米载药材料、假体表面构建载药纳米涂层、可灌注型纳米抗菌药物载体以及刺激响应型药物控释系统。本文综述了目前骨科手术假体感染防治的方法,尤其是纳米载药系统在假体周围感染防治中的研究现状。 | 潘振尧 王妍 李娇娇(综述) 陈佳龙(审校) | 2019 | 生物医学工程学杂志2019，36，5： | 0 |
| 4 | Surface-engineered liposomes for dual-drug delivery targeting strategy against methicillin-resistant Staphylococcus aureus(MRSA)显示文摘This study focused on the encapsulation of vancomycin(VAN) into liposomes coated with a red blood cell membrane with a targeting ligand, daptomycin–polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine, formed by conjugation of DAPT and Nhydroxysuccinimidyl-polyethylene glycol-1,2-distearoyl-sn-glycero-3-phosphoethanolamine.This formulation is capable of providing controlled and targeted drug delivery to the bacterial cytoplasm. We performed MALDI-TOF, NMR and FTIR analyses to confirm the conjugation of the targeting ligand via the formation of amide bonds. Approximately 45% of VAN could be loaded into the aqueous cores, whereas 90% DAPT was detected using UV–vis spectrophotometry. In comparison to free drugs, the formulations controlled the release of drugs for > 72 h. Additionally, as demonstrated using CLSM and flow cytometry, the resulting formulation was capable of evading detection by macrophage cells. In comparison to free drugs, red blood cell membrane–DAPT–VAN liposomes, DAPT liposomes, and VAN liposomes reduced the MIC and significantly increased bacterial permeability, resulting in > 80% bacterial death within 4 h. Cytotoxicity tests were performed in vitro and in vivo on mammalian cells,in addition to hemolytic activity tests in human erythrocytes, wherein drugs loaded into the liposomes and RBCDVL exhibited low toxicity. Thus, the findings of this study provide insight about a dual antibiotic targeting strategy that utilizes liposomes and red blood cell membranes to deliver targeted drugs against MRSA. | Nur Najihah Izzati Mat Rani Xiang Yi Chen Zahraa M.Al-Zubaidi Hanisah Azhari Tzar Mohd Nizam Khaitir Pei Yuen Ng Fhataheya Buang Geok Chin Tan Yin Ping Wong Mazlina Mohd Said Adeel Masood Butt Azmy A.Hamid Mohd Cairul Iqbal Mohd Amin | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，1： | 0 |
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