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| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | Analysis of main controlling factors for hydrocarbon accumulation in central rift zones of the Hailar-Tamtsag Basin using a fault-caprock dual control mode显示文摘The Hailar-Tamtsag Basin is a typical rift basin where two sets of regional caprocks are developed,i.e.,mudstone caprocks(containing a small amount of tuff)developed in strong rifting stage and fault-depression stage,respectively.The caprocks have a cumulative thickness of 50-120 m in general,and a single-layer thickness of 20-50 m,interbedded with sandstone about 1-2 m thick.The large set of mudstone is distributed continuously,as pure mudstone caprock.Forty-three mudstone and tuff samples were taken to perform displacement pressure test with our independently developed displacement pressure tester.Test result shows that the displacement pressure is 0.04-10.00 MPa,which is equivalent to 0.09-20.01 MPa after being corrected to the actual burial depth.As the burial depth increases,the displacement pressure rises gradually,and is 1-10 times greater than that of oil-bearing sandstone or conglomerate reservoir at the same burial depth.The difference between displacement pressure of mudstone caprock and sandstone or conglomerate reservoir increases greatly if the burial depth exceeds 1000 m.Because of the displacement pressure difference between caprock and reservoir,the maximum height of hydrocarbon column sealed by the caprock ranges from 300 m to 2000 m,much higher than the height of the trap closure at the same burial depth.No hydrocarbons will leak through such caprocks.Analysis of the reservoir GOI,homogeneous temperature,and crude maturity of both deep and shallow reservoirs in Well Wu-20 in the Wuerxun Depression shows that Damoguaihe II Member reservoir is a secondary reservoir developed during adjustment of early reservoir.It is mainly distributed in inverted structures.Faulting is one of the main factors breaking the integrity of caprocks.Three kinds of faults are often related to the migration of hydrocarbons across regional caprocks:the first type refers to the positive inverted faults breaking the early sealing conditions and making the hydrocarbons accumulated in the early period re-migration;the second type refers to the faults with shear mudstone smear structures which lose their continuity and open vertically when the fault throws exceed 5 times of the mudstone thickness;the third type refers to the normal faults developed in the structural inversion stage,which have a typical cataclastic structure and are easy to cause vertical migration of hydrocarbons.Hydrocarbon enriched horizons of the rift basins are co-controlled by 'fault-caprock'.Specifically,95% of the geological reserve is controlled by regional caprocks,and only 5% is controlled by open faults,secondary oil/gas reservoirs are developed over regional caprocks. | FU XiaoFei CHEN Zhe YAN BaiQuan YANG Mian SUN YongHe | 2013 | Science China Earth Sciences2013，56，8： | 15 |
| 3 | High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study显示文摘Background:Recent upsurge of new HIV infections among men who have sex with men(MSM)is a major concern in China.Paucity of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric,timely and comprehensive investigation.Methods:Mixed methods were used to recruit MSM from seven cities in China between 2012 and 2013.Recent and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme immunoassay.Syphilis and herpes simplex virus-2(HSV-2)were also tested.Results:A total of 4496 eligible MSM were recruited.The majority was aged≤35 years(77.5%),migrants(60.3%),never married(69.8%),and played receptive role in anal sex(70.5%).The HIV prevalence was 9.9%,and 41.9%were recently infected,with sensitivity/specificity adjusted HIV incidence of 8.9(95%CI:7.6-10.2)/100 Person-Years.The prevalence of history HSV-2 and syphilis were 12.5%and 8.5%,respectively.Recent HIV infection was associated with having multiple male partners(aOR=1.4,95%CI 1.1-1.9),recreational drug use(aOR=2.2,95%CI 1.6-3.0),anal bleeding(aOR=2.1,95%CI 1.4-3.0),syphilis infection(aOR=2.8,95%CI 1.9-4.3)and history HSV-2 infection(aOR=2.3,95%CI 1.5-3.3).Conclusion:High rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in China.Targeted interventions to address high-risk MSM including those having multiple partners,history of recreational drug use and syphilis or HSV-2 infection seemed to be the need of the hour. | Jun-Jie Xu Wei-Ming Tang Hua-Chun Zou Tanmay Mahapatra Qing-Hai Hu Geng-Feng Fu Zhe Wang Lin Lu Ming-Hua Zhuang Xi Chen Ji-Hua Fu Yan-Qiu Yu Jin-Xin Lu Yong-Jun Jiang Wen-Qing Geng Xiao-Xu Han Hong Shang | 2016 | Infectious Diseases of Poverty2016，5，1： | 14 |
| 4 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 5 | Carcinogenic potential of duodenal reflux juice from patients with long-standing postgastrectomy显示文摘AIM To determine, whether study on thecarcinogenic potential of reflux juice frompatients with remote gastrectomy could clarifythe inherent relationship between duodenalreflux and gastric stump cancer.METHODS A total of 37 reflux juice samples(13 Billroth T, 24 Billroth Ⅱ ) were employed inthe present study. A two- stage transformationassay using BALB/c 3T3 cells was carried out totest the initiating or promoting activity of thesesamples.RESULTS Two of 18 (11.1%) reflux samplesexerted initiating activities, whereas 9/19(47.4%) samples enhanced the MNNG-initiafingcell transformation, suggesting the duodenalreflux juice might more frequently possess thetumor-promoter activity (P = 0. 029). In addition,there was no difference in initiating activities ofthe samples irrespective of surgical procedures(P=0.488), while Billroth Ⅱ samples exhibitedstronger tumor-promoter activity than Billroth Ⅰsamples (P = 0.027). Furthermore, the promoteractivities were well correlated with thehistological changes of the stomas (rs = 0.625,P = 0.004), but neither their cytotoxicities norinitiating activities had this correlation( Probabilities were 0.523 and 0.085,respectively).CONCLUSION The duodenal reflux juice frompatients with remote postgastrectomy did havecarcinogenic potential, and suggested thattumor-promoting activity should principallyaccount for the high incidence of gastric cancerin gastrectomy patients. In contrast, it isdifficult to explain the high stump-cancerincidence with the 'N-nitroso compounds'theory-a popular theory for the intact stomachcarcinogenesis, and it seemed to be justified tofocus chemoprevention of this cancer on thetumor-promoting potential of reflux juice. | Zhe Fu Ma~1 Zhong Yu Wang~1 Jun Ran Zhang~2 Peng Gong~1 Hai Long Chen~1 ~1Departrnent of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China ~2Department of Radiation Oncology,Massachusetts General Hospital and Harvard Medical School,Charlestown,MA 02129,USADr.Zhe Fu Ma graduated from Shanxi Medical College in 1993,nowPh.D.,M.D.in Department of Surgery,Dalian Medical University,majoring gastroenteric cancer,having 4 papers published.Correspondence to:Dr.Zhe Fu Ma.Department of General Surgery,First Hospital,Dalian Medical University,Dalian 116011,China Tel.0086-411-4720334 | 2001 | World Journal of Gastroenterology2001，7，3： | 9 |
| 6 | Regional integrated environmental model system and its simulation of East Asia summer monsoon显示文摘A continuous 22-year simulation in Asia for the period of 1 January 1979 to 31 December 2000 was conducted using the Regional Integrated Environmental Model System (RIEMS 2.0) with NCEP Reanalysis Ⅱ data as the driving fields. The model processes include surface physics state package (BATS 1e), a Grell cumulus parameterization, and a modified radiation package (CCM3) with the focus on the ability of the model to simulate the summer monsoon over East Asia. The analysis results show that (1) RIEMS reproduces well the spatial pattern and the seasonal cycle of surface temperature. When regionally averaged, the summer mean temperature biases are within 1―2℃. (2) For precipitation, the model reproduces well the spatial pattern, and temporal evolution of the East Asia summer monsoon rain belt, with steady phases separated by more rapid transitions, is reproduced. The rain belt simulated by RIEMS 2.0 is closer to observation than by RIEMS 1.0. (3) RIEMS 2.0 can reasonably reproduce the large-scale circulation. | XIONG Zhe FU CongBin YAN XiaoDong | 2009 | Chinese Science Bulletin2009，54，22： | 9 |
| 7 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 8 | Correlation between the survival rate of the patients with synchronous hepatic metastases from gastric carcinoma after surgical resection and patient's index显示文摘许多研究报导了的背景肝的切除术为的利益独居并且从胃的 cancer.However 的 metachronous 转移,为从胃的癌的同步肝的转移的指示和外科的结果一直不清楚地是 defined.This 学习被执行估计主要胃的癌症和同步肝的转移的同时的联合切除术的好处和限制,以及识别影响在1月2日之间的 survival.Methods | YANG Xin-wei LI Zhe LIU Kai FU Xiao-hui YANG Jia-he WU Meng-chao | 2012 | Chinese Medical Journal2012，，5： | 8 |
| 9 | Extreme Cold Events from East Asia to North America in Winter 2020/21:Comparisons,Causes,and Future Implications显示文摘Three striking and impactful extreme cold weather events successively occurred across East Asia and North America during the mid-winter of 2020/21.These events open a new window to detect possible underlying physical processes.The analysis here indicates that the occurrences of the three events resulted from integrated effects of a concurrence of anomalous thermal conditions in three oceans and interactive Arctic-lower latitude atmospheric circulation processes,which were linked and influenced by one major sudden stratospheric warming(SSW).The North Atlantic warm blob initiated an increased poleward transient eddy heat flux,reducing the Barents-Kara seas sea ice over a warmed ocean and disrupting the stratospheric polar vortex(SPV)to induce the major SSW.The Rossby wave trains excited by the North Atlantic warm blob and the tropical Pacific La Nina interacted with the Arctic tropospheric circulation anomalies or the tropospheric polar vortex to provide dynamic settings,steering cold polar air outbreaks.The long memory of the retreated sea ice with the underlying warm ocean and the amplified tropospheric blocking highs from the midlatitudes to the Arctic intermittently fueled the increased transient eddy heat flux to sustain the SSW over a long time period.The displaced or split SPV centers associated with the SSW played crucial roles in substantially intensifying the tropospheric circulation anomalies and moving the jet stream to the far south to cause cold air outbreaks to a rarely observed extreme state.The results have significant implications for increasing prediction skill and improving policy decision making to enhance resilience in“One Health,One Future”. | Xiangdong ZHANG Yunfei FU Zhe HAN James E.OVERLAND Annette RINKE Han TANG Timo VIHMA Muyin WANG | 2022 | Advances in Atmospheric Sciences2022，39，4： | 7 |
| 10 | Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin ll-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts显示文摘Backgroud 血管收缩素Ⅱ(Ang Ⅱ) , renin-angiotensinsystem (地岬) 的一个主要受动器并且在老化纸巾增加了,能经由 theG-protein-coupled Ang Ⅱ受体类型Ⅰ(AT1 ) 刺激 JAK/STAT 小径并且导致信号变换器的原子 translocation 和抄写(STAT ) 的使活跃之物。为了推进,在老化探索 Ang Ⅱ的角色,我们在人的 replicative 上检验了 Ang Ⅱ的效果衰老的双成纤维细胞 WI-38 房间。方法人的衰老的 WI-38 房间与 Ang Ⅱ,受体对手 PD123319, valsartan, STAT3 感觉原生质标志,或 STAT3 反感觉原生质被孵化标志。方法被使用 includingelectrophoretic 活动性移动试金(EMSA ) ,西方的污点, transfection,并且激光扫描共焦的显微镜学。有教养的人的衰老的 WI-38 房间组成地表示了 metalloproteinase-1 (TIMP-1 ) 的织物禁止者,这被发现的结果,和 Ang Ⅱ在时间依赖者和剂量依赖者礼貌导致了 TIMP-1 蛋白质表示。Ang Ⅱ在两时间也导致了 STAT-DNA 有约束力的活动 -- 并且剂量依赖者礼貌。并且超级移动试金证明导致 sis 因素(SIF ) 乐队包含了 STAT3 蛋白质。STAT3 反感觉 oligonucleotides 能禁止两项 Ang Ⅱ - inducedSTAT3-DNA 绑定活动以及 TIMP-1 表示。结论 Ang Ⅱ通过激活 STAT3 的起来调整 TIMP-1expression 能在人的衰老的房间表明小径,显示那条 Ang Ⅱ - STAT3-TIMP-1 小径可以在老化纸巾涉及硬化的机制。 | WANG Xiao-dan CHEN Xiang-mei WANG Jian-zhong HONG Quan FENG Zhe FU Bo ZHOU Feng WANG Feng-yang FAN Dai-ming | 2006 | Chinese Medical Journal2006，，13： | 7 |
| 11 | Autoimmune liver disease-related autoantibodies in patients with biliary atresia显示文摘AIM To investigate the prevalence and clinical significance of autoimmune liver disease(ALD)-related autoantibodies in patients with biliary atresia(BA).METHODS Sera of 124 BA patients and 140 age-matched non-BA controls were assayed for detection of the following autoantibodies: ALD profile and specific anti-nuclear antibodies(ANAs), by line-blot assay; ANA and antineutrophil cytoplasmic antibody(ANCA), by indirect immunofluorescence assay; specific ANCAs and antiM2-3 E, by enzyme linked immunosorbent assay. Associations of these autoantibodies with the clinical features of BA(i.e., cytomegalovirus infection, degree of liver fibrosis, and short-term prognosis of Kasai procedure) were evaluated by Spearman's correlation coefficient.RESULTS The overall positive rate of serum autoantibodies in preoperative BA patients was 56.5%. ALD profile assay showed that the positive reaction to primary biliary cholangitis-related autoantibodies in BA patients was higher than that to autoimmune hepatitis-related autoantibodies. Among these autoantibodies, anti-BPO was detected more frequently in the BA patients than in the controls(14.8% vs 2.2%, P < 0.05). Accordingly, 32(25.8%) of the 124 BA patients also showed a high positive reaction for anti-M2-3 E. By comparison, the controls had a remarkably lower frequency of anti-M2-3 E(P < 0.05), with 6/92(8.6%) of patients with other liver diseases and 2/48(4.2%) of healthy controls. The prevalence of ANA in BA patients was 11.3%, which was higher than that in disease controls(3.3%, P < 0.05), but the reactivity to specific ANAs was only 8.2%. The prevalence of ANCAs(ANCA or specific ANCAs) in BA patients was also remarkably higher than that in the healthy controls(37.9% vs 6.3%, P < 0.05), but showed no difference from that in patients with other cholestasis. ANCA positivity was closely associated with the occurrence of postoperative cholangitis(r = 0.61, P < 0.05), whereas none of the autoantibodies showed a correlation to cytomegalovirus infection or the stages of liver fibrosis.CONCLUSION High prevalence of autoantibodies in the BA developmental process strongly reveals the autoimmunemediated pathogenesis. Serological ANCA positivity may be a useful predictive biomarker of postoperative cholangitis. | Shu-Yin Pang Yu-Mei Dai Rui-Zhong Zhang Yi-Hao Chen Xiao-Fang Peng Jie Fu Zheng-Rong Chen Yun-Feng Liu Li-Yuan Yang Zhe Wen Jia-Kang Yu Hai-Ying Liu | 2018 | World Journal of Gastroenterology2018，24，3： | 7 |
| 12 | Simulations and software development for the Hard X-ray Imager onboard ASO-S显示文摘China’s first solar mission,the Advanced Space-based Solar Observatory(ASO-S),is now changing from Phase B to Phase C.Its main scientific objectives are summarized as’1M2B’,namely magnetic field and two types of bursts(solar flares and coronal mass ejections).Among the three scientific payloads,Hard X-ray Imager(HXI)observes images and spectra of X-ray bursts in solar flares.In this paper,we briefly report on the progresses made by the HXI science team(data and software team)during the design phase(till May 2019).These include simulations of HXI imaging,optimization of HXI grids,development of imaging algorithms,estimation of orbital background,as well as in-orbit calibration plan.These efforts provided guidance for the engineering,improved HXI’s imaging capability and reduced the cost of the instrument. | Yang Su Wei Liu You-Ping Li Zhe Zhang Gordon JHurford Wei Chen Yu Huang Zhen-Tong Li Xian-Kai Jiang Hao-Xiang Wang Fan-Xiao-Yu Xia Chang-Xue Chen Wen-Hui Yu Fu Yu Jian Wu Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 7 |
| 13 | Temperature dependence of the point defect properties of GaN thin films studied by terahertz time-domain spectroscopy显示文摘The dielectric functions of GaN for the temperature and frequency ranges of 10–300 K and 0.3–1 THz are obtained using terahertz time-domain spectroscopy.It is found that there are oscillations of the dielectric functions at various temperatures.Physically,the oscillation behavior is attributed to the resonance states of the point defects in the material.Furthermore,the dielectric functions are well fitted by the combination of the simple Drude model together with the classical damped oscillator model.According to the values of the fitting parameters,the concentration and electron lifetime of the point defects for various temperatures are determined,and the temperature dependences of them are in accordance with the previously reported result.Therefore,terahertz time-domain spectroscopy can be considered as a promising technique for investigating the relevant characteristics of the point defects in semiconductor materials. | FANG HeNan ZHANG Rong LIU Bin LI YeCao FU DeYi LI Yi XIE ZiLi ZHUANG Zhe ZHENG YouDou WU JingBo JIN BiaoBing CHEN Jian WU PeiHeng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 6 |
| 14 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 15 | Effect of Mischmetal on As-cast Microstructure and Mechanical Properties of M2 High Speed Steel显示文摘High speed steel has been widely used in various fields due to their excellent red hardness and good wear resistance.However,the influence of mischmetal(Ce-La)on the as-cast microstructures and mechanical properties of high speed steel has rarely been reported.Thus,the microstructure and mechanical properties of M2 high speed steel with addition of mischmetal(Ce-La)were investigated.The morphology and distribution of the eutectic carbides of the steel were observed by using optical microscopy and scanning electron microscopy,and the impact toughness and bending strength were tested.The results show that adding mischmetal has an obvious effect on the microstructure and mechanical properties of M2 high speed steel.The coarse eutectic structure is refined,the weak connection of the carbide networks is broken and the flake carbides become short and fine.More networks of eutectic carbides dissolve into the matrix.When a suitable adding content of mischmetal is selected,for example,0.3mass%,the impact strength and bending strength can increase by 27% and 10.76% compared with that without mischmetal,respectively. | Qiu-xiang LIU De-ping LU Lei LU Qiang HU Qing-feng FU Zhe ZHOU | 2015 | Journal of Iron and Steel Research(International)2015，22，3： | 5 |
| 16 | Emission characteristics of offshore fishing ships in the Yellow Bo Sea, China显示文摘Maritime transport has been playing a decisive role in global trade. Its contribution to the air pollution of the sea and coastal areas has been widely recognized. The air pollutant emission inventories of several harbors in China have already been established. However,the emission factors of local ships have not been addressed comprehensively, and thus are lacking from the emission inventories. In this study, on-board emission tests of eight diesel-powered offshore fishing ships were conducted near the coastal region of the northern Yellow Bo Sea fishing ground of Dalian, China. Results show that large amounts of fine particles(< 0.5 μm, 90%) were found in maneuvering mode, which were about five times higher than those during cruise mode. Emission rates as well as emission factors based on both distance and fuel were determined during the cruise and maneuvering modes(including departure and arrival). Average emission rates and distance-based emission factors of CO, HC and PM were much higher during the maneuvering mode as compared with the cruise mode. However, the average emission rate of Nitrous Oxide(NOx) was higher during the cruise mode as compared with the maneuvering modes. On the contrary, the average distance-based emission factors of NOxwere lower during the cruise mode relative to the maneuvering mode due to the low sailing speed of the latter. | Yingshuai Liu Yunshan Ge Jianwei Tan Mingliang Fu Asad Naeem Shah Luqiang Li Zhe Ji Yan Ding | 2018 | Journal of Environmental Sciences2018，30，3： | 5 |
| 17 | Treatment-seeking behaviour and barriers to service access for sexually transmitted diseases among men who have sex with men in China:a multicentre cross-sectional survey显示文摘Background:Delayed or inappropriate treatment for sexually transmitted diseases(STDs)increases the risk of HIV acquisition and may cause other harmful outcomes.However,studies on STD treatment-seeking behaviour and correlated factors in men who have sex with men(MSM)are scarce.This information is crucial for the promotion of STD treatment-seeking behaviour and reduction of HIV transmission among Chinese MSM.Methods:During 2012-2013,a multicentre cross-sectional study was conducted in 7 Chinese cities.Participants completed an interview-questionnaire and gave venous blood samples,which were then tested for antibodies to HIV,syphilis,and herpes simplex virus-2(HSV-2).MSM who tested positive for syphilis/HSV-2 or had obvious STD-related symptoms within the last 12 months were defined as suspected STD-infected MSM.Results:Of the 4496 eligible MSM who completed this survey,24.4%(1096/4496)were categorized as suspected STD-infected MSM.35.7%(391/1096)of these MSM with suspected STD infections sought STD treatment in clinics within the last 12 months.Among MSM who did not attend STD clinics for treatment,the prevalence of syphilis and HSV-2 was significantly higher;the HIV prevalence and incidence within this subpopulation reached as high as 14.5%and 12.2/100 person-years,respectively.Multivariate logistic regression analysis indicated that having 7-12 years of education(vs.≤6 years;aOR,2.5;95%CI,1.0-6.1),≥13 years of education(vs.≤6 years:aOR,2.8;95%CI,1.2-7.0),monthly income>500 USD(vs.≤500 USD:aOR,1.5;95%CI,1.1-2.1),obvious STD-related symptoms within last 12 months(aOR,5.3;95%CI,3.7-7.5),being HIV infected(aOR,1.7;95%CI,1.1-2.6),currently syphilis infected(aOR,0.6;95%CI,0.4-0.9)and HSV-2 infected(aOR,0.6;95%CI,0.5-0.9)were independent correlates with seeking STD treatment in clinics among Chinese MSM.Conclusions:The high prevalence of STD infection coupled with a low proportion of individuals who exhibit appropriate treatment-seeking behaviour create a high risk of a growing HIV epidemic among Chinese MSM.Models that prioritize better screening for and education about STDs should be urgently implemented,especially among low-income MSM. | Jun-Jie Xu Yan-Qiu Yu Qing-Hai Hu Hong-Jing Yan Zhe Wang Lin Lu Ming-Hua Zhuang Xi Chen Ji-Hua Fu Wei-Ming Tang Wen-Qing Geng Yong-Jun Jiang Hong Shang | 2017 | Infectious Diseases of Poverty2017，6，1： | 5 |
| 18 | Evaluation of acute kidney injury as defined by the risk, injury, failure, loss, and end-stage criteria in critically ill patients undergoing abdominal aortic aneurysm repair显示文摘 | YUE Jia-ning LUO Zhe GUO Da-qiao XU Xin CHEN Bin JIANG Jun-hao YANG Jue SHI Zhen-yu ZHU Ting JU Min-jie TU Guo-wei WANG Yu-qi ZHU Du-ming FU Wei-guo | 2013 | Chinese Medical Journal2013，，3： | 4 |
| 19 | Magnetotail dipolarization fronts and particle acceleration:A review显示文摘In this paper, the particle acceleration processes around magnetotail dipolarization fronts(DFs) were reviewed. We summarize the spacecraft observations(including Cluster, THEMIS, MMS) and numerical simulations(including MHD, testparticle, hybrid, LSK, PIC) of these processes. Specifically, we(1) introduce the properties of DFs at MHD scale, ion scale, and electron scale,(2) review the properties of suprathermal electrons with particular focus on the pitch-angle distributions,(3)define the particle-acceleration process and distinguish it from the particle-heating process,(4) identify the particle-acceleration process from spacecraft measurements of energy fluxes, and(5) quantify the acceleration efficiency and compare it with other processes in the magnetosphere(e.g., magnetic reconnection and radiation-belt acceleration processes). We focus on both the acceleration of electrons and ions(including light ions and heavy ions). Regarding electron acceleration, we introduce Fermi,betatron, and non-adiabatic acceleration mechanisms;regarding ion acceleration, we present Fermi, betatron, reflection, resonance, and non-adiabatic acceleration mechanisms. We also discuss the unsolved problems and open questions relevant to this topic, and suggest directions for future studies. | Huishan FU Elena EGRIGORENKO Christine GABRIELSE Chengming LIU San LU KJHWANG Xuzhi ZHOU Zhe WANG Fang CHEN | 2020 | Science China Earth Sciences2020，63，2： | 4 |
| 20 | Three-dimensional fluorescence spectral characterization of soil dissolved organic matters in the fluctuating water-level zone of Kai County,Three Gorges Reservoir显示文摘Three-dimensional fluorescence spectroscopy was used to investigate the fluorescent properties of soil dissolved organic matter(DOM)in the water-levelfluctuation zone(WLFZ)of Kai County,Three Gorges Reservoir(TGR).Most of the soil DOM analyzed in this study was found to contain four fluorescence peaks.Peaks A and C represent humic-like fluorescence,whereas peaks B and D represent tryptophan-like fluorescence.Peaks E and F,which represent tyrosine-like fluorescence,only appeared in certain soils.Soil humus was the main source of DOM in soil,and higher concentration of soil DOM was found in the exposed soil than submerged soil.Compared to the peaks A and B,the fluorescence intensities of peaks C and D were strongly influenced by the fluctuating water level.Analysis of fluorescence intensities of different peaks in soil DOM showed that WLFZ soil was not contaminated significantly.Soil DOM contained at least two types of humic-like fluorescence groups and two types of protein-like fluorescence groups.The proportion of the content of peak A in soil organic matter was quite stable.The soil DOM in exposed soil had relatively high humification and aromaticity,and periodic submerging and exposure of soil had an impact on the humification of soil DOM. | Fang FANG Yan YANG Jinsong GUO Hong ZHOU Chuan FU Zhe LI | 2011 | Frontiers of Environmental Science & Engineering2011，5，3： | 4 |
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