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| 1 | Safety and Efficacy of Physical Thermal Ablation Combined Sorafenib for Hepatocellular Carcinoma:A Meta-analysis显示文摘Background and Aims:To compare the efficacy and safety of physical thermal ablation(PTA),including radiofrequency ablation(RFA)and microwave ablation(MWA),combined with sorafenib and physical thermal ablation alone for the control and treatment of hepatocellular carcinoma(HCC)according to the available literature.Methods:Comprehensive searches were performed on PubMed,Embase,CNKI,the Cochrane Library,China Biomedical Literature Database(known as CBM),Weipu Journal,and Wanfang Database.Meta-analysis was performed using Revman 5.3 software.Results:A total of 15 studies,consisting of 2,227 HCC patients,were selected and included in this meta-analysis.Compared with the RFA-alone group,the patients in the RFA+sorafenib group had longer 1-,2-,and 3-year overall survival(all p<0.05),better overall efficacy(p<0.0001),longer radiofrequency interval(p<0.001),and lower 2-year recurrence rate(p=0.02).The 1-year overall survival(p=0.003)and overall efficacy(p=0.002)of the MWA+sorafenib group were also higher than those of the MWA-alone group.The incidences of adverse reactions in the RFA+sorafenib group,such as hand-foot skin reactions(p<0.001),diarrhea and constipation(p=0.0001),hypertension(p=0.009),and alopecia(p<0.001),were significantly higher than those in the RFA-alone group.Conclusions:RFA or MWA combined with sorafenib has produced a better therapeutic effect on HCC than physical thermal ablation alone;however,adverse reactions have been obvious.It is necessary to evaluate the safety of combination therapy,and pay close attention to the adverse reactions that develop in patients. | Mengdi Jin Qiong Yu Yahui Liu Weiling Xu Xueqi Fu Bai Ji | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 6 |
| 2 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 3 | Sensitive and specific HBV genomic DNA detection using RCA-based QCM biosensor显示文摘 | Chunyan Yao Yang Xiang Kun Deng Han Xia Weiling Fu | 2013 | Sensors & Actuators: B Chemical2013，，： | 1 |
| 4 | Responses of ecosystem respiration and its components to fertilization in an alpine meadow on the Tibetan Plateau显示文摘 | Jing Jiang Ning Zong Minghua Song Peili Shi Weiling Ma Gang Fu Zhenxi Shen Xianzhou Zhang Hua Ouyang | 2013 | European Journal of Soil Biology2013，，： | 1 |
| 5 | Experimental Study of A Novel Piezoelectric Tumor Marker Micro-array Immunosensor显示文摘A novel 2×5 model of insert-plug piezoelectric quartz crystal tumor marker micro-array immunosensor constructed with screw clamp apparatus has been developed for quantitative detection of the tumor markers such as alpha-fetoprotein (AFP),carcino-embryonic antigen (CEA),prostate specific antigen (PSA),and human chorionic gonadotropin (hCG) in serum,in which every crystal unit can oscillate independently with the stability of±1 hertz (Hz) in air and±2 Hz in liquid.These response characteristics of Pz tumor marker micro-array immunosensor such as temperature, time-cost,reproducibility and specificity etc were also investigated.The detection ranges for AFP,CEA,PSA,and hCG obtained by Pz micro-array immunosensor were 20 ng/ml~640 ng/ml,1.56 ng/ml~50 ng/ml,1.25 ng/ml~50 ng/ml,and 2.5 mIU/ml~250 mlU/mi respectively with the coefficient of variance (CV) less than 5%.No cross-reactivates with other tumor markers in serum were observed.The results of AFP,CEA,PSA,and hCG obtained by this method from 68 serum samples were in good agreement with those given by chemiluminescence immunoassay with the correlation coefficients of 0.92,0.90,0.91,and 0.94 respectively.The Pz immunosensor regenerated by urea solution could be reused for five times without appreciable loss of response activity.Therefore,the proposed insert-plug immunosensor provides a rapid, sensitive,specific,reusable,convenient and reliable alternative for the detection of tumor markers in clinical laboratory. | Bo Zhang Weiling Fu Xue Zhang Qinghai Chen Shijun Xu Daihua Tang | 2006 | 稀有金属材料与工程2006，35，A03： | 0 |
| 6 | Loss of Heterozygosity on Chromosome 13 and its Association with the Development of Retinoblastoma显示文摘 | Xiaoli Zhang Ming Liu Hongxia Zhao Laixin Zhou Junfu Huang Jianghua Wang Weiling Fu | 2005 | Journal of US-China Medical Science2005，2，4： | 0 |
| 7 | New insights into the correlations between circulating tumor cells and target organ metastasis显示文摘Organ-specific metastasis is the primary cause of cancer patient death.The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironment.During an intermediate stage of metastasis,circulating tumor cells(CTCs)are released into the bloodstream from primary and metastatic tumors.CTCs harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth,leading to further lesions.In the past decade,numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis,assessing prognosis and monitoring treatment response et al.Furthermore,increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific metastasis.Based on the above molecules,more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs,which should provide promising prospects to administer advanced tumor.Recently,the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target,which may pave the way for us to make practical clinical strategies.In the present review,we mainly focus on the role of CTCs being involved in targeted organ metastasis,especially the latest molecular mechanism research and clinical intervention strategies related to CTCs. | Qinru Zhan Bixia Liu Xiaohua Situ Yuting Luo Tongze Fu Yanxia Wang Zhongpeng Xie Lijuan Ren Ying Zhu Weiling He Zunfu Ke | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
| 8 | Point mutation in regulatory region of msrA gene contributes to the telithromycin resistance induced by erythromycin in Staphylococcus aureus显示文摘msrA encodes an efflux protein in Staphylococcus spp.that confers inducible resistance to macrolides,such as erythromycin(ERY),but not telithromycin(TEL).Thus,msrA+S.aureus remain susceptible to TEL.Production of msrAis regulated by a 320-bp upstream region,presumably by translational attenuation,similar to regulation of erm.We investigated whether ERY could induce TEL resistance in msrA+S.aureus.MICs of ERY and TEL were determined by broth microdilution(BMD).Inducible TEL resistance was detected by a BMD checkerboard panel containing combinations of ERY and TEL and by a D-test where an ERY disk was placed 15mm from a TEL disk on a blood agar plate.Blunting of the TEL zones of inhibition proximal to the ERY disk indicated inducible resistance and no blunting indicated no inducible resistance.Approximately 400bp of the upstream regulatory region and 200bp of msrA were amplified by PCR and sequenced.The TEL MICs for 10 msrA+isolates ranged from 0.06-2g/mL(MIC90=0.25g/mL);ERY MICs were all≥32g/mL.All isolates showed an increase in TEL MICs of>2doubling dilutions(MIC90>4g/mL)in the presence of ERY;All were also positive by D-test.For 9isolates(initial TEL MIC<1g/mL),constitutive TEL resistance was selected by plating cells on Mueller-Hinton agar with 2g/mL TEL.All 9isolates grew on the selective media and were resistant to TEL(MIC ranged 2-8g/mL).Mutation to constitutive resistance occurred at a rate of 8×10-7 to 2.4×10-6.Eight of the 9resistant isolates had a single nucleotide substitution in the upstream regulatory region relative to the parent strain.Specifically,six isolates had a G to T mutation at position-222;one had a C to A mutation at-228;And one had a C to A mutation at-247.Transformation of the msrAgene with above point mutation in regulatory region into S.aureus RN4220conferred the strain resistant(MIC=8g/mL)to the telithromycin while transformants with the wild-type msrAgene remained susceptible(MIC=1g/mL)to telithromycin. | David Shafer Xiao Shali Xia Han Wang Jue Jason Loft Zhang Weidong Fu Weiling | 2013 | 国际检验医学杂志2013，34，21： | 0 |
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